Shin ichi Hayashi

Summary

Affiliation: Tohoku University
Country: Japan

Publications

  1. doi request reprint Estrogen signaling in cancer microenvironment and prediction of response to hormonal therapy
    Shin ichi Hayashi
    Department of Medical Technology, Course of Health Sciences, School of Medicine, Tohoku University, Seiryou machi, Sendai 980 8575, Japan
    J Steroid Biochem Mol Biol 109:201-6. 2008
  2. doi request reprint Estrogen signaling pathway and hormonal therapy
    Shin ichi Hayashi
    Department of Molecular and Functional Dynamics, Laboratory Medicine and Sciences, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Breast Cancer 15:256-61. 2008
  3. ncbi request reprint Estrogen signaling and prediction of endocrine therapy
    Shin ichi Hayashi
    Department of Medical Technology, School of Medicine, Course of Health Sciences, Tohoku University, 2 1 Seiryou machi, Aoba ku, Sendai, 980 8575, Japan
    Cancer Chemother Pharmacol 56:27-31. 2005
  4. ncbi request reprint Basic research for hormone-sensitivity of breast cancer
    Shin ichi Hayashi
    Department of Medical Technology, Course of Health Sciences, School of Medicine, Tohoku University, Sendai, Japan
    Breast Cancer 13:123-8. 2006
  5. doi request reprint Estrogen signaling pathway and its imaging in human breast cancer
    Shin ichi Hayashi
    Department of Molecular and Functional Dynamics, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Cancer Sci 100:1773-8. 2009
  6. ncbi request reprint 3-Dimensional microarray analysis of estrogen signal-related genes in breast cancer tissues
    Mitsuyo Matsumoto
    Department of Molecular and Functional Dynamics, Course of Health Science, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, 981 0872, Japan
    Anticancer Res 29:3971-5. 2009
  7. ncbi request reprint 5Alpha-reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Int J Cancer 120:285-91. 2007
  8. ncbi request reprint Aromatase localization in human breast cancer tissues: possible interactions between intratumoral stromal and parenchymal cells
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Res 67:3945-54. 2007
  9. doi request reprint Estrogen response element-GFP (ERE-GFP) introduced MCF-7 cells demonstrated the coexistence of multiple estrogen-deprivation resistant mechanisms
    Natsu Fujiki
    Department of Molecular and Functional Dynamics, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8575, Japan
    J Steroid Biochem Mol Biol 139:61-72. 2014
  10. doi request reprint Androgen metabolite-dependent growth of hormone receptor-positive breast cancer as a possible aromatase inhibitor-resistance mechanism
    Toru Hanamura
    Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Breast Cancer Res Treat 139:731-40. 2013

Collaborators

Detail Information

Publications56

  1. doi request reprint Estrogen signaling in cancer microenvironment and prediction of response to hormonal therapy
    Shin ichi Hayashi
    Department of Medical Technology, Course of Health Sciences, School of Medicine, Tohoku University, Seiryou machi, Sendai 980 8575, Japan
    J Steroid Biochem Mol Biol 109:201-6. 2008
    ....
  2. doi request reprint Estrogen signaling pathway and hormonal therapy
    Shin ichi Hayashi
    Department of Molecular and Functional Dynamics, Laboratory Medicine and Sciences, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8575, Japan
    Breast Cancer 15:256-61. 2008
    ..Furthermore, we touch upon basic studies into predicting the efficacy of hormonal therapy and new strategies in this field...
  3. ncbi request reprint Estrogen signaling and prediction of endocrine therapy
    Shin ichi Hayashi
    Department of Medical Technology, School of Medicine, Course of Health Sciences, Tohoku University, 2 1 Seiryou machi, Aoba ku, Sendai, 980 8575, Japan
    Cancer Chemother Pharmacol 56:27-31. 2005
    ..We hope that these approaches may provide not only new clues for elucidation of estrogen-dependent growth mechanisms of cancer, but also clinical benefits to patients by assessment of individual responses to endocrine therapy...
  4. ncbi request reprint Basic research for hormone-sensitivity of breast cancer
    Shin ichi Hayashi
    Department of Medical Technology, Course of Health Sciences, School of Medicine, Tohoku University, Sendai, Japan
    Breast Cancer 13:123-8. 2006
    ..We believe that these approaches could provide not only new clues to elucidate the estrogen-dependent mechanisms of cancer, but also clinical benefits to patients by predicting individual response to hormonal therapy...
  5. doi request reprint Estrogen signaling pathway and its imaging in human breast cancer
    Shin ichi Hayashi
    Department of Molecular and Functional Dynamics, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    Cancer Sci 100:1773-8. 2009
    ..We hope that these approaches provide new clues about the estrogen-dependent mechanisms of breast cancer development, and will be useful to advance the diagnosis and treatment of breast cancer patients...
  6. ncbi request reprint 3-Dimensional microarray analysis of estrogen signal-related genes in breast cancer tissues
    Mitsuyo Matsumoto
    Department of Molecular and Functional Dynamics, Course of Health Science, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai, 981 0872, Japan
    Anticancer Res 29:3971-5. 2009
    ..We produced a custom-made, 3-dimensional microarray system (3DMS), using previously identified ERGs, and analyzed expression of ERGs on breast cancer tissues...
  7. ncbi request reprint 5Alpha-reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Int J Cancer 120:285-91. 2007
    ..Aromatase inhibitors may be more effective in these patients, possibly due to increasing local DHT concentration with estrogen deprivation...
  8. ncbi request reprint Aromatase localization in human breast cancer tissues: possible interactions between intratumoral stromal and parenchymal cells
    Yasuhiro Miki
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Cancer Res 67:3945-54. 2007
    ....
  9. doi request reprint Estrogen response element-GFP (ERE-GFP) introduced MCF-7 cells demonstrated the coexistence of multiple estrogen-deprivation resistant mechanisms
    Natsu Fujiki
    Department of Molecular and Functional Dynamics, Tohoku University Graduate School of Medicine, Aoba ku, Sendai 980 8575, Japan
    J Steroid Biochem Mol Biol 139:61-72. 2014
    ..This finding also implies that breast cancers with different resistance mechanisms can concomitantly occur and mingle in an individual patient, and may be a cause of the recurrence of cancer. ..
  10. doi request reprint Androgen metabolite-dependent growth of hormone receptor-positive breast cancer as a possible aromatase inhibitor-resistance mechanism
    Toru Hanamura
    Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Breast Cancer Res Treat 139:731-40. 2013
    ..Androgen metabolite-dependent growth of breast cancer cells may therefore play a role in AI-resistance. ..
  11. doi request reprint Possible role of the aromatase-independent steroid metabolism pathways in hormone responsive primary breast cancers
    Toru Hanamura
    Department of Molecular and Functional Dynamics Graduate School of Medicine, Tohoku University, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Breast Cancer Res Treat 143:69-80. 2014
    ..These pathways might function as an alternative estrogenic steroid-producing, aromatase-independent pathways. ..
  12. pmc Individual transcriptional activity of estrogen receptors in primary breast cancer and its clinical significance
    Tatsuyuki Gohno
    Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University Aoba ku, Sendai, 980 8575, Japan
    Cancer Med 1:328-37. 2012
    ..Therefore, in addition to ER protein expression, determination of ERE activity as an ER functional marker will be helpful for analysis of a variety of diverse breast cancer cases and the subsequent course of treatment...
  13. doi request reprint Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment
    Kiyoshi Takagi
    Department of Pathology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Miyagi ken, Japan
    Endocr Relat Cancer 17:415-30. 2010
    ....
  14. ncbi request reprint Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma: possible regulator of insitu steroidogenesis
    Yasuhiro Miki
    Department of Pathology, Tohoku University, Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Cancer Lett 244:24-33. 2006
    ..These results suggest that LRH-1 is frequently detected in breast carcinoma tissues, and plays important roles including the regulation of in situ steroidogenesis...
  15. doi request reprint Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma: comparison with female breast carcinoma
    Kiyoshi Takagi
    Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi ken, 980 8575, Japan
    Horm Cancer 4:1-11. 2013
    ..Different expression profiles of the estrogen-induced genes may associate with different estrogen functions in MBC from FBC, which may be partly due to their ERα/ERβ status...
  16. ncbi request reprint Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for endocrine therapy
    Hironori Ishibashi
    Departments of Pathology and Molecular Medical Technology, Tohoku University School of Medicine, Sendai, Japan
    Cancer Res 65:6450-8. 2005
    ..Therefore, progesterone therapy may be clinically effective in suppressing development of progesterone receptor-positive NSCLC patients...
  17. ncbi request reprint Peroxisome proliferator-activated receptor gamma and growth inhibition by its ligands in uterine endometrial carcinoma
    Kyoko Ota
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 12:4200-8. 2006
    ..In this study, we evaluated the correlation between endometrial carcinoma and peroxisome proliferator-activated receptor gamma (PPARgamma) expression and assessed whether PPARgamma ligands influence carcinoma growth...
  18. doi request reprint Different epigenetic mechanisms of ERα implicated in the fate of fulvestrant-resistant breast cancer
    Kouki Tsuboi
    Department of Molecular and Functional Dynamics, Graduate Tohoku University School of Medicine, Sendai, Japan
    J Steroid Biochem Mol Biol . 2016
    ..This finding implies the presence of multiple fulvestrant resistance mechanisms and suggests that the optimal therapies differ among individual tumors as a result of differing epigenetic mechanisms regulating ERα gene expression...
  19. ncbi request reprint [Breast neoplasms: predictive factors for endocrine therapy ]
    Shin ichi Hayashi
    Department of Medical Technology, Course of Health Science, School of Medicine, Tohoku University
    Nihon Rinsho 65:148-53. 2007
  20. pmc Contribution of Estrone Sulfate to Cell Proliferation in Aromatase Inhibitor (AI) -Resistant, Hormone Receptor-Positive Breast Cancer
    Toru Higuchi
    Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan
    PLoS ONE 11:e0155844. 2016
    ..We suggest that E1S metabolism represents a new target in AI-resistant breast cancer treatment. ..
  21. doi request reprint Estrogen signaling ability in human endometrial cancer through the cancer-stromal interaction
    Mitsuyo Matsumoto
    Department of Medical Technology, Tohoku University School of Medicine, 2 1, Seiryo machi, Aoba ku, Sendai 981 0872, Japan
    Endocr Relat Cancer 15:451-63. 2008
    ..These results suggest that AI may have some therapeutic value in EC; however, the hormonal microenvironment must be assessed prior to initiating therapy...
  22. doi request reprint Increased androgen receptor activity and cell proliferation in aromatase inhibitor-resistant breast carcinoma
    Rika Fujii
    Department of Molecular and Functional Dynamics, Tohoku University Graduate School of Medicine, Sendai, Japan Department of Surgical Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Steroid Biochem Mol Biol 144:513-22. 2014
    ..AR inhibitors may thus be effective in a selected group of patients. ..
  23. doi request reprint Differences in stemness properties associated with the heterogeneity of luminal-type breast cancer
    Takako Ito
    Department of Blood and Cell Treatment, Tohoku University Hospital, Sendai, Japan
    Clin Breast Cancer 15:e93-103. 2015
    ..We investigated the relationship between the heterogeneity of luminal-type breast cancer and stemness properties...
  24. ncbi request reprint Early growth responsive gene 3 in human breast carcinoma: a regulator of estrogen-meditated invasion and a potent prognostic factor
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Endocr Relat Cancer 14:279-92. 2007
    ..These results suggest that EGR3 plays an important role in estrogen-meditated invasion and is an independent prognostic factor in breast carcinoma...
  25. doi request reprint Expression of retinoic acid receptors in human endometrial carcinoma
    Kojiro Tanabe
    Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan
    Cancer Sci 99:267-71. 2008
    ..AM580 might therefore be considered as a potential treatment for endometrial carcinoma...
  26. doi request reprint Loss of estrogen receptor beta isoform expression and its correlation with aberrant DNA methylation of the 5'-untranslated region in human epithelial ovarian carcinoma
    Fumihiko Suzuki
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Cancer Sci 99:2365-72. 2008
    ..The results of our present study suggest that ERbeta is inactivated mainly through aberrant DNA methylation. This process may play an important role in the pathogenesis of epithelial ovarian cancer...
  27. doi request reprint Estrogen receptor activation by tobacco smoke condensate in hormonal therapy-resistant breast cancer cells
    Toshifumi Niwa
    Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, Aoba ku, Sendai, Miyagi, 980 8575, Japan Electronic address
    J Steroid Biochem Mol Biol 165:448-457. 2017
    ..Tobacco smoke may have a possibility to interfere with hormonal therapy for breast cancer, which may have important implications for the management of therapy...
  28. doi request reprint Variation in use of estrogen receptor-α gene promoters in breast cancer compared by quantification of promoter-specific messenger RNA
    Toru Higuchi
    Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, Sendai, Japan Department of Thoracic and Visceral Organ Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan Electronic address
    Clin Breast Cancer 14:249-57. 2014
    ..To examine whether these promoters have differential effects in breast cancer, we quantified expression of promoter-specific ERα messenger RNA (mRNA), using real-time polymerase chain reaction (PCR) and statistical assessment...
  29. doi request reprint Midkine and its clinical significance in endometrial carcinoma
    Kojiro Tanabe
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Cancer Sci 99:1125-30. 2008
    ..Additionally, preoperative serum MK levels are significantly correlated with prognosis and the presence of lymph node metastasis. Thus, MK may be a useful serum biomarker for identifying high risk patients of endometrial carcinoma...
  30. pmc Adaptation to estradiol deprivation causes up-regulation of growth factor pathways and hypersensitivity to estradiol in breast cancer cells
    Richard J Santen
    Division of Endocrinology and Metabolism, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    Adv Exp Med Biol 630:19-34. 2008
    ....
  31. ncbi request reprint Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells
    Takayuki Yamada
    Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan
    Blood 101:2227-34. 2003
    ..Taken together, these findings indicate that Notch signaling affects both osteoclast precursors and stromal cells and thereby negatively regulates osteoclastogenesis...
  32. doi request reprint Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma
    Hiromichi Niikawa
    Department of Pathology, Tohoku University School of Medicine, Japan
    Clin Cancer Res 14:4417-26. 2008
    ..Therefore, we examined intratumoral estradiol concentrations in NSCLC to examine local actions of estrogens in NSCLC...
  33. pmc Demethylation of promoter C region of estrogen receptor alpha gene is correlated with its enhanced expression in estrogen-ablation resistant MCF-7 cells
    Tetsuya Sogon
    Department of Molecular Epidemiology, Hiroshima University Graduate School of Biomedical Sciences, Radiation Effects Research Foundation, 5 2, Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    J Steroid Biochem Mol Biol 105:106-14. 2007
    ..Our findings imply that demethylation of promoter C region in the ERalpha gene is in part responsible for the enhanced expression of ERalpha gene in LTED cells...
  34. ncbi request reprint Estrogen receptor-mediated effects of tamoxifen on human endometrial cancer cells
    Takako Sakamoto
    Department of Obstetrics and Gynecology, Teikyo University School of Medicine, 2 11 1 Kaga Itabashi ku, 173 8605, Tokyo, Japan
    Mol Cell Endocrinol 192:93-104. 2002
    ..This ERalpha activation pathway may be involved in the stimulatory effect of tamoxifen on the development and/or progression of endometrial cancer...
  35. ncbi request reprint Expression of estrogen receptor (ER) (beta)cx protein in ER(alpha)-positive breast cancer: specific correlation with progesterone receptor
    Shigehira Saji
    Department of Surgery, Breast Oncology Unit, Tokyo Metropolitan Komagome Hospital, 113 8677 Tokyo, Japan
    Cancer Res 62:4849-53. 2002
    ..This is the first evidence that evaluation of ER(beta)cx along with PR may contribute to a better characterization of ER(alpha)-positive breast cancers...
  36. ncbi request reprint A study of estrogen signaling using DNA microarray in human breast cancer
    Yoko Omoto
    Division of Endocrinology, Saitama Cancer Center Research Institute, 818 Komuro, Ina, Saitama 362 0806, Japan
    Breast Cancer 9:308-11. 2002
    ..These data indicate that a custom microarray is a useful tool for assessing the estrogen signaling pathway. Furthermore, DNA microarray could be a very efficacious application for predicting response to breast cancer treatments...
  37. ncbi request reprint Estrogen receptor (ER) beta1 and ERbetacx/beta2 inhibit ERalpha function differently in breast cancer cell line MCF7
    Yoko Omoto
    Division of Endocrinology, Saitama Cancer Center Research Institute, 818 Komuro, Ina, Saitama 362 0806, Japan
    Oncogene 22:5011-20. 2003
    ..These results indicate that ERbeta1 and ERbetacx/beta2 inhibit ERalpha function differently in MCF7 cells...
  38. ncbi request reprint A reporter gene assay for evaluation of tissue-specific responses to estrogens based on the differential use of promoters A to F of the human estrogen receptor alpha gene
    Akio Inoue
    National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, 305 8566, Japan
    J Pharmacol Toxicol Methods 47:129-35. 2002
    ..We report here a reporter gene assay for evaluating and monitoring estrogen activities by estrogen-like compounds and xenoestrogens, which is based on the promoters from the human estrogen receptor alpha (ERalpha) gene...
  39. ncbi request reprint Estrogen and growth factor signaling pathway: basic approaches for clinical application
    Shin ichi Hayashi
    Division of Endocrinology, Saitama Cancer Center Research Institute, 818 Komuro, Ina machi, Saitama 362 0806, Japan
    J Steroid Biochem Mol Biol 86:433-42. 2003
    ....
  40. ncbi request reprint Prediction of hormone sensitivity by DNA microarray
    Shin ichi Hayashi
    Division of Endocrinology, Saitama Cancer Center Research Institute, 818 Komuro, Ina machi, Saitama, 362 0806, Japan
    Biomed Pharmacother 58:1-9. 2004
    ..These studies could provide new clues for elucidation of the estrogen-dependent mechanisms of cancer and clinical benefit for patients...
  41. ncbi request reprint HDAC6 expression is correlated with better survival in breast cancer
    Zhenhuan Zhang
    Department of Breast and Endocrine Surgery, Nagoya City University Hospital, Nagoya, Japan
    Clin Cancer Res 10:6962-8. 2004
    ..This led us to hypothesize that there was a link between levels of HDAC6 expression and the metastatic potential of breast cancer and also, therefore, the prognosis of these patients...
  42. ncbi request reprint Enforced expression of PU.1 rescues osteoclastogenesis from embryonic stem cells lacking Tal-1
    Motokazu Tsuneto
    Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, 86 Nishi Machi, Yonago, Tottori, 683 8503, Japan
    Stem Cells 23:134-43. 2005
    ..These results suggest that the expression of PU.1 is a critical event for osteoclastogenesis and that Tal-1 may lie upstream of PU.1 in a regulatory hierarchy during osteoclastogenesis...
  43. ncbi request reprint Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer
    Shigehira Saji
    Department of Clinical Trials and Research, Breast Surgery, Tokyo Metropolitan Komagome Hospital, Honkomagome, Tokyo, Japan
    Oncogene 24:4531-9. 2005
    ..05, respectively). HDAC6 expression was an independent prognostic indicator by multivariate analysis (odds ratio = 2.82, P = 0.047). These results indicate the biological significance of HDAC6 regulation via estrogen signaling...
  44. ncbi request reprint Tumor-stromal interaction through the estrogen-signaling pathway in human breast cancer
    Yuri Yamaguchi
    Research Institute for Clinical Oncology, Saitama Cancer Center, Japan
    Cancer Res 65:4653-62. 2005
    ..These results suggest that this system to detect total ER activation based on the interaction with adipose stromal cells is a useful tool for analyzing local estrogen signals and for tumor-stromal interactions...
  45. ncbi request reprint Distinct promoter usage of mdm2 gene in human breast cancer
    Naoki Okumura
    Second Department of Surgery, Gifu University School of Medicine, Gifu 500 8705, Japan
    Oncol Rep 9:557-63. 2002
    ..Tumors with mutant p53 also showed expression of S-mdm2 in some cases. These results strongly suggest that other factor(s) is also implicated in the promoter usage of mdm2 gene in human breast cancer tissues...
  46. ncbi request reprint T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7
    Sherri W Christianson
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    J Autoimmun 18:119-30. 2002
    ..We conclude that abnormal T cell development in me(v)/ me(v) mice may in part be due to defects in the ability of bone marrow-derived accessory cells to provide bioavailable IL-7 to developing thymocytes...
  47. pmc VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice
    Shumpei Niida
    Department of Bone and Joint Disease, Research Institute, National Center for Geriatrics and Gerontology, Aichi 474 8522, Japan
    Proc Natl Acad Sci U S A 102:14016-21. 2005
    ..These results strongly suggest that the interaction of signals by means of VEGFR-1 and the CSF-1 receptor plays a predominant role not only in osteoclastogenesis but also in the maintenance of bone marrow functions...
  48. ncbi request reprint Estradiol stabilizes p53 protein in breast cancer cell line, MCF-7
    Naoki Okumura
    Second Department of Surgery, Gifu University School of Medicine, Gifu 500 8705, Japan
    Jpn J Cancer Res 93:867-73. 2002
    ..These results suggest that the ratio of the two MDM2 proteins, p90(MDM2) and p60(MDM2), may affect the accumulation of wild-type p53 protein in response to E2...
  49. ncbi request reprint Distinct osteoclast precursors in the bone marrow and extramedullary organs characterized by responsiveness to Toll-like receptor ligands and TNF-alpha
    Shin ichi Hayashi
    Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Tottori, Japan
    J Immunol 171:5130-9. 2003
    ....
  50. ncbi request reprint Generation of structures formed by lens and retinal cells differentiating from embryonic stem cells
    Mariko Hirano
    Department of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan
    Dev Dyn 228:664-71. 2003
    ..The present culture system opens up the possibility of examining early stages of eye development and also of producing cells for use in cellular therapy for various diseases of the eye...
  51. ncbi request reprint Prediction of prognosis of estrogen receptor-positive breast cancer with combination of selected estrogen-regulated genes
    Nobuyuki Yoshida
    Division of Endocrinology, Saitama Cancer Center Research Institute, Saitama Cancer Center Hospital, Kita adachi gun, Saitama 362 0806, Japan
    Cancer Sci 95:496-502. 2004
    ....
  52. ncbi request reprint Down-regulation of osteoprotegerin production in bone marrow macrophages by macrophage colony-stimulating factor
    Naoko Yamada
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Cytokine 31:288-97. 2005
    ..The expression of RANK mRNA was not significantly affected by M-CSF. The results showed that M-CSF suppresses the OPG production in BMMs, which may increase the sensitivity of BMMs to RANKL...
  53. ncbi request reprint Potential of dental mesenchymal cells in developing teeth
    Hidetoshi Yamazaki
    Department of Physiology and Regenerative Medicine, Division of Genomics and Regenerative Biology, Institute of Medical Science, Mie University Graduate School of Medicine, Tsu 514 8507, Japan
    Stem Cells 25:78-87. 2007
    ..Taken together, these results suggest that NC-derived cells with the potential to differentiate into chondrocyte-like and osteoblast-like cells are present in the developing tooth, and these cells may contribute to tooth organogenesis...
  54. ncbi request reprint Comparative profiling of the gene expression for estrogen responsiveness in cultured human cell lines
    Akio Inoue
    InfoGenes Co, Ltd, Tsukuba, Ibaraki 305 0047, Japan
    Toxicol In Vitro 21:741-52. 2007
    ....
  55. ncbi request reprint Prognostic significance of insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5 expression in breast cancer
    Keiko Mita
    Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Jpn J Clin Oncol 37:575-82. 2007
    ..Investigation of IGFBP-4 and IGFBP-5 expression would provide important information for predicting prognosis and endocrine responsiveness...
  56. ncbi request reprint Estrogen receptor beta is expressed in human stomach adenocarcinoma
    Satoru Matsuyama
    Department of Surgery, Saga Medical School, 5 1 1 Nabeshima, Saga City, Saga 849 8501, Japan
    J Cancer Res Clin Oncol 128:319-24. 2002
    ..In this paper, the expression of ER beta in stomach adenocarcinomas has been investigated for the first time, specifically in signet ring cell adenocarcinomas, together with surrounding non-cancerous tissues...