Jun ichi Akahiro

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Impact of serum interleukin-18 level as a prognostic indicator in patients with epithelial ovarian carcinoma
    Jun ichi Akahiro
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Int J Clin Oncol 9:42-6. 2004
  2. ncbi request reprint Decreased expression of RIZ1 and its clinicopathological significance in epithelial ovarian carcinoma: correlation with epigenetic inactivation by aberrant DNA methylation
    Jun ichi Akahira
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pathol Int 57:725-33. 2007
  3. ncbi request reprint Prognoses and prognostic factors of carcinosarcoma, endometrial stromal sarcoma and uterine leiomyosarcoma: a comparison with uterine endometrial adenocarcinoma
    Jun ichi Akahira
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Oncology 71:333-40. 2006
  4. ncbi request reprint 14-3-3sigma in endometrial cancer--a possible prognostic marker in early-stage cancer
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 11:7384-91. 2005
  5. ncbi request reprint Nuclear receptor DAX-1 in human common epithelial ovarian carcinoma: an independent prognostic factor of clinical outcome
    Manar Abd-Elaziz
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8575
    Cancer Sci 94:980-5. 2003
  6. ncbi request reprint Expression of estrogen-responsive finger protein (Efp) is associated with advanced disease in human epithelial ovarian cancer
    Michiko Sakuma
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Gynecol Oncol 99:664-70. 2005
  7. ncbi request reprint Immunolocalization of nuclear transcription factors, DAX-1 and Ad4BP/SF-1, in human common epithelial ovarian tumors: correlations with StAR and steroidogenic enzymes in epithelial ovarian carcinoma
    Manar Abd-Elaziz
    Department of Pathology, Tohoku University School of Medicine and Tohoku University Hospital, Sendai, Japan
    Int J Gynecol Pathol 24:153-63. 2005
  8. ncbi request reprint Progesterone receptor isoforms as a prognostic marker in human endometrial carcinoma
    Sumika Saito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Cancer Sci 97:1308-14. 2006
  9. ncbi request reprint Nuclear cyclin B1 in human breast carcinoma as a potent prognostic factor
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi ken, 980 8575, Japan
    Cancer Sci 98:644-51. 2007
  10. ncbi request reprint Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 10:2687-93. 2004

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Impact of serum interleukin-18 level as a prognostic indicator in patients with epithelial ovarian carcinoma
    Jun ichi Akahiro
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Int J Clin Oncol 9:42-6. 2004
    ..In this study, for the first time, the serum concentration of IL-18 and its significance as a prognostic indicator was evaluated in patients with epithelial ovarian cancer...
  2. ncbi request reprint Decreased expression of RIZ1 and its clinicopathological significance in epithelial ovarian carcinoma: correlation with epigenetic inactivation by aberrant DNA methylation
    Jun ichi Akahira
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pathol Int 57:725-33. 2007
    ..Reduced expression of RIZ1 may play an important role in the pathogenesis and/or development of epithelial ovarian carcinoma, and is considered to be caused in part by aberrant DNA methylation...
  3. ncbi request reprint Prognoses and prognostic factors of carcinosarcoma, endometrial stromal sarcoma and uterine leiomyosarcoma: a comparison with uterine endometrial adenocarcinoma
    Jun ichi Akahira
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Oncology 71:333-40. 2006
    ....
  4. ncbi request reprint 14-3-3sigma in endometrial cancer--a possible prognostic marker in early-stage cancer
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 11:7384-91. 2005
    ..We examined expression of 14-3-3sigma, a regulator of cell proliferation, and evaluated its clinical significance in endometrioid endometrial carcinoma...
  5. ncbi request reprint Nuclear receptor DAX-1 in human common epithelial ovarian carcinoma: an independent prognostic factor of clinical outcome
    Manar Abd-Elaziz
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8575
    Cancer Sci 94:980-5. 2003
    ..In conclusion, DAX-1 immunoreactivity is considered to be a new independent marker of poor prognosis or adverse clinical outcome in patients with epithelial ovarian carcinoma, possibly through altering in situ steroids production...
  6. ncbi request reprint Expression of estrogen-responsive finger protein (Efp) is associated with advanced disease in human epithelial ovarian cancer
    Michiko Sakuma
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Gynecol Oncol 99:664-70. 2005
    ..To understand the estrogenic action on ovarian cancer, we studied the relationships between Efp and ERs expressions and the correlations of Efp expression with clinicopathological parameters in epithelial ovarian cancer...
  7. ncbi request reprint Immunolocalization of nuclear transcription factors, DAX-1 and Ad4BP/SF-1, in human common epithelial ovarian tumors: correlations with StAR and steroidogenic enzymes in epithelial ovarian carcinoma
    Manar Abd-Elaziz
    Department of Pathology, Tohoku University School of Medicine and Tohoku University Hospital, Sendai, Japan
    Int J Gynecol Pathol 24:153-63. 2005
    ..The status of intratumoral DAX-1, Ad4BP/SF-1, and StAR and steroidogenic enzymes in epithelial cells and intratumoral stromal cells of epithelial ovarian carcinoma may contribute in the progression and/or aggressiveness of these tumors...
  8. ncbi request reprint Progesterone receptor isoforms as a prognostic marker in human endometrial carcinoma
    Sumika Saito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Cancer Sci 97:1308-14. 2006
    ..0258). The results of our study demonstrated that loss or absence of PR isoform expression determined by immunohistochemistry could become an important prognostic indicator in patients with endometrioid endometrial carcinoma...
  9. ncbi request reprint Nuclear cyclin B1 in human breast carcinoma as a potent prognostic factor
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi ken, 980 8575, Japan
    Cancer Sci 98:644-51. 2007
    ..Nuclear cyclin B1-positive breast carcinoma is resistant to adjuvant therapy, and nuclear cyclin B1 immunoreactivity is a potent prognostic factor in breast carcinoma patients...
  10. ncbi request reprint Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 10:2687-93. 2004
    ..In this study, we examined the promoter methylation status and expression of 14-3-3 sigma and evaluated its clinical significance in epithelial ovarian cancer...
  11. ncbi request reprint Promoter methylation status and expression of TMS1 gene in human epithelial ovarian cancer
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8574, Japan
    Cancer Sci 95:40-3. 2004
    ..Our results suggest that aberrant methylation of TMS1 may play a role in the pathogenesis of ovarian cancer...
  12. ncbi request reprint Promoter methylation status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer
    Michiko Sakuma
    Department of Obstetrics and Gynecology, Tohoku University, Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku Sendai, 980 8574 Japan
    Cancer Sci 98:380-6. 2007
    ..021). Our results suggest that aberrant promoter methylation of the Cyclin D2 gene is significantly associated with patient prognosis in epithelial ovarian cancer...
  13. ncbi request reprint StAR and progesterone producing enzymes (3beta-hydroxysteroid dehydrogenase and cholesterol side-chain cleavage cytochromes P450) in human epithelial ovarian carcinoma: immunohistochemical and real-time PCR studies
    Manar Abd-Elaziz
    Department of Pathology, Tohoku University School of Medicine and Tohoku University Hospital, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Cancer Sci 96:232-9. 2005
    ....
  14. ncbi request reprint Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer
    Kyoko Ota
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Gynecol Pathol 26:334-40. 2007
    ..In conclusion, SLC22A16 was abundantly expressed in clear-cell adenocarcinoma. Our results suggest that adriamycin-related chemicals that are taken up via SLC22A16 may have the potential to be effective against clear-cell adenocarcinoma...
  15. ncbi request reprint Expression of androgen receptor and 5alpha-reductases in the human normal endometrium and its disorders
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Int J Cancer 99:652-7. 2002
    ..Androgenic actions may be also regulated predominantly by serum testosterone and not by DHT in endometrial hyperplasia because of the absence of 5alpha-reductases in the site of its actions...
  16. ncbi request reprint Orphan nuclear receptor DAX-1 in human endometrium and its disorders
    Sumika Saito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendia 980 8575, Japan
    Cancer Sci 96:645-52. 2005
    ....
  17. ncbi request reprint Prognostic significance of second-look laparotomy for surgically confirmed early-stage epithelial ovarian cancer: a multicenter retrospective study
    Naoko Sato
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Int J Clin Oncol 8:40-4. 2003
    ..In the present study, we conducted a multicenter retrospective analysis to elucidate the prognostic significance of second-look laparotomy (SLL) in early-stage epithelial ovarian cancer that was confirmed by complete surgical exploration...
  18. doi request reprint Clinicopathological significance of circadian rhythm-related gene expression levels in patients with epithelial ovarian cancer
    Hideki Tokunaga
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Acta Obstet Gynecol Scand 87:1060-70. 2008
    ..In this study, we measured the expression levels of clock genes and correlated their expression levels with clinicopathological parameters in epithelial ovarian cancer...
  19. ncbi request reprint Expression of organic cation transporter SLC22A16 in human endometria
    Naoko Sato
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Gynecol Pathol 26:53-60. 2007
    ..Our findings also suggest that it may be possible to use progestins to increase the response of endometrioid endometrial carcinoma with SLC22A16 expression to adriamycin-based chemotherapeutic regimens...
  20. ncbi request reprint Clinical experience with combination paclitaxel and carboplatin therapy for advanced or recurrent carcinosarcoma of the uterus
    Masafumi Toyoshima
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Gynecol Oncol 94:774-8. 2004
    ..The purpose of the study was to evaluate the efficacy of combination chemotherapy with paclitaxel and carboplatin in patients with advanced or recurrent carcinosarcoma of the uterus...
  21. doi request reprint Intratumoral concentration of sex steroids and expression of sex steroid-producing enzymes in ductal carcinoma in situ of human breast
    Rie Shibuya
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Endocr Relat Cancer 15:113-24. 2008
    ..Therefore, estradiol and DHT may play important roles in the development of DCIS of the human breast...
  22. ncbi request reprint 17Beta-hydroxysteroid dehydrogenases in human endometrium and its disorders
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mol Cell Endocrinol 248:136-40. 2006
    ..These results indicated that 17-HSD types 2 and 5 play an important role in the regulation of in situ estrogen production in endometrial carcinoma...
  23. ncbi request reprint Differential expression of progesterone receptor isoforms A and B in the normal ovary, and in benign, borderline, and malignant ovarian tumors
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Aoba ku, Sendai 980 8574, Japan
    Jpn J Cancer Res 93:807-15. 2002
    ..These results suggest that down-regulation of PRA is associated with the development of ovarian epithelial carcinoma...
  24. ncbi request reprint Primary vaginal adenosarcoma with sarcomatous overgrowth
    Masafumi Toyoshima
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba, Sendai 980 8574, Japan
    Gynecol Oncol 95:759-61. 2004
    ..Primary vaginal adenosarcomas are extremely rare, and typical adenosarcomas are of low malignancy. However, aggressive forms with sarcomatous overgrowth have been reported, those appear to have a poor prognosis...
  25. ncbi request reprint Aromatase in human breast carcinoma as a key regulator of intratumoral sex steroid concentrations
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Health Sciences, Sendai, Japan
    Endocr J 55:455-63. 2008
    ..Aromatase inhibitors may thus have additional antiproliferative effects through increasing local DHT concentration with estrogen deprivation...
  26. ncbi request reprint Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma
    Osamu Dohi
    Department of Orthopaedic Surgery, Tohoku Kosai Hospital, 2 3 11 Kokubuncho, Aoba ku, Sendai, Japan
    Cancer Sci 99:518-23. 2008
    ..In addition, these data suggest the potential for a novel endocrine therapy in osteosarcoma using clinically available inhibitors of progesterone and estrogen actions...
  27. ncbi request reprint Progesterone production and actions in the human central nervous system and neurogenic tumors
    Tsukasa Inoue
    Department of Pathology, Second Department of Surgery, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Clin Endocrinol Metab 87:5325-31. 2002
    ....
  28. ncbi request reprint New trends of immunohistochemistry for making differential diagnosis of breast lesions
    Takuya Moriya
    Department of Pathology, Tohoku University Hospital, Aoba ku, Sendai, Japan
    Med Mol Morphol 39:8-13. 2006
    ..Some of the lobular carcinomas are positive for 34betaE12, but they are consistently negative for CK5/6. Comparison with histopathological findings of hematoxylin and eosin is essential to make proper diagnosis in the individual case...
  29. ncbi request reprint Gastrointestinal immunophenotype in adenocarcinomas of the uterine cervix and related glandular lesions: a possible link between lobular endocervical glandular hyperplasia/pyloric gland metaplasia and 'adenoma malignum'
    Yoshiki Mikami
    Department of Pathology, Tohoku University Graduate School of Medical Science, Sendai, Japan
    Mod Pathol 17:962-72. 2004
    ..p16INK4 immunohistochemistry appears to be a promising diagnostic tool, but pathologists should be aware of frequent negative staining in MDAs, which can be a source of erroneous diagnosis...
  30. ncbi request reprint Ovarian epithelial carcinoma with estrogen-producing stroma
    Hideki Tokunaga
    Department of Obstetrics and Gynecology, Tohuku University School of Medicine, Sendai, Japan
    Pathol Int 57:285-90. 2007
    ....