Koichi Tan-No

Summary

Affiliation: Tohoku Pharmaceutical University
Country: Japan

Publications

  1. ncbi request reprint Nociceptive behavior induced by poly-L-lysine and other basic compounds involves the spinal NMDA receptors
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Brain Res 1008:49-53. 2004
  2. doi request reprint Cysteine protease inhibitors suppress the development of tolerance to morphine antinociception
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
    Neuropeptides 42:239-44. 2008
  3. ncbi request reprint Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
    J Pharmacol Sci 104:39-45. 2007
  4. doi request reprint Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolerance to morphine
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Neurosci Lett 450:365-8. 2009
  5. ncbi request reprint S-(+)-fenfluramine-induced nociceptive behavior in mice: Involvement of interactions between spinal serotonin and substance P systems
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Neuropeptides 41:33-8. 2007
  6. ncbi request reprint Anti-inflammatory effect of propolis through inhibition of nitric oxide production on carrageenin-induced mouse paw edema
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
    Biol Pharm Bull 29:96-9. 2006
  7. ncbi request reprint Differential effects of N-peptidyl-O-acyl hydroxylamines on dynorphin-induced antinociception in the mouse capsaicin test
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, Aoba ku, Sendai, Japan
    Neuropeptides 39:569-73. 2005
  8. ncbi request reprint Intrathecally administered spermine produces the scratching, biting and licking behaviour in mice
    K Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai, Japan
    Pain 86:55-61. 2000
  9. ncbi request reprint Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Pain 113:301-9. 2005
  10. ncbi request reprint Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima Aoba ku, Sendai 981 8558, Japan
    Eur J Pharm Sci 20:357-63. 2003

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Nociceptive behavior induced by poly-L-lysine and other basic compounds involves the spinal NMDA receptors
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Brain Res 1008:49-53. 2004
    ....
  2. doi request reprint Cysteine protease inhibitors suppress the development of tolerance to morphine antinociception
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
    Neuropeptides 42:239-44. 2008
    ..These results suggest that cysteine protease inhibitors suppress the development of morphine tolerance presumably through the inhibition of dynorphin degradation...
  3. ncbi request reprint Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
    J Pharmacol Sci 104:39-45. 2007
    ....
  4. doi request reprint Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolerance to morphine
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Neurosci Lett 450:365-8. 2009
    ..These results indicate that the increased expression and activation of p53, and the nitric oxide and caspase systems related to p53 may contribute to the development of antinociceptive tolerance to morphine in the mouse spinal cord...
  5. ncbi request reprint S-(+)-fenfluramine-induced nociceptive behavior in mice: Involvement of interactions between spinal serotonin and substance P systems
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Neuropeptides 41:33-8. 2007
    ..These results suggest that i.t.-administered S-(+)-fenfluramine releases SP through the activation of 5-HT2 receptors subsequent to 5-HT release, and, as a result, produces nociceptive behavior...
  6. ncbi request reprint Anti-inflammatory effect of propolis through inhibition of nitric oxide production on carrageenin-induced mouse paw edema
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
    Biol Pharm Bull 29:96-9. 2006
    ..These results indicate that the anti-inflammatory effect of propolis on mouse paw edema acts via the inhibition of nitric oxide production, similar to that of L-NAME but not diclofenac...
  7. ncbi request reprint Differential effects of N-peptidyl-O-acyl hydroxylamines on dynorphin-induced antinociception in the mouse capsaicin test
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, Aoba ku, Sendai, Japan
    Neuropeptides 39:569-73. 2005
    ..The results suggest that Z-Phe-Phe-NHO-Bz is an inhibitor of cysteine proteases preferring cleavage of dynorphin A, with less specificity towards dynorphin B in the mouse spinal cord...
  8. ncbi request reprint Intrathecally administered spermine produces the scratching, biting and licking behaviour in mice
    K Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai, Japan
    Pain 86:55-61. 2000
    ..These results indicate that spermine-induced behaviour is mediated through the polyamine recognition site on NMDA receptor ion-channel complex without the involvement of substance P system in the mouse spinal cord...
  9. ncbi request reprint Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Pain 113:301-9. 2005
    ..The NEM effects may be mediated through inhibition of the degradation of endogenous dynorphins, presumably big dynorphin that in turn activates the NMDA receptor ion-channel complex by acting on the polyamine recognition site...
  10. ncbi request reprint Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima Aoba ku, Sendai 981 8558, Japan
    Eur J Pharm Sci 20:357-63. 2003
    ....
  11. doi request reprint Suppressive effects by cysteine protease inhibitors on naloxone-precipitated withdrawal jumping in morphine-dependent mice
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Neuropeptides 44:279-83. 2010
    ..The present results suggest that cysteine protease inhibitors suppress naloxone-precipitated withdrawal jumping in morphine-dependent mice, presumably through the inhibition of dynorphin degradation...
  12. ncbi request reprint Antinociceptive effect produced by intracerebroventricularly administered dynorphin A is potentiated by p-hydroxymercuribenzoate or phosphoramidon in the mouse formalin test
    K Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, 981 8558, Sendai, Japan
    Brain Res 891:274-80. 2001
    ..11 are involved in two steps in the degradation of dynorphin A in the mouse brain, and that phosphoramidon inhibits the degradation of intermediary delta-opioid receptor active fragments enkephalins which are formed from dynorphin A...
  13. ncbi request reprint Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Brain Res 952:7-14. 2002
    ....
  14. doi request reprint p-Hydroxyamphetamine causes prepulse inhibition disruptions in mice: contribution of dopamine neurotransmission
    Hiroshi Onogi
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Behav Brain Res 214:349-56. 2010
    ..These results indicate that selective blockade of either the D(2) or D(4) receptor subtype may prevent disruption of PPI induced by p-OHA via presynaptic DA release...
  15. doi request reprint Behavioral and neurochemical characterization of mice deficient in the N-type Ca2+ channel alpha1B subunit
    Osamu Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Behav Brain Res 208:224-30. 2010
    ....
  16. doi request reprint p-Hydroxyamphetamine causes prepulse inhibition disruption in mice: contribution of serotonin neurotransmission
    Hiroshi Onogi
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Behav Brain Res 224:159-65. 2011
    ..These data suggest that p-OHA-induced PPI disruption may involve increased serotonin release into the synaptic cleft, which then interacts with the post-synaptic 5-HT(2A) receptor...
  17. ncbi request reprint Inhibitory effect of pranidipine on N-type voltage-dependent Ca2+ channels in mice
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
    Neurosci Lett 367:118-22. 2004
    ....
  18. doi request reprint Pharmacological characterizations of memantine-induced disruption of prepulse inhibition of the acoustic startle response in mice: involvement of dopamine D2 and 5-HT2A receptors
    Kota Nakaya
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Behav Brain Res 218:165-73. 2011
    ..Conceivably, memantine may exacerbate psychotic symptoms in patients with PDD and LBD...
  19. doi request reprint Effect of non-selective dopaminergic receptor agonist on disrupted maternal behavior in olfactory bulbectomized mice
    Atsushi Sato
    Department of Pharmacology, Tohoku Pharmaceutical University, Aoba ku, Sendai, Japan
    Behav Brain Res 210:251-6. 2010
    ..These results suggest that maternal behavior deficits in OBX dams may involve brain hypodopaminergic function in the central nervous system induced by OBX...
  20. doi request reprint Nociceptive behavior induced by the endogenous opioid peptides dynorphins in uninjured mice: evidence with intrathecal N-ethylmaleimide inhibiting dynorphin degradation
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Int Rev Neurobiol 85:191-205. 2009
    ..Our findings support the notion that endogenous dynorphins are critical neurochemical mediators of spinal nociceptive transmission in uninjured animals. This chapter will review above-described phenomena and their mechanism...
  21. doi request reprint Central administration of p-hydroxyamphetamine produces a behavioral stimulant effect in rodents: evidence for the involvement of dopaminergic systems
    Hiroshi Onogi
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai, 981 8558, Japan
    Psychopharmacology (Berl) 208:323-31. 2010
    ..c.v.) administration of p-hydroxyamphetamine (p-OHA), an amphetamine metabolite, increases synaptic dopamine (DA) levels in the striatum. In the present study, we investigated the effect of p-OHA on locomotor activity in rodents...
  22. ncbi request reprint Effects of atomoxetine on levels of monoamines and related substances in discrete brain regions in mice intermittently deprived of rapid eye movement sleep
    Fukie Niijima
    Department of Pharmacology, Tohoku Pharmaceutical University, Japan
    Biol Pharm Bull 33:617-21. 2010
    ....
  23. doi request reprint Alterations in behavioral responses to dopamine agonists in olfactory bulbectomized mice: relationship to changes in the striatal dopaminergic system
    Kohei Takahashi
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai, 981 8558, Japan
    Psychopharmacology (Berl) 233:1311-22. 2016
    ....
  24. doi request reprint Influence of a long-term powdered diet on the social interaction test and dopaminergic systems in mice
    Fukie Niijima-Yaoita
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Neurochem Int 63:309-15. 2013
    ..These results suggest that the masticatory dysfunction induced by long-term powdered diet feeding may cause the increased SI time and the changes in the dopaminergic system, especially dopamine D4 receptor subtype in the frontal cortex...
  25. ncbi request reprint Combined low calcium and lack magnesium is a risk factor for motor deficit in mice
    Ryoo Taniguchi
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
    Biosci Biotechnol Biochem 77:266-70. 2013
    ..Moreover, our results support the hypothesis that LCa/Mg intake is one etiological factor in neurodegenerative disorders, including Parkinson's disease...
  26. doi request reprint Subchronic stress-induced depressive behavior in ovariectomized mice
    Osamu Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981 8558, Japan
    Life Sci 84:512-6. 2009
    ..Mood disorders including depression are more common in women than men, particularly in times of lower estradiol levels. In this study, we investigated the effect of estrogen on emotional behavior in mice in a stress environment...
  27. doi request reprint Influence of olfactory bulbectomy on maternal behavior and dopaminergic function in nucleus accumbens in mice
    Atsushi Sato
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Behav Brain Res 215:141-5. 2010
    ..However, our findings concerning dopaminergic function suggest that the deficits in OBX mice are not simply due to changes in TH levels or dopamine receptor number in the NAc...
  28. doi request reprint Phenylmethanesulfonyl fluoride, a serine protease inhibitor, suppresses naloxone-precipitated withdrawal jumping in morphine-dependent mice
    Wataru Nemoto
    Department of Pharmacology, Tohoku Pharmaceutical University, Aoba ku, Sendai, Japan
    Neuropeptides 47:187-91. 2013
    ....
  29. ncbi request reprint Immunohistochemical fluorescence intensity reduction of brain somatostatin in the impairment of learning and memory-related behaviour induced by olfactory bulbectomy
    Osamu Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Behav Brain Res 142:63-7. 2003
    ..These results suggest that SST in the hippocampus is related to the impairment of learning and memory-related behaviour induced by OBX...
  30. ncbi request reprint Preventive effect of kami-untan-to on performance in the forced swimming test in thiamine-deficient mice: relationship to functions of catecholaminergic neurons
    Osamu Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Behav Brain Res 177:315-21. 2007
    ..These results suggest that KUT treatment may prevent a sign of depressive behavior, the animal immobility time, induced by TD feeding through a mechanism that involves the decrease of TH in some brain areas of TD mice...
  31. ncbi request reprint Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
    Brain Res 1024:122-9. 2004
    ..The results of this study revealed the localization and functions of several calcium channels that are involved in nociceptive neurotransmission within the dorsal horn of the mouse spinal cord...
  32. ncbi request reprint Effect of nutritive and tonic crude drugs on physical fatigue-induced stress models in mice
    Takeshi Tadano
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Pharmacol Res 47:195-9. 2003
    ..However, the crude drugs were not effective in improving immobility after sleep deprivation or immobilization stress...
  33. doi request reprint Chronic fluvoxamine treatment changes 5-HT(2A/2C) receptor-mediated behavior in olfactory bulbectomized mice
    Akira Oba
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981 8558, Japan
    Life Sci 92:119-24. 2013
    ..This study was designed to shed further light on the impact of putative serotonergic neuronal degeneration in OBX mice and to assess the effect of a widely used antidepressant on serotonergic related behavioral changes induced by OBX...
  34. ncbi request reprint Influence of memantine on brain monoaminergic neurotransmission parameters in mice: neurochemical and behavioral study
    Hiroshi Onogi
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
    Biol Pharm Bull 32:850-5. 2009
    ..These findings suggest that the increased locomotor activity and enhanced 5-HT-induced HTR by memantine may result from the reuptake and turnover inhibitions of 5-HT and dopamine...
  35. ncbi request reprint Modified behavioral characteristics following ablation of the voltage-dependent calcium channel beta3 subunit
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, Akita, 1 1 1 Hondoh, Akita 010 8543, Japan
    Brain Res 1160:102-12. 2007
    ..These results suggest the importance of voltage-dependent calcium channels and the key role of the beta3 subunit in memory formation, nociceptive sensory transduction, and various neurological signal transduction pathways...
  36. ncbi request reprint Alterations in cognitive function in prepubertal mice with protein malnutrition: relationship to changes in choline acetyltransferase
    Osamu Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Behav Brain Res 167:111-7. 2006
    ..These results suggest the possibility that the memory-related behavior deficits observed in prepubertal mice with PM are caused by a dysfunction of the cholinergic neurons in the hippocampus...
  37. ncbi request reprint Executive functions of postweaning protein malnutrition in mice
    Shoko Sato
    Department of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Aoba ku, Sendai, Japan
    Biol Pharm Bull 34:1413-7. 2011
    ..These results suggest that hyperactivity and reduced anxiety behavior or higher impulsiveness in PM mice could be due to an immature brain...
  38. doi request reprint Chondroitin sulfate attenuates formalin-induced persistent tactile allodynia
    Wataru Nemoto
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    J Pharmacol Sci 131:275-8. 2016
    ..These findings suggest that CS attenuates formalin-induced tactile allodynia through the inhibition of p38 MAPK phosphorylation and subsequent up-regulation of c-Fos expression in the dorsal lumbar spinal cord. ..
  39. doi request reprint Effects of methylphenidate on the impairment of spontaneous alternation behavior in mice intermittently deprived of REM sleep
    Fukie Niijima-Yaoita
    Department of Pharmacology, Faculty of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai, 981 8558, Japan Electronic address
    Neurochem Int 100:128-137. 2016
    ..Further, the ameliorating effects of methylphenidate on the impairment of SAB may be mediated through NO production mainly by iNOS in the hippocampus of mice...
  40. doi request reprint Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice
    Wataru Nemoto
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai, 981 8558, Japan
    Neuropharmacology 99:221-31. 2015
    ....
  41. ncbi request reprint Enhanced behavioral response to serotonin-related agonists in postweaning protein malnourished mice
    Shoko Sato
    Department of Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Biol Pharm Bull 35:1697-702. 2012
    ..Moreover, they highlight the postweaning stage as a vulnerable period to malnutrition-induced alterations in central serotonergic systems...
  42. doi request reprint Involvement of Spinal Angiotensin II System in Streptozotocin-Induced Diabetic Neuropathic Pain in Mice
    Yoshiki Ogata
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Aoba ku, Sendai, Japan Y O, w n, O N, R Y, K T N Department of Health Care Medical Research, Venture Business Laboratory, Kanazawa University, Kanazawa, Japan T T
    Mol Pharmacol 90:205-13. 2016
    ..This increase in spinal Ang II was accompanied by the phosphorylation of p38 MAPK, which was shown to be mediated by AT1 receptors. ..
  43. doi request reprint Liver hydrolysate attenuates the sickness behavior induced by concanavalin A in mice
    Osamu Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981 8558, Japan Electronic address
    J Pharmacol Sci 127:489-92. 2015
    ..The decreased locomotor activity and TH levels were significantly reversed by LH treatment. LH may prove beneficial for preventing sickness behavior following ConA treatment, at least in part, by activating TH in the striatum. ..
  44. ncbi request reprint Characteristics of changes in cholinergic function and impairment of learning and memory-related behavior induced by olfactory bulbectomy
    Soichi Hozumi
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Behav Brain Res 138:9-15. 2003
    ..These results suggest that the impairment of learning and memory-related behavior induced by OBX may be caused by degeneration of cholinergic neurons and muscarinic M(1) receptors play an important role in the improvement process...
  45. doi request reprint BE360, a new selective estrogen receptor modulator, produces antidepressant and antidementia effects through the enhancement of hippocampal cell proliferation in olfactory bulbectomized mice
    Osamu Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan Electronic address
    Behav Brain Res 297:315-22. 2016
    ..These results indicate that BE360 may have valuable therapeutic potential against depression and neurodegenerative diseases. ..
  46. doi request reprint The intrathecal administration of losartan, an AT1 receptor antagonist, produces an antinociceptive effect through the inhibiton of p38 MAPK phosphorylation in the mouse formalin test
    Wataru Nemoto
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai981 8558, Japan
    Neurosci Lett 585:17-22. 2015
    ....
  47. ncbi request reprint Liver hydrolysate assists in the recovery from physical fatigue in a mouse model
    Osamu Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, Japan
    J Pharmacol Sci 123:328-35. 2013
    ..These findings indicate that LH produced an anti-fatigue effect and that this effect appears to involve the efficient glycogen utilization through activation of AMPK. ..
  48. doi request reprint Intraplantar injection of gangliosides produces nociceptive behavior and hyperalgesia via a glutamate signaling mechanism
    Shun Watanabe
    Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, Miyagi 981 8558, Japan
    Pain 152:327-34. 2011
    ..Ganglioside GT1b induced extracellular glutamate to accumulate in subdermal tissues, thereafter activating glutamate receptors, which in turn resulted in hyperalgesia and nociception...
  49. ncbi request reprint Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors
    Tsukasa Sakurada
    Department of Biochemistry, Daiichi College of Pharmaceutical Sciences, 22 1 Tamagawa cho, Minami Ku, 815 8511, Fukuoka, Japan
    Brain Res Mol Brain Res 98:111-8. 2002
    ..These results suggest that spinal NMDA receptors, but not non-NMDA receptors, may be largely involved in elicitation of the behavioral episode following i.t. injection of morphine in mice...
  50. ncbi request reprint Degradation of nociceptin (orphanin FQ) by mouse spinal cord synaptic membranes is triggered by endopeptidase-24.11: an in vitro and in vivo study
    Chikai Sakurada
    Department of Biochemistry, Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan
    Biochem Pharmacol 64:1293-303. 2002
    ..These data suggest that endopeptidase-24.11 plays a major role in initial stage of nociceptin metabolism at the spinal cord level in mice...
  51. ncbi request reprint Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca2+ channels
    Kunie Hagiwara
    Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, 2 1 Seiryomachi Aobaku, Sendai 980 8575, Japan
    Neurosci Res 46:493-7. 2003
    ....
  52. ncbi request reprint Degradation of endomorphin-2 at the supraspinal level in mice is initiated by dipeptidyl peptidase IV: an in vitro and in vivo study
    Chikai Sakurada
    Department of Biochemistry, Daiichi College of Pharmaceutical Sciences, 22 1 Tamagawa cho, Minami Ku, Fukuoka 815 8511, Japan
    Biochem Pharmacol 66:653-61. 2003
    ..These results indicate that dipeptidyl peptidase IV may be an important peptidase responsible for terminating endomorphin-2-induced antinociception at the supraspinal level in mice...