T Sakuma

Summary

Affiliation: Toyama Medical and Pharmaceutical University
Country: Japan

Publications

  1. ncbi A novel female-specific member of the CYP3A gene subfamily in the mouse liver
    T Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Arch Biochem Biophys 377:153-62. 2000
  2. ncbi Regulation of mouse hepatic CYP2D9 mRNA expression by growth and adrenal hormones
    Kanokwan Jarukamjorn
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Thailand
    Drug Metab Pharmacokinet 21:29-36. 2006
  3. ncbi Regulation of the expression of two female-predominant CYP3A mRNAs (CYP3A41 and CYP3A44) in mouse liver by sex and growth hormones
    Tsutomu Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Arch Biochem Biophys 404:234-42. 2002
  4. ncbi Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs
    Tsutomu Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Toyama 930 0194, Japan
    Drug Metab Dispos 32:376-8. 2004
  5. ncbi Suppression of female-specific murine Cyp2b9 gene expression by growth or glucocorticoid hormones
    Tsutomu Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Biochem Biophys Res Commun 323:776-81. 2004
  6. ncbi Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat
    T Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan
    Xenobiotica 31:223-37. 2001
  7. ncbi Induction of CYP1A2 by phenobarbital in the livers of aryl hydrocarbon-responsive and -nonresponsive mice
    T Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Drug Metab Dispos 27:379-84. 1999
  8. ncbi Collaborated regulation of female-specific murine Cyp3a41 gene expression by growth and glucocorticoid hormones
    Tsutomu Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930 0194 Toyama, Japan
    Biochem Biophys Res Commun 314:495-500. 2004
  9. ncbi Sex-associated expression of mouse hepatic and renal CYP2B enzymes by glucocorticoid hormones
    K Jarukamjorn
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
    Biochem Pharmacol 62:161-9. 2001
  10. ncbi Localization of estradiol-responsive region in the phenobarbital-responsive enhancer module of mouse Cyp2b-10 gene
    M Yamamoto
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-0194, Japan
    J Biochem Mol Toxicol 15:76-82. 2001

Collaborators

Detail Information

Publications31

  1. ncbi A novel female-specific member of the CYP3A gene subfamily in the mouse liver
    T Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Arch Biochem Biophys 377:153-62. 2000
    ..These observations indicated that CYP3A41 is a female-specific CYP3A and one of the major CYP3A forms in the female mouse liver...
  2. ncbi Regulation of mouse hepatic CYP2D9 mRNA expression by growth and adrenal hormones
    Kanokwan Jarukamjorn
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Thailand
    Drug Metab Pharmacokinet 21:29-36. 2006
    ..Dex-administration in adrenalectomized mice significantly elevated CYP2D9 mRNA expression levels. These findings suggest that an adrenal hormone participates in the regulatory mechanism of CYP2D9 mRNA expression in association with GH...
  3. ncbi Regulation of the expression of two female-predominant CYP3A mRNAs (CYP3A41 and CYP3A44) in mouse liver by sex and growth hormones
    Tsutomu Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Arch Biochem Biophys 404:234-42. 2002
    ..These observations suggest that endocrine control of expression might be similar, but not identical, for two female-predominant CYP3A mRNAs...
  4. ncbi Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs
    Tsutomu Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Toyama 930 0194, Japan
    Drug Metab Dispos 32:376-8. 2004
    ....
  5. ncbi Suppression of female-specific murine Cyp2b9 gene expression by growth or glucocorticoid hormones
    Tsutomu Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Biochem Biophys Res Commun 323:776-81. 2004
    ..These observations suggest that the sexually dimorphic expression of CYP2B9 is partly due to suppression by the masculine plasma GH profile and by glucocorticoid hormones...
  6. ncbi Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat
    T Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan
    Xenobiotica 31:223-37. 2001
    ..4. The results indicate that mouse P450s respond to insulin-dependent diabetes mellitus differently from those of the rat, and suggest that the expression of P450s in diabetes is not generally the same across animal species...
  7. ncbi Induction of CYP1A2 by phenobarbital in the livers of aryl hydrocarbon-responsive and -nonresponsive mice
    T Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Drug Metab Dispos 27:379-84. 1999
    ..Cyclobarbital, pentobarbital, and secobarbital also induced CYP1A2 mRNA in primary culture hepatocytes from C57BL/6 mice. Barbital, in contrast, did not show any clear inductive effect on CYP1A2 mRNA...
  8. ncbi Collaborated regulation of female-specific murine Cyp3a41 gene expression by growth and glucocorticoid hormones
    Tsutomu Sakuma
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930 0194 Toyama, Japan
    Biochem Biophys Res Commun 314:495-500. 2004
    ....
  9. ncbi Sex-associated expression of mouse hepatic and renal CYP2B enzymes by glucocorticoid hormones
    K Jarukamjorn
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
    Biochem Pharmacol 62:161-9. 2001
    ....
  10. ncbi Localization of estradiol-responsive region in the phenobarbital-responsive enhancer module of mouse Cyp2b-10 gene
    M Yamamoto
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-0194, Japan
    J Biochem Mol Toxicol 15:76-82. 2001
    ..These results indicate that estradiol induces Cyp2b-10 gene expression via PBREM...
  11. ncbi Marmoset CYP1A2: primary structure and constitutive expression in livers
    T Sakuma
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Hokkaido University, Japan
    Carcinogenesis 18:1985-91. 1997
    ..Marmoset CYP1A2 also showed ethoxyresorufin O-de-ethylase activity. Based on these results, we demonstrate that marmosets constitutively express CYP1A2 in the liver as in humans...
  12. ncbi Isolation and characterization of a new cDNA clone belonging to the cytochrome P450 2C gene subfamily in hamsters
    T Sakuma
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Arch Biochem Biophys 319:267-73. 1995
    ..On the other hand, administration of pregnenolone 16 alpha-carbonitrile induced CYP2C28 in females but not in males. These results indicate that CYP2C28 is a unique form in the hamster CYP2C subfamily...
  13. ncbi Molecular cloning and functional analysis of cynomolgus monkey CYP1A2
    T Sakuma
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochem Pharmacol 56:131-9. 1998
    ..These results indicate that cynomolgus monkeys have a functionally active CYPIA2 gene, but its expression level is very low in the liver of untreated cynomolgus monkeys...
  14. ncbi Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs
    T Igarashi
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Hokkaido University, Japan
    Arch Biochem Biophys 339:85-91. 1997
    ..These results indicate that the marmoset stands at a midpoint between human and nonprimate experimental animals...
  15. ncbi Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs
    T Sakuma
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Mol Pharmacol 45:228-36. 1994
    ..No sex-related difference was observed in the expression of CYP2C25 and CYP2C26. These results support our previous findings that sex-related differences in the expression of liver microsomal cytochromes P450 occur in hamsters...
  16. ncbi Molecular cloning and sequence analysis of hamster CYP2E1
    T Sakuma
    Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biochim Biophys Acta 1217:229-31. 1994
    ..The Northern blot analysis showed that CYP2E1 was expressed in livers and to lesser extents in kidneys and lungs...
  17. ncbi Stimulative effect of cadmium on prostaglandin E2 production in primary mouse osteoblastic cells
    T Miyahara
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama 939-0194, Japan
    Calcif Tissue Int 68:185-91. 2001
    ..From these results, it was found that Cd by itself stimulated PGE2 production by two successive steps that Cd increased cPLA2 activity and then COX-2 induction...
  18. ncbi A highly potent 26,27-Hexafluoro-1a,25-dihydroxyvitamin D3 on calcification in SV40-transformed human fetal osteoblastic cells
    T Miyahara
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Japan
    Calcif Tissue Int 70:488-95. 2002
    ....
  19. ncbi Molecular cloning of monkey liver cytochrome P-450 cDNAs: similarity of the primary sequences to human cytochromes P-450
    M Komori
    Division of Analytical Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Japan
    Biochim Biophys Acta 1171:141-6. 1992
    ..The deduced amino acid sequences of four monkey cytochrome P-450 cDNAs, including P450 1A1 (MKah1) which we isolated previously, were more than 92% identical with those of corresponding human cytochrome P-450 cDNAs...
  20. doi Forkhead box A2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene
    Tadahiro Hashita
    Department of Toxicology, Graduate School of Medical and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Drug Metab Dispos 36:1080-7. 2008
    ..Sexually dimorphic secretion of growth hormone is involved in female-predominant expression of the gene, and the -234/-194 region was also responsible for suppressing the expression by male-type secretion...
  21. doi Synergism of glucocorticoid hormone with growth hormone for female-specific mouse Cyp3a44 gene expression
    Tsutomu Sakuma
    Department of Toxicology, Graduate School of Medicine and Pharmaceutical, Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194 Japan
    Drug Metab Dispos 36:878-84. 2008
    ..Additionally, one or more nuclear receptors mediating induction by glucocorticoid hormone are employed for collaboration with GH...
  22. ncbi Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes
    Atika Jaruchotikamol
    Department of Toxicology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Toxicol Appl Pharmacol 224:156-62. 2007
    ..In addition, our findings suggest preparing advice for rational administration of A. paniculata, according to its ability to induce CYP1A1 expression...
  23. ncbi Involvement of glucocorticoid receptor and pregnane X receptor in the regulation of mouse CYP3A44 female-predominant expression by glucocorticoid hormone
    Wattanaporn Bhadhprasit
    Department of Toxicology, Graduate School of Medical and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan
    Drug Metab Dispos 35:1880-5. 2007
    ....
  24. ncbi Modified expression of cytochrome P450 mRNAs by growth hormone in mouse liver
    Kanokwan Jarukamjorn
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
    Toxicology 219:97-105. 2006
    ....
  25. ncbi Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes
    Hisako Tamaki
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930 0194, Japan
    Toxicology 216:224-31. 2005
    ..Modulation of CYP1A2 mRNA expression after exposing hepatocytes to agents affecting phosphorylation pathways differed from that of CYP1A1 mRNA. This implies that regulatory pathways for CYP1A1 and CYP1A2 expression may differ...
  26. ncbi Sexual dimorphic expression of mouse hepatic CYP2B: alterations during development or after hypophysectomy
    Kanokwan Jarukamjorn
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Japan
    Biochem Pharmacol 63:2037-41. 2002
    ..Hypophysectomy eliminated the sexual dimorphism in the mouse CYP2B subfamily by markedly increasing the expression of both CYP2B9 and CYP2B10 in males to levels similar to those in females...
  27. ncbi Enhancer elements in the mouse Cyp1a2 gene for constitutive expression
    Yo Ichi Uchida
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930 0194, Toyama, Japan
    Biochem Biophys Res Commun 297:1297. 2002
    ..Site-directed mutagenesis assay suggested that the TRE element in E1 is essential for constitutive expression of the mouse Cypla2 gene...
  28. ncbi Expression and characterization of Rab38, a new member of the Rab small G protein family
    Kazuhiro Osanai
    Department of Respiratory Medicine, Kanazawa Medical University, 1 1 Daigaku Uchinada, Kahokugun, Ishikawa 920 0293, Japan
    Biol Chem 386:143-53. 2005
    ....
  29. ncbi Immunoglobulin gamma3-heavy-chain deposition disease: report of a case and relationship with hypocomplementemia
    Jun Soma
    Department of Nephrology, Iwate Prefectural Central Hospital, Morioka, Japan
    Am J Kidney Dis 43:E10-6. 2004
    ..A review of previously reported cases of HCDD showed that some but not all HCDD cases were associated with hypocomplementemia. The authors also discuss here the relationship of HCDD to hypocomplementemia...
  30. ncbi Effect of uni-adrenalectomy on blood pressure in a patient with excessive adrenal 18-hydroxy-11-deoxycorticosterone production bilaterally
    Minoru Kawamura
    Department of General Internal Medicine, Iwate Prefectural Central Hospital, 1 4 1 Ueda, Morioka 020 0066
    Intern Med 42:507-12. 2003
    ..5 mEq/l. These results suggest that uni-adrenalectomy is, at least in part, effective in ameliorating not only BP but also potassium concentration in a patient of adrenal hyperplasia with excessive bilateral 18-OH-DOC production...
  31. ncbi Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung
    Lorraine B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    J Appl Physiol (1985) 93:1869-74. 2002
    ..Aerosolized beta(2)-adrenergic agonists may have therapeutic value for hastening the resolution of alveolar edema during the management of donors before resection of lungs for transplantation or in the posttransplant setting...