Kazuhiko Yanai

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. doi request reprint The roles of histamine H1 receptors on cognition
    K Yanai
    Department of Pharmacology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Inflamm Res 57:S39-40. 2008
  2. ncbi request reprint The physiological and pathophysiological roles of neuronal histamine: an insight from human positron emission tomography studies
    Kazuhiko Yanai
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Pharmacol Ther 113:1-15. 2007
  3. ncbi request reprint [Roles of histamine receptors in pain perception: a study using receptors gene knockout mice]
    Kazuhiko Yanai
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Nihon Yakurigaku Zasshi 122:391-9. 2003
  4. ncbi request reprint Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice
    Akiko Yoshida
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Pharmacol 522:55-62. 2005
  5. ncbi request reprint Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors
    Chizuko Watanabe
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Eur J Pharmacol 581:54-63. 2008
  6. ncbi request reprint Blocking histamine H(1) improves learning and mnemonic dysfunction in mice with social isolation plus repeated methamphetamine injection
    Feiyong Jia
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    J Pharmacol Sci 107:167-74. 2008
  7. ncbi request reprint Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography
    Manabu Tashiro
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Clin Pharmacol 44:890-900. 2004
  8. doi request reprint Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving
    Manabu Tashiro
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hum Psychopharmacol 23:139-50. 2008
  9. ncbi request reprint Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice
    Jalal Izadi Mobarakeh
    Department of Pharmacology, Tohoku University School of Medicine, Seiryo machi 2 1, Sendai 980 8575, Japan
    Pain 118:254-62. 2005
  10. doi request reprint Dose dependency of brain histamine H(1) receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [11C]doxepin
    Manabu Tashiro
    Division of Cyclotron Nuclear Medicine, Tohoku University, Sendai, Miyagi, Japan
    Hum Psychopharmacol 24:540-8. 2009

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. doi request reprint The roles of histamine H1 receptors on cognition
    K Yanai
    Department of Pharmacology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Inflamm Res 57:S39-40. 2008
  2. ncbi request reprint The physiological and pathophysiological roles of neuronal histamine: an insight from human positron emission tomography studies
    Kazuhiko Yanai
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Pharmacol Ther 113:1-15. 2007
    ..These molecular and functional PET studies in humans are useful for drug development in this millennium...
  3. ncbi request reprint [Roles of histamine receptors in pain perception: a study using receptors gene knockout mice]
    Kazuhiko Yanai
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Nihon Yakurigaku Zasshi 122:391-9. 2003
    ..These results suggest that existing H1 and H2 receptors play an inhibitory role in morphine-induced antinociception in the spinal and supra-spinal levels...
  4. ncbi request reprint Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice
    Akiko Yoshida
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Pharmacol 522:55-62. 2005
    ..These studies substantiate the evidence that nociceptive behavior induced by intrathecal injection of histamine is largely mediated through tachykinin NK(1) and histamine H(1) receptors in the spinal cord...
  5. ncbi request reprint Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors
    Chizuko Watanabe
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Eur J Pharmacol 581:54-63. 2008
    ..These results suggest that a polyamine site on spinal NMDA receptors is involved in eliciting the nociceptive behavioral episode following intrathecal injection of histamine...
  6. ncbi request reprint Blocking histamine H(1) improves learning and mnemonic dysfunction in mice with social isolation plus repeated methamphetamine injection
    Feiyong Jia
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    J Pharmacol Sci 107:167-74. 2008
    ....
  7. ncbi request reprint Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography
    Manabu Tashiro
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Clin Pharmacol 44:890-900. 2004
    ..H1RO was negligible with fexofenadine (-0.1%) but moderately high with cetirizine (26.0%). In conclusion, fexofenadine 120 mg is distinguishable from cetirizine 20 mg, as assessed by H1RO and psychomotor testing...
  8. doi request reprint Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving
    Manabu Tashiro
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hum Psychopharmacol 23:139-50. 2008
    ....
  9. ncbi request reprint Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice
    Jalal Izadi Mobarakeh
    Department of Pharmacology, Tohoku University School of Medicine, Seiryo machi 2 1, Sendai 980 8575, Japan
    Pain 118:254-62. 2005
    ..Thus, the blocking of the histamine H1 or H2 receptor may produce antinociception and enhance the orexin A-induced antinociception...
  10. doi request reprint Dose dependency of brain histamine H(1) receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [11C]doxepin
    Manabu Tashiro
    Division of Cyclotron Nuclear Medicine, Tohoku University, Sendai, Miyagi, Japan
    Hum Psychopharmacol 24:540-8. 2009
    ..The purpose of the present study is to measure histamine H(1) receptor (H(1)R) occupancy following oral administration of cetirizine (10 and 20 mg) in order to examine dose dependency...
  11. ncbi request reprint Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice
    Jalal Izadi Mobarakeh
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Seiryo machi 2 1, Aoba ku, Sendai 980 8575, Japan
    Neuropharmacology 51:612-22. 2006
    ..Our present and previous studies suggest that H1 and H2 receptors cooperatively function to modulate pain perception in the central nervous system...
  12. ncbi request reprint Blockage of histamine H1 receptor attenuates social isolation-induced disruption of prepulse inhibition: a study in H1 receptor gene knockout mice
    Hongmei Dai
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, 980 8575 Sendai, Japan
    Psychopharmacology (Berl) 183:285-93. 2005
    ..Although several atypical antipsychotics are potent H1 antagonists, the clinical significance of interaction between atypical antipsychotics and H1 receptors is still unknown...
  13. ncbi request reprint Simplified PET measurement for evaluating histamine H1 receptors in human brains using [11C]doxepin
    Hideki Mochizuki
    Department of Pharmacology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Nucl Med Biol 31:1005-11. 2004
    ..We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [(11)C]DOX-H1R binding...
  14. pmc Brain histamine H receptor occupancy of orally administered antihistamines measured by positron emission tomography with (11)C-doxepin in a placebo-controlled crossover study design in healthy subjects: a comparison of olopatadine and ketotifen
    Manabu Tashiro
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Br J Clin Pharmacol 61:16-26. 2006
    ..The purpose of the present study is to measure histamine H(1) receptor (H(1)R) occupancy due to olopatadine, a new second-generation antihistamine and to compare it with that of ketotifen...
  15. pmc Pharmacological effects of carcinine on histaminergic neurons in the brain
    Zhong Chen
    Department of Pharmacology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Br J Pharmacol 143:573-80. 2004
    ....
  16. pmc Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11C-doxepin
    Manabu Tashiro
    Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Centre, Tohoku University, Sendai, Miyagi, Japan
    Br J Clin Pharmacol 65:811-21. 2008
    ..However, only a few clinical studies regarding its sedative property are available. In addition, histamine H(1) receptor occupancy (H(1)RO) of this new antihistamine has never been measured by positron emission tomography (PET)...
  17. ncbi request reprint Modified behavioral characteristics following ablation of the voltage-dependent calcium channel beta3 subunit
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita, 1 1 1 Hondoh, Akita 010 8543, Japan
    Brain Res 1160:102-12. 2007
    ..These results suggest the importance of voltage-dependent calcium channels and the key role of the beta3 subunit in memory formation, nociceptive sensory transduction, and various neurological signal transduction pathways...
  18. doi request reprint A 18F-labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography
    Shozo Furumoto
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Mol Imaging Biol 15:497-506. 2013
    ..e., [18F] fluorinated amyloid imaging compound of Tohoku university ([18F]FACT)) as amyloid positron emission tomography (PET) tracers and to assess [18F]FACT efficacy in imaging of Alzheimer's disease (AD)...
  19. ncbi request reprint Use of reference tissue models for quantification of histamine H1 receptors in human brain by using positron emission tomography and [11c]doxepin
    Atsuro Suzuki
    Department of Quantum Science and Energy Engineering, Tohoku University, Sendai, Japan
    Ann Nucl Med 19:425-33. 2005
    ..By including the results of noise analysis, LGAR became a reliable method for parameter estimation of [11C]doxepin data in the cortical regions...
  20. doi request reprint Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease
    Masaaki Waragai
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Neurol Sci 285:100-8. 2009
    ..These findings suggest that amyloid PET using [11C]BF-227 is better suited for the prediction of conversion from MCI to AD, while VBM-MRI appears to be better suited for tracking the severity of dementia...
  21. doi request reprint Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology
    Ryuichi Harada
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Eur J Nucl Med Mol Imaging 40:125-32. 2013
    ..The purpose of this study was to compare the binding properties of [(18)F]THK-523 and other amyloid imaging agents, including PiB, BF-227 and FDDNP, to synthetic protein fibrils and human brain tissue...
  22. doi request reprint Predominant role of plasma membrane monoamine transporters in monoamine transport in 1321N1, a human astrocytoma-derived cell line
    Fumito Naganuma
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    J Neurochem 129:591-601. 2014
    ..These results might indicate that PMAT and OCT3 in human astrocytes are involved in monoamine clearance...
  23. ncbi request reprint Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors
    Hongmei Dai
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai, Japan
    Neurosci Res 57:306-13. 2007
    ..In conclusion, our results demonstrate that both H1 and H2 receptors are involved in learning and memory processes for which the frontal cortex, amygdala and hippocampus interact...
  24. ncbi request reprint Enhanced antinociception by intrathecally-administered morphine in histamine H1 receptor gene knockout mice
    Jalal Izadi Mobarakeh
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Neuropharmacology 42:1079-88. 2002
    ..These results suggest that existing H(1) receptors play an inhibitory role in morphine-induced antinociception at the spinal cord level...
  25. ncbi request reprint Involvement of the histaminergic system in the nociceptin-induced pain-related behaviors in the mouse spinal cord
    Shinobu Sakurada
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Pain 112:171-82. 2004
    ....
  26. doi request reprint Voxel-based analysis of amyloid positron emission tomography probe [C]BF-227 uptake in mild cognitive impairment and alzheimer's disease
    He Shao
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Dement Geriatr Cogn Disord 30:101-11. 2010
    ....
  27. ncbi request reprint Intrathecal histamine induces spinally mediated behavioral responses through tachykinin NK1 receptors
    Shinobu Sakurada
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Pharmacol Biochem Behav 74:487-93. 2003
    ..The present results suggest that elicitation of scratching, biting and licking behavior induced by intrathecal injection of histamine may be largely mediated by NK(1) receptors via H(1) receptors in the spinal cord...
  28. ncbi request reprint Roles of histamine in regulation of arousal and cognition: functional neuroimaging of histamine H1 receptors in human brain
    Manabu Tashiro
    Department of Pharmacology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Miyagi, 980 8575, Sendai shi, Japan
    Life Sci 72:409-14. 2002
    ..In summary, it was confirmed that histamine and H1Rs are involved in maintaining arousal and cognition in humans, and that the severity of clinical symptoms is correlated to the amount of antihistamine that penetrated into the brain...
  29. doi request reprint Histamine H₁ receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine: a positron emission tomography study in healthy volunteers
    Hirotoshi Sato
    Department of Psychiatry, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8574, Japan
    Psychopharmacology (Berl) 230:227-34. 2013
    ..Positron emission tomography (PET) can clarify the in vivo dynamics of antidepressants at histamine receptors...
  30. ncbi request reprint Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice
    Feiyong Jia
    Department of Pharmacology, Tohoku University School of Medicine, Aoba ku, Sendai, Japan
    Neuropharmacology 50:404-11. 2006
    ....
  31. doi request reprint The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H(3) receptor are involved in receptor-G-protein coupling
    Atsuo Kuramasu
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
    Cell Signal 23:1843-9. 2011
    ..Our results suggest that hydrophobic interface of putative helix 8 is important for the regulation of H(3) receptor activity, presumably by stabilizing the helix to the plasma membrane...
  32. doi request reprint Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study
    Masashi Kasuya
    Departments of Geriatric Behavioral Neurology, Tohoku University, Sendai, Japan
    Alzheimer Dis Assoc Disord 26:113-8. 2012
    ..Higher baseline attention may predict responsiveness to donepezil in patients with AD, and higher acetylcholinesterase levels result in a greater clinical effect...
  33. doi request reprint Enhanced morphine-induced antinociception in histamine H3 receptor gene knockout mice
    Jalal Izadi Mobarakeh
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Neuropharmacology 57:409-14. 2009
    ..These results suggest that histamine exerts inhibitory effects on morphine-induced antinociception through H3 receptors at the spinal level...
  34. ncbi request reprint [Molecular imaging of histamine receptors in the human brain]
    Manabu Tashiro
    Division of Cyclotron Nuclear Medicine, Tohoku University Cyclotron and Radioisotope Centre, 6 3 Aoba, Aramaki, Aoba ku, Sendai 980 8575, Japan
    Brain Nerve 59:221-31. 2007
    ..The authors hope that this line of research contributes more for the promotion of QOL in patients and people in daily lives...
  35. ncbi request reprint Histamine H1 receptors in schizophrenic patients measured by positron emission tomography
    Kentaro Iwabuchi
    Department of Psychiatry, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Eur Neuropsychopharmacol 15:185-91. 2005
    ..The results of our study suggest that the central histaminergic neuron system could be involved in the pathophysiology of schizophrenia, although further studies are needed to confirm this hypothesis...
  36. ncbi request reprint Effects of fexofenadine and hydroxyzine on brake reaction time during car-driving with cellular phone use
    Manabu Tashiro
    Department of Pharmacology, Graduate School of Medicine, Tohoku University, Japan
    Hum Psychopharmacol 20:501-9. 2005
    ..Fexofenadine did not impair CNS function in subjects involved in a divided attention task of driving and cellular phone operation...
  37. doi request reprint In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Nucl Med Mol Imaging 37:934-41. 2010
    ..The purpose of this study is to evaluate the amyloid imaging tracer BF-227 with positron emission tomography (PET) for the non-invasive detection of PrP amyloid in the brain...
  38. ncbi request reprint Chemical kindling induced by pentylenetetrazol in histamine H(1) receptor gene knockout mice (H(1)KO), histidine decarboxylase-deficient mice (HDC(-/-)) and mast cell-deficient W/W(v) mice
    Zhong Chen
    Department of Pharmacology, Tohoku University School of Medicine, Seiryo machi 2 1, Aoba ku, 980 8575, Sendai, Japan
    Brain Res 968:162-6. 2003
    ..The present study indicates that histamine plays a suppressive role in seizure development through H(1)-receptors...
  39. ncbi request reprint Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia
    Kotaro Hiraoka
    Division of Cyclotron Nuclear Medicin, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
    Eur Neurol 68:137-43. 2012
    ....
  40. ncbi request reprint Cerebral metabolic changes in men after chiropractic spinal manipulation for neck pain
    Takeshi Ogura
    Division of Cyclotron Nuclear Medicine, Tohoku University, Sendai, Japan
    Altern Ther Health Med 17:12-7. 2011
    ..The autonomic nervous system is often involved in spinal dysfunction. Although studies on the effects of CSM have been performed, no chiropractic study has examined regional cerebral metabolism using positron emission tomography (PET)...
  41. ncbi request reprint Methamphetamine- and 3,4-methylenedioxymethamphetamine-induced behavioral changes in histamine H3-receptor knockout mice
    Tomohiro Okuda
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    J Pharmacol Sci 111:167-74. 2009
    ..These findings suggest that deficiency in histamine H(3) receptors may have inhibitory effects on psychostimulant-induced increase in locomotion, but insignificant effects on the reward...
  42. ncbi request reprint Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography
    Dongying Zhang
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    J Clin Psychopharmacol 30:694-701. 2010
    ..Taking into account the possible hangover effect of OTC antihistamine sleep aids, care needs to be taken during their administration...
  43. ncbi request reprint Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and -2) in mice
    Jalal Izadi Mobarakeh
    Department of Pharmacology, Tohoku University School of Medicine, Seiryo machi 2 1, Aoba ku, Sendai 980 8575, Japan
    Peptides 26:767-77. 2005
    ..The present findings suggest that orexins have an antinociceptive role in at least four different types of pains, probably acting on both the brain and spinal cord...
  44. pmc In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Br J Clin Pharmacol 65:472-9. 2008
    ..The biodistribution of donepezil in the brain after administration is not precisely understood in vivo. * There is no method to measure the amount of binding of orally administered donepezil to AChE...
  45. ncbi request reprint Improgan antinociception does not require neuronal histamine or histamine receptors
    Jalal Izadi Mobarakeh
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Brain Res 974:146-52. 2003
    ..The present findings strongly support the hypothesis that neuronal histamine and its receptors fail to play a role in improgan-induced antinociception...
  46. doi request reprint Roles played by histamine in strenuous or prolonged masseter muscle activity in mice
    Hiroyuki Yoneda
    Division of Oral Molecular Regulation, Graduate School of Dentistry, Tohoku University, Sendai, Japan Division of Advanced Prosthetic Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Japan
    Clin Exp Pharmacol Physiol 40:848-55. 2013
    ....
  47. doi request reprint Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    J Nucl Med 54:1420-7. 2013
    ..After compound optimization, we developed novel (18)F-labeled arylquinoline derivatives, (18)F-THK-5105 and (18)F-THK-5117, for use as tau imaging PET tracers...
  48. doi request reprint Agonist-induced internalization of histamine H2 receptor and activation of extracellular signal-regulated kinases are dynamin-dependent
    A Jing Xu
    Departments of Pharmacology, Tohoku University School of Medicine, Seiryo machi, Aoba ku, Sendai, Japan
    J Neurochem 107:208-17. 2008
    ..These results suggest that the agonist-induced H2R internalization and ERK1/2 activation are partially dynamin-dependent. Furthermore, ERK1/2 activation via H2R is likely dependent of the endocytotic process rather than dynamin itself...
  49. doi request reprint Brain accumulation of amyloid β protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus
    Naoki Tomita
    Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan
    Geriatr Gerontol Int 13:215-21. 2013
    ..To discover the mechanism of developing dementia in AD patients with DM in a living state, we studied the distribution of amyloid β (Αβ) protein of diabetic AD patients...
  50. doi request reprint A modified method of 3D-SSP analysis for amyloid PET imaging using [¹¹C]BF-227
    Tomohiro Kaneta
    Department of Diagnostic Radiology, Tohoku University, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Ann Nucl Med 25:732-9. 2011
    ....
  51. ncbi request reprint Specific brain processing of facial expressions in people with alexithymia: an H2 15O-PET study
    Michiko Kano
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Brain 126:1474-84. 2003
    ....
  52. ncbi request reprint Correlation between alexithymia and hypersensitivity to visceral stimulation in human
    Michiko Kano
    Behavioral Medicine, Tohoku University School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai 980 8575, Japan
    Pain 132:252-63. 2007
    ....
  53. ncbi request reprint Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
    Brain Res 1024:122-9. 2004
    ..The results of this study revealed the localization and functions of several calcium channels that are involved in nociceptive neurotransmission within the dorsal horn of the mouse spinal cord...
  54. doi request reprint Roles of the histaminergic neurotransmission on methamphetamine-induced locomotor sensitization and reward: a study of receptors gene knockout mice
    Naoko Takino
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Int Rev Neurobiol 85:109-16. 2009
    ..Our results suggest that the neuronal histamine could inhibit the METH-induced abnormal behaviors through the interactions of H1, H2, and H3 receptors...
  55. doi request reprint Histamine H1 receptor occupancy by the new-generation antipsychotics olanzapine and quetiapine: a positron emission tomography study in healthy volunteers
    Hirotoshi Sato
    Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan
    Psychopharmacology (Berl) 232:3497-505. 2015
    ..Positron emission tomography (PET) can measure the H1R occupancy (H1RO) in vivo, although there are no reports regarding antipsychotics...
  56. doi request reprint 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease
    Ryuichi Harada
    Division of Neuro imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Nucl Med 57:208-14. 2016
    ..The radiotracers used in this imaging must be highly sensitive and specific for tau protein fibrils in the human brain. We developed a novel tau PET tracer, (18)F-THK5351, through compound optimization of arylquinoline derivatives...
  57. doi request reprint Effects of preceding stimulation on brain activation in response to colonic distention in humans
    Toyohiro Hamaguchi
    Department of Behavioral Medicine, Graduate School of Medicine, Tohoku University, Aoba, Sendai, Japan
    Psychosom Med 75:453-62. 2013
    ..Nevertheless, how the pattern of stimulation affects sensitization and/or desensitization to visceral stimulation remains unknown...
  58. doi request reprint Positron emission tomography evaluation of sedative properties of antihistamines
    Kazuhiko Yanai
    Tohoku University Graduate School of Medicine, Department of Pharmacology, Sendai, Japan
    Expert Opin Drug Saf 10:613-22. 2011
    ..These sedative properties have been evaluated using the incidence of subjective sleepiness, objective cognitive and psychomotor functions, and positron emission tomography (PET) measurement of H(1) receptor occupancy...
  59. doi request reprint Synthesis of [11C]interleukin 8 using a cell-free translation system and L-[11C]methionine
    Ryuichi Harada
    Department of Pharmacology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Nucl Med Biol 39:155-60. 2012
    ..This study clearly demonstrates that cell-free protein production system combined with positron emitter-labeled amino acid holds great promise as a novel approach to prepare radiolabeled proteins and peptides for PET imaging...
  60. ncbi request reprint 2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6- (2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients
    Yukitsuka Kudo
    Tohoku University Biomedical Engineering Research Organization, Sendai, Japan
    J Nucl Med 48:553-61. 2007
    ..This study reports a novel compound, 2-(2-[2-dimethylaminothiazol-5-yl]ethenyl)-6-(2-[fluoro]ethoxy)benzoxazole (BF-227), for in vivo detection of dense amyloid deposits using PET...
  61. ncbi request reprint Discrete cortical regions associated with the musical beauty of major and minor chords
    Miho Suzuki
    Department of Pharmacology, School of Medicine, Tohoku University, Sendai, Japan
    Cogn Affect Behav Neurosci 8:126-31. 2008
    ..These results suggest that major and minor keys, both of which are perceived as beautiful, are processed differently in the brain...
  62. doi request reprint Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-(11)C-methoxy]donepezil
    Kotaro Hiraoka
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Neuroimage 46:616-23. 2009
    ..In conclusion, this method enables quantitative analysis of AChE and direct investigation of the pharmacokinetics of donepezil in the human brain...
  63. ncbi request reprint Effects of activation of central nervous histamine receptors in cardiovascular regulation; studies in H(1) and H(2) receptor gene knockout mice
    Hideaki Suzuki
    Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Seiryo machi 2 1, Aoba ku, Sendai 980 8575, Japan
    Naunyn Schmiedebergs Arch Pharmacol 371:99-106. 2005
    ....
  64. ncbi request reprint Methamphetamine and brain histamine: a study using histamine-related gene knockout mice
    Kentaro Iwabuchi
    Department of Psychiatry, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Ann N Y Acad Sci 1025:129-34. 2004
    ..In addition, neurochemical study suggested the involvement of the GABAergic neuron system in the inhibitory effect of brain histamine...
  65. ncbi request reprint Social isolation stress significantly enhanced the disruption of prepulse inhibition in mice repeatedly treated with methamphetamine
    Hongmei Dai
    Department of Pharmacology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Ann N Y Acad Sci 1025:257-66. 2004
    ..Our data suggest that social isolation is involved in the development of METH-induced psychosis, schizophrenia, and other related psychiatric disorders...
  66. ncbi request reprint Imaging of central itch modulation in the human brain using positron emission tomography
    Hideki Mochizuki
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Pain 105:339-46. 2003
    ....
  67. ncbi request reprint Decreased histamine H1 receptor binding in the brain of depressed patients
    Michiko Kano
    Department of Behavioural Medicine, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Eur J Neurosci 20:803-10. 2004
    ..It is therefore suggested that the histaminergic neuron system plays an important role in the pathophysiology of depression and that its modulation may prove to be useful in the treatment of depression...
  68. ncbi request reprint The effects of a sedative antihistamine, d-chlorpheniramine, on visuomotor spatial discrimination and regional brain activity as measured by positron emission tomography (PET)
    Hideki Mochizuki
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Hum Psychopharmacol 17:413-8. 2002
    ..These findings clearly suggest that the alteration in the cortical and subcortical activity contributes to impaired spatial cognition caused by treatment with d-chlorpheniramine...
  69. ncbi request reprint Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene
    Yuji Owada
    Division of Histology, Graduate School of Medical Science, Tohoku University, 2 1 Seiryo machi, Aobaku, Sendai 980 8575, Japan
    Eur J Neurosci 24:175-87. 2006
    ..These data indicate that B-FABP is crucially involved in the fear memory and anxiety through its binding with FAs and/or its own direct effects on pertinent metabolism/signaling of FAs...
  70. pmc [(11)C]Doxepin binding to histamine H1 receptors in living human brain: reproducibility during attentive waking and circadian rhythm
    Katsuhiko Shibuya
    Department of Pharmacology, Tohoku University Graduate School of Medicine Sendai, Japan
    Front Syst Neurosci 6:45. 2012
    ..This study confirmed the reproducibility and reliability of [(11)C]doxepin in the previous imaging studies to measure the H1 receptor...
  71. doi request reprint Increased brain histamine H1 receptor binding in patients with anorexia nervosa
    Masahiko Yoshizawa
    Department of Psychosomatic Medicine, Tohoku University School of Medicine, Japan
    Biol Psychiatry 65:329-35. 2009
    ..We hypothesized that women have higher density of histamine H1 receptor (H1R) in the limbic system than men and that the density of central H1R is increased in patients with anorexia nervosa (AN)...
  72. ncbi request reprint The neural correlates of driving performance identified using positron emission tomography
    Etsuo Horikawa
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Japan
    Brain Cogn 58:166-71. 2005
    ..These brain regions may thus play roles in the maintenance of driving performance...
  73. ncbi request reprint Drug interaction between methamphetamine and antihistamines: behavioral changes and tissue concentrations of methamphetamine in rats
    Tomohiro Okuda
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Eur J Pharmacol 505:135-44. 2004
    ..These results suggest that the potentiating effects of antihistamines are due to not only central effects but also the alteration of the pharmacokinetics of methamphetamine...
  74. ncbi request reprint Roles of histamine in exercise-induced fatigue: favouring endurance and protecting against exhaustion
    Fukie Niijima-Yaoita
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Biol Pharm Bull 35:91-7. 2012
    ....
  75. ncbi request reprint Quantitative measurement of histamine H(1) receptors in human brains by PET and [11C]doxepin
    Hideki Mochizuki
    Department of Phamacology, Tohoku University School of Medicine, Sendai, Japan
    Nucl Med Biol 31:165-71. 2004
    ..This finding suggests that the H1R measured by the [(11)C]DOX and PET can be evaluated with a two-compartment model...
  76. doi request reprint In vivo detection of amyloid plaques in the mouse brain using the near-infrared fluorescence probe THK-265
    Nobuyuki Okamura
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan Innovation of New Biomedical Engineering Center, Tohoku University, Sendai, Japan
    J Alzheimers Dis 23:37-48. 2011
    ..These findings strongly support the usefulness of THK-265 as an NIRF imaging probe for the noninvasive measurement of brain amyloid load...
  77. doi request reprint Long-term performance evaluation of positron emission tomography: analysis and proposal of a maintenance protocol for long-term utilization
    Shoichi Watanuki
    Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, 6 3 Aoba, Aramaki, Aoba ku, Sendai, Miyagi 980 8578, Japan
    Ann Nucl Med 24:461-8. 2010
    ..Positron emission tomography (PET) scanners require periodic monitoring in order to maintain scanner performance. The aim of the present study was to examine the deterioration of PET scanner performance caused by aging...
  78. pmc Differential cognitive effects of ebastine and (+)-chlorpheniramine in healthy subjects: correlation between cognitive impairment and plasma drug concentration
    Masaaki Tagawa
    Department of Pharmacology, Tohoku University School of Medicine, Cyclotron and Radioisotope Center, Tohoku University, Japan
    Br J Clin Pharmacol 53:296-304. 2002
    ..In order to evaluate the sedative properties of ebastine, a second-generation antihistamine, its effect on cognitive performance in healthy subjects was compared with placebo and (+)-chlorpheniramine...
  79. ncbi request reprint Effects of serotonin-dopamine antagonists on prepulse inhibition and neurotransmitter contents in the rat cortex
    Terumasa Ojima
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Neurosci Lett 366:130-4. 2004
    ..Our results suggest that, of the three antipsychotic drugs, only perospirone promotes cognition, and this ability is associated with increase in dopamine turnover, reduction in serotonin turnover and increase in glycine contents...
  80. ncbi request reprint Studies on functional roles of the histaminergic neuron system by using pharmacological agents, knockout mice and positron emission tomography
    T Watanabe
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 195:197-217. 2001
    ..Here, we summarize the newly-discovered functions of histamine neurons mainly on the basis of results from our research groups...
  81. ncbi request reprint Effects of (S)-alpha-fluoromethylhistidine and (R)-alpha-methylhistamine on locomotion of W/Wv mice
    N Sakai
    Department of Pharmacology 1, Tohoku University School of Medicine, Sendai, Japan
    Pharmacol Biochem Behav 46:95-9. 1993
    ..These results support the hypothesis that the central histaminergic neuron system is involved in the control of spontaneous locomotion or alertness...
  82. ncbi request reprint Plasma extravasation induced by dietary supplemented histamine in histamine-free mice
    Hiroshi Ohtsu
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Eur J Immunol 32:1698-708. 2002
    ..Therefore, among the allergic skin reactions, histamine is revealed to be an important mediator especially for the plasma extravasation in an immediate-type allergy model...
  83. ncbi request reprint Florbetapir (18F), a PET imaging agent that binds to amyloid plaques for the potential detection of Alzheimer's disease
    Nobuyuki Okamura
    Tohoku University School of Medicine, Department of Pharmacology, 2 1, Seiryo machi, Aoba ku, Sendai 9808575, Japan
    IDrugs 13:890-9. 2010
    ..This tracer has a potential to serve as an agent for preclinical detection of AD-related pathology in the large elderly population...
  84. doi request reprint Application of positron emission tomography to neuroimaging in sports sciences
    Manabu Tashiro
    Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Aoba 6 3, Aramaki, Aoba ku, Sendai shi, Miyagi ken, Japan
    Methods 45:300-6. 2008
    ..Although the number of research papers is still limited, recent work has indicated that the [(18)F]FDG-PET technique is a useful tool to understand brain activity during exercise...
  85. ncbi request reprint Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain
    Nobuyuki Okamura
    BF Research Institute, Suita 565 0873, Japan
    J Neurosci 24:2535-41. 2004
    ..These findings strongly suggest that styrylbenzoxazole derivatives are promising candidate probes for positron emission tomography and single-photon emission computed tomography imaging for early detection of amyloid plaque formation...
  86. ncbi request reprint Inhibitory effect of pranidipine on N-type voltage-dependent Ca2+ channels in mice
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
    Neurosci Lett 367:118-22. 2004
    ....
  87. ncbi request reprint A novel imaging probe for in vivo detection of neuritic and diffuse amyloid plaques in the brain
    Nobuyuki Okamura
    BF Research Institute, c o National Cardiovascular Center, Fujishiro dai, Suita, Osaka, Japan
    J Mol Neurosci 24:247-55. 2004
    ..These findings suggest that BF-145 is a potential candidate as a probe for imaging early brain pathology in AD patients...
  88. ncbi request reprint [Development of neuroimaging research on human emotion]
    Manabu Tashiro
    Nihon Yakurigaku Zasshi 125:88-96. 2005
  89. ncbi request reprint [Molecular imaging techniques for research on brain function using PET]
    Nobuyuki Okamura
    Nihon Yakurigaku Zasshi 126:347-52. 2005
  90. ncbi request reprint Recent advances in molecular pharmacology of the histamine systems: roles of C-terminal tails of histamine receptors
    Atsuo Kuramasu
    Department of Pharmacology, Tohoku University School of Medicine, Seiryo machi, Sendai, Japan
    J Pharmacol Sci 101:7-11. 2006
    ..To date, there is no protein identified to interact with the C-termini of histamine receptors...
  91. ncbi request reprint [In-vivo imaging of amyloid plaques]
    Nobuyuki Okamura
    Nihon Yakurigaku Zasshi 131:333-7. 2008
  92. ncbi request reprint Recent advances in the development of amyloid imaging agents
    Shozo Furumoto
    Biomedical Engineering Research Organization, Tohoku University, Sendai 980 8575, Japan
    Curr Top Med Chem 7:1773-89. 2007
    ....
  93. ncbi request reprint Evaluation of the binding characteristics of [18F]fluoroproxyfan in the rat brain for in vivo visualization of histamine H3 receptor
    Yoshihito Funaki
    Department of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai 980 8578, Japan
    Nucl Med Biol 34:981-7. 2007
    ..These data suggest that [18F]fluoroproxyfan can be potentially useful to image histamine H3 receptor noninvasively in the human brain by positron emission tomography...
  94. doi request reprint Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention
    S Fukudo
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Neuroimage 47:946-51. 2009
    ..The amygdala is more activated during fearful face recognition in individuals with the s allele of 5-HTTLPR. Here, we tested our hypothesis that 5-HTTLPR differentially activates brain regions with colorectal distention in humans...
  95. ncbi request reprint A simple loop method for the automated preparation of (11C)raclopride from (11C)methyl triflate
    R Iwata
    Graduate School of Engineering, Tohoku University, Sendai, Japan
    Appl Radiat Isot 55:17-22. 2001
    ..By the simple-loop method [11C]raclopride could be prepared in over 40% radiochemical yields (decay-corrected and based on [11C]methyl triflate)...
  96. ncbi request reprint [Neurotransmission in human brains measured by positron emission tomography (PET)]
    K Yanai
    Department of Pharmacology I, Tohoku University, School of Medicine, Sendai, Japan
    Nihon Yakurigaku Zasshi 109:259-70. 1997
    ..The present review article provides an outline of the conceptual and methodological progress over the past several years that has made it possible to visualize neurotransmission in human brains by PET...
  97. ncbi request reprint The effect of haloperidol on the histaminergic neuron system in the rat brain
    C Ito
    Department of Psychiatry, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 183:285-92. 1997
    ..5 +/- 0.45 microM. These findings suggest that only a high dose of haloperidol increases HA synthesis and release as a histamine H3 receptor antagonist in the rat brain...
  98. ncbi request reprint Possible involvement of tachykinin NK(1) and NMDA receptors in histamine-induced hyperalgesia in mice
    Shinobu Sakurada
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Eur J Pharmacol 434:29-34. 2002
    ..In addition, spinal NMDA receptor-NO system may also contribute to elicitation of hyperalgesia following i.t. injection of histamine...
  99. ncbi request reprint Behavioural characterization and amounts of brain monoamines and their metabolites in mice lacking histamine H1 receptors
    K Yanai
    Department of Pharmacology I, Tohoku University School of Medicine, Sendai, Japan
    Neuroscience 87:479-87. 1998
    ....
  100. ncbi request reprint Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice
    J I Mobarakeh
    Department of Pharmacology, Tohoku University School of Medicine, Seiryo machi 2 1, Aoba ku, Sendai, Japan
    Eur J Pharmacol 391:81-9. 2000
    ..The difference in the effect of histamine H(1) receptors antagonist, the active (D-) and inactive (L-) isomers of chlorpheniramine on ICR mice further substantiates the evidence of the role of histamine H(1) receptors on pain threshold...
  101. ncbi request reprint Targeting disruption of histamine H1 receptors in mice: behavioral and neurochemical characterization
    K Yanai
    Department of Pharmacology I, Tohoku University School of Medicine, Sendai, Japan
    Life Sci 62:1607-10. 1998
    ..In correlation to the behavioral changes in the mutant mice, 5-hydroxytryptamine release was significantly increased in the brains of mutant mice...