Nobuaki Maeda

Summary

Affiliation: Tokyo Metropolitan Institute for Neuroscience
Country: Japan

Publications

  1. ncbi request reprint Heterogeneity of the chondroitin sulfate portion of phosphacan/6B4 proteoglycan regulates its binding affinity for pleiotrophin/heparin binding growth-associated molecule
    Nobuaki Maeda
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526
    J Biol Chem 278:35805-11. 2003
  2. ncbi request reprint [Mmorphogenesis of neurons and chondroitin sulfate]
    Nobuaki Maeda
    Tanpakushitsu Kakusan Koso 49:2348-53. 2004
  3. ncbi request reprint The binding of chondroitin sulfate to pleiotrophin/heparin-binding growth-associated molecule is regulated by chain length and oversulfated structures
    Nobuaki Maeda
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    J Biol Chem 281:4894-902. 2006
  4. ncbi request reprint Developmental change and function of chondroitin sulfate deposited around cerebellar Purkinje cells
    Yumiko Shimazaki
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Neurosci Res 82:172-83. 2005
  5. ncbi request reprint Chondroitin sulfate proteoglycans in neural development and plasticity
    Nobuaki Maeda
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Front Biosci (Landmark Ed) 15:626-44. 2010
  6. doi request reprint Spatiotemporal expression of chondroitin sulfate sulfotransferases in the postnatal developing mouse cerebellum
    Maki Ishii
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Musashidai, Fuchu, Tokyo 183 8526, Japan
    Glycobiology 18:602-14. 2008
  7. doi request reprint Oversulfated chondroitin sulfate plays critical roles in the neuronal migration in the cerebral cortex
    Maki Ishii
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Musashidai, Fuchu, Tokyo 183 8526, Japan
    J Biol Chem 283:32610-20. 2008
  8. pmc Receptor type protein tyrosine phosphatase zeta-pleiotrophin signaling controls endocytic trafficking of DNER that regulates neuritogenesis
    Nobuna Fukazawa
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    Mol Cell Biol 28:4494-506. 2008
  9. ncbi request reprint Structural variation of chondroitin sulfate and its roles in the central nervous system
    Nobuaki Maeda
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Japan
    Cent Nerv Syst Agents Med Chem 10:22-31. 2010
  10. ncbi request reprint Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain
    Tomio Yabe
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    Glycobiology 15:982-93. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Heterogeneity of the chondroitin sulfate portion of phosphacan/6B4 proteoglycan regulates its binding affinity for pleiotrophin/heparin binding growth-associated molecule
    Nobuaki Maeda
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526
    J Biol Chem 278:35805-11. 2003
    ..7 nM), whereas whale cartilage chondroitin sulfate A showed no binding to this growth factor. These results suggest that variation of chondroitin sulfate plays important roles in the regulation of signal transduction in the brain...
  2. ncbi request reprint [Mmorphogenesis of neurons and chondroitin sulfate]
    Nobuaki Maeda
    Tanpakushitsu Kakusan Koso 49:2348-53. 2004
  3. ncbi request reprint The binding of chondroitin sulfate to pleiotrophin/heparin-binding growth-associated molecule is regulated by chain length and oversulfated structures
    Nobuaki Maeda
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    J Biol Chem 281:4894-902. 2006
    ..These results suggest that the binding of pleiotrophin to CS is regulated by multivalency with CS approximately 20 mer as a unit and by the amounts of oversulfated structures...
  4. ncbi request reprint Developmental change and function of chondroitin sulfate deposited around cerebellar Purkinje cells
    Yumiko Shimazaki
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Neurosci Res 82:172-83. 2005
    ....
  5. ncbi request reprint Chondroitin sulfate proteoglycans in neural development and plasticity
    Nobuaki Maeda
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Front Biosci (Landmark Ed) 15:626-44. 2010
    ..These studies revealed unexpectedly complex mechanisms of CS-PG functions...
  6. doi request reprint Spatiotemporal expression of chondroitin sulfate sulfotransferases in the postnatal developing mouse cerebellum
    Maki Ishii
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Musashidai, Fuchu, Tokyo 183 8526, Japan
    Glycobiology 18:602-14. 2008
    ..These results suggest that the CS structures of various cerebellar neurons change during development and such changes of CS are involved in the regulation of various signaling pathways...
  7. doi request reprint Oversulfated chondroitin sulfate plays critical roles in the neuronal migration in the cerebral cortex
    Maki Ishii
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Musashidai, Fuchu, Tokyo 183 8526, Japan
    J Biol Chem 283:32610-20. 2008
    ..These results revealed that specific oversulfated structures in CS chains play critical roles in the migration of neuronal precursors during cortical development...
  8. pmc Receptor type protein tyrosine phosphatase zeta-pleiotrophin signaling controls endocytic trafficking of DNER that regulates neuritogenesis
    Nobuna Fukazawa
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    Mol Cell Biol 28:4494-506. 2008
    ..These observations suggest that pleiotrophin-PTPzeta signaling controls subcellular localization of DNER and thereby regulates neuritogenesis...
  9. ncbi request reprint Structural variation of chondroitin sulfate and its roles in the central nervous system
    Nobuaki Maeda
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Japan
    Cent Nerv Syst Agents Med Chem 10:22-31. 2010
    ..The synthesis of these structures is strictly regulated by the chondroitin sulfate synthase family and many sulfotransferases, which should be useful therapeutic targets in neurological disorders...
  10. ncbi request reprint Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain
    Tomio Yabe
    Department of Developmental Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    Glycobiology 15:982-93. 2005
    ..We discuss possible functional roles of these sulfotransferases in the signaling of several HS-binding proteins such as fibroblast growth factors, slit, netrin, and sonic hedgehog...
  11. ncbi request reprint Reduced expression of MAb6B4 epitopes on chondroitin sulfate proteoglycan aggrecan in perineuronal nets from cerebral cortices of SAMP10 mice: a model for age-dependent neurodegeneration
    Yuko Saitoh
    Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan
    J Neurosci Res 86:1316-23. 2008
    ..The biological significance of the MAb6B4/Cat-315 epitope in brain function and its relationship to the neurodegeneration and learning disabilities observed in SAMP10 mice remain to be elucidated...
  12. ncbi request reprint alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor
    Hisako Muramatsu
    Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Cell Sci 117:5405-15. 2004
    ..alpha4beta1- and alpha6beta1-Integrins are expected to co-operate with other midkine receptors, possibly in a multimolecular complex that contains other midkine receptors...
  13. ncbi request reprint A chondroitin sulfate proteoglycan PTPzeta /RPTPbeta regulates the morphogenesis of Purkinje cell dendrites in the developing cerebellum
    Masahiko Tanaka
    Division of Cell Biology, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    J Neurosci 23:2804-14. 2003
    ..Altogether, these findings suggest that PTN-PTPzeta signaling regulates the morphogenesis of Purkinje cell dendrites and that the mechanisms underlying that regulation involve the GLAST activity in Bergmann glial processes...
  14. ncbi request reprint Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons
    Nahoko Sakaguchi
    Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Neurosci Res 45:219-24. 2003
    ..The survival-promoting activity of MK was abolished by PP1, an inhibitor of src protein kinase, pertussis toxin, an inhibitor of G protein-linked signaling and sodium orthovanadate, an inhibitor of PTPs...
  15. ncbi request reprint Receptor-like protein tyrosine phosphatase zeta/RPTP beta is expressed on tangentially aligned neurons in early mouse neocortex
    Kyoji Ohyama
    Department of Anatomy, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Brain Res Dev Brain Res 148:121-7. 2004
    ..These results indicate that PTPzeta is a useful marker for early-generated neocortical neurons in mice: Cajal-Retzius neurons as well as the subplate neurons...