Tomio Arai

Summary

Affiliation: Tokyo Metropolitan Institute of Gerontology
Country: Japan

Publications

  1. ncbi request reprint Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan
    Mod Pathol 17:172-9. 2004
  2. ncbi request reprint Age-related alteration in the association of microsatellite instability with absent hMLH1 expression and histological types of colorectal carcinoma
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Pathol Int 56:597-603. 2006
  3. ncbi request reprint Microsatellite-unstable mucinous colorectal carcinoma occurring in the elderly: comparison with medullary type poorly differentiated adenocarcinoma
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Sakaecho, Tokyo, Japan
    Pathol Int 57:205-12. 2007
  4. ncbi request reprint Clinicopathological and molecular characteristics of gastric and colorectal carcinomas in the elderly
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Sakaecho, Tokyo, Japan
    Pathol Int 57:303-14. 2007
  5. pmc Association of the RYR3 gene polymorphisms with atherosclerosis in elderly Japanese population
    Chenxi Zhao
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    BMC Cardiovasc Disord 14:6. 2014
  6. doi request reprint Frequent microsatellite instability in papillary and solid-type, poorly differentiated adenocarcinomas of the stomach
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakaecho, Itabashi ku, Tokyo, 173 0015, Japan
    Gastric Cancer 16:505-12. 2013
  7. pmc Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases
    Koichi Fujimoto
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    BMC Med Genet 11:159. 2010
  8. pmc Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men
    Miao Liu
    Department of Urology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    BMC Genet 10:37. 2009
  9. ncbi request reprint Histological evidence for cell proliferation activity in cystic tumor (endodermal heterotopia) of the atrioventricular node
    T Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Japan
    Pathol Int 48:917-23. 1998
  10. ncbi request reprint Primary adenocarcinoma of the duodenum in the elderly: clinicopathological and immunohistochemical study of 17 cases
    T Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Japan
    Pathol Int 49:23-9. 1999

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan
    Mod Pathol 17:172-9. 2004
    ..These results indicated that hMLH1 hypermethylation, concurrent with a lack of its protein expression, may play an important role in the development of medullary-type poorly differentiated colorectal adenocarcinomas in the elderly...
  2. ncbi request reprint Age-related alteration in the association of microsatellite instability with absent hMLH1 expression and histological types of colorectal carcinoma
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Pathol Int 56:597-603. 2006
    ..These results indicate that an age-related increase of medullary-type tumors in poorly differentiated adenocarcinoma may play an important role in the increase of absent hMLH1 expression and MSI in colorectal carcinoma...
  3. ncbi request reprint Microsatellite-unstable mucinous colorectal carcinoma occurring in the elderly: comparison with medullary type poorly differentiated adenocarcinoma
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Sakaecho, Tokyo, Japan
    Pathol Int 57:205-12. 2007
    ....
  4. ncbi request reprint Clinicopathological and molecular characteristics of gastric and colorectal carcinomas in the elderly
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Sakaecho, Tokyo, Japan
    Pathol Int 57:303-14. 2007
    ..Methylation, apoptosis, and telomere dysfunction play important roles in the development of gastric and colorectal cancers in the elderly...
  5. pmc Association of the RYR3 gene polymorphisms with atherosclerosis in elderly Japanese population
    Chenxi Zhao
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    BMC Cardiovasc Disord 14:6. 2014
    ..We investigated the effect of these two SNPs as well as the 31.1 kilobases spanning region on atherosclerosis in Japanese population...
  6. doi request reprint Frequent microsatellite instability in papillary and solid-type, poorly differentiated adenocarcinomas of the stomach
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakaecho, Itabashi ku, Tokyo, 173 0015, Japan
    Gastric Cancer 16:505-12. 2013
    ..The purpose of the present study is to clarify the relationship between histological subtype and microsatellite status in gastric carcinomas...
  7. pmc Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases
    Koichi Fujimoto
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    BMC Med Genet 11:159. 2010
    ..Whether they are associated with emphysema is not known...
  8. pmc Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men
    Miao Liu
    Department of Urology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    BMC Genet 10:37. 2009
    ..Here, we evaluated whether the single-nucleotide polymorphisms rs1447295 and rs6983267 were associated with the risk of sporadic prostate cancer as well as latent prostate cancer in a native Japanese population...
  9. ncbi request reprint Histological evidence for cell proliferation activity in cystic tumor (endodermal heterotopia) of the atrioventricular node
    T Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Japan
    Pathol Int 48:917-23. 1998
    ..These findings support that this lesion originates from the endoderm. Moreover, it is likely that progression in the degree of AV block may be explained by the cell proliferation activity of the tumor...
  10. ncbi request reprint Primary adenocarcinoma of the duodenum in the elderly: clinicopathological and immunohistochemical study of 17 cases
    T Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Japan
    Pathol Int 49:23-9. 1999
    ..Furthermore, it is concluded that invasive duodenal adenocarcinomas with high PR should be considered as potentially aggressive tumors, although their histology may indicate a high degree of differentiation...
  11. ncbi request reprint Age-related mitochondrial DNA deletion in human heart: its relationship with cardiovascular diseases
    Tomio Arai
    Departments of Pathology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan
    Aging Clin Exp Res 15:1-5. 2003
    ..The aim of the present study was to clarify the relationship between aging, mtDNA deletion and cardiovascular (CV) diseases...
  12. doi request reprint Role of DNA repair systems in malignant tumor development in the elderly
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Geriatr Gerontol Int 8:65-72. 2008
    ....
  13. doi request reprint Role of methylation of the hMLH1 gene promoter in the development of gastric and colorectal carcinoma in the elderly
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Geriatr Gerontol Int 10:S207-12. 2010
    ....
  14. doi request reprint Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis: a pathological study of 1503 consecutive autopsy cases
    Shinobu Ikeda
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Atherosclerosis 221:458-60. 2012
    ..However, their effects on coronary atherosclerosis, an intermediate phenotype of MI, remain largely unknown...
  15. doi request reprint Changes of telomere length with aging
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 10:S197-206. 2010
    ..Our Q-FISH method using our original software program "Tissue Telo" is excellent for measuring telomere lengths using tissue sections and PNA probes...
  16. doi request reprint Palisade vessels as a new histologic marker of esophageal origin in ER specimens from columnar-lined esophagus
    Junko Aida
    Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Am J Surg Pathol 35:1140-5. 2011
    ..At least 1 of these 4 markers was seen in 88% of the sections. Therefore, ER specimens were confirmed to originate from CLE in 88% of single histologic sections of CLE on the basis of histologic examination alone...
  17. ncbi request reprint Lewy body-related alpha-synucleinopathy in aging
    Yuko Saito
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neuropathol Exp Neurol 63:742-9. 2004
    ..Our findings indicate that LBs are associated with cognitive decline, either independently or synergistically with neurofibrillary tangles and senile plaques...
  18. doi request reprint Association between genetic variations in surfactant protein d and emphysema, interstitial pneumonia, and lung cancer in a Japanese population
    Takeo Ishii
    Department of Pulmonary Medicine, Infection and Oncology, The Respiratory Care Clinic, Nippon Medical School, Tokyo, Japan
    COPD 9:409-16. 2012
    ..Our results suggested that SFTPD plays a role in the development of lung cancer and that the role for lung cancer may differ from that for interstitial pneumonia...
  19. pmc Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Breast Cancer Res 11:R48. 2009
    ..The aim of the present study is to elucidate whether there are any specific patterns in use of multiple exons 1 in elderly breast tissue...
  20. ncbi request reprint Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older
    Ken ichi Nakamura
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Exp Gerontol 42:944-50. 2007
    ..Our study lends indispensable support to the hypothesis that longer telomeres protect the genome from instability (a major cause of carcinogenesis) and are beneficial for longevity...
  21. doi request reprint Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb
    Renpei Sengoku
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neuropathol Exp Neurol 67:1072-83. 2008
    ..These results indicate a high incidence of LBAS in the aging human OB; they also suggest that LBAS extends from the periphery to the anterior olfactory nucleus and results in clinical manifestations of LB disease...
  22. doi request reprint Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    J Pathol 221:201-9. 2010
    ..We have demonstrated conclusively that oesophageal CIS arises from epithelium with short telomeres and chromosomal instability in the absence of histological inflammation...
  23. ncbi request reprint Developments of geriatric autopsy database and Internet-based database of Japanese single nucleotide polymorphisms for geriatric research (JG-SNP)
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, 35 2 Sakae cho, Itabashi, Tokyo 173 0015, Japan
    Mech Ageing Dev 125:547-52. 2004
    ..As autopsy studies can provide large amounts of accurate medical information, including the presence of undiagnosed diseases such as latent cancers, the GEAD is a unique and excellent database for research on genetic polymorphisms...
  24. ncbi request reprint Staging of argyrophilic grains: an age-associated tauopathy
    Yuko Saito
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    J Neuropathol Exp Neurol 63:911-8. 2004
    ..Our study further confirms that dementia with grains is an age-associated tauopathy with relatively uniform distribution and may independently contribute to cognitive decline in the elderly...
  25. doi request reprint Alcoholics show reduced telomere length in the oesophagus
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Pathol 223:410-6. 2011
    ..Further studies to clarify the reason for the large annual loss of telomere length with rapid turnover or lower telomerase activity in the oesophageal epithelium of alcoholics will be necessary...
  26. pmc Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    PLoS ONE 8:e63860. 2013
    ..Telomere shortening may not generate cancer directly, but may create conditions under which SCC can develop more easily, depending on subsequent exposure to carcinogens...
  27. pmc Telomere length dynamics in the human pituitary gland: robust preservation throughout adult life to centenarian age
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2 Itabashi ku, Tokyo, Japan
    Age (Dordr) 34:795-804. 2012
    ..These data indicate that innate telomere length is highly conserved in the pituitary and suggest that pituitary telomere length provides a good basic indicator for studies of telomere biology...
  28. doi request reprint Association between estrogen receptor-β dinucleotide repeat polymorphism and incidence of femoral fracture
    Naoko Honma
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo, 173 0015, Japan
    J Bone Miner Metab 31:96-101. 2013
    ..0133). Japanese subjects, especially women, bearing at least one allele of 20 CA repeats in the ESR2 may have a lower risk of femoral fracture than those without it, suggesting this polymorphism plays a role in bone metabolism...
  29. doi request reprint A replication study examining three common single-nucleotide polymorphisms and the risk of prostate cancer in a Japanese population
    Miao Liu
    Department of Urology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Prostate 71:1023-32. 2011
    ..In this study, we examined the association between three key single-nucleotide polymorphisms (SNPs) in these two regions and the risk of prostate cancer in a Japanese population...
  30. ncbi request reprint Association of estrogen receptor alpha gene polymorphisms with neurofibrillary tangles
    Hirohito Kazama
    Department of Endocrinology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Dement Geriatr Cogn Disord 18:145-50. 2004
    ..In conclusion, the PvuII polymorphism of the ERalpha gene is associated with Braak NFT stages and possession of the P allele may act as a risk factor for AD in Japanese men, especially in those without the epsilon4 allele...
  31. ncbi request reprint Nomogram of the relation of brachial-ankle pulse wave velocity with blood pressure
    Akira Yamashina
    Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Hypertens Res 26:801-6. 2003
    ....
  32. ncbi request reprint Aortic pulse wave velocity and the degree of atherosclerosis in the elderly: a pathological study based on 304 autopsy cases
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakae cho, Itabashi, Tokyo 173 0015, Japan
    Atherosclerosis 179:345-51. 2005
    ..Studies examining the correlation between aortic pulse wave velocity (PWV) and atherosclerosis have reported conflicting results. The present paper verifies this correlation by conducting autopsy examination of elderly subjects...
  33. ncbi request reprint Sustained progression and loss of the gender-related difference in atherosclerosis in the very old: a pathological study of 1074 consecutive autopsy cases
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakae cho, Itabashi, Tokyo 173 0015, Japan
    Atherosclerosis 186:374-9. 2006
    ..The objective of this paper is to reveal whether the atherosclerosis continues to progress, or the gender-related difference exists in the very old...
  34. ncbi request reprint Smoking confers a MTHFR 677C>T genotype-dependent risk for systemic atherosclerosis: results from a large number of elderly autopsy cases that died in a community-based general geriatric hospital
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    J Atheroscler Thromb 16:91-104. 2009
    ..We attempted to explore interactions between smoking and the genetic polymorphism of 24 atherosclerosis-related candidate genes in systemic atherosclerosis...
  35. pmc Telomere attrition in beta and alpha cells with age
    Yoshiaki Tamura
    Department of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Age (Dordr) 38:61. 2016
    ..There was a positive correlation between NTCRβ and NTCRα only among adult subjects (p < 0.001). In conclusion, the telomeres of β and α cells become shortened with normal aging process. ..
  36. doi request reprint Association of polymorphisms of the transporter associated with antigen processing (TAP2) gene with pulmonary tuberculosis in an elderly Japanese population
    Kaung Si Thu
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    APMIS 124:675-80. 2016
    ..48, p = 0.0008), while the TAP2 *0201 allele was protective against TB (OR = 0.73, p = 0.0007). Our results suggest that TAP2 polymorphisms influence TB susceptibility in a Japanese population. ..
  37. ncbi request reprint Pathologic characteristics of gastric cancer in the elderly: a retrospective study of 994 surgical patients
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, 35 2 Sakae cho, Itabashi ku, 173 0015 Tokyo, Japan
    Gastric Cancer 7:154-9. 2004
    ..The clinicopathologic features of gastric carcinoma in elderly people have been reported previously. The present study examined the patterns and distribution of gastric carcinomas in the elderly, especially in patients aged 85 and older...
  38. doi request reprint Telomere lengths in the oral epithelia with and without carcinoma
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo 173 0015, Japan
    Eur J Cancer 46:430-8. 2010
    ..Thus we have conclusively demonstrated that CIS arises from epithelium with short telomeres...
  39. doi request reprint Neuropathological asymmetry in argyrophilic grain disease
    Tadashi Adachi
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neuropathol Exp Neurol 69:737-44. 2010
    ..Thus, asymmetric involvement of the medial temporal lobe in patients with advanced argyrophilic grain disease may represent a diagnostic feature and contribute to distinguishing dementia with grains from Alzheimer disease...
  40. doi request reprint Lewy body pathology involves cutaneous nerves
    Masako Ikemura
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Graduate School of Medicine, The University of Tokyo, and Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    J Neuropathol Exp Neurol 67:945-53. 2008
    ..We demonstrate for the first time that the skin is involved and may be a highly specific and useful biopsy site for the pathological diagnosis of LB diseases...
  41. ncbi request reprint Elderly patients with minimal common carotid atherosclerosis not infrequently have severe coronary atherosclerosis and myocardial infarction
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Circ J 72:1946-52. 2008
    ..The presence of discordances between common carotid and coronary atherosclerosis in the same individual has not been previously reported...
  42. ncbi request reprint Mitochondrial haplogroups A and M7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly: an autopsy study of 1,536 patients
    Motoji Sawabe
    Department of Pathology and Bioresource Center for Geriatric Research, Tokyo Metropolitan Geriatric Hospital, Itabashi, Tokyo, Japan
    J Atheroscler Thromb 18:166-75. 2011
    ..Here, we assessed the hypothesis that mtSNPs may confer a risk for atherosclerosis, the most important intermediate phenotype of ischemic cardiovascular events...
  43. doi request reprint Clinicopathological Features of 15 Occult and 178 Clinical Pancreatic Ductal Adenocarcinomas in 8339 Autopsied Elderly Patients
    Yoko Matsuda
    From the Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Itabashi ku Department of Pathology and Integrative Oncological Pathology, Nippon Medical School, Bunkyo ku Division of Cancer Genomics, National Cancer Center Research Institute, Chuo ku and Research Team for Geriatric Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Pancreas 45:234-40. 2016
    ..The aim of the study was to investigate the clinicopathological features of pancreatic cancer at different stages using autopsy results...
  44. doi request reprint Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, 35 2, Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    Exp Gerontol 43:833-9. 2008
    ..The reduction of telomere length with age and in each cell layer is consistent with the telomere biology theory of cell proliferation and differentiation in oral mucosa...
  45. doi request reprint Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Mech Ageing Dev 131:614-24. 2010
    ..6%). Our results indicate that chromosomes having excessively shortened telomeres at late PDLs begin to show features of instability such as fusions and anaphase bridges...
  46. doi request reprint Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa
    Sayaka Funabe
    Departments of Neuropathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan
    Neuropathology 33:47-58. 2013
    ..Our studies further confirmed importance of the olfactory entry zone in propagation of LBAS in the human aging nervous system...
  47. doi request reprint Differences in the definitions used for esophageal and gastric diseases in different countries: endoscopic definition of the esophagogastric junction, the precursor of Barrett's adenocarcinoma, the definition of Barrett's esophagus, and histologic criteri
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology and Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Digestion 80:248-57. 2009
    ..Definitions and opinions in the field of gastroenterology vary widely in different countries...
  48. ncbi request reprint Oncocytic adenocarcinoma of the stomach: parietal cell carcinoma
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology and Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Am J Surg Pathol 26:458-65. 2002
    ..Previously reported cases of parietal cell carcinoma have been said to have a favorable prognosis, but it will be necessary to study a larger number of cases to determine the prognosis of oncocytic adenocarcinoma...
  49. doi request reprint Estrogen receptor-β gene polymorphism and colorectal cancer risk: effect modified by body mass index and isoflavone intake
    Naoko Honma
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Int J Cancer 132:951-8. 2013
    ..Aging and estrogenic condition may be important in the colon cancer pathogenesis associated with ESR2 CA repeat polymorphism...
  50. ncbi request reprint Association of COMT gene polymorphisms with systemic atherosclerosis in elderly Japanese
    Maung Kyi Chan Ko
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Atheroscler Thromb 19:552-8. 2012
    ..The objective of this study was to examine whether polymorphisms of the COMT gene affected the severity of atherosclerotic disease in a Japanese elderly population...
  51. pmc Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases
    Kako Takei
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 101 0062, Japan
    BMC Cancer 8:235. 2008
    ..Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer...
  52. ncbi request reprint Cut-off value of the ankle-brachial pressure index at which the accuracy of brachial-ankle pulse wave velocity measurement is diminished
    Koki Motobe
    Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Circ J 69:55-60. 2005
    ..The present study was conducted to establish the cutoff value of the ankle-brachial pressure index (ABI) at which the accuracy of brachial-ankle pulse wave velocity (baPWV) measurement is diminished...
  53. ncbi request reprint Polymorphisms in pro- and anti-inflammatory cytokine genes and susceptibility to atherosclerosis: a pathological study of 1503 consecutive autopsy cases
    Kanae Oda
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Hum Mol Genet 16:592-9. 2007
    ....
  54. doi request reprint Changes of telomere status with aging: An update
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 16:30-42. 2016
    ..In addition, we describe newly found factors that are thought to impact telomere dynamics, providing a new avenue for examining the unsolved issues related to telomere restoration and maintenance...
  55. ncbi request reprint Genetic risk score based on the lifetime prevalence of femoral fracture in 924 consecutive autopsies of Japanese males
    Heying Zhou
    Center for Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakae, Itabashi, Tokyo, 173 0015, Japan
    J Bone Miner Metab 34:685-691. 2016
    ..89-15.36, P < 0.001) relative to scores of 0-5 (n = 786). The GRS based on risk allele profiles of the five SNPs could help identify at-risk individuals and enable implementation of preventive measures for femoral fracture...
  56. doi request reprint Reduction of Small Fibers of Thoracic Ventral Roots and Neurons of Intermediolateral Nucleus in Parkinson Disease and Dementia with Lewy Bodies
    Hiroyuki Hatsuta
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Parkinsons Dis 6:325-34. 2016
    ....
  57. ncbi request reprint Is there a set of histologic changes that are invariably reflux associated?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Sakae cho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Arch Pathol Lab Med 129:159-63. 2005
    ..To develop a set of characteristic reflux-associated features, endoscopists may perform targeted biopsies from several sites with various endoscopic features and at different stages of disease...
  58. ncbi request reprint Telomere shortening with aging in the human pancreas
    Akio Ishii
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    Exp Gerontol 41:882-6. 2006
    ..4 kilobase pairs (kbp) in 16 neonates, as opposed to 8.4 kbp in 2 centenarians. Mean telomere length (+/-SD) in four age groups, 0-24, 25-49, 50-74, and 75-100 yr, was 13.5+/-1.5, 12.3+/-0.7, 11.3+/-2.5, and 10.7+/-1.8, respectively...
  59. doi request reprint Association of the formiminotransferase N-terminal sub-domain containing gene and thrombospondin, type 1, domain-containing 7A gene with the prevalence of vertebral fracture in 2427 consecutive autopsy cases
    Heying Zhou
    Center for Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    J Hum Genet 58:109-12. 2013
    ..The results suggest that Japanese subjects homozygous for the risk alleles of rs7605378 and rs12673629 have a higher risk of vertebral fracture...
  60. pmc Involvement of surfactant protein D in emphysema revealed by genetic association study
    Takeo Ishii
    Department of Internal Medicine, Division of Pulmonary Medicine, Infectious Diseases and Oncology, Nippon Medical School, Tokyo, Japan
    Eur J Hum Genet 20:230-5. 2012
    ..Subjects with a C allele at rs721917 have a lower serum SFTPD concentration and are more susceptible to emphysema. This suggests a protective effect of SFTPD against COPD and emphysema...
  61. ncbi request reprint Polymorphism of cytochrome P450 2B6 and prostate cancer risk: a significant association in a Japanese population
    Takayuki Kurosaki
    Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Urol 16:364-8. 2009
    ..To explore whether Lys262Arg polymorphism of the Cytochrome P450 2B6 (CYP2B6) gene could act as a genetic marker for prostate cancer risk among Japanese men...
  62. doi request reprint Polymorphisms of the formylpeptide receptor gene (FPR1) and susceptibility to stomach cancer in 1531 consecutive autopsy cases
    Tatsuro Otani
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, and Department of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan
    Biochem Biophys Res Commun 405:356-61. 2011
    ..Further studies on the relationship between stomach cancer and the FPR1 gene are warranted...
  63. doi request reprint A missense single nucleotide polymorphism, V114I of the Werner syndrome gene, is associated with risk of osteoporosis and femoral fracture in the Japanese population
    Heying Zhou
    Center for Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakae, Itabashi, Tokyo, 173 0015, Japan
    J Bone Miner Metab 33:694-700. 2015
    ..The results suggest that Japanese subjects bearing at least one A allele of rs2230009 of the WRN gene are at a significantly higher risk of femoral fracture, possibly due to decreased bone density...
  64. doi request reprint Association of the chromodomain helicase DNA-binding protein 4 (CHD4) missense variation p.D140E with cancer: potential interaction with smoking
    Miki Yamada
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Genes Chromosomes Cancer 54:122-8. 2015
    ..24; 95% CI, 1.43-7.33; P = 0.005), and rectum cancer (adjusted OR, 6.23; 95% CI, 2.31-16.8; P < 0.001). A nonsynonymous SNV of CHD4, p.D140E, confers a risk of cancer and may interact with smoking habit to increase the risk...
  65. ncbi request reprint Comparative study of monoclonal antibody B72.3 and gross cystic disease fluid protein-15 as markers of apocrine carcinoma of the breast
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    APMIS 114:712-9. 2006
    ..3 and GCDFP-15. Whether these two cases should be differentiated from ordinary apocrine carcinomas remains to be investigated...
  66. doi request reprint Markedly different clinical features in 2 diabetes mellitus patients with extremely high tissue levels of the mitochondrial DNA A3243G mutation
    Shinji Harihara
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan
    Gerontology 54:168-72. 2008
    ..Mitochondrial DNA (mtDNA) A3243G mutation is one of the major causative factors of mitochondrial diabetes mellitus. We found that tissues from 2 of 142 diabetes mellitus patients showed extremely high levels of the mutation...
  67. doi request reprint The normal anatomy around the oesophagogastric junction: a histopathologic view and its correlation with endoscopy
    Kaiyo Takubo
    Research Team for Geriatric Diseases Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Sakae cho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Best Pract Res Clin Gastroenterol 22:569-83. 2008
    ..The nature of the OGJ is clarified in detail through comparison between endoscopically evident and histological features...
  68. doi request reprint Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma
    Kaiyo Takubo
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Hum Pathol 40:65-74. 2009
    ..Also, it seems better to define Barrett esophagus as metaplastic columnar-lined esophagus alone, without requiring the presence of goblet cells, in accordance with histogenetic and practical standpoints...
  69. doi request reprint Oestrogen receptor-beta1 but not oestrogen receptor-betacx is of prognostic value in apocrine carcinoma of the breast
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    APMIS 116:923-30. 2008
    ..ER-beta1 itself, independent of ER-alpha expression and tamoxifen treatment, seems to have a tumor-suppressive effect, at least in apocrine carcinomas. Further study of ER-beta1 is desired to optimize breast cancer treatment...
  70. ncbi request reprint [Pathologic characteristics of malignant neoplasms occurring in the elderly]
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Gan To Kagaku Ryoho 38:1571-6. 2011
    ....
  71. ncbi request reprint Standard organ weights among elderly Japanese who died in hospital, including 50 centenarians
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Pathol Int 56:315-23. 2006
    ..In conclusion, the standard organ weights of elderly patients who died while hospitalized were determined. Undernutrition contributed significantly to a reduction in organ weights...
  72. ncbi request reprint [Analysis of multiple cancers in autopsy cases of elderly hematological malignancies]
    Yuko Osajima
    Division of Hematology, Tokyo Metropolitan Geriatric Hospital, Japan
    Rinsho Ketsueki 49:1599-603. 2008
    ..6%). Of 10 cases showing duplication of other hematological malignancies, 9 cases had NHL. The rate of multiple cancers in elderly patients with hematological malignancy was higher than that of non-hematological cancers...
  73. doi request reprint Short telomeres in an oral precancerous lesion: Q-FISH analysis of leukoplakia
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    J Oral Pathol Med 41:372-8. 2012
    ..Therefore, we consider OKD-type leukoplakia to be a true precancerous lesion...
  74. ncbi request reprint Early pathogenesis of cardiac amyloid deposition in senile systemic amyloidosis: close relationship between amyloid deposits and the basement membranes of myocardial cells
    Motoji Sawabe
    Departments of Pathology and Cardiology, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakae cho, Itabashi, 173 0015, Tokyo, Japan
    Virchows Arch 442:252-7. 2003
    ..Our results indicate that the basement membrane of myocardial cells is the initial site of amyloid deposition, providing a suitable place for concentration of TTR...
  75. doi request reprint Association of fucosyltransferase 8 (FUT8) polymorphism Thr267Lys with pulmonary emphysema
    Miki Yamada
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Hum Genet 56:857-60. 2011
    ..5±14.7 vs 32.7±13.9, P=0.02). The FUT8 gene Thr267Lys polymorphism is associated with human PE, and the Lys allele is the risk. The core fucosylation might be involved in the molecular pathogenesis of human PE...
  76. ncbi request reprint Detection of human papillomavirus infection of the cervix in very elderly women using PCR
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Clin Cancer Res 11:2919-23. 2005
    ....
  77. ncbi request reprint The Val158Met polymorphism of the catechol-O-methyltransferase gene is not associated with the risk of sporadic or latent prostate cancer in Japanese men
    Motofumi Suzuki
    Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Urol 14:800-4. 2007
    ..We attempted to investigate whether the Val158Met polymorphism of COMT was associated with the risk of prostate cancer...
  78. ncbi request reprint Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in lewy body disease
    Yuichi Fumimura
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neuropathol Exp Neurol 66:354-62. 2007
    ..Our results indicate that the adrenal gland can provide useful information for evaluation of the PANS in Lewy body disease...
  79. ncbi request reprint Ciliated surface in the esophagogastric junction zone: a precursor of Barrett's mucosa or ciliated pseudostratified metaplasia?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Am J Surg Pathol 29:211-7. 2005
    ..These findings may suggest that squamous metaplasia-like change at the EGJ is not a precursor of Barrett's mucosa but rather is a form of pseudostratified metaplasia...
  80. ncbi request reprint Insulin sensitivity and endothelial function in hypertension: a comparison of temocapril and candesartan
    Hirofumi Tomiyama
    Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Am J Hypertens 18:178-82. 2005
    ..The present study compared the effects of ACEi and ARB on END and IS in patients with hypertension...
  81. doi request reprint Undiagnosed cirrhosis occurs frequently in the elderly and requires periodic follow ups and medical treatments
    Koichi Fujimoto
    Department of Gastroenterology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Geriatr Gerontol Int 8:198-203. 2008
    ..Autopsy examinations frequently reveal undiagnosed cirrhosis, but its characteristics have rarely been addressed in the elderly...
  82. ncbi request reprint Telomere lengths are characteristic in each human individual
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173 0015, Japan
    Exp Gerontol 37:523-31. 2002
    ..However, there is no simple link between telomeres and tissue turnover. We recently proposed a hypothesis that telomere shortening with aging and telomere lengths in different organs are characteristic for human individuals...
  83. ncbi request reprint Islands of squamous epithelium and their surrounding mucosa in columnar-lined esophagus: a pathognomonic feature of Barrett's esophagus?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Japan
    Hum Pathol 36:269-74. 2005
    ..From a practical point of view, biopsy specimens from columnar-lined mucosa of the esophagus do not always show intestinal metaplasia (specialized intestinal metaplasia)...
  84. ncbi request reprint Estrogen-metabolizing enzymes in breast cancers from women over the age of 80 years
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    J Clin Endocrinol Metab 91:607-13. 2006
    ..These estrogen-metabolizing enzymes (EMEs) are important in postmenopausal breast cancers, but have never been systematically examined in breast cancers of the elderly...
  85. ncbi request reprint Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Hum Pathol 38:1192-200. 2007
    ....
  86. ncbi request reprint Accumulation of phosphorylated alpha-synuclein in aging human brain
    Yuko Saito
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neuropathol Exp Neurol 62:644-54. 2003
    ....
  87. ncbi request reprint Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk
    Akira Yamashina
    Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Hypertens Res 26:615-22. 2003
    ..While the discriminating powers are not sufficiently high, a cutoff value of 14.0 m/s serves to screen subjects, especially in middle-aged ones, of either gender...
  88. ncbi request reprint Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium
    Ken ichi Nakamura
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    J Invest Dermatol 119:1014-9. 2002
    ..842, p<0.0001). These results indicate that the telomeres in epidermis and lingual epithelium are characterized by tissue-specific loss rates...
  89. ncbi request reprint Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement--a survey of 12517 subjects
    Hirofumi Tomiyama
    The Second Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Atherosclerosis 166:303-9. 2003
    ..Thus, aging influences baPWV, and its effect is more prominent in female. Menopause seems to be the crucial phenomenon to explain the augmented increase in arterial stiffness with aging in females...
  90. ncbi request reprint Hepatitis C virus seropositivity, but not hepatitis B virus carrier or seropositivity, associated with increased pulse wave velocity
    Hirofumi Tomiyama
    Second Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Atherosclerosis 166:401-3. 2003
    ..Thus, hepatitis C virus seropositivity was associated with increased PWV...
  91. ncbi request reprint Incidence of apoptosis increases with age in colorectal cancer
    Kenichiro Tanaka
    Department of Pathology and Immunology, Aging and Developmental Sciences, Tokyo Medical and Dental University, Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Exp Gerontol 37:1469-79. 2002
    ..The potential roles of these regulatory molecules on age-change in the proliferation/apoptosis of colorectal cancers are discussed...
  92. ncbi request reprint Increased pulse wave velocity associated with reduced calcaneal quantitative osteo-sono index: possible relationship between atherosclerosis and osteopenia
    Ken ichi Hirose
    Second Department of Internal Medicine, Tokyo Medical University, Tokyo 160 0023, Japan
    J Clin Endocrinol Metab 88:2573-8. 2003
    ..In females, this association was independent from menopause. These results suggest that common or related mechanisms, which may be accelerated after menopause, control both atherosclerosis and osteoporosis from the early stages...
  93. ncbi request reprint Adenoma, adenocarcinoma and mixed carcinoid-adenocarcinoma arising in a small lesion of the colon
    Yu Fei Jiao
    Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University, Uchimaru, Morioka, Japan
    Pathol Int 53:457-62. 2003
    ..The morphological appearances of the present case strongly suggests the histogenesis of this tumor in an adenoma-adenocarcinoma-carcinoid tumor sequence...
  94. ncbi request reprint [Free/total prostate specific antigen ratio (%PSA) to predict probability of prostate cancer]
    Mikio Zenimoto
    Department of Clinical Laboratory, Tokyo Metropolitan Geriatric Hospital, Itabasi ku, Tokyo 173 0015
    Rinsho Byori 51:969-73. 2003
    ..Four samples of which T-PAS levels were in gray zone, were assayed for %PSA. Two of them, with %PSA values less than 20 ng/ml, were found to be PCA, while the remaining two, with %PSA over 20 ng/ml, were BPH...
  95. ncbi request reprint The relationship between high-sensitive C-reactive protein and pulse wave velocity in healthy Japanese men
    Hirofumi Tomiyama
    Second Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, 160 0023 Tokyo, Japan
    Atherosclerosis 174:373-7. 2004
    ....
  96. ncbi request reprint The age-related increase in arterial stiffness is augmented in phases according to the severity of hypertension
    Hirofumi Tomiyama
    Second Department of Internal Medicine, Tokyo Medical University, Japan
    Hypertens Res 27:465-70. 2004
    ..These results support the JNC-7 recommendations for a strict control of blood pressure even in the elderly...
  97. ncbi request reprint Cancer and aging: symposium of the 27th annual meeting of the Japanese society for biomedical gerontology, Tokyo
    Masanobu Kitagawa
    Department of Comprehensive Pathology, Aging and Developmental Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Immunol Immunother 54:623-34. 2005
    ..It was concluded that apoptosis plays a role in the aging process and carcinogenesis in vivo, likely as an inherent protective mechanism against various kinds of damages to genes/chromosomes...
  98. ncbi request reprint Menopause is an independent factor augmenting the age-related increase in arterial stiffness in the early postmenopausal phase
    Gulnisa Zaydun
    Second Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishi shinjuku, Tokyo 160 0023, Japan
    Atherosclerosis 184:137-42. 2006
    ..The contribution of this menopause-related increase in arterial stiffness to the risk of cardiovascular disease in postmenopausal women should be further evaluated...
  99. ncbi request reprint [Biopsy methods and pathology of Barrett's esophagus]
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology
    Nihon Rinsho 63:1429-33. 2005
    ....
  100. ncbi request reprint Chronological trend of calorie intake and the incidence of epithelial neoplasms of the large intestine during the past 30 years in Japan
    Kyotaro Kanazawa
    Department of Gastroenterological and General Surgery, Jichi Medical School, Tochigi, Japan
    Oncology 69:46-9. 2005
    ..The authors tried to elucidate the effects of food intake on the incidences of colorectal cancer and adenoma...
  101. ncbi request reprint Value of CK14 and CD56 immunostaining in distinguishing small cell carcinoma from squamous cell carcinoma of the esophagus
    Gopi Aryal
    Department of Pathology, Nepal Medical College, Nepal
    Nepal Med Coll J 8:75-81. 2006
    ..6%; p = 0.04). These findings suggest that the CK14 and CD56 may be useful markers for differentiating SQC from SCC and vice versa. The p53 may also be useful to differentiate normal esophageal epithelium from SCC or SQC tissue...