Yoshiyuki Ueno

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. pmc Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms
    Silvia Taffetani
    Department of Gastroenterology, Universita Politecnica delle Marche, Nuovo Polo Didattico, III piano, Ancona, Italy
    BMC Physiol 7:6. 2007
  2. doi request reprint Prevention of hepatocellular carcinoma complicating chronic hepatitis C
    Yoshiyuki Ueno
    Tohoku University Graduate School of Medicine, Division of Gastroenterology, 1 1 Seiryo, Aobaku, Sendai 980 8574, Japan
    J Gastroenterol Hepatol 24:531-6. 2009
  3. doi request reprint Enhanced intracellular retention of a hepatitis B virus strain associated with fulminant hepatitis
    Jun Inoue
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aoba, Sendai 980 8574, Japan
    Virology 395:202-9. 2009
  4. doi request reprint Murine models of autoimmune cholangitis
    Yoshiyuki Ueno
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Curr Opin Gastroenterol 26:274-9. 2010
  5. doi request reprint Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, Tohoku University, Sendai, Japan
    J Infect Dis 202:202-13. 2010
  6. pmc Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan
    Takayuki Kogure
    Division of Gastroenterology, Tohoku University Hospital, 1 1, Seiryo, Aobaku, Sendai 980 8574, Japan
    World J Gastroenterol 14:7225-4230. 2008
  7. doi request reprint Sequential immunological analysis of HBV/HCV co-infected patients during Peg-IFN/RBV therapy
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aobaku, Sendai, Miyagi, Japan
    J Gastroenterol 47:1323-35. 2012
  8. pmc 1(OH) vitamin D3 supplementation improves the sensitivity of the immune-response during Peg-IFN/RBV therapy in chronic hepatitis C patients-case controlled trial
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, Sendai City, Japan
    PLoS ONE 8:e63672. 2013
  9. doi request reprint Inhibitory effect on hepatitis B virus in vitro by a peroxisome proliferator-activated receptor-gamma ligand, rosiglitazone
    Yuta Wakui
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aobaku, Sendai 980 8574, Japan
    Biochem Biophys Res Commun 396:508-14. 2010
  10. pmc Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment
    Takayuki Kogure
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aoba, Sendai City 980 8574, Japan
    World J Gastroenterol 13:4394-7. 2007

Collaborators

Detail Information

Publications68

  1. pmc Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms
    Silvia Taffetani
    Department of Gastroenterology, Universita Politecnica delle Marche, Nuovo Polo Didattico, III piano, Ancona, Italy
    BMC Physiol 7:6. 2007
    ..We propose to evaluate the role and mechanisms of action by which prolactin regulates the growth of female cholangiocytes...
  2. doi request reprint Prevention of hepatocellular carcinoma complicating chronic hepatitis C
    Yoshiyuki Ueno
    Tohoku University Graduate School of Medicine, Division of Gastroenterology, 1 1 Seiryo, Aobaku, Sendai 980 8574, Japan
    J Gastroenterol Hepatol 24:531-6. 2009
    ....
  3. doi request reprint Enhanced intracellular retention of a hepatitis B virus strain associated with fulminant hepatitis
    Jun Inoue
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aoba, Sendai 980 8574, Japan
    Virology 395:202-9. 2009
    ..In conclusion, the fulminant HBV strain caused retention of the core particles and the core particle-associated HBV DNA in the cells...
  4. doi request reprint Murine models of autoimmune cholangitis
    Yoshiyuki Ueno
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Curr Opin Gastroenterol 26:274-9. 2010
    ..These models have great potential for illustrating the cause and the cellular events that lead to biliary-specific damage. The purpose of this review is to summarize recent progress in these models...
  5. doi request reprint Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, Tohoku University, Sendai, Japan
    J Infect Dis 202:202-13. 2010
    ..Soluble heat shock proteins, especially soluble heat shock protein 60 (sHSP60), could affect the function of T(reg) cells via Toll-like receptor...
  6. pmc Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan
    Takayuki Kogure
    Division of Gastroenterology, Tohoku University Hospital, 1 1, Seiryo, Aobaku, Sendai 980 8574, Japan
    World J Gastroenterol 14:7225-4230. 2008
    ..To evaluate the efficacy of pegylated interferon alpha-2b (peg-IFN alpha-2b) plus ribavirin (RBV) therapy in Japanese patients with chronic hepatitis C (CHC) genotype Ib and a high viral load...
  7. doi request reprint Sequential immunological analysis of HBV/HCV co-infected patients during Peg-IFN/RBV therapy
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aobaku, Sendai, Miyagi, Japan
    J Gastroenterol 47:1323-35. 2012
    ..In this study we aimed to analyze the virological and immunological parameters of HBV/HCV coinfected patients during pegylated interferon/ribavirin (Peg-IFN/RBV) therapy...
  8. pmc 1(OH) vitamin D3 supplementation improves the sensitivity of the immune-response during Peg-IFN/RBV therapy in chronic hepatitis C patients-case controlled trial
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, Sendai City, Japan
    PLoS ONE 8:e63672. 2013
    ..The aim of this study is to analyze the immunological response of 1(OH) vitamin D3 supplementation in CH-C patients...
  9. doi request reprint Inhibitory effect on hepatitis B virus in vitro by a peroxisome proliferator-activated receptor-gamma ligand, rosiglitazone
    Yuta Wakui
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aobaku, Sendai 980 8574, Japan
    Biochem Biophys Res Commun 396:508-14. 2010
    ....
  10. pmc Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment
    Takayuki Kogure
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aoba, Sendai City 980 8574, Japan
    World J Gastroenterol 13:4394-7. 2007
    ..The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH...
  11. doi request reprint Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan
    Jun Inoue
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    J Gastroenterol 44:329-37. 2009
    ..We aimed to clarify the characteristics of HEV infection in sporadic hepatitis patients during the last decade in Miyagi, northeast Japan...
  12. doi request reprint Transient elastography for measurement of liver stiffness measurement can detect early significant hepatic fibrosis in Japanese patients with viral and nonviral liver diseases
    Noriyuki Obara
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aoba, Sendai 980 8574, Japan
    J Gastroenterol 43:720-8. 2008
    ..We therefore compared the efficiency of transient elastography between CHC and nonviral CLD...
  13. pmc Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis
    Eiji Kakazu
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    PLoS ONE 6:e23402. 2011
    ..The aim of this study is to investigate the influence of the plasma L-Cys/L-Glu imbalance observed in patients with advanced cirrhosis on the function of circulating monocytes...
  14. doi request reprint Analysis of the entire nucleotide sequence of hepatitis B causing consecutive cases of fatal fulminant hepatitis in Miyagi Prefecture Japan
    Futoshi Nagasaki
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Med Virol 80:967-73. 2008
    ..Further studies could disclose the mechanism of severe inflammation of liver that finally leads to fulminant hepatitis...
  15. doi request reprint Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice
    Noriyuki Obara
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aobaku, Sendai 980 8574, Japan
    J Hepatol 53:326-34. 2010
    ..We aimed to clarify the impact of TFA-rich oil consumption on the hepatic pathophysiology compared to natural oil...
  16. ncbi request reprint Dynamics of immature subsets of dendritic cells during antiviral therapy in HLA-A24-positive chronic hepatitis C patients
    Masaaki Shiina
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Gastroenterol 41:758-64. 2006
    ..To better understand its mechanism, we examined dendritic cells (DCs) and hepatitis C virus (HCV)-specific cytotoxic T cells (CTLs), which are thought to contribute to liver injury and viral clearance...
  17. ncbi request reprint Autoimmune cholangitis in NOD.c3c4 mice is associated with cholangiocyte-specific Fas antigen deficiency
    Yu Nakagome
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980 8574, Japan
    J Autoimmun 29:20-9. 2007
    ..c3c4 mice secondary to impaired biliary cell apoptosis with exposure of mitochondrial antigens, loss of tolerance and subsequent development of multi-lineage anti-mitochondrial responses...
  18. pmc Mechanism of T cell hyporesponsiveness to HBcAg is associated with regulatory T cells in chronic hepatitis B
    Yasuteru Kondo
    Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    World J Gastroenterol 12:4310-7. 2006
    ..To study the mechanisms of hyporesponsiveness of HBV-specific CD4+ T cells by testing TH1 and TH2 commitment and regulatory T cells...
  19. doi request reprint Enhanced replication of hepatitis B virus with frameshift in the precore region found in fulminant hepatitis patients
    Jun Inoue
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Infect Dis 204:1017-25. 2011
    ..The genotype B of hepatitis B virus (HBV) was reported to associate with fulminant hepatitis (FH). We aimed to clarify the characteristics of HBV obtained from FH patients in an area of Japan where genotype B HBV is prevalent...
  20. doi request reprint Analysis of the full-length genome of hepatitis B virus in the serum and cerebrospinal fluid of a patient with acute hepatitis B and transverse myelitis
    Jun Inoue
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    J Clin Virol 41:301-4. 2008
    ..One clone of the 6 CSF clones had an additional substitution at nt 2119. These substitutions were not found in 16 serum clones. The presence of HBV clones unique to CSF suggests that HBV was a possible causative agent of the myelitis...
  21. pmc Distinct microRNAs expression profile in primary biliary cirrhosis and evaluation of miR 505-3p and miR197-3p as novel biomarkers
    Masashi Ninomiya
    Division of Gastroenterology, Tohoku University Hospital, Sendai, Japan
    PLoS ONE 8:e66086. 2013
    ..MicroRNAs are small endogenous RNA molecules with specific expression patterns that can serve as biomarkers for numerous diseases. However, little is known about the expression profile of serum miRNAs in PBC...
  22. ncbi request reprint Sustained clinical improvement of a patient with decompensated hepatitis B virus-related cirrhosis after treatment with lamivudine monotherapy
    Futoshi Nagasaki
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 210:29-36. 2006
    ..The administration of lamivudine to patients with HBV-related cirrhosis, like our present case, should be considered as an initial medical therapeutic option, especially in countries where liver transplantation is not reliably available...
  23. doi request reprint Association between S21 substitution in the core protein of hepatitis B virus and fulminant hepatitis
    Jun Inoue
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Clin Virol 55:147-52. 2012
    ..The viral factors of hepatitis B virus (HBV), such as genotypes and mutations, were reported to affect the development of fulminant hepatitis B (FHB), but the mechanism is still unclear...
  24. pmc Lymphotropic HCV strain can infect human primary naïve CD4+ cells and affect their proliferation and IFN-γ secretion activity
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aobaku, Sendai 980 8574, Japan
    J Gastroenterol 46:232-41. 2011
    ..Recently, we showed that a lymphotropic HCV (SB strain) could infect established T-cell lines and B-cell lines. However, whether HCV replication interferes with cell proliferation and function in primary T lymphocytes is still unclear...
  25. doi request reprint Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis
    Eiji Kakazu
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hepatology 50:1936-45. 2009
    ..In patients with advanced cirrhosis, peripheral blood mononuclear cells stimulated in the autologous plasma after oral administration of branched-chain amino acid (BCAA) granules had significantly increased interferon gamma production...
  26. ncbi request reprint The high incidence of the emergence of entecavir-resistant mutants among patients infected with lamivudine-resistant hepatitis B virus
    Futoshi Nagasaki
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 213:181-6. 2007
    ..Our observation draws attention to the possibility that the usage of entecavir for lamivudine-resistant HBV could promptly induce entecavir-resistant mutations in addition to lamivudine-resistance...
  27. ncbi request reprint Recovery of functional cytotoxic T lymphocytes during lamivudine therapy by acquiring multi-specificity
    Yasuteru Kondo
    Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    J Med Virol 74:425-33. 2004
    ..Since recovered CTLs maintained the ability to produce interferon-gamma in response to peptides, these CTLs apparently contribute to the efficacy of lamivudine therapy in patients with hepatitis B...
  28. pmc Sustained viral response of a case of acute hepatitis C virus infection via needle-stick injury
    Takayuki Kogure
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aoba, Sendai 980 8574, Japan
    World J Gastroenterol 12:4757-60. 2006
    ..HCV was eradicated without severe adverse effects. In acute hepatitis C, delaying therapy is considered to reduce the efficacy but interferon-beta therapy is one of the useful treatments for hepatitis C infection in chronic phase...
  29. doi request reprint The nutritional index 'CONUT' is useful for predicting long-term prognosis of patients with end-stage liver diseases
    Koji Fukushima
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 224:215-9. 2011
    ..The c-static was 0.081 for the 6-month (M) survival rate, 0.172 for 12M, 0.517 for 36M, 0.821 for 48M, and 0.938 for 60M for CONUT. In conclusion, CONUT shows best predictability for the distant prognoses of patients with ELD...
  30. doi request reprint Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein
    Keiichi Tamai
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 399:384-90. 2010
    ..These data indicated that Hrs is involved in the regulation of antigen-presentation activity through the exosome secretion...
  31. doi request reprint Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway
    Keiichi Tamai
    Division of Cancer Biology and Therapeutics, Miyagi Cancer Center Research Institute, Natori 981 1293, Japan
    Virology 422:377-85. 2012
    ..These results suggested that HCV secretion from host cells requires Hrs-dependent exosomal pathway in which the viral assembly is also involved...
  32. ncbi request reprint A case of HIV co-infected with hepatitis B virus precore/core deletion mutant treated by entecavir
    Koji Fukushima
    Department of Internal Medicine, Tohoku University Hospital, Sendai, Japan
    Hepatol Res 38:842-6. 2008
    ..HBV was genotyped as A2 with the quasispecies pool consisting of the -1G precore/core deletion mutant strain...
  33. pmc Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration
    Keiichi Tamai
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Pathol 173:1806-17. 2008
    ..These data suggest that Hrs plays an important role in neural cell survival in vivo and provide an animal model for neurodegenerative diseases that are known to be commonly affected by the generation of proteinaceous aggregates...
  34. pmc Use of illumina deep sequencing technology to differentiate hepatitis C virus variants
    Masashi Ninomiya
    Division of Gastroenterology, Tohoku University of Medicine, Sendai, Japan
    J Clin Microbiol 50:857-66. 2012
    ..In conclusion, deep sequencing technologies are powerful tools for obtaining more profound insight into the dynamics of variants in the HCV quasispecies in human serum...
  35. ncbi request reprint Ribavirin upregulates interleukin-12 receptor and induces T cell differentiation towards type 1 in chronic hepatitis C
    Masaaki Shiina
    Department of Gastroenterology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Gastroenterol Hepatol 19:558-64. 2004
    ..The aim of the present study was to evaluate the function of ribavirin in cellular immunity...
  36. ncbi request reprint Living related liver transplantation for acute fulminant hepatitis B: experience from two possible hyper-acute cases
    Jun Inoue
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Tohoku J Exp Med 205:197-204. 2005
    ..Although emergency liver transplantation may be an only option to rescue in such a case, living related liver transplantation has an advantage in view of urgent organ donation over cadeveric transplantation...
  37. pmc Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma
    Takayuki Kogure
    Division of Gastroenterology, Graduate School of Medicine, Tohoku University, Sendai 980 8574, Japan
    World J Gastroenterol 15:1267-72. 2009
    ..This case was an extremely rare LCA, which had no background of risk for LCA and developed the sequential alteration of the radiological findings to suspect well-differentiated HCC...
  38. ncbi request reprint Lack of evidence that bone marrow cells contribute to cholangiocyte repopulation during experimental cholestatic ductal hyperplasia
    Yuki Moritoki
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai Miyagi, Japan
    Liver Int 26:457-66. 2006
    ..Recently, bone marrow cells (BMCs) have been reported to behave as hepatic stem cells; however, their capability to differentiate into cholangiocytes in cholestasis remains unclear...
  39. ncbi request reprint Analysis of the entire nucleotide sequence of hepatitis B virus genotype B in the Philippines reveals a new subgenotype of genotype B
    Futoshi Nagasaki
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    J Gen Virol 87:1175-80. 2006
    ..The present study identified that HBV/B isolates throughout the world are divided genetically into five subgenotypes, the relationships between geographical distances and the genetic distances of HBV/B being well-correlated...
  40. ncbi request reprint Filopodia formation via a specific Eph family member and PI3K in immortalized cholangiocytes
    Koji Fukushima
    Division of Gastroenterology, Tohoku University School of Medicine, 1 1 Seiryo Aoba, Sendai 980 8574, Japan
    Am J Physiol Gastrointest Liver Physiol 291:G812-9. 2006
    ....
  41. doi request reprint Rapid reduction of hepatitis C virus-Core protein in the peripheral blood improve the immunological response in chronic hepatitis C patients
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Graduate School of Medicine Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Hepatol Res 41:1153-68. 2011
    ..Conclusions:  The rapid reduction of HCV-Core antigens and changes in the distribution of lymphoid cells could contribute to the favorable immunological response during DFPP/Peg-IFN/RBV therapy...
  42. doi request reprint Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines
    Osamu Kimura
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Sci 101:2145-55. 2010
    ....
  43. ncbi request reprint A case of severe recurrent hepatitis with common variable immunodeficiency
    Koji Fukushima
    Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hepatol Res 38:415-20. 2008
    ..Diagnostic criteria and therapeutic options of persistent hepatitis with CVID are to be established, as discussed in the current report...
  44. ncbi request reprint The model for end-stage liver disease score is useful for predicting economic outcomes in adult cases of living donor liver transplantation
    Takayuki Kogure
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Sendai, Japan
    J Gastroenterol 41:1005-10. 2006
    ..The application of MELD for living donor liver transplantation (LDLT) is under investigation. Thus, the aim of this study was to analyze the impact of the MELD score in LDLT in Japan...
  45. ncbi request reprint Primary biliary cirrhosis: what we know and what we want to know about human PBC and spontaneous PBC mouse models
    Yoshiyuki Ueno
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aoba, Sendai, Miyagi, 980 8574, Japan
    J Gastroenterol 42:189-95. 2007
    ..In this brief review, we discuss what we know and we do not know regarding the pathogenesis of PBC...
  46. doi request reprint Compensatory role of inducible annexin A2 for impaired biliary epithelial anion-exchange activity of inflammatory cholangiopathy
    Osamu Kido
    Tohoku University Graduate School of Medicine, Sendai, Japan
    Lab Invest 89:1374-86. 2009
    ....
  47. ncbi request reprint A novel third generation bisphosphonate, minodronate (YM529), prevented proliferation and migration of hepatocellular carcinoma cells through inhibition of mevalonate pathway
    Takayuki Kogure
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Hepatol Res 39:479-89. 2009
    ..Conclusion: YM529 inhibited the cell proliferation and migration of HCC cells, implicating the involvement of the mevalonate pathway. These results suggest that N-BPs are potential agents for the treatment of HCC skeletal metastases...
  48. ncbi request reprint Taurocholic acid feeding prevents tumor necrosis factor-alpha-induced damage of cholangiocytes by a PI3K-mediated pathway
    Yoshiyuki Ueno
    Department of Medicine, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    Exp Biol Med (Maywood) 232:942-9. 2007
    ..The PI3K survival pathway is important in bile acid protection against immune-mediated cholangiocyte injury in cholestatic liver diseases...
  49. ncbi request reprint A patient with clinical features of acute hepatitis E viral infection and autoimmune hepatitis
    Futoshi Nagasaki
    Division of Gastroenterology, Tohoku University Hospital, Sendai 980 8574, Japan
    Tohoku J Exp Med 206:173-9. 2005
    ..Further studies are feasible to understand the pathogenesis of liver injuries induced by HEV infections...
  50. doi request reprint The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH)
    Eiji Kakazu
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aobaku, Sendai, 980 8574, Japan
    Hepatol Int 7:577-85. 2013
    ..Thus, we investigated the relation between the therapeutic effect and the AA profile in NASH patients with a prospective study...
  51. pmc Plasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell
    Eiji Kakazu
    1 Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aobaku, Sendai, 980 8574 Japan 2 Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, 2 1 Seiryo, Aobaku, Sendai, 980 8573 Japan
    Sci Rep 3:3459. 2013
    ..Consistent with in vitro, In CD1c(+) or CD14(+) cells from cirrhotic patients, the gene expression of 2-oxoglutarate-succinate-fumarate transition enzymes were significantly different from the cells of healthy controls. ..
  52. ncbi request reprint Amniotic epithelial cell-derived cholangiocytes in experimental cholestatic ductal hyperplasia
    Yuki Moritoki
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Miyagi, Japan and Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, California, USA
    Hepatol Res 37:286-94. 2007
    ....
  53. ncbi request reprint Extracellular branched-chain amino acids, especially valine, regulate maturation and function of monocyte-derived dendritic cells
    Eiji Kakazu
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    J Immunol 179:7137-46. 2007
    ..An elevated extracellular concentration of valine could improve the DC function in cirrhotic patients. These data provide a rationale for nutrition therapy that could be beneficial to patients with cirrhosis...
  54. ncbi request reprint Mapping of a disease susceptibility locus in the HLA region for Primary Biliary Cirrhosis in Japan
    Kaichiro Yahagi
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hepatol Res 37:270-5. 2007
    ..Further studies seem feasible using more closely distributed microsatellite markers or single nucleotide polymorphisms (SNPs) to narrow the susceptibility locus in PBC in Japanese populations...
  55. pmc Bioinformatic approach for understanding the heterogeneity of cholangiocytes
    Koji Fukushima
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1Seiryo, Sendai, 980 8574, Japan
    World J Gastroenterol 12:3481-6. 2006
    ..Omic study will be of great help in understanding the heterogeniety of cholangiocytes...
  56. ncbi request reprint Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice
    Yoshiyuki Ueno
    Division of Gastroenterology, Tohoku University School of Medicine, Seiryo, Aobaku, Sendai, Japan
    Liver Int 23:449-59. 2003
    ..To evaluate the differential gene expression between small and large cholangiocytes, microarray analysis was performed...
  57. ncbi request reprint Distribution of the HLA class I allele in chronic hepatitis C and its association with serum ALT level in chronic hepatitis C
    Yasuteru Kondo
    Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Tohoku J Exp Med 201:109-17. 2003
    ..These results suggest a possibility that the alterations of host response, which depends on genetic background, influence disease activities of HCV infection...
  58. ncbi request reprint Bioinformatic approach for cholangiocyte pathophysiology
    Yoshiyuki Ueno
    Tohoku University Graduate School of Medicine, Division of Gastroenterology, A Seiryo, Aobaku, Sendai, Japan
    Hepatol Res 37:S444-8. 2007
    ....
  59. ncbi request reprint Expression of galectin-3 involved in prognosis of patients with hepatocellular carcinoma
    Yasunori Matsuda
    Tohoku University Graduate School of Medicine, Division of Gastroenterology, Sendai, Japan
    Hepatol Res 38:1098-111. 2008
    ..Conclusions: Galectin-3 expression was involved in the tumor progression and related to the prognosis of HCC. Our observations suggested that galectin-3 could be a novel tumor marker and therapeutic target...
  60. pmc Retrospective evaluation of tumor-mass-reduction therapy for the prognosis of recurrent hepatocellular carcinoma
    Emiko Mikami
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo, Aoba, Sendai, 980 8574, Japan
    Hepatol Int 1:460-8. 2007
    ..Patients with Child-Pugh B who experience several recurrence episodes and any patients with Child-Pugh C may benefit more from modalities other than tumor-mass-reduction therapies...
  61. pmc Biological significance of HCV in various kinds of lymphoid cells
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai City, Miyagi 980 8574, Japan
    Int J Microbiol 2012:647581. 2012
    ..In this paper, we summarize the reports regarding the biological significance of lymphotropic HCV in representative lymphoid cells...
  62. pmc PBC: Animal Models of Cholangiopathies and Possible Endogenous Viral Infections
    Masashi Ninomiya
    Division of Gastroenterology, Department of Gastroenterology, Tohoku University Graduate School of Medicine, Seiryo, Aoba ku, Sendai 980 8575, Japan
    Int J Hepatol 2012:649290. 2012
    ..c3c4 mouse, are enumerated and described, and we discuss previous reports of viral infection associated with PBC and consider the etiology of PBC from our analysis of results in NOD.c3c4 mouse...
  63. ncbi request reprint Treatment of Primary Biliary Cirrhosis: A new challenge?
    Koji Fukushima
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Seiryo, Aobaku, Sendai, Japan
    Hepatol Res 40:61-8. 2010
    ..Here, we reviewed the articles that address the etiology of PBC and the therapy for this disease for the confirmation of our current positions and future directions...
  64. ncbi request reprint The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors
    Takayuki Kogure
    Division of Gastroenterology, Tohoku University School of Medicine, 1 1 Seiryo, Aobaku, 980 8574 Sendai, Japan
    Cancer Chemother Pharmacol 53:296-304. 2004
    ..Therefore, we aimed to clarify the effects of a combination of the three drugs against hepatoma cells and to determine the role of these two enzymes using in vitro models...
  65. pmc Toll-like receptors signaling contributes to immunopathogenesis of HBV infection
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Miyagi, Sendai City 980 8574, Japan
    Gastroenterol Res Pract 2011:810939. 2011
    ..Thus, a review of TLRs involved in the pathogenesis of HBV infection may be needed toward better understanding of the immunopathogenesis of HBV infection...
  66. pmc Dysfunction of Immune Systems and Host Genetic Factors in Hepatitis C Virus Infection with Persistent Normal ALT
    Yasuteru Kondo
    Division of Gastroenterology, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai City, Miyagi 980 8574, Japan
    Hepat Res Treat 2011:713216. 2011
    ..Then, we summarize and speculate on the immunological aspects of PNALT including innate and adaptive immune systems and genetic polymorphisms of HLA and cytokines...
  67. ncbi request reprint Up-regulation of CD11a (LFA-1) expression on peripheral CD4+ T cells in primary biliary cirrhosis
    Masaaki Shiina
    Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Dig Dis Sci 47:1209-15. 2002
    ..295) or serum interleukin-4 level (P = 0.685) with the population of CD4+ CD11a(high) CD2(low) cells. These results suggest that CD4+ CD11a(high) cells play a role in Th-1-predominance and in the autoimmune process of PBC...
  68. ncbi request reprint Role of Hrs in maturation of autophagosomes in mammalian cells
    Keiichi Tamai
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 360:721-7. 2007
    ..Based on these results, we propose a novel function of Hrs, as a crucial player in the maturation of autophagosomes...