Takeshi Hirano

Summary

Affiliation: The University of Kitakyushu
Country: Japan

Publications

  1. ncbi Analysis of 8-hydroxydeoxyguanosine 5'-monophosphate (8-OH-dGMP) as a reliable marker of cellular oxidative DNA damage after gamma-irradiation
    Nan Mei
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan
    Environ Mol Mutagen 41:332-8. 2003
  2. doi Enhancement of adipogenesis induction by conditioned media obtained from cancer cells
    Takeshi Hirano
    Graduate School of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka, Japan
    Cancer Lett 268:286-94. 2008
  3. ncbi Repair system of 7, 8-dihydro-8-oxoguanine as a defense line against carcinogenesis
    Takeshi Hirano
    Department of Life and Environment Engineering, Faculty of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka, Japan
    J Radiat Res 49:329-40. 2008
  4. doi Chronic alcohol consumption prevents 8-hydroxyguanine accumulation in 3'-methyl-4-dimethylaminoazobenzene-treated mouse liver
    Takeshi Hirano
    Department of Life and Environment Engineering, Faculty of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka 808 0135, Japan
    Biochem Biophys Res Commun 387:316-20. 2009
  5. pmc Alcohol consumption and oxidative DNA damage
    Takeshi Hirano
    Department of Life and Environment Engineering, Faculty of Environmental Engineering, The University of Kitakyushu, 1 1 Hibikino, Wakamatsu ku, Kitakyushu, Fukuoka 808 0135, Japan
    Int J Environ Res Public Health 8:2895-906. 2011
  6. doi 8-Hydroxyguanine levels and repair capacity during mouse embryonic stem cell differentiation
    Ayumi Kuboyama
    Department of Chemical Processes and Environments, Faculty of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka, 808 0135, Japan
    Free Radic Res 45:527-33. 2011
  7. ncbi Detection of a mouse OGG1 fragment during caspase-dependent apoptosis: oxidative DNA damage and apoptosis
    Takeshi Hirano
    Department of Environmental Oncology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Fukuoka 807 8555, Japan
    Cancer Sci 95:634-8. 2004
  8. ncbi Detection of a smaller, 32-kDa 8-oxoguanine DNA glycosylase 1 in 3'-methyl-4-dimethylamino-azobenzene-treated mouse liver
    Takeshi Hirano
    Department of Environmental Oncology, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Fukuoka 807 8555, Japan
    Cancer Sci 95:118-22. 2004
  9. doi 8-hydroxydeoxyguanosine generated in the earthworm Eisenia fetida grown in metal-containing soil
    Tamiji Nakashima
    Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, Fukuoka 807 8555, Japan
    Mutat Res 654:138-44. 2008
  10. doi Bisphenol A induces endoplasmic reticulum stress-associated apoptosis in mouse non-parenchymal hepatocytes
    Junpei Asahi
    Graduate School of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka, 808 0135, Japan
    Life Sci 87:431-8. 2010

Collaborators

  • Hiroshi Kasai
  • Nan Mei
  • Naoki Kunugita
  • Masaki Kobayashi
  • Ken Iseki
  • Shirou Itagaki
  • Satoru Yasuda
  • Junpei Asahi
  • Tamiji Nakashima
  • Ayumi Kuboyama
  • Kazuaki Kawai
  • Akihisa Yamashita
  • Toshiki Kagawa
  • Takashi Yamamoto
  • Koji Nakatani
  • Haruto Egawa
  • Haruki Morii
  • Kazuyoshi Tamae
  • Shoichi Tanaka
  • Yoshiaki Doi
  • Ayuko Hanada
  • Hanako Kamo
  • Daisuke Murakami
  • Ryoko Baba
  • Koji Matsuno
  • Katsuya Narumi
  • Ikumi Chisaki
  • Shinobu Gamou
  • Satoko Hasui
  • Kazuhiro Hidaka
  • Toshihiro Okada
  • Kenichi Kuniki
  • Mitsuru Sugawara
  • Yoh Takekuma
  • Fumie Kaido
  • Baohui Xu
  • Itaru Fujita
  • Seiichi Ando
  • Toyohiro Kato
  • Kohji Aoyama
  • Masaharu Komatsu
  • Toru Takeuchi
  • Akira Wagatsuma
  • Hiroaki Takekura
  • Takao Yamanaka
  • Takahiro Nakayama
  • Keiji Tatsumi
  • Shingo Fujii
  • Hiroshi Fujiwara
  • Toshihiro Higuchi
  • Takahide Mori

Detail Information

Publications21

  1. ncbi Analysis of 8-hydroxydeoxyguanosine 5'-monophosphate (8-OH-dGMP) as a reliable marker of cellular oxidative DNA damage after gamma-irradiation
    Nan Mei
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan
    Environ Mol Mutagen 41:332-8. 2003
    ..Using an endonuclease nicking assay, we also found that gamma-rays decreased 8-OH-Gua repair activity. The results indicate that 8-OH-dGMP is a useful and sensitive marker for estimating oxidative damage in DNA...
  2. doi Enhancement of adipogenesis induction by conditioned media obtained from cancer cells
    Takeshi Hirano
    Graduate School of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka, Japan
    Cancer Lett 268:286-94. 2008
    ..Although we could not define the factors, these undefined factors derived from cancer cells may induce adipogenesis, and the resulting adipogenesis may affect cancer development...
  3. ncbi Repair system of 7, 8-dihydro-8-oxoguanine as a defense line against carcinogenesis
    Takeshi Hirano
    Department of Life and Environment Engineering, Faculty of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka, Japan
    J Radiat Res 49:329-40. 2008
    ..These studies revealed that the 8-oxo-Gua repair system is crucial for the prevention of mutation-related diseases, such as cancer. In this review, the advances in this field during the last two decades are described...
  4. doi Chronic alcohol consumption prevents 8-hydroxyguanine accumulation in 3'-methyl-4-dimethylaminoazobenzene-treated mouse liver
    Takeshi Hirano
    Department of Life and Environment Engineering, Faculty of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka 808 0135, Japan
    Biochem Biophys Res Commun 387:316-20. 2009
    ..These findings suggested that 12% ethanol consumption may reduce the risk of 3'-MeDAB-induced carcinogenesis by decreasing 8-OH-Gua accumulation...
  5. pmc Alcohol consumption and oxidative DNA damage
    Takeshi Hirano
    Department of Life and Environment Engineering, Faculty of Environmental Engineering, The University of Kitakyushu, 1 1 Hibikino, Wakamatsu ku, Kitakyushu, Fukuoka 808 0135, Japan
    Int J Environ Res Public Health 8:2895-906. 2011
    ..Taken together, the effects of ethanol consumption on cancer risk depend on the ethanol concentration and the diet pattern...
  6. doi 8-Hydroxyguanine levels and repair capacity during mouse embryonic stem cell differentiation
    Ayumi Kuboyama
    Department of Chemical Processes and Environments, Faculty of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka, 808 0135, Japan
    Free Radic Res 45:527-33. 2011
    ..Taken together, ES cells are more resistant to DNA oxidative stresses than differentiated cells...
  7. ncbi Detection of a mouse OGG1 fragment during caspase-dependent apoptosis: oxidative DNA damage and apoptosis
    Takeshi Hirano
    Department of Environmental Oncology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Fukuoka 807 8555, Japan
    Cancer Sci 95:634-8. 2004
    ....
  8. ncbi Detection of a smaller, 32-kDa 8-oxoguanine DNA glycosylase 1 in 3'-methyl-4-dimethylamino-azobenzene-treated mouse liver
    Takeshi Hirano
    Department of Environmental Oncology, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Fukuoka 807 8555, Japan
    Cancer Sci 95:118-22. 2004
    ..Although the function of mOGG1-32 remains unclear, these findings suggest that 3'-MeDAB may alter the function of the DNA repair protein, and this action may be related to 3'-MeDAB carcinogenesis...
  9. doi 8-hydroxydeoxyguanosine generated in the earthworm Eisenia fetida grown in metal-containing soil
    Tamiji Nakashima
    Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, Fukuoka 807 8555, Japan
    Mutat Res 654:138-44. 2008
    ..Although some points remain unresolved, a bio-monitoring system analyzing the DNA damage generated in the earthworm might be useful for the assessment of the mutagenicity of soil contaminated with various heavy metals, such as Cd...
  10. doi Bisphenol A induces endoplasmic reticulum stress-associated apoptosis in mouse non-parenchymal hepatocytes
    Junpei Asahi
    Graduate School of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka, 808 0135, Japan
    Life Sci 87:431-8. 2010
    ..the effects of bisphenol A (BPA) on NCTC Clone 1469, non-parenchymal hepatocytes, were examined to clarify the molecular basis of BPA-induced liver injury...
  11. pmc Earthworms and soil pollutants
    Takeshi Hirano
    Department of Life and Environment Engineering, Faculty of Environmental Engineering, University of Kitakyushu, Kitakyushu, Fukuoka, 808 0135, Japan
    Sensors (Basel) 11:11157-67. 2011
    ..In this short review, we describe recent studies concerning the relationship between earthworms and soil pollutants, and discuss the possibility of using the earthworm as a bio-monitoring organism for soil pollution...
  12. ncbi Acute arsenite-induced 8-hydroxyguanine is associated with inhibition of repair activity in cultured human cells
    Nan Mei
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807 8555, Japan
    Biochem Biophys Res Commun 297:924-30. 2002
    ....
  13. doi Association between risk of myopathy and cholesterol-lowering effect: a comparison of all statins
    Masaki Kobayashi
    Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 chome, Kita ku, Sapporo 060 0812, Japan
    Life Sci 82:969-75. 2008
    ..Thus, it is necessary to consider the association between risk of myopathy and cholesterol-lowering effect of a statin for precise use of statins...
  14. ncbi The mechanism of carrier-mediated transport of folates in BeWo cells: the involvement of heme carrier protein 1 in placental folate transport
    Satoru Yasuda
    Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmascience, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Biosci Biotechnol Biochem 72:329-34. 2008
    ..We conclude that pH-dependent folate uptake in BeWo cells is mediated by at least two carriers. RFC is not involved in folate uptake, but FRalpha (high affinity phase) and HCP1 (low affinity phase) transport folate in BeWo cells...
  15. ncbi The inhibitory effects of fluoroquinolones on L-carnitine transport in placental cell line BeWo
    Takeshi Hirano
    Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 chome, Kita ku, Sapporo 060 0812, Japan
    Int J Pharm 351:113-8. 2008
    ..However, we found that LVFX transport was Na+-independent and l-carnitine had no inhibitory effect on LVFX transport, suggesting that LVFX acts as inhibitor of OCTN2, not as a substrate for OCTN2...
  16. ncbi Preventive effects of bicarbonate on cerivastatin-induced apoptosis
    Masaki Kobayashi
    Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 chome, Kita ku, Sapporo 060 0812, Japan
    Int J Pharm 341:181-8. 2007
    ..Accordingly, bicarbonate suppressed statin-induced apoptosis. The strategy to combine statins with bicarbonate can lead to reduction in the chance of the severe adverse events including myopathy or rhabdmyolysis...
  17. ncbi Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters
    Takashi Yamamoto
    Department of Pharmacy, Hokkaido University Hospital, Sapporo 060 8648, Japan
    Eur J Pharmacol 557:1-8. 2007
    ..These results suggest that ribavirin is taken up by BeWo cells via both the high-affinity Na(+)-dependent transporter hCNT3 and the low-affinity Na(+)-independent transporters hENT1 and hENT2...
  18. ncbi Effects of sex hormones on regulation of ABCG2 expression in the placental cell line BeWo
    Satoru Yasuda
    Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    J Pharm Pharm Sci 9:133-9. 2006
    ..The aim of this study was to elucidate the effects of sex hormones that are secreted during gestation from the placenta on ABCG2 mRNA and protein expression levels by using the placental cell line BeWo...
  19. ncbi Habitual exercise induced resistance to oxidative stress
    Koji Nakatani
    Department of Environmental Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, 890 8544, Japan
    Free Radic Res 39:905-11. 2005
    ..These results suggest that HE induces resistance to oxidative stress and, at least at the initiation stage, inhibits carcinogenesis...
  20. ncbi Transport mechanism for L-lactic acid in human myocytes using human prototypic embryonal rhabdomyosarcoma cell line (RD cells)
    Masaki Kobayashi
    Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biol Pharm Bull 28:1197-201. 2005
    ..MCT4 mRNA was found to be present significantly greater than that MCT2. We conclude that MCT1 is responsible for L-lactic acid uptake and L-lactic acid efflux is mediated by MCT4 in RD cells...
  21. ncbi Peripheral blood mononuclear cells in early pregnancy promote invasion of human choriocarcinoma cell line, BeWo cells
    Haruto Egawa
    Department of Gynaecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Hum Reprod 17:473-80. 2002
    ..To determine the physiological significance of this interaction, the effects of PBMC obtained from pregnant women on the proliferative and invasive properties of a human choriocarcinoma cell line, BeWo cells, were examined...