Hitoshi Oshitani

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. pmc Evolutionary analyses on the HA gene ofpandemic H1N1/09: early findings
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryou machi Aoba ku, Sendai, Japan
    Bioinformation 5:7-10. 2010
  2. pmc Major issues and challenges of influenza pandemic preparedness in developing countries
    Hitoshi Oshitani
    Tohoku University Graduate School of Medicine, Sendai, Japan
    Emerg Infect Dis 14:875-80. 2008
  3. ncbi request reprint [Influenza pandemic (H1N1) 2009]
    Hitoshi Oshitani
    Department of Virology Tohoku University Graduate School of Medicine
    Uirusu 59:139-44. 2009
  4. pmc Measles outbreaks in displaced populations: a review of transmission, morbidity and mortality associated factors
    Isidore K Kouadio
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    BMC Int Health Hum Rights 10:5. 2010
  5. ncbi request reprint Potential benefits and limitations of various strategies to mitigate the impact of an influenza pandemic
    Hitoshi Oshitani
    Tohoku University Graduate School of Medicine, Department of Virology, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Infect Chemother 12:167-71. 2006
  6. doi request reprint Genetic characterization of human respiratory syncytial virus detected in hospitalized children in the Philippines from 2008 to 2012
    Ayumu Ohno
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryou machi, Aoba, Sendai, Miyagi 980 8575, Japan
    J Clin Virol 57:59-65. 2013
  7. doi request reprint Reassortment between amantadine-resistant and -sensitive H1N1 influenza A viruses generated an amantadine-sensitive virus during the 2007-2008 season
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Infect Dis 200:1766-73. 2009
  8. pmc Antigenic and receptor binding properties of enterovirus 68
    Tadatsugu Imamura
    Tohoku University Graduate School of Medicine, Sendai, Japan
    J Virol 88:2374-84. 2014
  9. pmc Detection of human rhinovirus C viral genome in blood among children with severe respiratory infections in the Philippines
    Naoko Fuji
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    PLoS ONE 6:e27247. 2011
  10. pmc Molecular evolution of enterovirus 68 detected in the Philippines
    Tadatsugu Imamura
    Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 8:e74221. 2013

Collaborators

Detail Information

Publications79

  1. pmc Evolutionary analyses on the HA gene ofpandemic H1N1/09: early findings
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryou machi Aoba ku, Sendai, Japan
    Bioinformation 5:7-10. 2010
    ..Among them, position 206 is located in an antigenic site. We did not find significant negative selection on any of the receptor binding sites. The virus has been evolving under unique selective pressure...
  2. pmc Major issues and challenges of influenza pandemic preparedness in developing countries
    Hitoshi Oshitani
    Tohoku University Graduate School of Medicine, Sendai, Japan
    Emerg Infect Dis 14:875-80. 2008
    ..Such an event will inevitably have a global effect. Therefore, improving pandemic preparedness in every country, particularly developing ones, is urgently needed...
  3. ncbi request reprint [Influenza pandemic (H1N1) 2009]
    Hitoshi Oshitani
    Department of Virology Tohoku University Graduate School of Medicine
    Uirusu 59:139-44. 2009
    ..Many aspects of pandemic (H1N1) 2009 are different from what we had been expecting. We should reconsider the concepts and the strategies for influenza pandemic by reviewing current pandemic (H1N1)...
  4. pmc Measles outbreaks in displaced populations: a review of transmission, morbidity and mortality associated factors
    Isidore K Kouadio
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    BMC Int Health Hum Rights 10:5. 2010
    ..In recent years, refugees and internally displaced persons have been increasing. Our study aims to define the epidemiological characteristics and risk factors associated with measles outbreaks in displaced populations...
  5. ncbi request reprint Potential benefits and limitations of various strategies to mitigate the impact of an influenza pandemic
    Hitoshi Oshitani
    Tohoku University Graduate School of Medicine, Department of Virology, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Infect Chemother 12:167-71. 2006
    ..There are still significant gaps in the scientific evidence of the way in which influenza viruses are transmitted. Further studies should be conducted to define the basic transmission patterns of influenza viruses...
  6. doi request reprint Genetic characterization of human respiratory syncytial virus detected in hospitalized children in the Philippines from 2008 to 2012
    Ayumu Ohno
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryou machi, Aoba, Sendai, Miyagi 980 8575, Japan
    J Clin Virol 57:59-65. 2013
    ..Human respiratory syncytial virus (HRSV) is the leading cause of acute lower respiratory tract infection in infants and young children. However, molecular characteristic of HRSV is still unknown in the Philippines...
  7. doi request reprint Reassortment between amantadine-resistant and -sensitive H1N1 influenza A viruses generated an amantadine-sensitive virus during the 2007-2008 season
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Infect Dis 200:1766-73. 2009
    ..The results suggest that it is necessary to monitor genome dynamics to understand the evolution and mechanism of the emergence and spread of antiviral resistance among influenza A viruses...
  8. pmc Antigenic and receptor binding properties of enterovirus 68
    Tadatsugu Imamura
    Tohoku University Graduate School of Medicine, Sendai, Japan
    J Virol 88:2374-84. 2014
    ..Additionally, we found that EV68 preferably binds to α2-6 SAs, which suggests that EV68 might have affinity for the upper respiratory tract...
  9. pmc Detection of human rhinovirus C viral genome in blood among children with severe respiratory infections in the Philippines
    Naoko Fuji
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    PLoS ONE 6:e27247. 2011
    ..This finding suggests that the 5'NCR region may be associated with viremia...
  10. pmc Molecular evolution of enterovirus 68 detected in the Philippines
    Tadatsugu Imamura
    Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 8:e74221. 2013
    ..Detection of Enterovirus 68 (EV68) has recently been increased. However, underlying evolutionary mechanism of this increasing trend is not fully understood...
  11. pmc Respiratory viruses from hospitalized children with severe pneumonia in the Philippines
    Akira Suzuki
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    BMC Infect Dis 12:267. 2012
    ..Pneumonia remains a leading cause of child death in developing countries. The viruses in severe pneumonia remain poorly defined...
  12. pmc Occurrence of mixed populations of influenza A viruses that can be maintained through transmission in a single host and potential for reassortment
    Yuki Furuse
    Department of Virology, Tohoku University, Graduate School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai, 980 8575, Japan
    J Clin Microbiol 48:369-74. 2010
    ..However, the proportion of these, which can be less than 1%, is too low to be detected by conventional methods. Such mixed populations in which reassortment occurs may have a significant role in the evolution of viruses...
  13. pmc Molecular evolution of the hemagglutinin and neuraminidase genes of pandemic (H1N1) 2009 influenza viruses in Sendai, Japan, during 2009-2011
    Irona Khandaker
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryomachi, Aoba, Sendai, Miyagi, 9807585, Japan
    Virus Genes . 2013
    ..The effect on control of the influenza A(H1N1)pdm09 virus, including vaccine strain selection, requires continuous monitoring of the strain by genetic surveillance...
  14. pmc Detection of non-polio enteroviruses from 17 years of virological surveillance of acute flaccid paralysis in the Philippines
    Lea Necitas Apostol
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Med Virol 84:624-31. 2012
    ..Despite some limitations in this study, plural NPEVs with multiple patterns of circulation in the Philippines for 17 years were identified...
  15. doi request reprint Comparison of selection pressures on the HA gene of pandemic (2009) and seasonal human and swine influenza A H1 subtype viruses
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, 980 8575, Japan
    Virology 405:314-21. 2010
    ..The evolutionary characteristics of the H1 gene of the 2009 H1N1 virus differed from those of seasonal and swine viruses...
  16. doi request reprint Local persistence and global dissemination play a significant role in the circulation of influenza B viruses in Leyte Island, Philippines
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Virology 492:21-4. 2016
    ..Furthermore, we found evidence on the local persistence of the virus over years in the Philippines. Taken together, both local persistence and global dissemination play a significant role in the circulation of influenza B virus. ..
  17. pmc Molecular Characterization of Human Respiratory Syncytial Virus in the Philippines, 2012-2013
    Rungnapa Malasao
    Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 10:e0142192. 2015
    ..Both genotypes were detected for the first time in the Philippines. ..
  18. ncbi request reprint Monitoring of influenza viruses in the aftermath of the Great East Japan earthquake
    Kentaro Tohma
    Department of Virology, Tohoku University School of Medicine, Sendai, Japan
    Jpn J Infect Dis 65:542-4. 2012
    ..The Yamagata lineage of influenza B was detected in one patient from western Japan, indicating the importing of viruses into the affected area...
  19. pmc Genetic diversity and molecular characterization of enteroviruses from sewage-polluted urban and rural rivers in the Philippines
    Lea Necitas G Apostol
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Virus Genes 45:207-17. 2012
    ....
  20. pmc Comparative Evaluation of Real-Time PCR Methods for Human Noroviruses in Wastewater and Human Stool
    Yoshifumi Masago
    New Industry Creation Hatchery Center, Tohoku University, Sendai, Miyagi, Japan
    PLoS ONE 11:e0160825. 2016
    ..Significant differences in positive rates and quantification cycles were observed by non-parametric analysis. The present study identifies the best assay for norovirus GI and GII to amplify norovirus genomes efficiently. ..
  21. doi request reprint Temporal dynamics of norovirus determined through monitoring of municipal wastewater by pyrosequencing and virological surveillance of gastroenteritis cases
    Shinobu Kazama
    New Industry Creation Hatchery Center, Tohoku University, Sendai, Miyagi, 980 8479, Japan
    Water Res 92:244-53. 2016
    ..Thus, wastewater monitoring by pyrosequencing is expected to provide an effective analysis of the distribution of norovirus genotypes causing symptomatic and asymptomatic infections in human populations. ..
  22. pmc Enterovirus 68 among children with severe acute respiratory infection, the Philippines
    Tadatsugu Imamura
    Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Emerg Infect Dis 17:1430-5. 2011
    ..All 21 patients we identified had severe illness, and 2 died, possibly the first reported fatal cases associated with EV68 infection. Our study suggests that EV68 may be a possible causative agent of severe respiratory illnesses...
  23. pmc Large-scale sequence analysis of M gene of influenza A viruses from different species: mechanisms for emergence and spread of amantadine resistance
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine 2 1 Seiryou mach, Aoba ku, Sendai, 980 8575, Japan
    Antimicrob Agents Chemother 53:4457-63. 2009
    ..Because the recent rapid increase in drug-resistant virus is associated with the substitution at position 31, the resistance may not be related to drug use...
  24. doi request reprint Differentiation of human influenza A viruses including the pandemic subtype H1N1/2009 by conventional multiplex PCR
    Yuki Furuse
    Tohoku University Graduate School of Medicine, Department of Virology, 2 1 Seiryou machi Aoba ku Sendai 980 8575, Japan
    J Virol Methods 168:94-7. 2010
    ..This is a highly sensitive method and its cost is low. Influenza surveillance using this assay would provide significant information on the epidemiology of both pandemic and seasonal influenza...
  25. pmc Differences in viral load among human respiratory syncytial virus genotypes in hospitalized children with severe acute respiratory infections in the Philippines
    Francois Marie Ngako Kadji
    Tohoku University Graduate School of Medicine, Sendai, Japan
    Virol J 13:113. 2016
    ..ON1 is a newly emerged genotype with a 72-nucleotide duplication in the G gene as observed previously with BA genotypes in HRSV-B...
  26. pmc Molecular epidemiology of enterovirus d68 from 2013 to 2014 in Philippines
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Clin Microbiol 53:1015-8. 2015
    ..Here we report the molecular epidemiology of EV-D68 in Philippines from 2013 to 2014; we found cases in areas affected by Typhoon Haiyan and found new strains in the country. ..
  27. pmc Isolation and characterization of influenza C viruses in the Philippines and Japan
    Takashi Odagiri
    Department of Virology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Miyagi, Japan
    J Clin Microbiol 53:847-58. 2015
    ..These observations suggest that the influenza C viruses analyzed here had emerged through different reassortment events; however, the time and place at which the reassortment events occurred were not determined. ..
  28. doi request reprint Phylogeographic analysis of rabies viruses in the Philippines
    Kentaro Tohma
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan Electronic address
    Infect Genet Evol 23:86-94. 2014
    ....
  29. pmc Detection of enterovirus 68 in serum from pediatric patients with pneumonia and their clinical outcomes
    Tadatsugu Imamura
    Tohoku University School of Medicine, Sendai, Japan
    Influenza Other Respir Viruses 8:21-4. 2014
    ..Our results suggest that EV68 can cause viremia by which the virus may exhibit systemic manifestations. ..
  30. pmc Laboratory Diagnosis for Outbreak-Prone Infectious Diseases after Typhoon Yolanda (Haiyan), Philippines
    Mariko Saito-Obata
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan RITM Tohoku Collaborating Research Center on Emerging and Re Emerging Infectious Diseases, Muntinlupa City, Philippines
    PLoS Curr 8:. 2016
    ..Discussion: Our results confirmed the importance of PCR for the laboratory diagnosis of infectious diseases in post-disaster situations when  diagnostic options are limited...
  31. doi request reprint Molecular and mathematical modeling analyses of inter-island transmission of rabies into a previously rabies-free island in the Philippines
    Kentaro Tohma
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan Electronic address
    Infect Genet Evol 38:22-8. 2016
    ..Local government units try to control dog transport; however, it should be more strictly controlled, and a continuous rabies control program should be implemented to prevent rabies spread even in rabies-free areas. ..
  32. doi request reprint Molecular detection and characterization of sapovirus in hospitalized children with acute gastroenteritis in the Philippines
    Xiaofang Liu
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Clin Virol 68:83-8. 2015
    ..Human sapovirus (SaV) is a causative agent of acute gastroenteritis. Recently, SaV detection has been increasing worldwide due to the emerging SaV genotype I.2. However, SaV infection has not been reported in the Philippines...
  33. pmc Seroprevalence and molecular characteristics of hepatitis E virus in household-raised pig population in the Philippines
    Xiaofang Liu
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    BMC Vet Res 11:11. 2015
    ..To assess the HEV infection status among pigs in rural areas, we investigated the molecular characteristics and seroprevalence of HEV among household-raised pigs in San Jose, Tarlac Province, the Philippines...
  34. pmc Influenza and other respiratory viruses detected by influenza-like illness surveillance in Leyte Island, the Philippines, 2010-2013
    Hirono Otomaru
    Department of Virology, Tohoku University School of Medicine, Sendai, Japan
    PLoS ONE 10:e0123755. 2015
    ..Age was an important factor that affected positive rates of influenza and other respiratory viruses. Involvement of older age children may be useful to detect influenza more effectively. ..
  35. pmc Incidence and Risk Factors of Childhood Pneumonia-Like Episodes in Biliran Island, Philippines--A Community-Based Study
    Hisato Kosai
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 10:e0125009. 2015
    ..Improved access to healthcare facilities is important for early and effective management. Further studies are warranted to understand the causal relationship between asthma and pneumonia. ..
  36. pmc Human G3P[4] rotavirus obtained in Japan, 2013, possibly emerged through a human-equine rotavirus reassortment event
    Rungnapa Malasao
    Department of Virology, Tohoku University Graduate School of Medicine, Seiryo cho 2 1, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    Virus Genes 50:129-33. 2015
    ..The other gene segments were related to human group A rotaviruses. This report suggests a possible reassortment event between human and equine rotaviruses...
  37. ncbi request reprint [Researches on virology at the Tohoku University Research Center in the Philippines]
    Hitoshi Oshitani
    Department of Virology, Tohoku University Graduate School of Medicine
    Uirusu 63:45-50. 2013
    ..Based on these studies, we initiated more comprehensive researches in the Philippines since 2010. ..
  38. ncbi request reprint Detection and serotyping of human adenoviruses from patients with influenza-like illness in mongolia
    Kentaro Tohma
    Department of Virology, Tohoku University School of Medicine, Sendai, Japan
    Jpn J Infect Dis 65:289-94. 2012
    ..There was no difference between the amino acid sequences of the hexon and fiber genes that may affect tissue tropism in Mongolian strains and those in EKC-causing strains...
  39. doi request reprint Viruses that cross borders: factors responsible for global dissemination of viral infections
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Intervirology 54:246-52. 2011
    ..In contrast, for some other viruses, genetically similar strains can spread and circulate all over the world. This study addresses global dissemination of various viral infections...
  40. doi request reprint Reassortment between swine influenza A viruses increased their adaptation to humans in pandemic H1N1/09
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryou machi Aoba ku, Sendai 980 8575, Japan
    Infect Genet Evol 10:569-74. 2010
    ..We indicate the sites that probably contributed to the acquisition of efficient human-to-human transmission...
  41. doi request reprint Simplified screening method for detecting oseltamivir resistant pandemic influenza A (H1N1) 2009 virus by a RT-PCR/restriction fragment length polymorphism assay
    Nao Nukiwa
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    J Virol Methods 170:165-8. 2010
    ..This RT-PCR/RFLP assay is a simple method and also very specific and sensitive for detecting the H275Y mutation of pandemic influenza A (H1N1) 2009 viruses, and can be used in resource-limited settings...
  42. pmc Interruption of the circulation of an indigenous measles genotype and the introduction of other genotypes after a mass vaccination campaign in the Philippines
    Naoko Fuji
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    J Med Virol 83:1424-7. 2011
    ..However, a re-emergence of measles cases occurred in 2007, which was caused by other genotypes and the previous circulating genotype had disappeared...
  43. pmc Seasonality of Influenza and Respiratory Syncytial Viruses and the Effect of Climate Factors in Subtropical-Tropical Asia Using Influenza-Like Illness Surveillance Data, 2010 -2012
    Taro Kamigaki
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 11:e0167712. 2016
    ..Previous studies suggest that climate factors are involved in the seasonality of these viruses. However, the extent of the effect of each climate variable is yet to be defined...
  44. pmc Burden of Influenza and Respiratory Syncytial Virus Infection in Pregnant Women and Infants Under 6 Months in Mongolia: A Prospective Cohort Study
    Liling Chaw
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 11:e0148421. 2016
    ..Pregnant women and infants under 6 months are at risk of influenza-related complications. Limited information exists on their community burden of respiratory viruses...
  45. pmc Genetic diversity and geographic distribution of genetically distinct rabies viruses in the Philippines
    Mariko Saito
    Tohoku University Graduate School of Medicine, Sendai City, Miyagi, Japan
    PLoS Negl Trop Dis 7:e2144. 2013
    ..Understanding the phylogeography of rabies viruses is important for establishing a more effective and feasible control strategy...
  46. pmc Evaluating influenza disease burden during the 2008-2009 and 2009-2010 influenza seasons in Mongolia
    Nao Nukiwa
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Western Pac Surveill Response J 2:16-22. 2011
    ..Although mortality impact also should be considered, we believe that our findings can be useful in formulating an influenza control strategy during influenza epidemic periods in Mongolia. ..
  47. pmc Cumulative incidence of pandemic influenza A (H1N1) 2009 by a community-based serological cohort study in Selenghe Province, Mongolia
    Alexanderyn Burmaa
    National Influenza Center, National Center of Communicable Diseases, Ulaanbaatar, Mongolia
    Influenza Other Respir Viruses 6:e97-e104. 2012
    ..None of the study participants had been vaccinated for pandemic A (H1N1) 2009 before the second samples were collected...
  48. pmc Influenza transmission in a community during a seasonal influenza A(H3N2) outbreak (2010-2011) in Mongolia: a community-based prospective cohort study
    Nao Nukiwa-Souma
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 7:e33046. 2012
    ..However, the overall picture of community transmission is not well defined during actual outbreaks. We conducted a community-based prospective cohort study to describe the transmission characteristics of influenza in Mongolia...
  49. pmc Evolution of the M gene of the influenza A virus in different host species: large-scale sequence analysis
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Virol J 6:67. 2009
    ..Besides, novel vaccines targeting M1 or M2 protein to confer cross subtype protection have been under development. We conducted the present study to investigate the evolution of the M gene by analyzing its sequence in different species...
  50. pmc Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai City, Japan
    Virol J 7:52. 2010
    ..In such cases, investigating measles would give important information about the course of emerging infectious diseases...
  51. doi request reprint Detection of novel respiratory viruses from influenza-like illness in the Philippines
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Med Virol 82:1071-4. 2010
    ..Human metapneumovirus, human bocavirus, human coronavirus HKU1, KI virus, and WU virus were detected for the first time in the Philippines; Melaka virus was not found...
  52. pmc Analysis of influenza transmission in the households of primary and junior high school students during the 2012-13 influenza season in Odate, Japan
    Taro Kamigaki
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    BMC Infect Dis 15:282. 2015
    ....
  53. pmc Role of Preschool and Primary School Children in Epidemics of Influenza A in a Local Community in Japan during Two Consecutive Seasons with A(H3N2) as a Predominant Subtype
    Satoshi Mimura
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 10:e0125642. 2015
    ..Further investigations are needed to investigate the effect of pre-existing immunity on influenza transmission in the community. ..
  54. pmc Investigation of an Influenza A (H3N2) outbreak in evacuation centres following the Great East Japan earthquake, 2011
    Taro Kamigaki
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 9808575, Japan
    BMC Public Health 14:34. 2014
    ..At the time of the Great East Japan Earthquake on 11 March 2011, influenza A (H3N2) was still circulating and there was a heightened concern regarding severe outbreaks due to influenza A (H3N2)...
  55. pmc Reversion of influenza A (H3N2) virus from amantadine resistant to amantadine sensitive by further reassortment in Japan during the 2006-to-2007 influenza season
    Yuki Furuse
    Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8575, Japan
    J Clin Microbiol 47:841-4. 2009
    ..Whole-genome sequencing results indicated that this was due to a further reassortment event...
  56. ncbi request reprint [Lessons learned from pandemic (H1N1) 2009: Japan and global prospective]
    Taro Kamigaki
    Department of Virology, Tohoku University Graduate School of Medicine
    Nihon Rinsho 68:1605-10. 2010
    ..It is important to identify some gaps in the implementation of interventions for further preparedness...
  57. ncbi request reprint [Epidemiological study of health impact on influenza outpatients during 2008-2009 influenza season, Shonai, Yamagata]
    Nao Nukiwa
    Department of Virology, Tohoku University Graduate School of Medicine
    Kansenshogaku Zasshi 84:52-8. 2010
    ..This in turns means that an urgent need will arise for appropriate measures reducing this potentially huge burden during pandemic (H1N1) 2009 outbreak in Japan...
  58. ncbi request reprint [Encephalitis and encephalopathy associated with pandemic flu]
    Raita Tamaki
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Brain Nerve 61:153-60. 2009
    ..In addition, we have also reviewed a few human cases of avian influenza A (H5N1) infection where the central nervous system (CNS) are involved...
  59. pmc Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan
    Viruses 8:. 2016
    ..The unique evolutionary dynamics of the influenza C virus must be shaped by multiple factors, including virological, immunological, and epidemiological characteristics...
  60. pmc Evolutionary Dynamics of Tat in HIV-1 Subtypes B and C
    Chandra Nath Roy
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai City, Japan
    PLoS ONE 10:e0129896. 2015
    ..Our study highlights the importance of examining the internal/regulatory genes of HIV-1 to understand its complete evolutionary dynamics. The study results will therefore contribute to better understanding of HIV-1 evolution...
  61. doi request reprint Intersubtype Genetic Variation of HIV-1 Tat Exon 1
    Chandra Nath Roy
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    AIDS Res Hum Retroviruses 31:641-8. 2015
    ..Our study findings on HIV-1 Tat genetic variability may contribute to a better understanding of HIV-1 evolution as well as to the development of effective Tat-targeted therapeutics and vaccines. ..
  62. doi request reprint Conservation of nucleotide sequences for molecular diagnosis of Middle East respiratory syndrome coronavirus, 2015
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Japan Electronic address
    Int J Infect Dis 40:25-7. 2015
    ..Protocols for the molecular diagnosis of viral infections should be reviewed regularly after they are established, particularly for viruses that pose a great threat to public health such as MERS-CoV. ..
  63. doi request reprint Analysis of medical consultation interval between the symptom onset and consultation observed in multiple medical facilities in Odate city, Japan, 2011/2012 and 2012/2013 seasons
    Xiang Huo
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan Department of Acute Infectious Disease, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China
    J Infect Chemother 20:370-4. 2014
    ..And the predictors or determinants for longer medical consultation interval have not been well-defined...
  64. doi request reprint Lancet Conferences: Influenza in the Asia-Pacific
    Taro Kamigaki
    Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Expert Rev Vaccines 8:1527-9. 2009
    ..In this article, the authors have tried to summarize this conference and discuss future prospects of pandemic preparedness and response...
  65. doi request reprint Evolution of the influenza A virus untranslated regions
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryou machi Aoba ku, Sendai 980 8575, Japan
    Infect Genet Evol 11:1150-4. 2011
    ..In the future, clarifying the detailed mechanisms of packaging as well as the function of the RNA sequence in the untranslated region will increase the understanding of viral life cycles and evolution...
  66. pmc Novel insights into human respiratory syncytial virus-host factor interactions through integrated proteomics and transcriptomics analysis
    Clyde Dapat
    a Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Miyagi Prefecture, Japan
    Expert Rev Anti Infect Ther 14:285-97. 2016
    ....
  67. pmc Global reemergence of enterovirus D68 as an important pathogen for acute respiratory infections
    Tadatsugu Imamura
    Tohoku University Graduate School of Medicine, Sendai, Japan
    Rev Med Virol 25:102-14. 2015
    ..However, the lack of suitable animal model constrains comprehensive understanding of the pathogenesis of EV-D68...
  68. ncbi request reprint [Infectious disease surveillance in Miyagi after the Great East Japan Earthquake]
    Mihyun Kim
    Department of Virology, Tohoku University Graduate School of Medicine
    Nihon Koshu Eisei Zasshi 60:659-64. 2013
    ..In this study, we summarized the monitoring activities of infectious diseases through this surveillance after the earthquake...
  69. doi request reprint Acute respiratory infections due to enterovirus 68 in Yamagata, Japan between 2005 and 2010
    Tatsuya Ikeda
    Department of Microbiology, Yamagata Prefectural Institute of Public Health, Yamagata, Japan
    Microbiol Immunol 56:139-43. 2012
    ..Phylogenetic analysis indicated that plural genetically distinct clusters co-circulated. These results suggest that that difficulty in EV68 isolation leads to an underestimation of the prevalence of EV68 infections...
  70. ncbi request reprint Mucosal immunity against influenza induced by attenuated recombinant Sendai virus
    Tadatsugu Imamura
    Department of Virology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Expert Rev Vaccines 10:1393-5. 2011
    ..Intranasal immunization of mice with GP42-H1 induced HA-specific IgG and IgA antibodies in sera and mucosal sites without causing any disease symptoms. Immunized mice were also protected from lethal dose challenge of influenza A virus...
  71. pmc Epidemiological characteristics and low case fatality rate of pandemic (H1N1) 2009 in Japan
    Taro Kamigaki
    Department of Virology, Tohoku University Graduate School of Medicine
    PLoS Curr 1:RRN1139. 2009
    ..However, CFRs are higher in small children (<5 years) and adults. The transmission to these age groups may possibly have been minimized through aggressive suspension of classes in schools...
  72. ncbi request reprint Hitoshi Oshitani: watching out for an influenza pandemic
    Ned Stafford
    Lancet 366:1601. 2005
  73. ncbi request reprint The effectiveness of influenza vaccine against influenza a (H3N2) virus infections in nursing homes in Niigata, Japan, during the 1998-1999 and 1999-2000 seasons
    Reiko Saito
    Department of Public Health, Niigata University School of Medicine, Niigata City, Japan
    Infect Control Hosp Epidemiol 23:82-6. 2002
    ..To evaluate the effectiveness of influenza vaccines against influenza-like illness (ILI) among nursing home residents...
  74. pmc Frequency of amantadine-resistant influenza A viruses during two seasons featuring cocirculation of H1N1 and H3N2
    Reiko Saito
    Department of Public Health, Graduate School of Medical and Dental Sciences, Niigata City, Niigata Prefecture 951 8510, Japan
    J Clin Microbiol 41:2164-5. 2003
    ..Predominant amino acid substitutions in M2 protein occurred at position 31 (serine to asparagine) in H3N2 strains and at position 27 (valine to alanine) in H1N1 strains...
  75. ncbi request reprint Emergence of amantadine-resistant influenza A viruses: epidemiological study
    Hiroshi Suzuki
    Department of Public Health, Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Infect Chemother 9:195-200. 2003
    ..Measures should be taken to reduce contact, as much as possible, between persons taking and those not taking antiviral drugs for treatment or chemoprophylaxis...
  76. ncbi request reprint Can oral cholera vaccination play a role in controlling a cholera outbreak?
    Philippe Calain
    WHO Western Pacific Regional Office, Manila, Philippines
    Vaccine 22:2444-51. 2004
    ..Retrospective analysis suggests that mass vaccination with oral cholera vaccines can be a useful adjunct tool for controlling outbreaks, particularly if implemented early in association with other standard control measures...
  77. pmc Rumor surveillance and avian influenza H5N1
    Gina Samaan
    Western Pacific Regional Office of the World Health Organization, Manila, Philippines
    Emerg Infect Dis 11:463-6. 2005
    ..The World Health Organization's Western Pacific Regional Office identified 40 rumors; 9 were verified to be true. Rumor surveillance informed immediate public health action and prevented unnecessary and costly responses...
  78. pmc Detection of amantadine-resistant influenza A virus strains in nursing homes by PCR-restriction fragment length polymorphism analysis with nasopharyngeal swabs
    Reiko Saito
    Department of Public Health, Niigata University, School of Medicine, Niigata City, Niigata, 951 8510, Japan
    J Clin Microbiol 40:84-8. 2002
    ....
  79. ncbi request reprint Implementing the new International Health Regulations in the Pacific--challenges and opportunities
    Hitoshi Oshitani
    Communicable Disease Surveillance and Response, WHO Regional Office for the Western Pacific, Manila, Philippines
    Pac Health Dialog 12:135-43. 2005
    ....