Kazuhiro Takahashi

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. ncbi request reprint Decreased expression of adrenomedullin during adipocyte-differentiation of 3T3-L1 cells
    Yin Li
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575 Japan
    Hypertens Res 26:S41-4. 2003
  2. ncbi request reprint Repression of heme oxygenase-1 expression as a defense strategy in humans
    Shigeki Shibahara
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Exp Biol Med (Maywood) 228:472-3. 2003
  3. ncbi request reprint Raloxifene inhibits estrogen-induced up-regulation of telomerase activity in a human breast cancer cell line
    Jun Kawagoe
    Department of Obstetrics and Gynecology, Yamagata University, School of Medicine, Iidanishi, Yamagata, Japan
    J Biol Chem 278:43363-72. 2003
  4. ncbi request reprint Both estrogen and raloxifene protect against beta-amyloid-induced neurotoxicity in estrogen receptor alpha-transfected PC12 cells by activation of telomerase activity via Akt cascade
    Botao Du
    Department of Obstetrics and Gynecology, Yamagata University, School of Medicine, 2 2 2 Iidanishi, Yamagata 990 9585, Japan
    J Endocrinol 183:605-15. 2004
  5. ncbi request reprint Identification of adipocyte differentiation-related regulatory element for adrenomedullin gene repression (ADRE-AR) in 3T3-L1 cells
    Yin Li
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Peptides 27:1405-14. 2006
  6. ncbi request reprint Increased secretion of adrenomedullin from cultured human astrocytes by cytokines
    K Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    J Neurochem 74:99-103. 2000
  7. ncbi request reprint The brainstem is a key target for neuroendocrine research on obesity
    Kazuhiro Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Endocrinology 144:4690-1. 2003
  8. ncbi request reprint Expression of urotensin II and its receptor in adrenal tumors and stimulation of proliferation of cultured tumor cells by urotensin II
    Kazuhiro Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Miyagi 980 8574, Sendai, Japan
    Peptides 24:301-6. 2003
  9. ncbi request reprint Adrenocortical peptides: autocrine or paracrine regulators for the steroid hormone secretion or the cell proliferation?
    K Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Exp Clin Endocrinol Diabetes 110:373-80. 2002
  10. ncbi request reprint Suppression of cytokine-induced expression of adrenomedullin and endothelin-1 by dexamethasone in T98G human glioblastoma cells
    Kazuhiro Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Peptides 24:1053-62. 2003

Collaborators

Detail Information

Publications89

  1. ncbi request reprint Decreased expression of adrenomedullin during adipocyte-differentiation of 3T3-L1 cells
    Yin Li
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575 Japan
    Hypertens Res 26:S41-4. 2003
    ..The present study thus showed that AM expression was decreased, and resistin expression increased, during adipocyte-differentiation of 3T3-L1 cells...
  2. ncbi request reprint Repression of heme oxygenase-1 expression as a defense strategy in humans
    Shigeki Shibahara
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Exp Biol Med (Maywood) 228:472-3. 2003
    ..Here, we discuss the repression of HO-1 expression as a potential defense strategy in humans by highlighting a regulatory role of HO-1 in its own expression...
  3. ncbi request reprint Raloxifene inhibits estrogen-induced up-regulation of telomerase activity in a human breast cancer cell line
    Jun Kawagoe
    Department of Obstetrics and Gynecology, Yamagata University, School of Medicine, Iidanishi, Yamagata, Japan
    J Biol Chem 278:43363-72. 2003
    ....
  4. ncbi request reprint Both estrogen and raloxifene protect against beta-amyloid-induced neurotoxicity in estrogen receptor alpha-transfected PC12 cells by activation of telomerase activity via Akt cascade
    Botao Du
    Department of Obstetrics and Gynecology, Yamagata University, School of Medicine, 2 2 2 Iidanishi, Yamagata 990 9585, Japan
    J Endocrinol 183:605-15. 2004
    ..Our findings suggest that and raloxifene exert neuroprotective effects by E2 telomerase activation via a post-transcriptional cascade in an experimental model relevant to Alzheimer's disease...
  5. ncbi request reprint Identification of adipocyte differentiation-related regulatory element for adrenomedullin gene repression (ADRE-AR) in 3T3-L1 cells
    Yin Li
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Peptides 27:1405-14. 2006
    ..The present study has raised the possibility that ADRE-AR may play important roles in the AM gene expression in preadipocytes, and that the AM gene may be repressed through the ADRE-AR in adipocytes...
  6. ncbi request reprint Increased secretion of adrenomedullin from cultured human astrocytes by cytokines
    K Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    J Neurochem 74:99-103. 2000
    ..The present study has shown the production and secretion of adrenomedullin by human astrocytes and increased secretion of adrenomedullin by cytokines...
  7. ncbi request reprint The brainstem is a key target for neuroendocrine research on obesity
    Kazuhiro Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Endocrinology 144:4690-1. 2003
  8. ncbi request reprint Expression of urotensin II and its receptor in adrenal tumors and stimulation of proliferation of cultured tumor cells by urotensin II
    Kazuhiro Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Miyagi 980 8574, Sendai, Japan
    Peptides 24:301-6. 2003
    ..These findings raise the possibility that urotensin II may act as an autocrine/paracrine growth stimulating factor in adrenal tumors...
  9. ncbi request reprint Adrenocortical peptides: autocrine or paracrine regulators for the steroid hormone secretion or the cell proliferation?
    K Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Exp Clin Endocrinol Diabetes 110:373-80. 2002
    ..a novel autocrine or paracrine regulatory system for the steroid hormone secretion and the cell proliferation in the adrenal cortex, and involve in the pathophysiology of inflammatory, ischemic or neoplastic diseases of the adrenal cortex..
  10. ncbi request reprint Suppression of cytokine-induced expression of adrenomedullin and endothelin-1 by dexamethasone in T98G human glioblastoma cells
    Kazuhiro Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Peptides 24:1053-62. 2003
    ..These findings raised the possibility that effects of dexamethasone on brain inflammation and glioblastomas may be partly mediated or modulated by its effects on expression of adrenomedullin and endothelin-1...
  11. ncbi request reprint Three vasoactive peptides, endothelin-1, adrenomedullin and urotensin-II, in human tumour cell lines of different origin: expression and effects on proliferation
    Kazuhiro Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Clin Sci (Lond) 103:35S-38S. 2002
    ..These results suggest that endothelin-1 acts as a paracrine or autocrine growth stimulator in tumours. The effect of endothelin-1 on tumour growth appears to be mediated by the ET(A) receptor...
  12. ncbi request reprint Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas
    Kazuhiro Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Miyagi 980 8575, Sendai, Japan
    Peptides 23:1135-40. 2002
    ..The high expression of PrRP receptor in pheochromocytomas suggests potential pathophysiological roles of PrRP in these tumors...
  13. ncbi request reprint Expression of urotensin II and urotensin II receptor mRNAs in various human tumor cell lines and secretion of urotensin II-like immunoreactivity by SW-13 adrenocortical carcinoma cells
    K Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Peptides 22:1175-9. 2001
    ..The present study has shown for the first time expression of urotensin II and urotensin II receptor mRNAs in various tumor cell lines and the secretion of urotensin II-like immunoreactivity by SW-13 adrenocortical carcinoma cells...
  14. ncbi request reprint Adrenomedullin from a pheochromocytoma to the eye: implications of the adrenomedullin research for endocrinology in the 21st century
    K Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 193:79-114. 2001
    ....
  15. ncbi request reprint Production and secretion of two vasoactive peptides, adrenomedullin and endothelin-1, by cultured human adrenocortical carcinoma cells
    K Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, Japan
    Peptides 21:251-6. 2000
    ..These findings indicate that SW-13 human adrenocortical carcinoma cells produce and secrete two vasoactive peptides, adrenomedullin, and endothelin-1 and that the secretion of these two peptides is modulated differently by cytokines...
  16. ncbi request reprint Secretion of endothelin-1 and adrenomedullin by SW-13 human adrenocortical carcinoma cells
    K Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    J Cardiovasc Pharmacol 36:S393-4. 2000
    ..This study has shown that ET-1 and ADM are the two unique vasoactive peptides that are produced and secreted by adrenocortical carcinoma cells...
  17. doi request reprint Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats: comparison with endothelin-1
    Takuo Hirose
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Peptides 30:1124-9. 2009
    ....
  18. ncbi request reprint Microphthalmia-associated transcription factor in the Wnt signaling pathway
    Hideo Saito
    Department of Molecular Biology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi, Japan
    Pigment Cell Res 16:261-5. 2003
    ..MITF-M therefore plays dual roles in the Wnt signaling pathway; MITF-M represents a downstream target and a nuclear mediator of Wnt signals in melanocytes...
  19. ncbi request reprint Expression of heme oxygenase-1 is repressed by interferon-gamma and induced by hypoxia in human retinal pigment epithelial cells
    Reiko Udono-Fujimori
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Eur J Biochem 271:3076-84. 2004
    ..These results indicate that RPE cells maintain retinal homeostasis by repressing or inducing the expression of HO-1, depending on the microenvironment...
  20. ncbi request reprint Differential expression of adrenomedullin and resistin in 3T3-L1 adipocytes treated with tumor necrosis factor-alpha
    Yin Li
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Eur J Endocrinol 149:231-8. 2003
    ..Moreover, we studied the effects of tumor necrosis factor-alpha (TNF-alpha), a known mediator of insulin resistance, on the expression of AM and resistin in 3T3-L1 adipocytes...
  21. doi request reprint Expression of adrenomedullin 2/intermedin, a possible reno-protective peptide, is decreased in the kidneys of rats with hypertension or renal failure
    Takuo Hirose
    Dept of Clinical Pharmacology and Therapeutics, Tohoku Univ Graduate School of Pharmaceutical Sciences and Medicine, 6 3 Aramaki Aza Aoba, Aoba ku, Sendai 980 8578, Japan
    Am J Physiol Renal Physiol 299:F128-34. 2010
    ..Given the organ-protective effects of AM2/IMD, the downregulation of AM2/IMD as an endogenous regulatory peptide may have a role in the progression of renal impairment...
  22. ncbi request reprint Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1
    Hideo Saito
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Biol Chem 277:28787-94. 2002
    ..We suggest that MITF-M haploinsufficiency may impair the dosage-sensitive role of MITF-M or the correct assembly of multiple transcription factors, involving MITF-M, on the M promoter, which could account for dominant inheritance of WS2...
  23. ncbi request reprint Expression of urocortin 3/stresscopin in human adrenal glands and adrenal tumors
    Kazuhiro Takahashi
    Department of Analytical Medical Technology, Tohoku University School of Health Sciences, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Peptides 27:178-82. 2006
    ....
  24. doi request reprint Expression of (pro)renin receptor in human kidneys with end-stage kidney disease due to diabetic nephropathy
    Kazuhiro Takahashi
    Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Miyagi, Japan
    Peptides 31:1405-8. 2010
    ..The present study has raised the possibility that (P)RR expressed in the diabetic kidney may play a pathophysiological role in angiotensin I generation and renal fibrosis found in end-stage renal disease...
  25. doi request reprint Expression of adrenomedullin 2/intermedin in human adrenal tumors and attached non-neoplastic adrenal tissues
    Ryo Morimoto
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8574, Japan
    J Endocrinol 198:175-83. 2008
    ..In conclusion, AM2/IMD is expressed in human adrenal tumors and attached non-neoplastic adrenal tissues and may play (patho-)physiological roles in normal and neoplastic adrenals as an autocrine/paracrine regulator...
  26. doi request reprint Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: the Ohasama study
    Takuo Hirose
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Aoba ku, Sendai, Japan
    Hypertens Res 34:1327-32. 2011
    ..4, P=0.01) and WMH (OR: 2.7, P=0.003), compared with II carriers. The AM2/IMD I/D polymorphism is associated with renal dysfunction, blood pressure regulation and asymptomatic cerebrovascular diseases in the Japanese general population...
  27. ncbi request reprint Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells
    Tomomi Kitamuro
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Biol Chem 278:9125-33. 2003
    ..Therefore, Bach1 functions as a hypoxia-inducible repressor for the HO-1 gene, thereby contributing to fine-tuning of oxygen homeostasis in human cells...
  28. pmc Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling
    Ken ichi Yasumoto
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    EMBO J 21:2703-14. 2002
    ..This study therefore suggests that the MITF/TFE3 family is a new class of nuclear modulators for LEF-1, which may ensure efficient propagation of Wnt signals in many types of cells...
  29. ncbi request reprint Germ cell-specific expression of microphthalmia-associated transcription factor mRNA in mouse testis
    Hideo Saito
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575
    J Biochem 134:143-50. 2003
    ..Notably, Mitf mRNA is undetectable in somatic Leydig cells and peritubular cells. Therefore, multiple promoters may direct differential expression of the Mitf gene in the testis and contribute to functional diversity of Mitf isoforms...
  30. ncbi request reprint Expression of adrenomedullin2/intermedin in human brain, heart, and kidney
    Ryo Morimoto
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Sendai, Miyagi 980 8574, Japan
    Peptides 28:1095-103. 2007
    ..The present study has shown expression of AM2/IMD in various types of cells in the central nervous system and the cardiovascular system, and suggested possible (patho)physiological roles of AM2/IMD in these systems...
  31. ncbi request reprint Hypoxia increases endothelin-1 mRNA expression but not immunoreactive endothelin in the medium of T98G glioblastoma cells under cytokine treatment
    Yan Zhang
    Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Peptides 27:3003-6. 2006
    ..These findings indicate that hypoxia induces ET-1 mRNA expression in the treatment of three cytokines, but IR-ET levels in the medium do not reflect this induction in T98G glioblastoma cells...
  32. ncbi request reprint Enhanced antinociception by intracerebroventricularly administered orexin A in histamine H1 or H2 receptor gene knockout mice
    Jalal Izadi Mobarakeh
    Department of Pharmacology, Tohoku University School of Medicine, Seiryo machi 2 1, Sendai 980 8575, Japan
    Pain 118:254-62. 2005
    ..Thus, the blocking of the histamine H1 or H2 receptor may produce antinociception and enhance the orexin A-induced antinociception...
  33. ncbi request reprint Suppression of cytokine-induced expression of endothelin-1 by dexamethasone in human retinal pigment epithelial cells
    Reiko Udono-Fujimori
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    J Cardiovasc Pharmacol 44:S471-3. 2004
    ..These findings raise the possibility that antiinflammatory effects of dexamethasone in eyes may be partly mediated or modulated by its effects on expression of ET-1...
  34. ncbi request reprint Expression of urocortin III/stresscopin in human heart and kidney
    Kazuhiro Takahashi
    Department of Molecular Biology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Clin Endocrinol Metab 89:1897-903. 2004
    ..Ucn III/SCP may therefore regulate the cardiac and renal function as a local factor and a circulating hormone...
  35. ncbi request reprint Immunolocalization of urotensin II and its receptor in human adrenal tumors and attached non-neoplastic adrenal tissues
    Ryo Morimoto
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Peptides 29:873-80. 2008
    ..The present study showed that both UII and UT-R were expressed in the adrenal tumors and attached non-neoplastic adrenal tissues, and suggests possible roles of UII and UT-R in tumor growth and/or secretory activities of these tumors...
  36. ncbi request reprint Expression of endothelin-1 and adrenomedullin was not altered by leptin or resistin in bovine brain microvascular endothelial cells
    Kazuhiro Takahashi
    Department of Analytical Medical Technology, Tohoku University School of Health Sciences, Sendai, Japan
    Hypertens Res 29:443-8. 2006
    ..The present study thus showed that neither leptin nor resistin affects the expression of endothelin-1 or adrenomedullin in bovine brain microvascular endothelial cells...
  37. ncbi request reprint Expression of orexin-A and orexin receptors in the kidney and the presence of orexin-A-like immunoreactivity in human urine
    Kazuhiro Takahashi
    Department of Analytical Medical Technology, Tohoku University School of Health Sciences, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Peptides 27:871-7. 2006
    ..These findings suggest that orexin-A is produced by the renal tubular cells and secreted into urine. Orexin-A may act on the kidney in the autocrine or paracrine fashion, or via the urine (urocrine fashion)...
  38. doi request reprint Expression of kisspeptins and kisspeptin receptor in the kidney of chronic renal failure rats
    Itaru Shoji
    Department of Endocrinology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Peptides 31:1920-5. 2010
    ..The present study has shown that expression of kisspeptins and kisspeptin receptor are altered in the kidney tissues of chronic renal impairment, raising the possibility of their pathophysiological roles in chronic renal failure...
  39. ncbi request reprint Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney
    Kazuhiro Takahashi
    Department of Analytical Medical Technology, Tohoku University School of Health Sciences, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Peptides 27:1383-9. 2006
    ....
  40. ncbi request reprint OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium
    Kazuhisa Takeda
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 300:908-14. 2003
    ..Therefore, OTX2 may regulate RPE-specific target genes, such as DCT, thereby maintaining the homeostasis of RPE...
  41. doi request reprint Expression of peptide YY in human brain and pituitary tissues
    Ryo Morimoto
    Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Nutrition 24:878-84. 2008
    ....
  42. doi request reprint Increased expression of (pro)renin receptor in the remnant kidneys of 5/6 nephrectomized rats
    Takuo Hirose
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, 6 3 Aramaki Aza Aoba, Aoba ku, Sendai 980 8578, Japan
    Regul Pept 159:93-9. 2010
    ..These findings indicate that the intra-renal (P)RR expression is increased in the remnant kidneys of 5/6 nephrectomized rats, and suggest that (P)RR may contribute to the renal injury...
  43. ncbi request reprint Identification of a distal enhancer for the melanocyte-specific promoter of the MITF gene
    Ken ichi Watanabe
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Pigment Cell Res 15:201-11. 2002
    ..Thus, SOX10 regulates transcription from the M promoter in a developmental stage-specific manner...
  44. ncbi request reprint Adrenomedullin in the eye
    Reiko Udono-Fujimori
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai 980 8575, Aoba, Japan
    Regul Pept 112:95-101. 2003
    ....
  45. doi request reprint Enhanced morphine-induced antinociception in histamine H3 receptor gene knockout mice
    Jalal Izadi Mobarakeh
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Neuropharmacology 57:409-14. 2009
    ..These results suggest that histamine exerts inhibitory effects on morphine-induced antinociception through H3 receptors at the spinal level...
  46. ncbi request reprint Urocortin 3/stresscopin in human colon: possible modulators of gastrointestinal function during stressful conditions
    Masayuki Saruta
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai, Miyagi 980 8575, Japan
    Peptides 26:1196-206. 2005
    ..These findings all suggest that Ucn 3 plays some physiological or pathological roles in the modulation of gastrointestinal functions during stressful conditions in different manners from Ucn 1...
  47. doi request reprint Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women: the Ohasama study
    Takuo Hirose
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Hypertens Res 34:530-5. 2011
    ..The polymorphism of the (P)RR gene +1513A>G is associated with lacunar infarction and LVH in Japanese women. These results suggest that (P)RR has a role in organ damage in humans...
  48. doi request reprint Increased expression of (pro)renin receptor in aldosterone-producing adenomas
    Hajime Yamamoto
    Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan Department of Clinical Laboratory, Takeda General Hospital, Aizu Wakamatsu, Fukushima 965 8585, Japan
    Peptides 49:68-73. 2013
    ....
  49. ncbi request reprint Orexin-A expression in human peripheral tissues
    Masao Nakabayashi
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, 980 8575 Sendai, Japan
    Mol Cell Endocrinol 205:43-50. 2003
    ..These results suggest the production of orexin-A in various human peripheral tissues and orexin-A may also play important roles in some peripheral organs...
  50. ncbi request reprint Urocortin 1, urocortin 3/stresscopin, and corticotropin-releasing factor receptors in human adrenal and its disorders
    Tsuyoshi Fukuda
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Clin Endocrinol Metab 90:4671-8. 2005
    ..Ucn1 binds to both CRF type 1 (CRF1) and type 2 receptors (CRF2), whereas Ucn3 is a specific agonist for CRF2. Recently, direct involvement of the locally synthesized CRF family in adrenocortical function has been proposed...
  51. ncbi request reprint Effects of adipokines on expression of adrenomedullin and endothelin-1 in cultured vascular endothelial cells
    Kazuhiro Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Peptides 26:845-51. 2005
    ..These findings have raised the possibility that decreased expression of adrenomedullin by tumor necrosis factor-alpha may be related to the increased risk of hypertension and other cardiovascular diseases in obese subjects...
  52. ncbi request reprint Increased plasma urotensin II levels in patients with diabetes mellitus
    Kazuhito Totsune
    Division of Nephrology, Endocrinology and Vascular Medicine, Department of Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8574, Japan
    Clin Sci (Lond) 104:1-5. 2003
    ..These findings suggest that elevation of plasma UII levels may be an important background factor in diabetic cardiovascular and organ complications in diabetic subjects without renal failure...
  53. ncbi request reprint Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice
    Jalal Izadi Mobarakeh
    Department of Pharmacology, Tohoku University Graduate School of Medicine, Seiryo machi 2 1, Aoba ku, Sendai 980 8575, Japan
    Neuropharmacology 51:612-22. 2006
    ..Our present and previous studies suggest that H1 and H2 receptors cooperatively function to modulate pain perception in the central nervous system...
  54. doi request reprint Association of (pro)renin receptor gene polymorphism with blood pressure in Japanese men: the Ohasama study
    Takuo Hirose
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
    Am J Hypertens 22:294-9. 2009
    ..However, there is no information on (P)RR in humans. We investigated the association of (P)RR gene polymorphisms with blood pressure in a Japanese population...
  55. ncbi request reprint Synergistic activation of the human adrenomedullin gene promoter by Sp1 and AP-2alpha
    Yan Zhang
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Peptides 29:465-72. 2008
    ..Thus, the synergistic activation of the human AM gene promoter by Sp1 and AP-2alpha may be mediated by the binding of Sp1 to the promoter region (-70/-29) and the interaction with AP-2alpha, which binds to the promoter region (-103/-71)...
  56. doi request reprint Increased gene expression of urotensin II-related peptide in the hearts of rats with congestive heart failure
    Takashi Nakayama
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, 6 3 Aramaki Aza Aoba, Aoba ku, Sendai 980 8578, Japan
    Peptides 29:801-8. 2008
    ..These findings suggest that the expression of URP, UII and UT-R is enhanced in failing heart, and the UII/URP/UT-R system has important pathophysiological roles in the progression of heart failure...
  57. ncbi request reprint Bilateral congenital cataracts result from a gain-of-function mutation in the gene for aquaporin-0 in mice
    Tadashi Okamura
    Institute for Animal Experimentation, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    Genomics 81:361-8. 2003
    ..The cataract phenotype of Cat(Tohm) is caused by a gain-of-function mutation in the mutated AQP0 protein and not by a loss-of-function mutation...
  58. doi request reprint Expression of (pro)renin receptor in human erythroid cell lines and its increased protein accumulation by interferon-γ
    Kiriko Kaneko
    Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
    Peptides 37:285-9. 2012
    ..The present study has shown for the first time expression of (P)RR in erythroid cells, raising the possibility that (P)RR may have a role in erythropoiesis and the pathophysiology of certain types of anemia...
  59. doi request reprint The renin-angiotensin system, adrenomedullins and urotensin II in the kidney: possible renoprotection via the kidney peptide systems
    Kazuhiro Takahashi
    Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Peptides 30:1575-85. 2009
    ..Thus, in addition to the renin inhibitor and (pro)renin receptor, adrenomedullins and urotensin II may be novel targets to develop therapeutic strategies against chronic kidney disease...
  60. doi request reprint Presence of kisspeptin-like immunoreactivity in human adrenal glands and adrenal tumors
    Kazuhiro Takahashi
    Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    J Mol Neurosci 41:138-44. 2010
    ..The present study has shown for the first time the presence of kisspeptin-LI in adrenal glands and adrenal tumors...
  61. ncbi request reprint Expression of (pro)renin receptor in breast cancers and its effect on cancercell proliferation
    Koji Ohba
    Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    Biomed Res 35:117-26. 2014
    ..These findings have raised the possibility that the blockade of the (P)RR signaling may be a novel therapeutic strategy against breast carcinomas...
  62. ncbi request reprint Peritumoral CpG oligodeoxynucleotide treatment inhibits tumor growth and metastasis of B16F10 melanoma cells
    Nagisa Kunikata
    Department of Dermatology, Tohoku University, Graduate School of Medicine, Sendai, Japan
    J Invest Dermatol 123:395-402. 2004
    ..These results suggest that CpG ODN are promising as a preventive and therapeutic anti-metastatic measure against melanoma...
  63. doi request reprint Adrenomedullin 2/intermedin in the hypothalamo-pituitary-adrenal axis
    Kazuhiro Takahashi
    Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Mol Neurosci 43:182-92. 2011
    ..AM2/IMD may act as a neurotransmitter or modulator in the brain and as a paracrine/autocrine regulator in the hypothalamo-pituitary-adrenal axis...
  64. ncbi request reprint Urocortins as cardiovascular peptides
    Kazuhiro Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Peptides 25:1723-31. 2004
    ..Ucn 1 and 3 appear to have important pathophysiological roles in some cardiovascular diseases...
  65. ncbi request reprint Elevated plasma levels of immunoreactive urotensin II and its increased urinary excretion in patients with Type 2 diabetes mellitus: association with progress of diabetic nephropathy
    Kazuhito Totsune
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Miyagi 980 8578, Japan
    Peptides 25:1809-14. 2004
    ....
  66. ncbi request reprint Urocortin 1 in colonic mucosa in patients with ulcerative colitis
    Masayuki Saruta
    Department of Pathology, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Clin Endocrinol Metab 89:5352-61. 2004
    ..Ucn1 therefore may act as a possible local immune-inflammatory mediator in UC...
  67. ncbi request reprint [Urotensin II]
    Kazuhiro Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine
    Nihon Rinsho 63:603-5. 2005
  68. ncbi request reprint Heme degradation and human disease: diversity is the soul of life
    Shigeki Shibahara
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Antioxid Redox Signal 4:593-602. 2002
    ..Implications of such a variety are discussed in relevance to the pathogenesis of severe malaria caused by Plasmodium falciparum, the most ancient foe of humans...
  69. ncbi request reprint Mouse transgenic for murine oviduct-specific glycoprotein promoter-driven simian virus 40 large T-antigen: tumor formation and its hormonal regulation
    Ichiro Miyoshi
    Institute for Animal Experimentation, Tohoku University Graduate School of Medicine, Sendai, Japan
    Mol Reprod Dev 63:168-76. 2002
    ..Estrogen response elements present in the promoter region were functional in vivo. These transgenic mice represent a unique model, since they develop tumors in the oviducts as well as in other tissues derived from the Mullerian duct...
  70. doi request reprint Increased expression of adrenomedullin 2/intermedin in rat hearts with congestive heart failure
    Takuo Hirose
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, 6 3 Aramaki Aza Aoba, Sendai 980 8578, Japan
    Eur J Heart Fail 10:840-9. 2008
    ..These findings suggest that the expression of AM2/IMD is enhanced in the failing heart, and AM2/IMD has a certain pathophysiological role in heart failure...
  71. ncbi request reprint Expression of urocortin and corticotropin-releasing factor receptor subtypes in the human heart
    Yuichiro Kimura
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 87:340-6. 2002
    ..Endogenously produced Ucn may therefore exert its effects mostly through CRF-R2 in an autocrine and/or paracrine manner in the human heart...
  72. ncbi request reprint Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and -2) in mice
    Jalal Izadi Mobarakeh
    Department of Pharmacology, Tohoku University School of Medicine, Seiryo machi 2 1, Aoba ku, Sendai 980 8575, Japan
    Peptides 26:767-77. 2005
    ..The present findings suggest that orexins have an antinociceptive role in at least four different types of pains, probably acting on both the brain and spinal cord...
  73. ncbi request reprint Progesterone production and actions in the human central nervous system and neurogenic tumors
    Tsukasa Inoue
    Department of Pathology, Second Department of Surgery, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Clin Endocrinol Metab 87:5325-31. 2002
    ....
  74. ncbi request reprint Translational medicine in fish-derived peptides: from fish endocrinology to human physiology and diseases
    Kazuhiro Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Miyagi, Japan
    Endocr J 51:1-17. 2004
    ..Development of antagonists/agonists against the receptors for these peptides may open new strategies for the treatment of various diseases, including obesity-related diseases, hypertension, heart failure and malignant tumors...
  75. ncbi request reprint [Urotensin receptors and urotensin-mediated signal transduction]
    Kazuhiro Takahashi
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine
    Nihon Rinsho 62:698-701. 2004
  76. ncbi request reprint Mitf-D, a newly identified isoform, expressed in the retinal pigment epithelium and monocyte-lineage cells affected by Mitf mutations
    Kazuhisa Takeda
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Biochim Biophys Acta 1574:15-23. 2002
    ....
  77. ncbi request reprint Cutaneous late phase reaction in adult atopic dermatitis patients with high serum IgE antibody to Dermatophagoides farinae: correlation with IL-5 production by allergen-stimulated peripheral blood mononuclear cells
    Mikiko Okada
    Department of Dermatology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Dermatol Sci 29:73-84. 2002
    ..e. LPR-positive and LPR-negative ones. The observation of LPR can be an important and practical way to classify AD patients into subgroups, which may enable us to regard IL-5 or eosinophils as a target for treatment...
  78. ncbi request reprint Plasma orexin-A-like immunoreactivity in patients with sleep apnea hypopnea syndrome
    Tsuguo Nishijima
    Third Department of Internal Medicine, Iwate Medical University School of Medicine, 19 1 Uchimaru, Morioka 020 8505, Japan
    Peptides 24:407-11. 2003
    ..These findings raise the possibility that a low plasma level of orexin-A-LI may be a marker to show the severity of the disease in patients with SAHS...
  79. ncbi request reprint [Measurement of urotensin]
    Kazuhito Totsune
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine
    Nihon Rinsho 62:705-8. 2004
  80. ncbi request reprint Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin
    Emi Arimoto-Ishida
    Department of Obstetrics and Gynecology, Osaka University Medical School, Suita, Japan
    Endocrinology 145:2014-22. 2004
    ..Our findings suggest that cisplatin causes the phosphorylation of FKHRL1 via a phosphatidylinositol 3-kinase/Akt cascade, and inhibition of this cascade sensitizes ovarian cancer cells to cisplatin...
  81. ncbi request reprint Tamoxifen inhibits cell proliferation via mitogen-activated protein kinase cascades in human ovarian cancer cell lines in a manner not dependent on the expression of estrogen receptor or the sensitivity to cisplatin
    Seiji Mabuchi
    Departmentof Obstetrics and Gynecology, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    Endocrinology 145:1302-13. 2004
    ....
  82. ncbi request reprint Low plasma orexin-A levels were improved by continuous positive airway pressure treatment in patients with severe obstructive sleep apnea-hypopnea syndrome
    Shigeru Sakurai
    Third Department of Internal Medicine, Iwate Medical University School of Medicine, 19 1, Uchimaru, Morioka, 020 8505, Japan
    Chest 127:731-7. 2005
    ..We have previously shown that plasma levels of orexin-A, a neuropeptide with an arousal-stimulating action, were decreased in parallel with the severity of the disease in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS)...
  83. ncbi request reprint Medroxyprogesterone acetate attenuates estrogen-induced nitric oxide production in human umbilical vein endothelial cells
    Akira Oishi
    Department of Obstetrics and Gynecology, Dokkyo University School of Medicine, 880, Kitakobayashi, Mibumachi, Shimotuga, Tochigi 321 0293, Japan
    Biochem Biophys Res Commun 324:193-8. 2004
    ..In COS cells transfected with either PRA or PRB, MPA attenuated E2-induced Akt phosphorylation. These results indicate that MPA attenuated E2-induced NO production via an Akt cascade through PRA or PRB in a non-genomic manner...
  84. ncbi request reprint [Cardiovascular effects of SERM]
    Masahide Ohmichi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine
    Clin Calcium 14:61-7. 2004
    ..We now await the results of currently ongoing prospective large scale randomized control trial, Raloxifene Use of The Heart...
  85. ncbi request reprint Raloxifene increases proliferation and up-regulates telomerase activity in human umbilical vein endothelial cells
    Masakazu Doshida
    Department of Obstetrics and Gynecology, Yamagata University School of Medicine, 2 2 2 Iidanishi, Yamagata, Yamagata 990 9585, Japan
    J Biol Chem 281:24270-8. 2006
    ..Thus, the up-regulation of telomerase activity in vascular endothelial cells might be one mechanism contributing to the potential atheroprotective effect of raloxifene...
  86. ncbi request reprint Raloxifene improves the ovariectomy-induced impairment in endothelium-dependent vasodilation
    Kazuhiro Takahashi
    Department of Obstetrics and Gynecology, Yamagata University School of Medicine, Iidanishi, Yamagata, Japan
    Menopause 14:656-61. 2007
    ..To examine the effect of raloxifene on the endothelial dysfunction caused by surgical menopause...
  87. ncbi request reprint Plasma orexin-A levels in obstructive sleep apnea-hypopnea syndrome
    Shigeru Sakurai
    Chest 125:1963; author reply 1963-4. 2004
  88. doi request reprint A case of multiple endocrine neoplasia type II accompanied by thyroid medullary carcinoma and pheochromocytomas expressing corticotropin-releasing factor and urocortins
    Kazunori Kageyama
    Department of Endocrinology and Metabolism, Hirosaki University School of Medicine, Aomori 036 8562, Japan
    Am J Med Sci 335:398-402. 2008
    ....
  89. ncbi request reprint Adrenomedullin is a novel adipokine: adrenomedullin in adipocytes and adipose tissues
    Yin Li
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100083, PR China
    Peptides 28:1129-43. 2007
    ..These findings indicate that AM is a new member of the adipokine family...