Koji Nakanishi

Summary

Affiliation: Toranomon Hospital
Country: Japan

Publications

  1. ncbi request reprint Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin
    Shimon Ben-Shabat
    Department of Chemistry, Columbia University, New York, NY 10028, USA
    J Biol Chem 277:7183-90. 2002
  2. pmc Characterization of dihydro-A2PE: an intermediate in the A2E biosynthetic pathway
    So R Kim
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Biochemistry 46:10122-9. 2007
  3. pmc Capture of type 1 diabetes-susceptible HLA DR-DQ haplotypes in Japanese subjects using a tag single nucleotide polymorphism
    Koji Nakanishi
    Department of General Internal Medicine and Metabolism, Toranomon Hospital, Kawasaki, Japan
    Diabetes Care 33:162-4. 2010
  4. ncbi request reprint Analysis of eluted peptides from type 1 diabetes-susceptible HLA class II molecules identified novel islet protein, heparin/heparan sulfate-interacting protein
    Koji Nakanishi
    Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan
    Biochem Biophys Res Commun 329:356-61. 2005
  5. ncbi request reprint Single nucleotide polymorphisms of vascular endothelial growth factor gene intron 2 are markers for early progression of diabetic retinopathy in Japanese with type 1 diabetes
    Koji Nakanishi
    Department of General Internal Medicine and Metabolism, Toranomon Hospital, 1 3 1 Kajigaya, Takatsu ku, Kawasaki, Kanagawa 213 8587, Japan
    Clin Chim Acta 402:171-5. 2009
  6. doi request reprint Rate of beta-cell destruction in type 1 diabetes influences the development of diabetic retinopathy: protective effect of residual beta-cell function for more than 10 years
    Koji Nakanishi
    Department of General Internal Medicine and Metabolism, Toranomon Hospital, 1 3 1 Kajigaya, Takatsu ku, Kawasaki, Kanagawa 213 8587, Japan
    J Clin Endocrinol Metab 93:4759-66. 2008
  7. ncbi request reprint Combination of HLA-A24, -DQA1*03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: longitudinal study of residual beta-cell function
    Koji Nakanishi
    Department of Endocrinology and Metabolism, Toranomon Hospital, 2 2 2 Toranomon, Minato ku, Tokyo 105 8470, Japan
    Diabetes 55:1862-8. 2006
  8. pmc Clinical and genetic characteristics of patients with type 1 diabetes associated with interferon therapy
    Koji Nakanishi
    Okinaka Memorial Institute for Medical Research, Tokyo, Japan
    Diabetes Care 34:471-3. 2011
  9. ncbi request reprint A case of fulminant type 1 diabetes associated with significant elevation of mumps titers
    Atsushi Goto
    Department of Diabetes and Metabolic Medicine, International Medical Center of Japan, Tokyo, Japan
    Endocr J 55:561-4. 2008
  10. ncbi request reprint Hypoglycemia and hyperglycemia due to insulin antibodies against therapeutic human insulin: treatment with double filtration plasmapheresis and prednisolone
    Rikako Koyama
    Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan
    Am J Med Sci 329:259-64. 2005

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin
    Shimon Ben-Shabat
    Department of Chemistry, Columbia University, New York, NY 10028, USA
    J Biol Chem 277:7183-90. 2002
    ..The identities of additional minor components of retinal pigment epithelium lipofuscin, A2E isomers with cis olefins at positions other than the C13-C14 double bond, are also described...
  2. pmc Characterization of dihydro-A2PE: an intermediate in the A2E biosynthetic pathway
    So R Kim
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Biochemistry 46:10122-9. 2007
    ..An understanding of the biosynthetic pathways of retinal pigment epithelial lipofuscin pigments is critical to the development of therapies for macular degeneration that are based on limiting the formation of these damaging compounds...
  3. pmc Capture of type 1 diabetes-susceptible HLA DR-DQ haplotypes in Japanese subjects using a tag single nucleotide polymorphism
    Koji Nakanishi
    Department of General Internal Medicine and Metabolism, Toranomon Hospital, Kawasaki, Japan
    Diabetes Care 33:162-4. 2010
    ..To identify type 1 diabetes-susceptible HLA DR-DQ haplotypes using tag single nucleotide polymorphisms (SNPs) and to estimate the disease risk using these tag SNPs...
  4. ncbi request reprint Analysis of eluted peptides from type 1 diabetes-susceptible HLA class II molecules identified novel islet protein, heparin/heparan sulfate-interacting protein
    Koji Nakanishi
    Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan
    Biochem Biophys Res Commun 329:356-61. 2005
    ..Immunostaining of pancreatic sections using antiserum for HIP peptide revealed exclusive staining of the islets. Thus, HIP was identified as an islet protein naturally processed and presented by HLA-DR4 molecules...
  5. ncbi request reprint Single nucleotide polymorphisms of vascular endothelial growth factor gene intron 2 are markers for early progression of diabetic retinopathy in Japanese with type 1 diabetes
    Koji Nakanishi
    Department of General Internal Medicine and Metabolism, Toranomon Hospital, 1 3 1 Kajigaya, Takatsu ku, Kawasaki, Kanagawa 213 8587, Japan
    Clin Chim Acta 402:171-5. 2009
    ..Few studies investigated the relationship between single nucleotide polymorphisms (SNPs) of vascular endothelial growth factor (VEGF) gene and time to the development and progression of diabetic retinopathy...
  6. doi request reprint Rate of beta-cell destruction in type 1 diabetes influences the development of diabetic retinopathy: protective effect of residual beta-cell function for more than 10 years
    Koji Nakanishi
    Department of General Internal Medicine and Metabolism, Toranomon Hospital, 1 3 1 Kajigaya, Takatsu ku, Kawasaki, Kanagawa 213 8587, Japan
    J Clin Endocrinol Metab 93:4759-66. 2008
    ..Although residual beta-cell function delays the onset and progression of diabetic retinopathy in patients with type 1 diabetes, the rate of beta-cell destruction is variable...
  7. ncbi request reprint Combination of HLA-A24, -DQA1*03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: longitudinal study of residual beta-cell function
    Koji Nakanishi
    Department of Endocrinology and Metabolism, Toranomon Hospital, 2 2 2 Toranomon, Minato ku, Tokyo 105 8470, Japan
    Diabetes 55:1862-8. 2006
    ....
  8. pmc Clinical and genetic characteristics of patients with type 1 diabetes associated with interferon therapy
    Koji Nakanishi
    Okinaka Memorial Institute for Medical Research, Tokyo, Japan
    Diabetes Care 34:471-3. 2011
    ..This study clarified characteristics of interferon-associated type 1 diabetes...
  9. ncbi request reprint A case of fulminant type 1 diabetes associated with significant elevation of mumps titers
    Atsushi Goto
    Department of Diabetes and Metabolic Medicine, International Medical Center of Japan, Tokyo, Japan
    Endocr J 55:561-4. 2008
    ..This case suggests an association between fulminant type 1 diabetes and mumps virus infection...
  10. ncbi request reprint Hypoglycemia and hyperglycemia due to insulin antibodies against therapeutic human insulin: treatment with double filtration plasmapheresis and prednisolone
    Rikako Koyama
    Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan
    Am J Med Sci 329:259-64. 2005
    ..This condition can be treated with double filtration plasmapheresis and subsequent administration of prednisolone...
  11. ncbi request reprint Corticosteroid-responsive diabetes mellitus associated with autoimmune pancreatitis: pathological examinations of the endocrine and exocrine pancreas
    Shoichiro Tanaka
    Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo 105 8470, Japan
    Ann N Y Acad Sci 958:152-9. 2002
    ..These findings provide new insight toward understanding the pathological mechanisms of corticosteroid treatment-responsive diabetes associated with ACP...
  12. ncbi request reprint Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis
    Keiichiro Osame
    Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo
    Intern Med 46:873-7. 2007
    ..Based on the putative molecular mimicry of GAD65 by cytomegalovirus antigen, we hypothesize that the type 1 diabetes in this case was associated with cytomegalovirus infection...
  13. ncbi request reprint Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    J Clin Endocrinol Metab 92:1791-5. 2007
    ..It is suggested that insulin autoimmunity plays an important role in the development of type 1 diabetes in humans. However, the association between insulin gene (INS) region (IDDM2) and type 1 diabetes has been uncertain in Asians...
  14. ncbi request reprint Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
    Am J Med Genet A 140:586-93. 2006
    ..In conclusion, the type 1 diabetes association with PTPN22 is confirmed, but it cannot be attributed solely to the +1858C > T variant. The promoter -1123G > C SNP is a more likely causative variant in PTPN22...
  15. ncbi request reprint The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan
    Hiroshi Ikegami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Endocrinol Metab 91:1087-92. 2006
    ..The low incidence of type 1 diabetes in Asian countries, however, makes it difficult to perform large-scale studies in Asia...
  16. ncbi request reprint Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes
    Tetsuro Kobayashi
    Third Department of Internal Medicine, Yamanashi Medical University, Tamaho, Yamanashi 409 3898, Japan
    J Clin Endocrinol Metab 88:4768-75. 2003
    ..Association is suggested between GAD65Ab targeted to this region and slowly progressive beta-cell failure in SPIDDM...
  17. ncbi request reprint Association of HLA-DQ genotype in autoantibody-negative and rapid-onset type 1 diabetes
    Shoichiro Tanaka
    Third Department of Internal Medicine, Yamanashi Medical University, Japan
    Diabetes Care 25:2302-7. 2002
    ..However, little is known about genetic factors of this distinct subtype of diabetes (fulminant autoantibody-negative type 1 diabetes)...
  18. ncbi request reprint Distinct diagnostic criteria of fulminant type 1 diabetes based on serum C-peptide response and HbA1c levels at onset
    Shoichiro Tanaka
    Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Tamaho, Yamanashi 409 3898, Japan
    Diabetes Care 27:1936-41. 2004
    ..Diagnostic criteria in fulminant type 1 diabetes, a novel subtype of type 1 diabetes, remain unclear...
  19. ncbi request reprint Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in Japanese
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Autoimmun 30:207-11. 2008
    ..Based upon these results, we propose that it may be worthwhile to focus on subjects with the BB genotype of this gene polymorphism as having high risk for type 1 diabetes...
  20. doi request reprint Synthesis and spectroscopic characterization of photo-affinity peptide ligands to study rhodopsin-G protein interaction
    Yihui Chen
    Department of Chemistry, Columbia University, New York, NY, USA
    Photochem Photobiol 84:831-8. 2008
    ..Such peptides will enable an improved experimental strategy to probe rhodopsin-G(t) interaction and to map so far unknown interaction sites between both proteins...
  21. ncbi request reprint A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation
    Janet R Sparrow
    Department of Ophthalmology and Chemistry, Columbia University, New York, New York 10028, USA
    J Biol Chem 278:18207-13. 2003
    ..Conversely, vitamin C and ginkgolide B were not efficient quenchers of singlet oxygen under these conditions...
  22. doi request reprint Synthesis and characterization of water-soluble free-base, zinc and copper porphyrin-oligonucleotide conjugates
    Angela Mammana
    Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA
    Bioorg Med Chem 16:6544-51. 2008
    ....
  23. pmc Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate
    Nathan E Fishkin
    Department of Chemistry, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:7091-6. 2005
    ....
  24. ncbi request reprint Efficient extraction of ginkgolides and bilobalide from Ginkgo biloba leaves
    Dirk Lichtblau
    Department of Chemistry, Columbia University, 3000 Broadway, New York, New York 10027, USA
    J Nat Prod 65:1501-4. 2002
    ..The four ginkgolides (ginkgolides A, B, C, J) and bilobalide isolated from the extract were identical in all respects with authentic specimens...
  25. ncbi request reprint Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 43:1222-7. 2002
    ..The purpose of this study was to evaluate the role of oxidative mechanisms in mediating the cellular damage...
  26. ncbi request reprint Spectroscopic investigation of Ginkgo biloba terpene trilactones and their interaction with amyloid peptide Abeta(25-35)
    Jiangtao He
    Department of Chemistry, Columbia University, New York, NY 10027, USA
    Spectrochim Acta A Mol Biomol Spectrosc 69:1213-22. 2008
    ..It is possible that the therapeutic effect of G. biloba extract does not originate from direct interactions between TTLs and the Abeta(25-35) peptide and is more complex...
  27. ncbi request reprint No contribution of a GT microsatellite polymorphism in the promoter region of the FOXP3 gene to susceptibility to type 1 diabetes in the Japanese population
    Koji Nakanishi
    Clin Chim Acta 384:171-3. 2007
  28. ncbi request reprint A cleavable affinity biotinylating agent reveals a retinoid binding role for RPE65
    Wan Jin Jahng
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 45 Shattuck Street, Boston, Massachusetts 02115, USA
    Biochemistry 42:6159-68. 2003
    ..These studies validate the approach that was used, and furthermore demonstrate that RPE65, a major membrane-associated protein of the RPE, is a RBP...
  29. ncbi request reprint Association of the SNP-19 genotype 22 in the calpain-10 gene with elevated body mass index and hemoglobin A1c levels in Japanese
    Yukio Shima
    Laboratory of Biochemistry, Kyorin University School of Health Sciences, 476 Miyashita machi, Hachioji, Tokyo 192 8508, Japan
    Clin Chim Acta 336:89-96. 2003
    ..An association of variations in the calpain-10 gene (CAPN10) with type 2 diabetes was originally reported in Mexican Americans. However, some studies in other racial groups were contradictory...
  30. ncbi request reprint Metabolic improvement of male prisoners with type 2 diabetes in Fukushima Prison, Japan
    Masamitsu Hinata
    Medical Affairs Section, Fukushima Prison, 1 Uehara, Minamisawamata, Fukushima 960 8254, Japan
    Diabetes Res Clin Pract 77:327-32. 2007
    ..These findings suggest that a well-regulated lifestyle and long-term intake of high dietary fiber may have beneficial effects on metabolic control in patients with type 2 diabetes...
  31. ncbi request reprint Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2
    Bing Xia
    Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Mol Cell 22:719-29. 2006
    ..Thus, PALB2 licenses key cellular biochemical properties of BRCA2 and ensures its tumor suppression function...
  32. ncbi request reprint Photooxidation of A2-PE, a photoreceptor outer segment fluorophore, and protection by lutein and zeaxanthin
    So Ra Kim
    Department of Ophthalmology, Columbia University, NY 10032, USA
    Exp Eye Res 82:828-39. 2006
    ....
  33. pmc Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells
    Young P Jang
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Photochem Photobiol 81:529-36. 2005
    ..Cells that had taken up anthocyanins also exhibited a resistance to the membrane permeabilization that occurs as a result of the detergent-like action of A2E...
  34. ncbi request reprint Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin
    Young P Jang
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    J Biol Chem 280:39732-9. 2005
    ..Because the cytotoxicity of endoperoxide moieties is well known, the production of endoperoxide-containing oxo-A2E may account, at least in part, for cellular damage ensuing from A2E photooxidation...