Genomes and Genes
Affiliation: Tokyo Metropolitan Institute of Medical Science
- Circumvention of chaperone requirement for aggregate formation of a short polyglutamine tract by the co-expression of a long polyglutamine tractYoko Kimura
Department of Tumor Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3 18 22, Honkomagome, Bunkyo, Tokyo 113 8613, Japan
J Biol Chem 277:37536-41. 2002..The co-localization of aggregates of long and short polyglutamine tracts suggests the possibility that the enhancement occurs due to the seeding of aggregates of the long polyglutamine tracts...
- Initial process of polyglutamine aggregate formation in vivoY Kimura
Department of Tumor Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3 18 22, Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
Genes Cells 6:887-97. 2001..The expansion has toxic effects on neural cells as well as results in forming aggregates. Using yeast, we examined the initial process of polyglutamine aggregate formation in vivo...
- The role of pre-existing aggregates in Hsp104-dependent polyglutamine aggregate formation and epigenetic change of yeast prionsYoko Kimura
Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, 3 18 22, Honkomagome, Bunkyo, 113 8613, Japan
Genes Cells 9:685-96. 2004..These findings highlight the role of pre-existing aggregates in chaperone-dependent establishment of the epigenetic trait in yeast prions, and possibly in the pathology of several neurodegenerative diseases...
- [Mechanism of polyglutamine aggregate formation]Yoko Kimura
Tanpakushitsu Kakusan Koso 49:1122-3. 2004
- Analysis of yeast prion aggregates with amyloid-staining compound in vivoYoko Kimura
Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Honkomagome, Bunkyo, Tokyo 113 8613, Japan
Cell Struct Funct 28:187-93. 2003..These results suggested that yeast prion domains take the form of amyloid in vivo, and supported the idea that the self-propagating property of amyloids is responsible for the heritable traits of yeast prions...
- The ESCRT-III adaptor protein Bro1 controls functions of regulator for free ubiquitin chains 1 (Rfu1) in ubiquitin homeostasisYoko Kimura
From the Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Setagaya Ku, Tokyo 113 8613 and the Department of Applied Biological Chemistry, Graduate School of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
J Biol Chem 289:21760-9. 2014..Rfu1 degradation partly involved the proteasome and a ubiquitin ligase Rsp5, suggesting that Rfu1 stability was regulated by ubiquitin-proteasome pathways. ..
- Ubiquitin is phosphorylated by PINK1 to activate parkinFumika Koyano
1 Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Setagaya Ku, Tokyo 156 8506, Japan 2 Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277 8561, Japan
Nature 510:162-6. 2014..Our results show that PINK1-dependent phosphorylation of both parkin and ubiquitin is sufficient for full activation of parkin E3 activity. These findings demonstrate that phosphorylated ubiquitin is a parkin activator. ..
- An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasisYoko Kimura
Tokyo Metropolitan Institute of Medical Science, Kamikitazawa, Setagaya, Japan
Cell 137:549-59. 2009..We propose that free ubiquitin chains function as a ubiquitin reservoir that allows maintenance of monomeric ubiquitins at adequate levels under normal conditions and rapid supply for substrate conjugation under stress conditions...
- Polyglutamine diseases and molecular chaperonesYoko Kimura
Tokyo Metropolitan Institute of Medical Science, Tokyo 113 8613, Japan
IUBMB Life 55:337-45. 2003..In this review, we summarize recent findings on such ambiguous effects of molecular chaperones on polyglutamine diseases, and discuss possible mechanisms by which molecular chaperones, especially VCP, are involved in the pathogenesis...
- Regulatory mechanisms involved in the control of ubiquitin homeostasisYoko Kimura
Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa, Setagaya Ku, Tokyo 156 8506, Japan
J Biochem 147:793-8. 2010..Here, we review the current understandings of the regulatory mechanisms that control Ub expression and its metabolism and maintain Ub homeostasis...
- Conserved Mode of Interaction between Yeast Bro1 Family V Domains and YP(X)nL Motif-Containing Target ProteinsYoko Kimura
Department of Agriculture, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka, Japan Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
Eukaryot Cell 14:976-82. 2015..Moreover, the specificities of each V domain to their target protein suggest that unidentified elements determine the binding specificity. ..
- Different dynamic movements of wild-type and pathogenic VCPs and their cofactors to damaged mitochondria in a Parkin-mediated mitochondrial quality control systemYoko Kimura
Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Setagaya Ku, Tokyo, 156 8506, Japan
Genes Cells 18:1131-43. 2013..Failure of pathogenic VCPs to function on damaged mitochondria may be related to the pathogenesis of IBMPFD and ALS. ..
- ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motifMasakatsu Noguchi
Laboratory of Functional Biology, Kyoto University Graduate School of Biostudies and Solution Oriented Research for Science and Technology JST, Kyoto 606 8501, Japan
J Biol Chem 280:41332-41. 2005..This regulatory mechanism may play a key role in the conversion of oxidative stress to endoplasmic reticulum stress response in multicellular organisms and also in the pathological process of various neurodegenerative disorders...
- Therapeutic prospects for the prevention of neurodegeneration in Huntington's disease and the polyglutamine repeat disordersYoko Kimura
Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 46 3243, 43 Vassar St Cambridge, MA 02139, USA
Mini Rev Med Chem 7:99-106. 2007..Recent approaches using genetic models systems have begun to uncover nuclear and cytoplasmic pathologies that represent potential targets for therapeutic intervention...
- Interaction between the N-terminal and middle regions is essential for the in vivo function of HSP90 molecular chaperoneShigeki Matsumoto
Department of Dental Anesthesiology, Nagasaki University School of Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
J Biol Chem 277:34959-66. 2002..Moreover, the interaction between the N-terminal and middle regions is essential for the in vivo function of HSP90 in yeast...