Hiroaki Yanagawa

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. pmc View of physicians on and barriers to patient enrollment in a multicenter clinical trial: experience in a Japanese rural area
    Hiroaki Yanagawa
    Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan
    Int Arch Med 3:7. 2010
  2. ncbi request reprint The views of doctors on registration trials in a Japanese rural area: a survey of medical institutions registered to the Tokushima Network for Clinical Trials
    H Yanagawa
    Clinical Trial Centre for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan
    J Int Med Res 36:1117-22. 2008
  3. ncbi request reprint Long-term follow-up of pulmonary function in bronchial asthma patients treated with pranlukast
    H Yanagawa
    Department of Internal Medicine and Molecular Therapeutics, The University of Tokushima School of Medicine, Tokushima, 770 8503, Japan
    Lung 182:51-8. 2004
  4. ncbi request reprint A case of resectable lung adenocarcinoma associated with sarcoidosis
    H Yanagawa
    Third Department of Internal Medicine, The University of Tokushima School of Medicine, Japan
    Med Oncol 16:216-20. 1999
  5. ncbi request reprint Intrapleural therapy with MDP-Lys (L18), a synthetic derivative of muramyl dipeptide, against malignant pleurisy associated with lung cancer
    H Yanagawa
    The University of Tokushima, School of Medicine, Third Department of Internal Medicine, Japan
    Lung Cancer 27:67-73. 2000
  6. pmc Role of clinical research coordinators in promoting clinical trials of drugs for surgical patients
    Hiroaki Yanagawa
    Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan
    Int Arch Med 1:26. 2008
  7. ncbi request reprint Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia
    Shusuke Yagi
    Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Atheroscler Thromb 17:173-80. 2010
  8. doi request reprint Effect of low-dose (1 mg/day) pitavastatin on left ventricular diastolic function and albuminuria in patients with hyperlipidemia
    Shusuke Yagi
    Department of Cardiovascular Medicine, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    Am J Cardiol 107:1644-9. 2011
  9. doi request reprint Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors
    Takayuki Ise
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima, Japan
    Hypertens Res 34:225-31. 2011
  10. doi request reprint Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue
    Yoichiro Hirata
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    J Am Coll Cardiol 58:248-55. 2011

Collaborators

Detail Information

Publications76

  1. pmc View of physicians on and barriers to patient enrollment in a multicenter clinical trial: experience in a Japanese rural area
    Hiroaki Yanagawa
    Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan
    Int Arch Med 3:7. 2010
    ..Nevertheless, there is still little information concerning physicians participating in a clinical trial and among them, those who could not recruit any patients (unsuccessful physician recruiters)...
  2. ncbi request reprint The views of doctors on registration trials in a Japanese rural area: a survey of medical institutions registered to the Tokushima Network for Clinical Trials
    H Yanagawa
    Clinical Trial Centre for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan
    J Int Med Res 36:1117-22. 2008
    ..The survey indicates that the TNCT needs to develop the infrastructure and enlighten participants to promote registration trials in this rural regional area...
  3. ncbi request reprint Long-term follow-up of pulmonary function in bronchial asthma patients treated with pranlukast
    H Yanagawa
    Department of Internal Medicine and Molecular Therapeutics, The University of Tokushima School of Medicine, Tokushima, 770 8503, Japan
    Lung 182:51-8. 2004
    ..Although the present investigation is a retrospective analysis, these data may suggest that pranlukast has no tachyphylaxis and its effect continues for more than 1 year...
  4. ncbi request reprint A case of resectable lung adenocarcinoma associated with sarcoidosis
    H Yanagawa
    Third Department of Internal Medicine, The University of Tokushima School of Medicine, Japan
    Med Oncol 16:216-20. 1999
    ..Since it is still controversial as to the incidence of malignant diseases in sarcoidosis patients, it is important to accumulate data on these associations...
  5. ncbi request reprint Intrapleural therapy with MDP-Lys (L18), a synthetic derivative of muramyl dipeptide, against malignant pleurisy associated with lung cancer
    H Yanagawa
    The University of Tokushima, School of Medicine, Third Department of Internal Medicine, Japan
    Lung Cancer 27:67-73. 2000
    ..These results suggest MDP-Lys (L18) instilled by intrapleural route had a potential local immunomodulatory activity. Further study is warranted to further determine the critical factors which correlate with the clinical response...
  6. pmc Role of clinical research coordinators in promoting clinical trials of drugs for surgical patients
    Hiroaki Yanagawa
    Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan
    Int Arch Med 1:26. 2008
    ..In the present study, we examine the dedicated role of the CRC considering the specialty of a registration trial of a drug for surgical patients used during the operation period...
  7. ncbi request reprint Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia
    Shusuke Yagi
    Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Atheroscler Thromb 17:173-80. 2010
    ..We investigated whether it also has beneficial effects on metabolic disorder and/or renal insufficiency in patients with hypercholesterolemia...
  8. doi request reprint Effect of low-dose (1 mg/day) pitavastatin on left ventricular diastolic function and albuminuria in patients with hyperlipidemia
    Shusuke Yagi
    Department of Cardiovascular Medicine, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    Am J Cardiol 107:1644-9. 2011
    ..In conclusion, pitavastatin decreases E/e' and albuminuria, which is associated with suppression of oxidative stress...
  9. doi request reprint Plasma heparin cofactor II activity is inversely associated with left atrial volume and diastolic dysfunction in humans with cardiovascular risk factors
    Takayuki Ise
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima, Japan
    Hypertens Res 34:225-31. 2011
    ..These findings suggest that cardiac tissue thrombin inactivation by HCII is a novel therapeutic target for cardiac remodeling and atherosclerosis...
  10. doi request reprint Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue
    Yoichiro Hirata
    Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    J Am Coll Cardiol 58:248-55. 2011
    ..The purpose of this report was to assess the link between macrophage polarization in epicardial adipose tissue and atherosclerosis in patients with coronary artery disease (CAD)...
  11. doi request reprint High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension
    Shusuke Yagi
    Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    Hypertens Res 34:74-8. 2011
    ..In conclusion, increased PAC is associated with impaired cognitive function and mineral corticoid receptor blockade may protect against not only cardiovascular mortality, but also cognitive impairment in patients with hypertension...
  12. doi request reprint Antiallergic and anti-inflammatory effects of a novel I kappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation
    Akemi Sugita
    Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Int Arch Allergy Immunol 148:186-98. 2009
    ..This study aimed to elucidate the antiallergic effects of a newly synthesized IKK beta inhibitor, IMD-0354, in a mouse model of allergic inflammation...
  13. doi request reprint Clinical utility of single-beat E/e' obtained by simultaneous recording of flow and tissue Doppler velocities in atrial fibrillation with preserved systolic function
    Kenya Kusunose
    Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    JACC Cardiovasc Imaging 2:1147-56. 2009
    ..We evaluated the usefulness of the ratio of the early diastolic transmitral flow velocity (E) to the mitral annular velocity (e') calculated from simultaneously recorded E and e' in atrial fibrillation (AF)...
  14. ncbi request reprint Heparin cofactor II is an independent protective factor against peripheral arterial disease in elderly subjects with cardiovascular risk factors
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Atheroscler Thromb 16:127-34. 2009
    ....
  15. doi request reprint Local persistent hypercoagulability after sirolimus-eluting stent implantation in patients with stable angina
    Koji Yamaguchi
    Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan
    Int J Cardiol 153:272-6. 2011
    ..Although incomplete neointimal coverage after SES implantation has been reported, local long-term hypercoagulability remains unknown...
  16. doi request reprint Androgen-androgen receptor system protects against angiotensin II-induced vascular remodeling
    Yasumasa Ikeda
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    Endocrinology 150:2857-64. 2009
    ....
  17. ncbi request reprint Activation of peroxisome proliferator-activated receptor α in megakaryocytes reduces platelet-derived growth factor-BB in platelets
    Shunji Hashizume
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Atheroscler Thromb 18:138-47. 2011
    ..The objective of this study was to clarify the pleiotropic effect of peroxisome proliferator-activated receptor α (PPARα) activators on PDGF-BB expression in megakaryocytes and platelets...
  18. ncbi request reprint Clinical trials for drug approval: a pilot study of the view of doctors at Tokushima University Hospital
    Hiroaki Yanagawa
    Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital
    J Med Invest 53:292-6. 2006
    ..Further refinement in the support process by CRC should be considered in our hospital, and the views of the doctors should be investigated in a larger study, in order to promote clinical trials for drug approval in Japan...
  19. doi request reprint Elevated concentrations of pentraxin 3 are associated with coronary plaque vulnerability
    Takeshi Soeki
    Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Cardiol 58:151-7. 2011
    ..Next, we determined whether assays for inflammatory molecules can be used to monitor the therapeutic effects of telmisartan on stabilization of vulnerable atherosclerotic plaques...
  20. ncbi request reprint Motor neuron involvement in a patient with long-term corticosteroid administration
    Takao Mitsui
    First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto 3 Tokushima
    Intern Med 42:862-6. 2003
    ..These findings are consistent with the assumption that long-term corticosteroid administration potentially induces not only myopathy but also motor neuron involvement as in mitochondrial diseases...
  21. ncbi request reprint Synthesis and secretion of interleukin-15 by freshly isolated human bronchial epithelial cells
    Ning Ge
    Department of Internal Medicine and Molecular Therapeutics, Course of Medical Oncology, University of Tokushima School of Medicine, Tokushima, Japan
    Int Arch Allergy Immunol 135:235-42. 2004
    ....
  22. doi request reprint A case of neurogenic myocardial stunning presenting transient left ventricular mid-portion ballooning simulating atypical takotsubo cardiomyopathy
    Koji Yamaguchi
    Division of Cardiovascular Medicine, Tokushima University Hospital, 2 50 1 Kuramoto cho, Tokushima 770 8503, Japan
    J Cardiol 52:53-8. 2008
    ..Although the clinical course of this patient was similar to that of neurogenic myocardial stunning, the shape of her left ventricle was not typical...
  23. ncbi request reprint Decrease in plasma brain natriuretic peptide level in the early phase after the start of carvedilol therapy is a novel predictor of long-term outcome in patients with chronic heart failure
    Mitsunori Fujimura
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    Acta Cardiol 64:589-95. 2009
    ....
  24. ncbi request reprint Heparin cofactor II as a novel vascular protective factor against atherosclerosis
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima, Graduate School of Health Biosciences, Tokushima, Japan
    J Atheroscler Thromb 16:523-31. 2009
    ..These results demonstrate that HCII protects against thrombin-induced vascular remodeling in both humans and mice and suggest that HCII is a predictive biomarker and therapeutic target for atherosclerosis...
  25. ncbi request reprint Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction
    Takahiko Iuchi
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Tokushima, Japan
    Circ Res 92:81-7. 2003
    ..These findings suggest that GC excess causes overproduction of ROS and thereby perturbs NO availability in the vascular endothelium, leading to vascular complications in patients with GC excess...
  26. ncbi request reprint Validation of longitudinal peak systolic strain by speckle tracking echocardiography with visual assessment and myocardial perfusion SPECT in patients with regional asynergy
    Kenya Kusunose
    Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Circ J 75:141-7. 2011
    ....
  27. ncbi request reprint Inhaled steroid therapy and hospitalization for bronchial asthma: trend in Tokushima University Hospital
    Hiroaki Yanagawa
    Department of Internal Medicine and Molecular Therapeutics, The University of Tokushima School of Medicine, Tokushima, Japan
    J Med Invest 50:72-7. 2003
    ....
  28. pmc Transforming Growth Factor-β1 as a Common Target Molecule for Development of Cardiovascular Diseases, Renal Insufficiency and Metabolic Syndrome
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, The University of Tokushima, Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Cardiol Res Pract 2011:175381. 2010
    ....
  29. doi request reprint Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury
    Shusuke Yagi
    Department of Cardiovascular Medicine, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Hypertension 55:918-23. 2010
    ..In conclusion, pitavastatin exerts endothelial NO synthase-independent protective actions against Ang II-induced atrial remodeling and atrial fibrillation with enhanced thrombogenicity through suppression of oxidant injury...
  30. ncbi request reprint Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Japan
    J Biol Chem 279:35798-802. 2004
    ..These results demonstrate that activation of nuclear VDR elicits antithrombotic effects in vivo, and suggest that the VDR system may play a physiological role in the maintenance of antithrombotic homeostasis...
  31. ncbi request reprint Congenital ventricular aneurysm as an unexpected complication of monomorphic premature ventricular contractions
    Shusuke Yagi
    Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences
    Intern Med 49:907-12. 2010
    ..Here, we report two successfully followed cases of CVA which were diagnosed from premature ventricular contractions...
  32. ncbi request reprint Apoptosis-related changes in skeletal muscles of patients with mitochondrial diseases
    Yoshifumi Umaki
    First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto 3, Tokushima 770 8503, Japan
    Acta Neuropathol 103:163-70. 2002
    ..It is thought that these changes are induced by superoxide overproduction and cytochrome c release resulting from an inherent mitochondrial defect and that the events are associated with DNase I activation...
  33. ncbi request reprint Improvement of cardiac diastolic function and prognosis after autologous peripheral blood stem cell transplantation in AL cardiac amyloidosis
    Shusuke Yagi
    Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
    Intern Med 46:1705-10. 2007
    ..This treatment resulted in significant improvement in cardiac function and good prognosis for about 3.5 years after the diagnosis. Therefore, auto-PBSCT is a possible option as up-front therapy for AL cardiac amyloidosis...
  34. ncbi request reprint Effect of aspirin treatment on serum concentrations of lipoprotein(a) in patients with atherosclerotic diseases
    Masashi Akaike
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Clin Chem 48:1454-9. 2002
    ..We previously reported that aspirin reduced Lp(a) production by cultured hepatocytes via the reduction of apolipoprotein(a) [apo(a)] gene transcription...
  35. ncbi request reprint Bosentan ameliorated exercise-induced pulmonary arterial hypertension complicated with systemic sclerosis
    Shusuke Yagi
    Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, Tokushima
    Intern Med 49:2309-12. 2010
    ..The results suggest that administration of bosentan in patients with early-stage PAH ameliorates pulmonary arterial vasodilatation through improvement of endothelial function...
  36. ncbi request reprint Aggressive antiplatelet therapy before coronary stent implantation in acute coronary syndrome with essential thrombocythemia--a case report
    Mitsunori Fujimura
    First Department of Internal Medicine, University of Tokushima School of Medicine, Kuramoto 3 18 15, Tokushima 770 8503, Japan
    Angiology 54:485-90. 2003
    ....
  37. ncbi request reprint Mitochondrial damage in patients with long-term corticosteroid therapy: development of oculoskeletal symptoms similar to mitochondrial disease
    Takao Mitsui
    First Department of Internal Medicine, School of Medicine, The University of Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Acta Neuropathol 104:260-6. 2002
    ..These findings may suggest that long-term corticosteroid administration potentially induces oxidative stress-mediated mitochondrial damage, resulting in the development of the oculoskeletal symptoms in some patients...
  38. ncbi request reprint Overexpressions of myoglobin and antioxidant enzymes in ragged-red fibers of skeletal muscle from patients with mitochondrial encephalomyopathy
    Makoto Kunishige
    First Department of Internal Medicine, University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Muscle Nerve 28:484-92. 2003
    ..However, the Mb-mediated oxidative damage may become more extensive and result in further mitochondrial dysfunction and progressive atrophy of RRF with impaired upregulation of Mb...
  39. pmc Nurse awareness of clinical research: a survey in a Japanese University Hospital
    Hiroaki Yanagawa
    Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Kuramoto cho 2, Tokushima 770 8503, Japan
    BMC Med Res Methodol 14:85. 2014
    ..Although clinical nurses collaborate with clinical research teams, extended clinical research teams that include clinical nurses may contribute to the ethical and scientific pursuit of clinical research...
  40. doi request reprint Role of hypoxia-inducible factor 1alpha in T cells as a negative regulator in development of vascular remodeling
    Hirotsugu Kurobe
    epartment of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Arterioscler Thromb Vasc Biol 30:210-7. 2010
    ..We show that hypoxia-inducible factor 1 (Hif-1) (specifically expressed in T cells) is involved in the immune response to vascular remodeling that accompanies arteriosclerosis...
  41. ncbi request reprint CD13/aminopeptidase N in collagen vascular diseases
    Hirohumi Dan
    Course of Medical Oncology, Department of Internal Medicine and Molecular Therapeutics, University of Tokushima School of Medicine, 18 15 Kuramoto cho 3, Tokushima 770 8503, Japan
    Rheumatol Int 23:271-6. 2003
    ..This study suggests that the activity of CD13/aminopeptidase N, locally produced in the disease site, is a useful marker for CVD and that CD13/aminopeptidase N may have an important role in the pathogenesis of CVD...
  42. ncbi request reprint View and present status of personnel involved in clinical trials: a survey of participants from the First Symposium of the Shikoku Collaborative Group for Promotion of Clinical Trials
    Hiroaki Yanagawa
    Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan
    J Med Invest 58:81-5. 2011
    ..Due to the limitations of this study, further analysis is warranted to determine the optimal strategy for training support staff...
  43. doi request reprint Research ethics committees in Japan: A perspective from thirty years of experience at Tokushima University
    Hiroaki Yanagawa
    Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital
    J Med Invest 62:114-8. 2015
    ..In addition, we address the issues that ethics committees now face and discuss future directions. J. Med. Invest. 62: 114-118, August, 2015. ..
  44. doi request reprint Characteristics of and risk factors for interstitial lung disease induced by chemotherapy for lung cancer
    Takumi Sakurada
    Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan
    Ann Pharmacother 49:398-404. 2015
    ..Cancer pharmacotherapy is strongly associated with DILD, and the risk of DILD has been suggested to be higher in patients with lung cancer because of preexisting pneumonic disease...
  45. ncbi request reprint Present status of Japanese ethics committees: a survey in Tokushima Prefecture
    Rumi Katashima
    Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital
    J Med Invest 61:399-403. 2014
    ..3%), 6 (37.5%) and 4 (25.0%), respectively. Research ethics education was active in 4 (25.0%). Based on the results, we attempt to establish an appropriate system for ethical conduct of health-related research in Tokushima Prefecture...
  46. pmc Serious adverse events and compensation in registration trials: a review of data from a Japanese university hospital
    Miho Watanabe
    Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Kuramoto cho 2, Tokushima 770 8503, Japan
    BMC Res Notes 7:245. 2014
    ..We present herein the results of our analysis...
  47. ncbi request reprint Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor
    Kazuo Yoneda
    Department of Internal Medicine and Molecular Therapeutics, University of Tokushima School of Medicine, Kuramoto Cho 3, Tokushima 770 8503, Japan
    Am J Physiol Lung Cell Mol Physiol 286:L174-81. 2004
    ..Our results demonstrate for the first time that HRF p23 can stimulate nonimmune epithelium. HRF p23 derived from bronchial epithelial cells may regulate complex cytokine networks in eosinophil-dependent inflammation of the human airway...
  48. ncbi request reprint Enhanced inflammation in epicardial fat in patients with coronary artery disease
    Yoichiro Hirata
    Department of Cardiovascular Medicine, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Tokushima City, Japan
    Int Heart J 52:139-42. 2011
    ..Chronic inflammation in epicardial fat may influence the pathogenesis of coronary atherosclerosis...
  49. ncbi request reprint Chronic corticosteroid administration causes mitochondrial dysfunction in skeletal muscle
    Takao Mitsui
    First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto 3 18 15, Tokushima 770 8503, Japan
    J Neurol 249:1004-9. 2002
    ..001). The results suggest that chronic corticosteroid administration induces mitochondrial dysfunction and oxidative damage in skeletal muscles, which may be the pathogenesis, at least in part, of corticosteroid-induced myopathy...
  50. doi request reprint Changed preference for sweet taste in adulthood induced by perinatal exposure to bisphenol A-A probable link to overweight and obesity
    Xiaobin Xu
    Department of Psychiatry, School of Medicine, Showa University, 6 11 11 Kitakarasuyama, Setagaya Ku, Tokyo 157 8577, Japan
    Neurotoxicol Teratol 33:458-63. 2011
    ....
  51. pmc Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences and 21st Century Center of Excellence Program, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Clin Invest 117:1514-26. 2007
    ....
  52. doi request reprint Platypnea-orthodeoxia syndrome associated with patent foramen ovale and aortic ectasia
    Kenya Kusunose
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokushima, Tokushima, Japan
    Echocardiography 26:114-7. 2009
    ..Therefore, he was diagosed as platypnea-orthodeoxia syndrome due to the patent foramen ovale. Surgical closure was done and all of his symptoms had improved...
  53. ncbi request reprint Cisplatin induces apoptosis in oral squamous carcinoma cells by the mitochondria-mediated but not the NF-kappaB-suppressed pathway
    M Azuma
    Second Department of Oral and Maxillofacial Surgery and Oncology, Tokushima University School of Dentistry, 3 Kuramoto cho, Tokushima 770 8504, Japan
    Oral Oncol 39:282-9. 2003
    ....
  54. ncbi request reprint Rapid induction of CD95 ligand and CD4+ T cell-mediated apoptosis by CD137 (4-1BB) costimulation
    T Ebata
    Department of Pathology, National Children's Medical Research Center, Tokyo, Japan
    Eur J Immunol 31:1410-6. 2001
    ..This biological function of CD137 in CD4+ T cells may play an important role for immune homeostasis...
  55. pmc CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages
    Y Nishioka
    Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    Clin Exp Immunol 149:317-26. 2007
    ..These findings suggest that Mig/CXCL9 and I-TAC/CXCL11 as well as IP-10/CXCL10 play important roles in the accumulation of Th1 lymphocytes in sarcoid lungs...
  56. ncbi request reprint Anemia and anti-erythrocyte antibodies developed after repeated injections of sonicated preparations of Plasmodium berghei and Babesia rodhaini
    T Kanbara
    Department of Veterinary Surgery, College of Agriculture, University of Osaka Prefecture, Japan
    Zentralbl Bakteriol Mikrobiol Hyg A 269:100-8. 1988
    ..rodhaini organisms have some materials capable of inducing production of the anti-erythrocyte antibodies which mediate erythrophagocytosis by macrophages of the mononuclear phagocyte system during Plasmodium and Babesia infections...
  57. ncbi request reprint Preferential blockade of CD8(+) T cell responses by administration of anti-CD137 ligand monoclonal antibody results in differential effect on development of murine acute and chronic graft-versus-host diseases
    K Nozawa
    Department of Immunology, National Children's Medical Research Center, Tokyo, Japan
    J Immunol 167:4981-6. 2001
    ..Otherwise, a combinatorial approach will be required for intervention of CD4(+) T cell function...
  58. ncbi request reprint Replication-deficient adenovirus-mediated transfer of B7-1 (CD80) cDNA induces anti-tumour immunity in isolated human lung cancer
    S I Iwakami
    Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Respirology 6:135-44. 2001
    ..Adenovirus-mediated-hB7-1 gene transfer may be a useful means for gene therapy of lung cancer using adoptive immunotherapy...
  59. ncbi request reprint Efficient gene transduction by RGD-fiber modified recombinant adenovirus into dendritic cells
    R Asada-Mikami
    Pharmacology Division, National Cancer Center Hospital, Chuo-ku, Tokyo 104-0045, Japan
    Jpn J Cancer Res 92:321-7. 2001
    ..Recombinant Ad5 fiber knob protein blocked AdCMVLuc- and Ad5lucRGD-mediated gene transduction by 90% and 20%, respectively. Surface markers and cytokine production were not affected by Ad5lucRGD-mediated transduction...
  60. ncbi request reprint Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization
    H Ma
    Department of Oral Molecular Biology, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Biol Chem 276:28525-31. 2001
    ..In conclusion, calpain 10 seems to be a ubiquitous calpain, the expression level and subcellular distribution of which are dynamically influenced by calcium...
  61. ncbi request reprint CD40 and IFN-gamma dependent T cell activation by human bronchial epithelial cells
    H Tanaka
    Third Department of Internal Medicine, University of Tokushima School of Medicine, Japan
    J Med Invest 48:109-17. 2001
    ..Thus, bronchial epithelial cells have the ability to present allogeneic antigens to T cells in both CD40- and IFN-gamma-dependent manners under the presence of third party cells that transduce co-stimulatory signals...
  62. ncbi request reprint Identification and characterization of a retina-specific calpain (Rt88) from rat
    M Azuma
    Department of Oral Molecular Biology and Ophthalmology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Curr Eye Res 21:710-20. 2000
    ..To identify and characterize a newly discovered calpain termed Rt88 from rat retina...
  63. ncbi request reprint Adenoviral interleukin-12 gene transduction into human bronchial epithelial cells: up-regulation of pro-inflammatory cytokines and its prevention by corticosteroids
    H Ogawa
    Department of Internal Medicine and Molecular Therapeutics, University of Tokushima, School of Medicine, Tokushima, Japan
    Clin Exp Allergy 33:921-9. 2003
    ..The effects of dexamethasone on the gene-modified cells were also examined...
  64. ncbi request reprint B70 antigen is a second ligand for CTLA-4 and CD28
    M Azuma
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Nature 366:76-9. 1993
    ..These findings indicate that B70 is a second ligand for CD28 and CTLA-4 and may play an important role for costimulation of T cells in a primary immune response...
  65. ncbi request reprint Successful treatment of S-1 + CDDP followed by salvage EMR for a case with metastatic Barrett's esophageal cancer
    K Nakatani
    Department of Gastroenterology, Kitasato University East Hospital, School of Medicine, 2 1 1, Asamizodai, Sagamihara, Kanagawa, Japan
    Dis Esophagus 20:173-7. 2007
    ..This is a rare case of metastatic Barrett's esophageal cancer in which the metastases were eradicated by S-1 + cisplatin, and the primary tumor successfully excised by endoscopic mucosal resection after downstaging...
  66. ncbi request reprint Cloning and expression of mRNA for calpain Lp82 from rat lens: splice variant of p94
    H Ma
    Department of Oral Molecular Biology, Oregon Health Sciences University, Portland 97201, USA
    Invest Ophthalmol Vis Sci 39:454-61. 1998
    ..To describe mRNA for Lp82, a lens-specific form of calcium-activated protease (EC 34.22.17, calpain) in rat...
  67. pmc Involvement of programmed death-ligand 2 (PD-L2) in the development of experimental allergic conjunctivitis in mice
    A Fukushima
    Department of Ophthalmology, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku city 783 8505, Japan
    Br J Ophthalmol 90:1040-5. 2006
    ..Here, the authors aimed to examine whether PD-1 and its ligands are involved in the development of experimental allergic conjunctivitis (EC) in mice...
  68. ncbi request reprint Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester
    T Oka
    Kobe Creative Center, Senju Pharmaceutical Co, Ltd, 1 5 4 Murotani, Nishiku, Kobe, Hyogo 651 2241, Japan
    Neuroscience 141:2139-45. 2006
    ....
  69. ncbi request reprint Low activity by the calpain system in primate lenses causes resistance to calcium-induced proteolysis
    E Nakajima
    Department of Integrative Biosciences, Oregon Health and Science University, 611 SW Campus Drive, Portland, OR 97239 3097, USA
    Exp Eye Res 83:593-601. 2006
    ..We found that the lack of appreciable calpain-induced proteolysis in primate lenses is most likely due to relatively low levels of endogenous calpain activity compared to the high levels of endogenous calpain inhibitor, calpastatin...
  70. ncbi request reprint Involvement of Egr-1 in lens epithelial cell death induced by selenite
    T Nakajima
    Research Laboratory of Ocular Sciences, Senju Pharmaceutical Co Ltd, Kobe, Hyogo, Japan
    Exp Eye Res 82:874-8. 2006
    ..Antisense oligonucleotide for Egr-1 significantly diminished expression of Egr-1 protein and leakage of LDH. These results suggested that increased activity of Egr-1 may be a factor in lens epithelial cell death induced by selenite...
  71. ncbi request reprint CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL
    L L Lanier
    Department of Human Immunology, DNAX Research Institute of Molecular and Cellular Biology, Inc, Palo Alto, CA 94304
    J Immunol 154:97-105. 1995
    ..Therefore, the role of CD80 and CD86 in an immune response may be determined primarily by their differential expression on APC...
  72. ncbi request reprint Expression of calpain small subunit 2 in mammalian tissues
    H Ma
    Department of Integrative Biosciences, Oregon Health and Science University, Portland, Oregon 97239, USA
    Curr Eye Res 29:337-47. 2004
    ..The purpose of the current experiments was to more closely define the distribution and the function of calpain small subunit 2 (css2). Css2 is a newly discovered regulatory protein for the calcium activated proteases, mu- and m-calpains...
  73. ncbi request reprint Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa
    A Nakazawa
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Gastroenterology 117:536-45. 1999
    ..The aim of this study was to demonstrate expression of costimulatory molecules CD86 and CD80 in human colonic epithelial cells and assess their functional roles in the activation of T cells in inflamed colonic mucosa...
  74. ncbi request reprint Expression changes in mRNAs and mitochondrial damage in lens epithelial cells with selenite
    P B Belusko
    Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co Ltd, Beaverton, OR 97006, USA
    Biochim Biophys Acta 1623:135-42. 2003
    ..Up-regulation of mRNAs involved in maintenance of DNA, regulation of metabolism, and induction of apoptosis may also play roles...
  75. ncbi request reprint Effect of a mutant form of IkappaB-alpha on 5-fluorouracil-induced apoptosis in transformed human salivary gland cells
    K Motegi
    Department of Oral and Maxillofacial Surgery 2, Tokushima University School of Dentistry, 3 Kuramoto-cho, Tokushima 770-8504, Japan
    Oral Oncol 37:185-92. 2001
    ..Accordingly, our data provide evidence that the combination of 5-FU and NF-kappaB suppression cooperatively functions in the growth inhibition of NS-SV-AC cells...
  76. ncbi request reprint Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyes
    T Nakajima
    Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co, Ltd, Kobe, Hyogo 650 0047 Japan
    Exp Eye Res 85:651-8. 2007
    ..In primates, lacritin was produced in the lacrimal gland and secreted into tear fluid. These results suggest that lacritin might be important for the maintenance of the ocular surface in higher animals, such as monkeys and humans...