Tatsuya Higashi

Summary

Affiliation: Tokyo University of Science
Country: Japan

Publications

  1. ncbi request reprint LC/MS/MS of steroids having vicinal diol as electrospray-active boronates
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan
    Chem Pharm Bull (Tokyo) 61:326-32. 2013
  2. doi request reprint Overestimation of salivary 25-hydroxyvitamin D3 level when using stimulated saliva with gum-chewing
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Steroids 78:884-7. 2013
  3. doi request reprint Chemical derivatization for enhancing sensitivity during LC/ESI-MS/MS quantification of steroids in biological samples: a review
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda shi, Chiba 278 8510, Japan Electronic address
    J Steroid Biochem Mol Biol 162:57-69. 2016
  4. doi request reprint Methods for determination of fingernail steroids by LC/MS/MS and differences in their contents between right and left hands
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda shi, Chiba 278 8510, Japan Electronic address
    Steroids 109:60-5. 2016
  5. doi request reprint Isotope-coded ESI-enhancing derivatization reagents for differential analysis, quantification and profiling of metabolites in biological samples by LC/MS: A review
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan Electronic address
    J Pharm Biomed Anal 130:181-193. 2016
  6. doi request reprint Methods for differential and quantitative analyses of brain neurosteroid levels by LC/MS/MS with ESI-enhancing and isotope-coded derivatization
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan Electronic address
    J Pharm Biomed Anal 117:155-62. 2016
  7. doi request reprint Development and validation of a method for determination of plasma 25-hydroxyvitamin D3 3-sulfate using liquid chromatography/tandem mass spectrometry
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda shi, Chiba 278 8510, Japan Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 969:230-4. 2014
  8. doi request reprint Derivatization of chiral carboxylic acids with (S)-anabasine for increasing detectability and enantiomeric separation in LC/ESI-MS/MS
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan
    J Sep Sci 35:2840-6. 2012
  9. doi request reprint Influence of saliva flow rate stimulated by gum-chewing on salivary concentrations of catecholamine metabolites
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278 8510, Japan
    Clin Chim Acta 414:248-52. 2012
  10. ncbi request reprint Salivary hormone measurement using LC/MS/MS: specific and patient-friendly tool for assessment of endocrine function
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan
    Biol Pharm Bull 35:1401-8. 2012

Collaborators

Detail Information

Publications31

  1. ncbi request reprint LC/MS/MS of steroids having vicinal diol as electrospray-active boronates
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan
    Chem Pharm Bull (Tokyo) 61:326-32. 2013
    ....
  2. doi request reprint Overestimation of salivary 25-hydroxyvitamin D3 level when using stimulated saliva with gum-chewing
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Steroids 78:884-7. 2013
    ..The aim of this study was to clarify whether the concentration of 25(OH)D3 in whole saliva is influenced by gum-chewing...
  3. doi request reprint Chemical derivatization for enhancing sensitivity during LC/ESI-MS/MS quantification of steroids in biological samples: a review
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda shi, Chiba 278 8510, Japan Electronic address
    J Steroid Biochem Mol Biol 162:57-69. 2016
    ..The stable isotope-coded derivatization procedures for the steroid analysis are also described. ..
  4. doi request reprint Methods for determination of fingernail steroids by LC/MS/MS and differences in their contents between right and left hands
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda shi, Chiba 278 8510, Japan Electronic address
    Steroids 109:60-5. 2016
    ..In fact, the nail TST content showed a significant sex difference, just like its serum/plasma concentration. ..
  5. doi request reprint Isotope-coded ESI-enhancing derivatization reagents for differential analysis, quantification and profiling of metabolites in biological samples by LC/MS: A review
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan Electronic address
    J Pharm Biomed Anal 130:181-193. 2016
    ....
  6. doi request reprint Methods for differential and quantitative analyses of brain neurosteroid levels by LC/MS/MS with ESI-enhancing and isotope-coded derivatization
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan Electronic address
    J Pharm Biomed Anal 117:155-62. 2016
    ..7%] and accuracy (analytical recovery ranged from 98.7 to 106.7%). ..
  7. doi request reprint Development and validation of a method for determination of plasma 25-hydroxyvitamin D3 3-sulfate using liquid chromatography/tandem mass spectrometry
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda shi, Chiba 278 8510, Japan Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 969:230-4. 2014
    ..5ng/mL. The developed method was applied to the determination of plasma 25(OH)D3S in infants; the result revealed that preterm infants have lower plasma 25(OH)D3S concentrations. ..
  8. doi request reprint Derivatization of chiral carboxylic acids with (S)-anabasine for increasing detectability and enantiomeric separation in LC/ESI-MS/MS
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan
    J Sep Sci 35:2840-6. 2012
    ....
  9. doi request reprint Influence of saliva flow rate stimulated by gum-chewing on salivary concentrations of catecholamine metabolites
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278 8510, Japan
    Clin Chim Acta 414:248-52. 2012
    ..However, the rate of saliva production may affect the salivary concentrations of these catecholamine metabolites. We clarified whether the salivary concentrations of HVA and MHPG are dependent on the rate of salivation...
  10. ncbi request reprint Salivary hormone measurement using LC/MS/MS: specific and patient-friendly tool for assessment of endocrine function
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan
    Biol Pharm Bull 35:1401-8. 2012
    ..Practical derivatization to enhance the detectabilities of hormones in ESI-MS/MS is also discussed, because a major disadvantage of using saliva is low hormone concentrations...
  11. doi request reprint Diels-Alder derivatization for sensitive detection and characterization of conjugated linoleic acids using LC/ESI-MS/MS
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan
    Anal Bioanal Chem 403:495-502. 2012
    ....
  12. ncbi request reprint Studies on neurosteroids XVI. Levels of pregnenolone sulfate in rat brains determined by enzyme-linked immunosorbent assay not requiring solvolysis
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Kanazawa University, Takara machi, Japan
    Biol Pharm Bull 26:709-11. 2003
    ..37-1.29 ng/g tissue). These results demonstrate that, in rats, the brain PREGS may be derived from peripheral sources, and its actual levels are much lower than those previously measured by indirect methods...
  13. pmc A Method for Simultaneous Determination of 25-Hydroxyvitamin D3 and Its 3-Sulfate in Newborn Plasma by LC/ESI-MS/MS after Derivatization with a Proton-Affinitive Cookson-Type Reagent
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science
    Mass Spectrom (Tokyo) 5:S0051. 2016
    ....
  14. doi request reprint A novel Cookson-type reagent for enhancing sensitivity and specificity in assessment of infant vitamin D status using liquid chromatography/tandem mass spectrometry
    Shoujiro Ogawa
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278 8510, Japan
    Rapid Commun Mass Spectrom 27:2453-60. 2013
    ..The objective of this study was the development of a novel Cookson-type reagent surpassing PTAD in terms of sensitivity and specificity in the LC/ESI-MS/MS assay of 25(OH)D3...
  15. ncbi request reprint Application of 4-(4-nitrophenyl)-1,2,4-triazoline-3,5-dione to analysis of 25-hydroxyvitamin D3 in human plasma by liquid chromatography/electron capture atmospheric pressure chemical ionization-mass spectrometry
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Anal Sci 19:941-3. 2003
    ..This derivatization-LC/ECAPCI-MS method was applied to a plasma 25-hydroxyvitamin D3 assay, and gave satisfactory results in sensitivity, specificity, measurable range and throughput of the analysis...
  16. doi request reprint Comparative evaluation of new Cookson-type reagents for LC/ESI-MS/MS assay of 25-hydroxyvitamin D3 in neonatal blood samples
    Shoujiro Ogawa
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278 8510, Japan
    Biomed Chromatogr 30:938-45. 2016
    ..Thus, DEAPTAD was proved useful in the measurement of 25(OH)D3 in neonatal blood samples. Copyright © 2015 John Wiley & Sons, Ltd. ..
  17. ncbi request reprint Detection and characterization of 20-oxosteroids in rat brains using LC-electron capture APCI-MS after derivatization with 2-nitro-4-trifluoromethylphenylhydrazine
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Analyst 128:130-3. 2003
    ..Pregnenolone, progesterone, 5alpha-dihydroprogesterone, allopregnanolone and epiallopregnanolone were clearly detected with a 50 mg sample of the brain tissue...
  18. doi request reprint An efficient synthesis of 7α,12α-dihydroxy-4-cholesten-3-one and its biological precursor 7α-hydroxy-4-cholesten-3-one: Key intermediates in bile acid biosynthesis
    Shoujiro Ogawa
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 278 8510, Japan
    Steroids 78:927-37. 2013
    ....
  19. doi request reprint Enhancing analysis throughput, sensitivity and specificity in LC/ESI-MS/MS assay of plasma 25-hydroxyvitamin D3 by derivatization with triplex 4-(4-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues
    Shoujiro Ogawa
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda shi, Chiba 278 8510, Japan
    J Pharm Biomed Anal 136:126-133. 2016
    ..The multiplexing of samples by the isotopologue derivatization was applied to the analysis of plasma samples of healthy subjects and the developed method was proven to have a satisfactory applicability...
  20. doi request reprint Application of Cookson-type reagents for biomedical HPLC and LC/MS analyses: a brief overview
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, 278 8510, Japan
    Biomed Chromatogr 31:. 2017
    ..This paper is a brief overview of the applications of the reagents for biomedical analyses mainly using HPLC or LC/MS(/MS)...
  21. ncbi request reprint Development and validation of the simultaneous measurement of four vitamin D metabolites in serum by LC-MS/MS for clinical laboratory applications
    Mamoru Satoh
    Division of Clinical Mass Spectrometry, Chiba University Hospital, 1 8 1 Inohana, Chuo Ku, Chiba shi, Chiba, 260 8670, Japan
    Anal Bioanal Chem 408:7617-7627. 2016
    ..This method will aid further understanding of low-abundance vitamin D metabolites, as well as the accurate determination of 25(OH)D3 and 25(OH)D2...
  22. doi request reprint LC/ESI-MS/MS method for determination of salivary eicosapentaenoic acid concentration to arachidonic acid concentration ratio
    Shoujiro Ogawa
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278 8510, Japan
    Biomed Chromatogr 30:29-34. 2016
    ..0%). The method was successfully applied to the measurement of the salivary EPA/AA ratios of healthy Japanese subjects and their changes owing to the supplementation of EPA...
  23. ncbi request reprint Derivatization of neutral steroids to enhance their detection characteristics in liquid chromatography-mass spectrometry
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, 920 0934 Kanazawa, Japan
    Anal Bioanal Chem 378:875-82. 2004
    ..The introduction of moieties with proton affinity or electron affinity enhances the analyte signals in positive and negative atmospheric pressure chemical ionization MS, respectively...
  24. ncbi request reprint Electron-capturing derivatization of neutral steroids for increasing sensitivity in liquid chromatography/negative atmospheric pressure chemical ionization-mass spectrometry
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Anal Sci 18:1301-7. 2002
    ..The developed derivatization procedures were applied to analyses of small amounts of steroids in human plasma and gave satisfactory results...
  25. doi request reprint Enantioselective determination of ibuprofen in saliva by liquid chromatography/tandem mass spectrometry with chiral electrospray ionization-enhancing and stable isotope-coded derivatization
    Shoujiro Ogawa
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    J Pharm Biomed Anal 98:387-92. 2014
    ..twice that of the (R)-enantiomer due to the unidirectional chiral inversion of the (R)- to (S)-enantiomer in vivo. Thus, saliva-based noninvasive pharmacokinetic analyses of IBU enantiomers were achieved by this method. ..
  26. doi request reprint (S)-1-(4-Dimethylaminophenylcarbonyl)-3-aminopyrrolidine: a derivatization reagent for enantiomeric separation and sensitive detection of chiral carboxylic acids by LC/ESI-MS/MS
    Shoujiro Ogawa
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 940:7-14. 2013
    ....
  27. doi request reprint Stereoselective synthesis and NMR characterization of C-24 epimeric pairs of 24-alkyl oxysterols
    Shoujiro Ogawa
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 278 8510, Japan
    Lipids 48:197-207. 2013
    ..The present method may be useful for determining the stereochemical configuration at C-24 of this type of 24-alkyl oxysterols...
  28. ncbi request reprint Characterization of urinary metabolites of vitamin D(3) in man under physiological conditions using liquid chromatography-tandem mass spectrometry
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, 920 0934, Kanazawa, Japan
    J Pharm Biomed Anal 29:947-55. 2002
    ..In addition, 23S,25-dihydroxy-24-oxovitamin D(3) occurred as its glucuronide in most of the urine, which suggested that this metabolite also plays a part in the excretion of vitamin D(3) in man...
  29. doi request reprint Analysis of urinary vitamin D₃ metabolites by liquid chromatography/tandem mass spectrometry with ESI-enhancing and stable isotope-coded derivatization
    Shoujiro Ogawa
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278 8510, Japan
    Anal Bioanal Chem 406:6647-54. 2014
    ..5%]. The method was successfully applied to urine sample analyses and detected the increases of the urinary 25(OH)D₃ and 24,25(OH)₂D₃ levels due to vitamin D₃ administration...
  30. ncbi request reprint Studies on neurosteroids XV. Development of enzyme-linked immunosorbent assay for examining whether pregnenolone sulfate is a veritable neurosteroid
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    J Pharm Biomed Anal 30:1907-17. 2003
    ..These results practically agreed with our previous results by liquid chromatography (LC)-electrospray ionization (ESI)-MS without deconjugation...
  31. ncbi request reprint Liquid chromatography--mass spectrometric method combined with derivatization for determination of 1 alpha-hydroxyvitamin D(3) in human plasma
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 772:229-38. 2002
    ..The limit of quantitation was 25 pg/ml for a 1.0-ml plasma aliquot. The application of the developed method to the sample of a volunteer orally given 1 alpha(OH)D(3) was also described...