Genomes and Genes
University of Tokyo
Organization: University of Tokyo
- What should we do to raise awareness on the issue of cancer in the global health agenda?Norie Kawahara
Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo, 153 8904, Japan
Jpn J Clin Oncol 40:i82-85. 2010..Based on the challenges and outlook for placing cancer on the global health agenda, we conduct analysis that focuses on top-down mechanisms and bottom-up mechanisms...
- Modular synthesis of benzo[b]phosphole derivatives via BuLi-mediated cyclization of (o-alkynylphenyl)phosphineHayato Tsuji
Department of Chemistry, School of Science, The University of Tokyo, Hongo, Tokyo, Japan
Org Lett 10:2263-5. 2008..An example is given for the synthesis of a bis-benzo[b]phosphole, which can be further converted to the corresponding benzo[b]phosphole oxide possessing high electron affinity...
- The encoding process of nonconfigural information in contextual cuingHirokazu Ogawa
Cognitive Science Research Group, Research Center for Advanced Science and Technology, University of Tokyo, Japan
Percept Psychophys 70:329-36. 2008....
- Chemiluminescent-based method for heme determination by reconstitution with horseradish peroxidase apo-enzymeTatsuru Masuda
Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro ku, Tokyo 153 8902, Japan
Anal Biochem 355:307-9. 2006
- Lepidopteran ortholog of Drosophila breathless is a receptor for the baculovirus fibroblast growth factorSusumu Katsuma
Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
J Virol 80:5474-81. 2006..In these cells, cell motility triggered by vFGF was markedly reduced. These results strongly suggest that the Btl orthologs, BmBtl and SfBtl, are the receptors for vFGF, which mediate vFGF-induced host cell chemotaxis...
- Individual variation in feeding habitat use by adult female green sea turtles (Chelonia mydas): are they obligately neritic herbivores?Hideo Hatase
Ocean Research Institute, University of Tokyo, Nakano, Tokyo 164 8639, Japan
Oecologia 149:52-64. 2006..These results and previous findings suggest that ontogenetic habitat shifts by sea turtles are facultative, and consequently, their life histories are polymorphic...
- Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XLT Konishi
Department of Surgical Oncology, The University of Tokyo, Hongo, Tokyo, Japan
Oncogene 25:3160-9. 2006..hRFI might be a novel therapeutic target for gene therapy in colorectal cancer...
- A novel culture system for porcine odontogenic epithelial cells using a feeder layerM J Honda
Tooth Regeneration, Division of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Tokyo, Japan
Arch Oral Biol 51:282-90. 2006..These results show that the system is capable of sustaining the multiplication of odontogenic epithelial cells with the characteristics of ameloblasts...
- Expression of the floral B-function gene SLM2 in female flowers of Silene latifolia infected with the smut fungus Microbotryum violaceumYusuke Kazama
Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, FSB 601, 5 1 5 Kashiwanoha, Kashiwa, Chiba, 277 8562 Japan
Plant Cell Physiol 46:806-11. 2005..Smut-infected females provide a useful system for clarifying the relationship between the B-function gene and the sex determination factor...
- Computational strategies for analyzing data in gene expression microarray experimentsTero Aittokallio
Department of Computational Biology, University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa shi, Chiba 277 8562, Japan
J Bioinform Comput Biol 1:541-86. 2003..Solid knowledge of microarray informatics contributes to the implementation of more efficient computational protocols for the given data obtained through microarray experiments...
- Pseudomonas aeruginosa isolated from marine environments in Tokyo BayN Kimata
Ocean Research Institute, The University of Tokyo, Nakano, Tokyo 164 8639, Japan
Microb Ecol 47:41-7. 2004..The results confirmed that the majority of isolates from the bay were P. aeruginosa. Immuno-chemical analyses of the seawater results indicate that P. aeruginosa is commonly present in coastal marine environments and sheds OprP...
- Dibasic amino acid residues at the carboxy-terminal end of kinase homology domain participate in the plasma membrane localization and function of phosphatidylinositol 5-kinase gammaManabu Arioka
Department of Biotechnology, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
Biochem Biophys Res Commun 319:456-63. 2004....
- Ancestral loss of short wave-sensitive cone visual pigment in lorisiform prosimians, contrasting with its strict conservation in other prosimiansShoji Kawamura
Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Seimeitou 502, 5 1 5 Kashiwanoha, Kashiwa, Chiba 277 8562, Japan
J Mol Evol 58:314-21. 2004....
- Influences of age and sex on abdominal muscle and subcutaneous fat thicknessHiroaki Kanehisa
Department of Life Sciences Sports Sciences, University of Tokyo, Komaba 3 8 1, Meguro ku, 153 8902 Tokyo, Japan
Eur J Appl Physiol 91:534-7. 2004..subcutaneous fat rather than muscle thickness reflected waist circumference, regardless of age and gender...
- Anthropogenic lead inputs to the western Pacific during the 20th centuryMayuri Inoue
Ocean Research Institute, The University of Tokyo, 1 15 1 Minamidai Nakano ku, Tokyo 164 8639, Japan
Sci Total Environ 406:123-30. 2008....
- In-fiber microchannel device filled with a carbon nanotube dispersion for passive mode-lock lasingAmos Martinez
Department of Electronic Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
Opt Express 16:15425-30. 2008..All-fiber high-energy, passive mode-locked lasing is demonstrated with an output power of 13.5 dBm. The key characteristics of the device are compactness and robustness against optical, mechanical and thermal damage...
- Cyanobacteriochromes: a new superfamily of tetrapyrrole-binding photoreceptors in cyanobacteriaMasahiko Ikeuchi
Department of Life Sciences, Biology, The University of Tokyo, Komaba, Meguro, Tokyo, 153 8902, Japan
Photochem Photobiol Sci 7:1159-67. 2008..We also discussed the functionality of the other candidate GAFs, structure and evolution...
- Development of structured ICD-10 and its application to computer-assisted ICD codingTakeshi Imai
Graduate School of Medicine, The University of Tokyo, Japan
Stud Health Technol Inform 160:1080-4. 2010..These results not only demonstrate the basic feasibility of our coding framework but might also inform the development of the information model for formal description framework in the ICD11 revision...
- Relationship between muscle fiber type and tendon properties in young malesKeitaro Kubo
Department of Life Science Sports Sciences, University of Tokyo, Komaba 3 8 1, Meguro ku, Tokyo 153 8902, Japan
Muscle Nerve 42:127-9. 2010..TPT did not correlate significantly with the maximal elongation and stiffness of tendon. In conclusion, we found that the muscle fiber type was not related to the properties of tendons...
- Correlates of sharing injection equipment among male injecting drug users in Kathmandu, NepalKrishna C Poudel
Department of Community and Global Health, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Int J Drug Policy 21:507-10. 2010..We explored the correlates of sharing injection equipment (having injected with a needle or syringe previously used by another) among male IDUs in Kathmandu, Nepal...
- Influence of polymorphism in dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related (DC-SIGNR) gene on HIV-1 trans-infectionDayong Zhu
Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Biochem Biophys Res Commun 393:598-602. 2010..95). Thus, our results suggest that the variation of the tested DC-SIGNR genotypes affects the efficacy of trans-infection by affecting the amounts of the protein expressed on the cell surface...
- Permuted tRNA genes in the nuclear and nucleomorph genomes of photosynthetic eukaryotesShinichiro Maruyama
Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 0033, Japan
Mol Biol Evol 27:1070-6. 2010..Taken together, our data demonstrate that permuted tRNA is an evolutionarily conserved and fundamental element in tiny eukaryotic genomes...
- Major orthopaedic surgeries for haemophilia with inhibitors using rFVIIaH Takedani
Department of Joint Surgery, Research Hospital of the Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Haemophilia 16:290-5. 2010..In addition, our data also concurs with the data of several previous reports which showed that orthopaedic surgery for haemophilia patients with inhibitors by means of rFVIIa is safe and effective...
- Subcellular distribution of urea transporter in the collecting tubule of shark kidney is dependent on environmental salinityYoko Yamaguchi
Laboratory of Physiology, Ocean Research Institute, University of Tokyo, 1 15 1 Minamidai, Nakano, Tokyo 164 8639, Japan
J Exp Zool A Ecol Genet Physiol 311:705-18. 2009..These results indicate that the accumulation of UT to the apical plasma membrane of the collecting tubule of Triakis is an important factor for regulating urea reabsorption in the kidney...
- Inconsistencies of genome annotations in apicomplexan parasites revealed by 5'-end-one-pass and full-length sequences of oligo-capped cDNAsHiroyuki Wakaguri
Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha, Kashiwa, Chiba, Japan
BMC Genomics 10:312. 2009..To improve upon the current genome annotations, as well as to validate the importance for physical cDNA clone resources, we generated a large-scale collection of full-length cDNAs for several apicomplexa parasites...
- Nucleation and growth of aragonite crystals at the growth front of nacres in pearl oyster, Pinctada fucataKazuko Saruwatari
Department of Earth and Planetary Science, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Biomaterials 30:3028-34. 2009..These results indicate that the crystal growth of aragonite at the growth front results from not only biotic process but also inorganic ones such as geometrical selection and mineral bridges...
- Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutationsEugene Futai
Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan
J Biol Chem 284:13013-22. 2009..These results suggest that NCT is dispensable for the protease activity of gamma-secretase...
- Properties of cytochrome bd plastoquinol oxidase from the cyanobacterium Synechocystis sp. PCC 6803Tatsushi Mogi
Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
J Biochem 145:395-401. 2009....
- Regulatory molecules required for nucleotide-sensing Toll-like receptorsShin Ichiroh Saitoh
Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Immunol Rev 227:32-43. 2009..These molecules are potential therapeutic targets for controlling dysregulated TLR7/9 responses in autoimmune diseases...
- Phospholipase Cgamma2 is necessary for separation of blood and lymphatic vasculature in miceHirotake Ichise
Laboratory of Gene Expression and Regulation, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
Development 136:191-5. 2009..These findings indicate that PLCgamma2 plays an essential role in initiating and maintaining the separation of the blood and lymphatic vasculature...
- CCLS96.1, a member of a multicopy gene family, may encode a non-coding RNA preferentially transcribed in reproductive organs of Silene latifoliaRyuji Sugiyama
Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 0033, Japan
DNA Res 10:213-20. 2003..Genomic Southern hybridization showed that the S. latifolia genome contains numerous CCLS96.1 homologs. These results suggest that the transcripts of CCLS96.1 play some role as multiple non-coding RNAs in S. latifolia...
- Molecular strategies to treat vascular diseases: circulating vascular progenitor cell as a potential target for prophylactic treatment of atherosclerosisMasataka Sata
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo and PRESTO, Japan Science and Technology Agency, Kawaguchi
Circ J 67:983-91. 2003....
- Analysis of dose distribution in gamma knife radiosurgery for multiple targetsA Terahara
Department of Radiology, Faculty of Medicine, University of Tokyo, Japan
Int J Radiat Oncol Biol Phys 47:1431-4. 2000..The aim of this study is to evaluate the actual effect of irradiation for other targets in dose planning for the treatment of multiple metastases with Gamma Knife...
- Adhesion formation can be reduced by the suppression of transforming growth factor-beta1 activityN Fukui
Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, Japan
J Orthop Res 18:212-9. 2000..Considering the various possible measures to control the activity of the growth factor, suppression of transforming growth factor-beta may be a novel, potent approach to preventing adhesions...
- The p44/42 mitogen-activated protein kinase cascade is involved in the induction and maintenance of astrocyte stellation mediated by protein kinase CK Abe
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
Neurosci Res 36:251-7. 2000..These results suggest that the MEK/ERK cascade is involved in the induction and maintenance of astrocyte stellation mediated by PKC, but not by cyclic AMP signaling...
- Genetic alterations in pediatric medulloblastomas detected by comparative genomic hybridizationT Nishizaki
Department of Neurosurgery, Yamaguchi University School of Medicine, Yamaguchi, Japan
Pediatr Neurosurg 31:27-32. 1999..Our results may indicate that further acquisition of genetic alterations detected by comparative genomic hybridization are associated with unfavorable prognosis in patients with medulloblastomas...
- Pulmonary nodule mimicking lung cancer in a human immunodeficiency virus type-1 infected patientT Takahashi
Department of Infectious Diseases, Institute of Medical Science, University of Tokyo, Japan
J Med 30:93-9. 1999....
- Cohesin Rec8 is required for reductional chromosome segregation at meiosisY Watanabe
Cell Cycle Laboratory, Imperial Cancer Research Fund, London, UK
Nature 400:461-4. 1999..This results in the reductional pattern of chromosome segregation necessary to reduce a diploid zygote to haploid gametes...
- Preparation and application of anti-idiotypic antibody against anti-gibberellin A4 antibodyY Suzuki
Department of Applied Biological Chemistry, University of Tokyo, Japan
Biosci Biotechnol Biochem 63:648-54. 1999..These results suggest the possible application of anti-idiotypic antibody as a handy and stable source of an enzymatic tracer for ELISA by production of fusion protein of the scFv and an appropriate enzyme...
- Magnetic resonance imaging of acute cerebellar ataxia: report of a case with gadolinium enhancement and review of the literatureZ Kato
Department of Pediatrics, Gifu University School of Medicine, Japan
Acta Paediatr Jpn 40:138-42. 1998..This is the first report of an ACA case with positive gadolinium enhancement. Cases of ACA with MRI abnormalities are reviewed and the clinical entity of ACA is discussed in association with autoimmune encephalitis...
- Formation of lipofuscin-like autofluorescent materials in NG108-15 cells: involvement of lysosomal protein degradationY Mochizuki
Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo ku, Japan
Gerontology 44:1-8. 1998....
- Direct detection of Mycobacterium tuberculosis using polymerase chain reaction assay among patients with hepatic granulomaD E Alcantara-Payawal
Department of Internal Medicine II, Faculty of Medicine, University of Tokyo, Japan
J Hepatol 27:620-7. 1997....
- Unfused C2C12 mouse skeletal muscle cells express neurofilament 140K proteinR Matsuda
Department of Life Sciences, University of Tokyo, Japan
Cell Struct Funct 22:117-21. 1997..NF140K and desmin double-positive cells were also found in a primary culture of adult mouse skeletal muscle cells. The results suggest that NF140K may be a unique marker for uncommitted myoblasts...
- Ca2+-dependent membrane bound protein fraction from rabbit gastric mucosa contains a protein whose histidyl residue is phosphorylatedT Urushidani
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Hongo, Japan
Biochim Biophys Acta 1356:71-83. 1997..These results suggest that p40 is extramitochondrial alpha subunit of succinyl-CoA synthetase or its homologue...
- Linkage-disequilibrium mapping narrows the Fukuyama-type congenital muscular dystrophy (FCMD) candidate region to <100 kbT Toda
Department of Human Genetics, University of Tokyo, Japan
Am J Hum Genet 59:1313-20. 1996..Thus, the FCMD gene is most likely to lie within a region of <100 kb containing D9S2107...
- Multiple signaling pathways in gene expression during sugar starvation. Pharmacological analysis of din gene expression in suspension-cultured cells of ArabidopsisY Fujiki
Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo ku, Hongo, Tokyo 113 0033, Japan
Plant Physiol 124:1139-48. 2000..These results indicate that multiple signaling pathways, mediated by different types of protein phosphatases, regulate gene expression during sugar starvation...
- Redox regulation of the glucocorticoid receptorH Tanaka
Department of Clinical Immunology and AIDS Research Center, Institute of Medical Science, University of Tokyo, Japan
Antioxid Redox Signal 1:403-23. 1999..Moreover, it is suggested that redox regulation of the receptor function is one of dynamic cellular responses to environmental stimuli and plays an important role in orchestrated crosstalk between central and peripheral stress responses...
- X-ray magnetic circular dichroism imaging with hard X-raysK Sato
Department of Applied Physics, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 8656, Japan
J Synchrotron Radiat 8:1021-6. 2001..The observed contrast in the image was reversed by inversion of the magnetic field. Furthermore, the contrast was reversed again at a photon energy of 32 eV above the cobalt K-absorption edge...
- Identification of a novel adrenomedullin gene family in teleost fishMaho Ogoshi
Ocean Research Institute, The University of Tokyo, Nakano, 164 8639, Tokyo, Japan
Biochem Biophys Res Commun 311:1072-7. 2003..The present study shows for the first time the presence of a novel AM family in teleost fish that is independent from CGRP and amylin, which further suggests the possible existence of multiple AMs in mammals...
- Age-related changes of Alzheimer's disease-associated proteins in cynomolgus monkey brainsNobuyuki Kimura
Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
Biochem Biophys Res Commun 310:303-11. 2003....
- Structural development of synthetic retinoids and thalidomide-related moleculesYuichi Hashimoto
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, 113 0032, Tokyo, Japan
Cancer Chemother Pharmacol 52:S16-23. 2003....
- Impaired liver regeneration after partial hepatectomy in db/db miceHirofumi Yamauchi
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
Exp Toxicol Pathol 54:281-6. 2003..This suggests that db/db mice may be valuable as one of the animal models for the investigation of the effects of steatosis on the liver regeneration...
- Midazolam can potentiate the analgesic effects of intrathecal bupivacaine on thermal- or inflammatory-induced painTomoki Nishiyama
Department of Anesthesiology, The University of Tokyo, Japan
Anesth Analg 96:1386-91, table of contents. 2003..In conclusion, intrathecally administered midazolam and bupivacaine had synergistic analgesic effects on acute thermal- or inflammatory-induced pain, with decreased behavioral side effects...
- Coronary-coronary bypass and pulmonary artery reconstruction related to Wegener granulomatosis in a 22-year-old womanArata Murakami
Department of Cardiothoracic Surgery, Faculty of Medicine, University of Tokyo, Japan
J Thorac Cardiovasc Surg 125:721-3. 2003
- Analysis of the conformational energy landscape of human snRNA with a metric based on tree representation of RNA structuresJunji Kitagawa
Information Science Seminar, Graduate School of Engineering, University of Tokyo, Japan
Nucleic Acids Res 31:2006-13. 2003..This result reflects different biological functions of these snRNAs in the pre-mRNA splicing process. The results of analyzing tRNAs and rRNAs show that the conformational energy landscapes of these sequences have multi-valley profiles...
- The HAT2 gene, a member of the HD-Zip gene family, isolated as an auxin inducible gene by DNA microarray screening, affects auxin response in ArabidopsisShinichiro Sawa
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1, Hongo, Tokyo 113 0033, Japan
Plant J 32:1011-22. 2002..Together with the results of RNA blotting and biochemical analyses, these findings suggest that HAT2 plays opposite roles in the shoot and root tissues in regulating auxin-mediated morphogenesis...
- Saphenous vein homograft containing a valve as a right ventricle-pulmonary artery conduit in the modified Norwood operationArata Murakami
Department of Cardiothoracic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
J Thorac Cardiovasc Surg 124:1041-2. 2002
- Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pyloriS Maeda
Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Gut 50:771-8. 2002..Although it is reported that Helicobacter pylori induces apoptosis on gastric epithelial cells, the mechanism remains unknown. Antiapoptotic effects generated by H pylori have not yet been evaluated...
- Seasonal atopic dermatitis in dogs sensitive to a major allergen of Japanese cedar (Cryptomeria japonica) pollenKenichi Masuda
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
Vet Dermatol 13:53-59. 2002..These findings indicated that Cry j 1 was the major allergen recognized by IgE and lymphocytes and resulted in the development of type I hypersensitivity to CJ pollen allergen in these atopic dogs...
- Eradication of poliomyelitisAkio Nomoto
Department of Microbiology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Nat Immunol 3:205-8. 2002
- Differential growth regulation in human melanoma cell lines by TIMP-1 and TIMP-2T Hoashi
Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Biochem Biophys Res Commun 288:371-9. 2001..The growth of the primary melanoma cell lines was stimulated by TIMP-1 and inhibited by TIMP-2. In contrast, the growth of the visceral metastatic melanoma cell line was stimulated by TIMP-2...
- Isolation, characterization and chromosomal assignment of the human WNT7A geneS Ikegawa
Laboratory of Molecular Medicine, University of Tokyo, Japan
Cytogenet Cell Genet 74:149-52. 1996..Furthermore, we have isolated a genomic clone of WNT7A and mapped it to chromosome 3p25 by fluorescent in situ hybridization...