Junko Aida

Summary

Affiliation: Tokyo Metropolitan Institute of Gerontology
Country: Japan

Publications

  1. pmc Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    PLoS ONE 8:e63860. 2013
  2. doi request reprint Short telomeres in an oral precancerous lesion: Q-FISH analysis of leukoplakia
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    J Oral Pathol Med 41:372-8. 2012
  3. doi request reprint Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, 35 2, Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    Exp Gerontol 43:833-9. 2008
  4. doi request reprint Alcoholics show reduced telomere length in the oesophagus
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Pathol 223:410-6. 2011
  5. doi request reprint Telomere lengths in the oral epithelia with and without carcinoma
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo 173 0015, Japan
    Eur J Cancer 46:430-8. 2010
  6. ncbi request reprint Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Hum Pathol 38:1192-200. 2007
  7. ncbi request reprint Microsatellite-unstable mucinous colorectal carcinoma occurring in the elderly: comparison with medullary type poorly differentiated adenocarcinoma
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Sakaecho, Tokyo, Japan
    Pathol Int 57:205-12. 2007
  8. doi request reprint Changes of telomere length with aging
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 10:S197-206. 2010
  9. doi request reprint Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    J Pathol 221:201-9. 2010
  10. doi request reprint Palisade vessels as a new histologic marker of esophageal origin in ER specimens from columnar-lined esophagus
    Junko Aida
    Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Am J Surg Pathol 35:1140-5. 2011

Collaborators

Detail Information

Publications44

  1. pmc Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    PLoS ONE 8:e63860. 2013
    ..Telomere shortening may not generate cancer directly, but may create conditions under which SCC can develop more easily, depending on subsequent exposure to carcinogens...
  2. doi request reprint Short telomeres in an oral precancerous lesion: Q-FISH analysis of leukoplakia
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    J Oral Pathol Med 41:372-8. 2012
    ..Therefore, we consider OKD-type leukoplakia to be a true precancerous lesion...
  3. doi request reprint Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, 35 2, Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    Exp Gerontol 43:833-9. 2008
    ..The reduction of telomere length with age and in each cell layer is consistent with the telomere biology theory of cell proliferation and differentiation in oral mucosa...
  4. doi request reprint Alcoholics show reduced telomere length in the oesophagus
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Pathol 223:410-6. 2011
    ..Further studies to clarify the reason for the large annual loss of telomere length with rapid turnover or lower telomerase activity in the oesophageal epithelium of alcoholics will be necessary...
  5. doi request reprint Telomere lengths in the oral epithelia with and without carcinoma
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo 173 0015, Japan
    Eur J Cancer 46:430-8. 2010
    ..Thus we have conclusively demonstrated that CIS arises from epithelium with short telomeres...
  6. ncbi request reprint Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Hum Pathol 38:1192-200. 2007
    ....
  7. ncbi request reprint Microsatellite-unstable mucinous colorectal carcinoma occurring in the elderly: comparison with medullary type poorly differentiated adenocarcinoma
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Sakaecho, Tokyo, Japan
    Pathol Int 57:205-12. 2007
    ....
  8. doi request reprint Changes of telomere length with aging
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 10:S197-206. 2010
    ..Our Q-FISH method using our original software program "Tissue Telo" is excellent for measuring telomere lengths using tissue sections and PNA probes...
  9. doi request reprint Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    J Pathol 221:201-9. 2010
    ..We have demonstrated conclusively that oesophageal CIS arises from epithelium with short telomeres and chromosomal instability in the absence of histological inflammation...
  10. doi request reprint Palisade vessels as a new histologic marker of esophageal origin in ER specimens from columnar-lined esophagus
    Junko Aida
    Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Am J Surg Pathol 35:1140-5. 2011
    ..At least 1 of these 4 markers was seen in 88% of the sections. Therefore, ER specimens were confirmed to originate from CLE in 88% of single histologic sections of CLE on the basis of histologic examination alone...
  11. doi request reprint Frequent microsatellite instability in papillary and solid-type, poorly differentiated adenocarcinomas of the stomach
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakaecho, Itabashi ku, Tokyo, 173 0015, Japan
    Gastric Cancer 16:505-12. 2013
    ..The purpose of the present study is to clarify the relationship between histological subtype and microsatellite status in gastric carcinomas...
  12. pmc Telomere length dynamics in the human pituitary gland: robust preservation throughout adult life to centenarian age
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2 Itabashi ku, Tokyo, Japan
    Age (Dordr) 34:795-804. 2012
    ..These data indicate that innate telomere length is highly conserved in the pituitary and suggest that pituitary telomere length provides a good basic indicator for studies of telomere biology...
  13. pmc Accelerated in vivo epidermal telomere loss in Werner syndrome
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Aging (Albany NY) 3:417-29. 2011
    ....
  14. pmc Association of telomere shortening in myocardium with heart weight gain and cause of death
    Masanori Terai
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Sci Rep 3:2401. 2013
    ..Here we show that telomeres in myocardial tissue become shortened with aging and heart disease, and that heart disease was associated with a gain of heart weight and telomere shortening in the myocardium. ..
  15. ncbi request reprint Telomere metabolism and diagnostic demonstration of telomere measurement in the human esophagus for distinguishing benign from malignant tissue by tissue quantitative fluorescence in situ hybridization
    Makoto Kammori
    Department of Breast, Tokyo Metropolitan Tama Cancer Detection Center, Fuchu shi, Tokyo, Japan
    Oncology 71:430-6. 2006
    ..We hypothesized that the very rapid cell proliferation observed in esophageal squamous cell carcinomas might accelerate the telomere shortening and chromosomal instability associated with carcinogenesis...
  16. doi request reprint Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Mech Ageing Dev 131:614-24. 2010
    ..6%). Our results indicate that chromosomes having excessively shortened telomeres at late PDLs begin to show features of instability such as fusions and anaphase bridges...
  17. doi request reprint Role of methylation of the hMLH1 gene promoter in the development of gastric and colorectal carcinoma in the elderly
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Geriatr Gerontol Int 10:S207-12. 2010
    ....
  18. doi request reprint Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts
    Rie Kurabayashi
    Division of Metabolic Care and Endocrine Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Hum Pathol 39:1647-55. 2008
    ..Tissue quantitative fluorescence in situ hybridization, applicable to analysis of individual cells in tissue sections, is considered to be a powerful technique with considerable promise for studies in oncology...
  19. doi request reprint Differences in the definitions used for esophageal and gastric diseases in different countries: endoscopic definition of the esophagogastric junction, the precursor of Barrett's adenocarcinoma, the definition of Barrett's esophagus, and histologic criteri
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology and Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Digestion 80:248-57. 2009
    ..Definitions and opinions in the field of gastroenterology vary widely in different countries...
  20. pmc Telomere attrition in beta and alpha cells with age
    Yoshiaki Tamura
    Department of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Age (Dordr) 38:61. 2016
    ..There was a positive correlation between NTCRβ and NTCRα only among adult subjects (p < 0.001). In conclusion, the telomeres of β and α cells become shortened with normal aging process. ..
  21. doi request reprint Investigation of telomere length dynamics in induced pluripotent stem cells using quantitative fluorescence in situ hybridization
    Masanori Terai
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan Department of Judotherapy, Faculty of Health Sciences, Tokyo Ariake University of Medical and Health Sciences, Tokyo 135 0063, Japan Electronic address
    Tissue Cell 45:407-13. 2013
    ....
  22. doi request reprint Arm-specific telomere dynamics of each individual chromosome in induced pluripotent stem cells revealed by quantitative fluorescence in situ hybridization
    Masanori Terai
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan Department of Judotherapy, Faculty of Health Sciences, Tokyo Ariake University of Medical and Health Sciences, Tokyo 135 0063, Japan Electronic address
    Tissue Cell 46:470-6. 2014
    ..We have thus demonstrated the specific telomere dynamics of each individual chromosomal arm in iPSCs derived from parental cells, and in the parental cells themselves, using Q-FISH. ..
  23. doi request reprint Columnar metaplasia in a surgical mouse model of gastro-esophageal reflux disease is not derived from bone marrow-derived cell
    Susumu Aikou
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 104:1154-61. 2013
    ..However, bone marrow-derived cells do not contribute directly to columnar metaplasia in this mouse model...
  24. doi request reprint Quantitative fluorescence in situ hybridization measurement of telomere length in skin with/without sun exposure or actinic keratosis
    Hiroyuki Ikeda
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan Department of Dermatology, Dokkyo Medical University, School of Medicine, Mibu, Tochigi 321 0293, Japan
    Hum Pathol 45:473-80. 2014
    ..Our findings demonstrate that sun exposure induces telomere shortening and that actinic keratosis arises from epidermis with shorter telomeres despite the absence of any histologic atypia. ..
  25. doi request reprint Short telomeres and chromosome instability prior to histologic malignant progression and cytogenetic aneuploidy in papillary urothelial neoplasms
    Naotaka Izumiyama-Shimomura
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Urol Oncol 32:135-45. 2014
    ..Evaluation of the relationships existing among 3 histologic types of urothelial tumors, chromosomal instability, and telomere length...
  26. ncbi request reprint Telomere shortening with aging in the human pancreas
    Akio Ishii
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    Exp Gerontol 41:882-6. 2006
    ..4 kilobase pairs (kbp) in 16 neonates, as opposed to 8.4 kbp in 2 centenarians. Mean telomere length (+/-SD) in four age groups, 0-24, 25-49, 50-74, and 75-100 yr, was 13.5+/-1.5, 12.3+/-0.7, 11.3+/-2.5, and 10.7+/-1.8, respectively...
  27. doi request reprint Changes of telomere status with aging: An update
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 16:30-42. 2016
    ..In addition, we describe newly found factors that are thought to impact telomere dynamics, providing a new avenue for examining the unsolved issues related to telomere restoration and maintenance...
  28. doi request reprint Mitotic index and multipolar mitosis in routine histologic sections as prognostic markers of pancreatic cancers: A clinicopathological study
    Yoko Matsuda
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan Electronic address
    Pancreatology 16:127-32. 2016
    ..In the present study, we determined the frequency and the clinicopathological and prognostic significance of mitotic figures in pancreatic cancers...
  29. pmc Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas
    Yoko Matsuda
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakae cho, Itabashi ku, Tokyo, 173 0015, Japan
    PLoS ONE 10:e0117575. 2015
    ..Determination of telomere length in pancreatic ductal lesions may be valuable for accurate detection and risk assessment of pancreatic cancer. ..
  30. pmc Q-FISH measurement of hepatocyte telomere lengths in donor liver and graft after pediatric living-donor liver transplantation: donor age affects telomere length sustainability
    Youichi Kawano
    Department of Surgery, Nippon Medical School, Tokyo, Japan Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    PLoS ONE 9:e93749. 2014
    ....
  31. doi request reprint Telomere lengths at birth in trisomies 18 and 21 measured by Q-FISH
    Ken ichi Nakamura
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan Electronic address
    Gene 533:199-207. 2014
    ..Therefore, it would be advisable for them to avoid lifestyle habits and characteristics such as obesity, cigarette smoking, chronic stress, and alcohol intake, which lead to marked telomere shortening. ..
  32. doi request reprint Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma
    Kaiyo Takubo
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Hum Pathol 40:65-74. 2009
    ..Also, it seems better to define Barrett esophagus as metaplastic columnar-lined esophagus alone, without requiring the presence of goblet cells, in accordance with histogenetic and practical standpoints...
  33. doi request reprint Clinicopathological Features of 15 Occult and 178 Clinical Pancreatic Ductal Adenocarcinomas in 8339 Autopsied Elderly Patients
    Yoko Matsuda
    From the Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Itabashi ku Department of Pathology and Integrative Oncological Pathology, Nippon Medical School, Bunkyo ku Division of Cancer Genomics, National Cancer Center Research Institute, Chuo ku and Research Team for Geriatric Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Pancreas 45:234-40. 2016
    ..The aim of the study was to investigate the clinicopathological features of pancreatic cancer at different stages using autopsy results...
  34. doi request reprint Gastric high-grade dysplasia can be associated with submucosal invasion: evaluation of its prevalence in a series of 121 endoscopically resected specimens
    Urara Sakurai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital Department of Surgery, Kudanzaka Hospital Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan Department of Pathology, Massachusetts General Hospital, Boston, MA Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany
    Am J Surg Pathol 38:1545-50. 2014
    ....
  35. doi request reprint Oestrogen receptor-beta1 but not oestrogen receptor-betacx is of prognostic value in apocrine carcinoma of the breast
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    APMIS 116:923-30. 2008
    ..ER-beta1 itself, independent of ER-alpha expression and tamoxifen treatment, seems to have a tumor-suppressive effect, at least in apocrine carcinomas. Further study of ER-beta1 is desired to optimize breast cancer treatment...
  36. ncbi request reprint Accelerated in vivo epidermal telomere loss in Werner syndrome
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Aging (Albany NY) 3:417-29. 2011
    ....
  37. doi request reprint The normal anatomy around the oesophagogastric junction: a histopathologic view and its correlation with endoscopy
    Kaiyo Takubo
    Research Team for Geriatric Diseases Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Sakae cho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Best Pract Res Clin Gastroenterol 22:569-83. 2008
    ..The nature of the OGJ is clarified in detail through comparison between endoscopically evident and histological features...
  38. ncbi request reprint Age-related alteration in the association of microsatellite instability with absent hMLH1 expression and histological types of colorectal carcinoma
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Pathol Int 56:597-603. 2006
    ..These results indicate that an age-related increase of medullary-type tumors in poorly differentiated adenocarcinoma may play an important role in the increase of absent hMLH1 expression and MSI in colorectal carcinoma...
  39. doi request reprint β-cell telomere attrition in diabetes: inverse correlation between HbA1c and telomere length
    Yoshiaki Tamura
    Departments of Diabetes, Metabolism, and Endocrinology Y T, Y K, Y C, S M, A A, H I and Pathology T Ar, Tokyo Metropolitan Geriatric Hospital, and Research Team for Geriatric Pathology and Department of Pathology N I S, K N, N I, J A, K T, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo 173 0015, Japan and Diabetes Center T Ai, Aizawa Hospital, Matsumoto, Nagano 390 8510, Japan
    J Clin Endocrinol Metab 99:2771-7. 2014
    ..Although accelerated β-cell telomere shortening may be associated with diabetes that shows a dramatically increased incidence with aging, β-cell telomere length in diabetes has never been explored...
  40. doi request reprint Maternal grafts protect daughter recipients from acute cellular rejection after pediatric living donor liver transplantation for biliary atresia
    Yukihiro Sanada
    Department of Transplant Surgery, Jichi Medical University, Shimotsuke City, Japan Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Transpl Int 27:383-90. 2014
    ..Our findings support the possibility that maternal antigens may have an important clinical impact on graft tolerance in LDLT for patients with BA...
  41. ncbi request reprint [Pathologic characteristics of malignant neoplasms occurring in the elderly]
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Gan To Kagaku Ryoho 38:1571-6. 2011
    ....
  42. doi request reprint Telomere attrition and diabetes mellitus
    Yoshiaki Tamura
    Department of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Geriatr Gerontol Int 16:66-74. 2016
    ..Inhibition of telomere attrition in various organs, including pancreatic β-cells, could be a new approach for preventing the progression of DM and its complications...
  43. doi request reprint Telomere Length of Human Adult Bronchial Epithelium and Bronchogenic Squamous Cell Carcinoma Measured Using Tissue Quantitative Fluorescence in situ Hybridization
    Shinsuke Aida
    Department of Pathology, Mita Hospital, International University of Health and Welfare, Tokyo, Japan
    Respiration 90:321-6. 2015
    ..Telomeres are repetitive DNA sequences located at the ends of chromosomes. Chromosomal and genomic instability due to telomere dysfunction has been known to play an important role in the carcinogenesis of some organs...
  44. doi request reprint Prostate cancer-producing granulocyte colony-stimulating factor
    Yoh Matsuoka
    Department of Urology, Tokyo Metropolitan Tama Geriatric Hospital, Tokyo, Japan
    Urol Int 82:113-5. 2009
    ..To our knowledge, this is the first case of prostate cancer with G-CSF production, which was confirmed immunohistochemically...