The University of Tokyo

Summary

Organization: The University of Tokyo
Country: Japan

Top Publications

  1. pmc Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study
    Aya Kawasaki
    Molecular and Genetic Epidemiology Laboratory, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Arthritis Res Ther 12:R174. 2010
  2. doi Stiripentol open study in Japanese patients with Dravet syndrome
    Yushi Inoue
    Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 50:2362-8. 2009
  3. ncbi Development of a work improvement checklist for occupational mental health focused on requests from workers
    Hiroyuki Tahara
    Department of Mental Health, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan
    J Occup Health 51:340-8. 2009
  4. doi A case of Baraitser-Winter syndrome with unusual brain MRI findings: pachygyria, subcortical-band heterotopia, and periventricular heterotopia
    Takashi Shiihara
    Department of Neurology, Gunma Children s Medical Center, 779 Shimohakoda, Hokkitsu machi, Shibukawa, Gunma 377 8577, Japan
    Brain Dev 32:502-5. 2010
  5. doi Impaired PRMT1 activity in the liver and pancreas of type 2 diabetic Goto-Kakizaki rats
    Hiroaki Iwasaki
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Toshiba Rinkan Hospital, 7 9 1 Kami tsuruma, Sagamihara, Kanagawa 228 8585, Japan
    Life Sci 85:161-6. 2009
  6. ncbi Impact of reduced endogenous anti-coagulation protein activity on vascular events of peripheral arterial disease
    H Komai
    Department of Cardiovascular Surgery, Saiseikai Wakayama Hospital, Wakayama, Japan
    Int Angiol 28:138-43. 2009
  7. doi Echocardiographic and electrocardiographic analyses of patients with severe motor and intellectual disabilities
    Keiichi Hirono
    Department of Pediatrics, Faculty of Medicine, University of Toyama, 2630 Sugitani, 930 0194 Toyama, Japan
    Heart Vessels 24:46-53. 2009
  8. doi Intracardiac calipers for artificial chordae replacement in mitral valve repair
    Atsuo Doi
    Department of Cardiovascular Surgery, Narita Red Cross Hospital, Narita, Chiba, Japan
    Ann Thorac Surg 87:326-8. 2009
  9. pmc Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of human renal carcinoma cells
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1, Sakamoto, Nagasaki 851 0251, Japan
    Int J Oncol 34:89-96. 2009
  10. ncbi Increasing the number of SNP loci does not necessarily improve prediction power at least in the comparison of MTHFR SNP and haplotypes
    Koichi Miyaki
    Preventive Medicine for Cerebrovascular Disease, Department of Neurology, Shool of Medicine, Keio University, Tokyo, Japan
    J Epidemiol 18:243-50. 2008

Scientific Experts

Detail Information

Publications62

  1. pmc Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study
    Aya Kawasaki
    Molecular and Genetic Epidemiology Laboratory, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Arthritis Res Ther 12:R174. 2010
    ..In this study, we investigated whether the association of TNIP1 with SLE was replicated in a Japanese population. In addition, association of TNIP1 with RA was also examined...
  2. doi Stiripentol open study in Japanese patients with Dravet syndrome
    Yushi Inoue
    Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 50:2362-8. 2009
    ..To survey the treatment situation of Dravet syndrome in Japan and to compare this result with effectiveness of stiripentol (STP) add-on therapy in an open-label multicenter study...
  3. ncbi Development of a work improvement checklist for occupational mental health focused on requests from workers
    Hiroyuki Tahara
    Department of Mental Health, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan
    J Occup Health 51:340-8. 2009
    ..This research was a part of the Mental Health Improvement & Reinforcement Study (MIR study), conducted from October 2004 to March 2006...
  4. doi A case of Baraitser-Winter syndrome with unusual brain MRI findings: pachygyria, subcortical-band heterotopia, and periventricular heterotopia
    Takashi Shiihara
    Department of Neurology, Gunma Children s Medical Center, 779 Shimohakoda, Hokkitsu machi, Shibukawa, Gunma 377 8577, Japan
    Brain Dev 32:502-5. 2010
    ..However, the results of the genome-wide array comparative genomic hybridization did not reveal any chromosomal rearrangements...
  5. doi Impaired PRMT1 activity in the liver and pancreas of type 2 diabetic Goto-Kakizaki rats
    Hiroaki Iwasaki
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Toshiba Rinkan Hospital, 7 9 1 Kami tsuruma, Sagamihara, Kanagawa 228 8585, Japan
    Life Sci 85:161-6. 2009
    ..This study aims to investigate whether alteration of PRMT1 activity contributes to the clinical features of type 2 diabetes...
  6. ncbi Impact of reduced endogenous anti-coagulation protein activity on vascular events of peripheral arterial disease
    H Komai
    Department of Cardiovascular Surgery, Saiseikai Wakayama Hospital, Wakayama, Japan
    Int Angiol 28:138-43. 2009
    ..Aim of the study is to elucidate the prevalence and the prognosis of patients with peripheral arterial disease (PAD) who have reduced endogenous anti-coagulation protein activity...
  7. doi Echocardiographic and electrocardiographic analyses of patients with severe motor and intellectual disabilities
    Keiichi Hirono
    Department of Pediatrics, Faculty of Medicine, University of Toyama, 2630 Sugitani, 930 0194 Toyama, Japan
    Heart Vessels 24:46-53. 2009
    ..This may be one of the reasons why the incidence of sudden death is higher in SMID patients...
  8. doi Intracardiac calipers for artificial chordae replacement in mitral valve repair
    Atsuo Doi
    Department of Cardiovascular Surgery, Narita Red Cross Hospital, Narita, Chiba, Japan
    Ann Thorac Surg 87:326-8. 2009
    ..With this technique, the length of the neo-chordae is easily decided and the knot can be tied surely without change in the length using only one instrument...
  9. pmc Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of human renal carcinoma cells
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1, Sakamoto, Nagasaki 851 0251, Japan
    Int J Oncol 34:89-96. 2009
    ....
  10. ncbi Increasing the number of SNP loci does not necessarily improve prediction power at least in the comparison of MTHFR SNP and haplotypes
    Koichi Miyaki
    Preventive Medicine for Cerebrovascular Disease, Department of Neurology, Shool of Medicine, Keio University, Tokyo, Japan
    J Epidemiol 18:243-50. 2008
    ..This study aimed to assess the effect of folic acid supplementation quantitatively in MTHFR haplotypes, and compare its prediction power with that of the C677T single nucleotide polymorphism (SNP) alone...
  11. doi The cyst-branch difference in developing chick lung results from a different morphogen diffusion coefficient
    Takashi Miura
    Department of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Yoshida Konoe chou, Sakyo ku, Kyoto 606 8501, Japan
    Mech Dev 126:160-72. 2009
    ....
  12. pmc Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice
    J Kitanaka
    Department of Pharmacology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    Psychopharmacology (Berl) 203:781-92. 2009
    ..The effects of sigma receptor antagonists on methamphetamine (METH)-induced stereotypy have not been examined. We examined the effects of sigma antagonists on METH-induced stereotypy in mice...
  13. doi Quality of life, day hospice needs, and satisfaction of community-dwelling patients with advanced cancer and their caregivers in Japan
    Mitsunori Miyashita
    Department of Adult Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Palliat Med 11:1203-7. 2008
    ....
  14. doi Perioperative complications of primary posterior lumbar interbody fusion for nonisthmic spondylolisthesis: analysis of risk factors
    Noboru Hosono
    Department of Orthopaedic Surgery, Osaka Kosei Nenkin Hospital, Fukushima, Osaka, Japan
    J Neurosurg Spine 9:403-7. 2008
    ..The authors retrospectively reviewed consecutive patients with nonisthmic spondylolisthesis who underwent PLIF to reveal the incidence and risk factors for perioperative complications of PLIF...
  15. doi The human leukocyte antigen class II gene has different contributions to autoimmune type 1 diabetes with or without autoimmune thyroid disease in the Japanese population
    Masahito Katahira
    Department of Endocrinology, Ichinomiya Municipal Hospital, 2 2 22 Bunkyo, Ichinomiya, Aichi 491 8558, Japan
    Diabetes Res Clin Pract 85:293-7. 2009
    ..The human leukocyte antigen (HLA) has been extensively studied in these diseases. We aimed to clarify the contribution of AITD on the susceptibility and resistance of the HLA subtype to autoimmune T1D in the Japanese population...
  16. pmc Tailor-made Surgical Guide Reduces Incidence of Outliers of Cup Placement
    Takehito Hananouchi
    Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Clin Orthop Relat Res 468:1088-95. 2010
    ..The surgical guide provided more reliable cup insertion compared with conventional techniques. Level of Evidence: Level II, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence...
  17. doi Low health-related quality of life is associated with all-cause mortality in patients with diabetes on haemodialysis: the Japan Dialysis Outcomes and Practice Pattern Study
    Y Hayashino
    Department of Epidemiology and Healthcare Research, Kyoto University Graduate School of Medicine, Kyoto, Japan 606 8501
    Diabet Med 26:921-7. 2009
    ..We investigated the impact of HRQoL on mortality risk in patients with diabetes on haemodialysis...
  18. ncbi [Acute idiopathic autonomic neuropathy with local autonomic failure in a child]
    Hidee Arai
    Department of Neurology, Chiba Children s Hospital, Chiba
    No To Hattatsu 42:372-6. 2010
    ..These findings suggested autonomic neuropathy with local sympathetic dysfunction and a mild sensory nerve disturbance...
  19. doi Cost-effectiveness of administering oral adsorbent AST-120 to patients with diabetes and advance-stage chronic kidney disease
    Yasuaki Hayashino
    Department of Epidemiology and Healthcare Research, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606 8501, Japan
    Diabetes Res Clin Pract 90:154-9. 2010
    ..The objective of this study is to evaluate the cost-effectiveness of using AST-120 to treat patients with type 2 diabetes and advanced-stage CKD...
  20. ncbi Neuropsychological improvement in patients with cervical spondylotic myelopathy after posterior decompression surgery
    Minoru Hoshimaru
    Department of Neurosurgery, Ohtsu Municipal Hospital, Ohtsu, Shiga, Japan
    Neurol Med Chir (Tokyo) 50:554-9. 2010
    ..05). The practice effect may have contributed to the neuropsychological improvements, but this study suggests that cervical spinal disorders may affect cognitive functions and that surgical treatment can ameliorate such effects...
  21. ncbi Genetic polymorphisms in homocysteine metabolism and response to folate intake: a comprehensive strategy to elucidate useful genetic information
    Koichi Miyaki
    Division of Clinical Epidemiology, Department of Clinical Research and Informatics, National Center for Global Health and Medicine, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    J Epidemiol 20:266-70. 2010
    ..International statements, such as CONSORT and STREGA, provide useful principles for conducting such research...
  22. doi Obsessive-compulsive disorder and obsessive-compulsive symptoms in Japanese inpatients with chronic schizophrenia - a possible schizophrenic subtype
    Toshimi Owashi
    Department of Psychiatry, Showa University Fujigaoka Hospital, Fujigaoka, Aoba ku, Yokohama, Japan
    Psychiatry Res 179:241-6. 2010
    ..However, negative symptoms were associated with comorbidity of OCD in chronic schizophrenia. Our findings suggest there is a subtype of schizophrenia with OCS, which is related to earlier onset and more severe psychotic symptoms...
  23. doi Association between number of comorbid conditions, depression, and sleep quality using the Pittsburgh Sleep Quality Index: results from a population-based survey
    Yasuaki Hayashino
    Department of Epidemiology and Healthcare Research, Kyoto University Graduate School of Medicine, Japan
    Sleep Med 11:366-71. 2010
    ..Although sleep problems are a serious public concern, it is not clear if the presence of depression or multiple comorbid conditions has an additive or multiplicative effect on sleep quality...
  24. pmc Association of short sleep duration with weight gain and obesity at 1-year follow-up: a large-scale prospective study
    Mayumi Watanabe
    Department of Occupational Mental Health, Graduate School of Medical Sciences, Kitasato University, Sagamihara City, Japan
    Sleep 33:161-7. 2010
    ..To investigate the association between short sleep duration and elevated body mass index (BMI) and obesity in a large sample of Japanese adults over a short period...
  25. ncbi The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: pathophysiology and pharmacotherapy of overactive bladder
    Masaki Yoshida
    Department of Urology, Kumamoto Hospital of Japan Labor Health and Welfare Organization, 1670 Takehara cho, Yatsushiro City, Kumamoto 866 8533, Japan
    J Pharmacol Sci 112:128-34. 2010
    ..In this review, the pathophysiology of OAB, especially the role of non-neuronal acetylcholine, is discussed. In addition, new drugs with new action mechanisms will be introduced...
  26. doi The effects of chronic hyperlipidemia on bladder function in myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits
    Masaki Yoshida
    Department of Urology, Kumamoto Hospital of Japan Labor Health and Welfare Organization, Kumamoto, Japan
    Neurourol Urodyn 29:1350-4. 2010
    ..To evaluate chronic hyperlipidemia on bladder function, we examined the functional and histological changes of the bladder in myocardial infarction-prone Watanabe Heritable Hyperlipidemic (WHHLMI) rabbits...
  27. doi Reduced gray matter volume of Brodmann's Area 45 is associated with severe psychotic symptoms in patients with schizophrenia
    Motomu Suga
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Eur Arch Psychiatry Clin Neurosci 260:465-73. 2010
    ..The present study further demonstrated that BA 45 might especially contribute to the production of psychotic symptoms in the patients with schizophrenia...
  28. doi Comparison of physicians' compliance, clinical efficacy, and drug cost before and after introduction of Asthma Prevention and Management Guidelines in Japan (JGL2003)
    Tomoko Suzuki
    Deparment of Pharmacokinetics and Pharmacodynamics, Faculty of Pharmaceutical Sciences, Showa University, and Department of Respiratory Medicine, Showa University Fujigaoka Hospital, Tokyo, Japan
    Allergol Int 59:33-41. 2010
    ..This study investigated the variations in the clinical efficacy and drug cost following the introduction of the Asthma Prevention and Management Guidelines in Japan (JGL2003)...
  29. doi Conditional selection of contra- and ipsilateral forelimb movements by the dorsal premotor cortex in monkeys
    Kiyoshi Kurata
    Department of Physiology, Hirosaki University School of Medicine, Hirosaki, Japan
    J Neurophysiol 103:262-77. 2010
    ..These results suggest that the left and right PMdc cooperate to transform conditional sensory cues into appropriate motor output and can affect both contra- and ipsilateral body movement...
  30. ncbi Issues on evaluating the usability of a pen-tablet system using server-based computing
    Kei Teramoto
    Division of Medical Informatics, Tottori University Hospital, Tottori 683 8504, Japan
    Stud Health Technol Inform 150:415. 2009
    ..It was found that the relation of the usability with the drawing velocity and the delay is the crucial issue for a further study...
  31. doi Care burden and depression in caregivers caring for patients with intractable neurological diseases at home in Japan
    Mitsunori Miyashita
    Department of Adult Nursing Palliative Care Nursing, School of Health Science and Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Neurol Sci 276:148-52. 2009
    ..The aims of this study are to describe the care burden on caregivers of individuals with intractable neurological diseases and to clarify the prevalence of depression in caregivers and factors related to the presence of depression...
  32. doi Maternity blues as predictor of postpartum depression: a prospective cohort study among Japanese women
    Mayumi Watanabe
    Department of Occupational Mental Health, Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan
    J Psychosom Obstet Gynaecol 29:206-12. 2008
    ..We carried out a longitudinal study among Japanese women to show that maternity blues is a useful factor for predicting postpartum depression...
  33. ncbi Motor evoked potential mapping and monitoring by direct brainstem stimulation. Technical note
    Satoshi Tanaka
    Department of Neurosurgery, Kawasaki Hospital, Hitachiohta, Japan
    J Neurosurg 107:1053-7. 2007
    ..Motor evoked potentials elicited by direct brainstem stimulation seem to be an accurate neurophysiological monitoring method during operations around the anterior and lateral aspects of the brainstem...
  34. ncbi Coronary artery bypass grafting versus coronary implantation of sirolimus-eluting stents in patients with diabetic retinopathy
    Takayuki Ohno
    Department of Cardiothoracic Surgery, The University of Tokyo, Tokyo, Japan
    Ann Thorac Surg 84:1474-8. 2007
    ....
  35. ncbi Normal fasting plasma glucose levels and type 2 diabetes: the high-risk and population strategy for occupational health promotion (HIPOP-OHP) [corrected] study
    Y Hayashino
    Department of Epidemiology and Healthcare Research, Kyoto University Graduate School of Medicine, Konoe cho, Yoshida, Sakyo ku, Kyoto, 606 8501, Japan
    Acta Diabetol 44:164-6. 2007
    ..726). In conclusion, higher fasting glucose level was associated with the risk of diabetes, and we found a threshold in the association between fasting blood glucose levels and risk of diabetes in an Asian population...
  36. ncbi [Preventive effects of newquinolones for endogenous infection in patients receiving allogeneic hematopoietic stem cell transplantation--comparison between bone marrow transplantation, peripheral blood stem cell transplantation, and cord blood transplantat
    Hitoshi Kawazoe
    Department of Pharmacy, Kagawa University Hospital, Japan
    Yakugaku Zasshi 127:1301-7. 2007
    ..We should be careful when interpreting the results of this small study; however, newquinolones are clinically effective for endogenous infection of gram-negative bacteria in patients receiving not only BMT, but also PBSCT and CBT...
  37. pmc Relation between sleep quality and quantity, quality of life, and risk of developing diabetes in healthy workers in Japan: the High-risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) Study
    Yasuaki Hayashino
    Department of Epidemiology and Healthcare Research, Kyoto University Graduate School of Medicine, Kyoto, Japan
    BMC Public Health 7:129. 2007
    ..The objective of this study is to investigate the effect of self-reported sleep duration and sleep quality on the risk of developing diabetes in a prospective cohort in Japan...
  38. ncbi Essential role of p53 in trophoblastic apoptosis induced in the developing rodent placenta by treatment with a DNA-damaging agent
    Hirofumi Yamauchi
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Apoptosis 12:1743-54. 2007
    ..These results indicate that p53 is essential for DNA damage-induced trophoblastic apoptosis and suggest that the mechanisms that regulate the damage-induced apoptosis differ from those that regulate physiological apoptosis...
  39. ncbi Preoperative templating of femoral components on plain X-rays. Rotational evaluation with synthetic X-rays on ORTHODOC
    Takehito Hananouchi
    Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka Suita, Osaka 565 0871, Japan
    Arch Orthop Trauma Surg 127:381-5. 2007
    ....
  40. pmc Marital status and mortality among Japanese men and women: the Japan Collaborative Cohort Study
    Ai Ikeda
    Department of Public Health Medicine, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennoudai, Tsukuba shi, Ibaraki, Japan
    BMC Public Health 7:73. 2007
    ....
  41. ncbi Three-dimensional analysis of pathological characteristics of a microaneurysm
    H Kojima
    Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan
    Clin Neuropathol 26:74-9. 2007
    ..The etiology of Charcot-Bouchard microaneurysms (MAs), especially before rupture, has been unclear...
  42. ncbi Diabetes, glycaemic control and mortality risk in patients on haemodialysis: the Japan Dialysis Outcomes and Practice Pattern Study
    Y Hayashino
    Department of Epidemiology and Healthcare Research, Kyoto University Graduate School of Medicine, Konoe cho, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Diabetologia 50:1170-7. 2007
    ..There are few data on the target level of glycaemic control among patients with diabetes on haemodialysis. We investigated the impact of glycaemic control on mortality risk among diabetic patients on haemodialysis...
  43. ncbi The current status of palliative care teams in Japanese university hospitals: a nationwide questionnaire survey
    Mitsunori Miyashita
    Department of Adult Nursing Palliative Care Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japa
    Support Care Cancer 15:801-6. 2007
    ..We conducted a nationwide survey of the current status of PCTs in all (123) Japanese university hospitals...
  44. ncbi The beneficial effect of coronary-artery-bypass surgery on survival in patients with diabetic retinopathy
    Takayuki Ohno
    Department of Cardiothoracic Surgery, The University of Tokyo, Tokyo, Japan
    Eur J Cardiothorac Surg 30:881-6. 2006
    ..We studied whether revascularization by coronary-artery-bypass surgery (CABG), as compared with percutaneous coronary intervention (PCI), influences the prognosis in diabetics with retinopathy...
  45. ncbi Acute cerebellar ataxia and consecutive cerebellitis produced by glutamate receptor delta2 autoantibody
    Takashi Shiihara
    Department of Pediatrics, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Brain Dev 29:254-6. 2007
    ..Furthermore, glutamate receptor delta2 autoantibody was detected in serum and cerebro-spinal fluid. Thus, we believe that the glutamate receptor delta2 autoantibody may play a role in cerebellar ataxia and consecutive cerebellitis...
  46. ncbi Long-term exposure of human renal carcinoma cells to PD98059 induces epithelial-mesenchymal transition-like phenotype and enhanced motility
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Science, 1 7 1, Sakamoto, Nagasaki, Japan
    Mol Cell Biochem 309:69-76. 2008
    ..Our results suggest that long-term exposure of human renal carcinoma cells to PD98059 increases cell motility by upregulating Rho A-Rho kinase signaling...
  47. ncbi Repair of traumatic tricuspid regurgitation by bicuspidization
    Atsuo Doi
    Division of Cardiovascular Surgery, Funabashi Municipal Medical Center, 1 21 1, Kanasugi, Funabashi, Chiba, 273 8588, Japan
    Gen Thorac Cardiovasc Surg 55:499-501. 2007
    ..The operative technique consisted of plication of the anteroposterior commissure to create a bicuspid valve, along with ring annuloplasty...
  48. pmc Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma
    Shioto Suzuki
    Ludwig Institute for Cancer Research, Uppsala Branch, Uppsala, Sweden
    BMC Cancer 7:224. 2007
    ..This allowed us to investigate, in an orthotopic tumor model, the role of increased stromal PDGFR-beta signaling in tumor-stroma interactions...
  49. pmc Consistent aspirin use associated with improved arteriovenous fistula survival among incident hemodialysis patients in the dialysis outcomes and practice patterns study
    Takeshi Hasegawa
    Division of Nephrology, Fujiyoshida Municipal Hospital, Yamanashi, Japan
    Clin J Am Soc Nephrol 3:1373-8. 2008
    ..The relationship between aspirin use and arteriovenous fistula (AVF) survival has been lacking. The aim of this study was to evaluate the association between AVF survival and aspirin use...
  50. doi Management of fungal infections following allogeneic stem cell transplantation
    Hiroto Narimatsu
    Division of The Strategic Outcome Research Program for Cancer Control MHLW commission, Japan Cancer Society, Yurakucho Center Bldg Mullion 13F, 2 5 1, Yurakucho Chiyoda ku Tokyo, 100 0006, Japan
    Expert Rev Anti Infect Ther 6:373-84. 2008
    ..Various antifungals have recently been developed and applied to clinical use. A major change in antifungal management will probably occur in the next few years...
  51. doi The Japan HOspice and Palliative Care Evaluation study (J-HOPE study): study design and characteristics of participating institutions
    Mitsunori Miyashita
    Department of Adult Nursing Palliative Care Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Hosp Palliat Care 25:223-32. 2008
    ..In addition, the authors describe available treatments at the Japanese inpatient palliative care units and home hospices...
  52. doi Effect of a population-based educational intervention focusing on end-of-life home care, life-prolonging treatment and knowledge about palliative care
    M Miyashita
    Department of Adult Nursing Palliative Care Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Palliat Med 22:376-82. 2008
    ..This population-based educational intervention was effective in changing beliefs regarding the feasibility of home care, preference for life-prolonging treatment and attitudes toward end-of-life care...
  53. ncbi Intracranial meningioma with polygonal granular cell appearance in a Chihuahua
    Yoshinori Takeuchi
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 70:529-32. 2008
    ..Ultrastructurally, the neoplastic cells contained vesicular structures with a few small round-shaped bodies in the cytoplasm. We diagnosed the case as canine meningioma with granular cell appearance...
  54. ncbi Defect of the cerebellar vermis induced by prenatal gamma-ray irradiation in radiosensitive BALB/c mice
    Aya Saito
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Histol Histopathol 23:953-64. 2008
    ....
  55. doi Molecular analysis of endoderm regionalization
    Sadao Yasugi
    Department of Biological Sciences, Tokyo Metropolitan University, 1 1 Minamiohsawa, Hachioji, Tokyo 192 0397, Japan
    Dev Growth Differ 50:S79-96. 2008
    ....
  56. doi Midpoint fixation task: quantitative assessment of visual neglect
    Yu Chiba
    Department of Sensory and Motor System Medicines, University of Tokyo, Japan
    J Clin Neurosci 15:647-9. 2008
    ..Newly designed stimuli that lead to stable fixation and an effective calibration procedure are proposed. The method is suggested as useful in the assessment of visual neglect...
  57. ncbi Intimal sarcoma of aortic arch treated with proton therapy following surgery
    Naoyuki Ishigami
    Department of Cardiovascular Thoracic Surgery, Fujieda Municipal General Hospital, 4 1 11 Surugadai, Fujieda City 426 8677, Japan
    Asian Cardiovasc Thorac Ann 16:e12-4. 2008
    ..The newly developed proton-beam radiation therapy was applied to treat a local recurrence of the sarcoma following surgery. Positron-emission tomography/computed tomography revealed complete remission of the lesion...
  58. ncbi [Classification of acute encephalopathy with emphasis on acute encephalopathy with febrile convulsive status]
    M Mizuguchi
    No To Hattatsu 40:117-21. 2008
  59. doi Reevaluation of human leukocyte antigen DR-DQ haplotype and genotype in type 1 diabetes in the Japanese population
    Masahito Katahira
    Department of Endocrinology, Ichinomiya Municipal Hospital, Ichinomiya, Japan
    Horm Res 69:284-9. 2008
    ..This study aims at clarifying the human leukocyte antigen haplotypes and genotypes conferring susceptibility or resistance to type 1 diabetes in the Japanese population...
  60. doi Diabetic retinopathy and coronary artery disease from the cardiac surgeon's perspective
    Takayuki Ohno
    Department of Cardiothoracic Surgery, The University of Tokyo, Tokyo, Japan
    Ann Thorac Surg 85:681-9. 2008
    ....
  61. doi Clinical significance of low level human chorionic gonadotropin in the management of testicular germ cell tumor
    Akitoshi Takizawa
    Department of Urology, Yokohama City University Medical Center, Yokohama, Japan
    J Urol 179:930-4; discussion 934-5. 2008
    ..To avoid unnecessary treatment we suggest a new classification and algorithm for testicular germ cell tumors to discriminate real human chorionic gonadotropin from false-positive results...
  62. ncbi Current status and perspective of antiangiogenic therapy for cancer: urinary cancer
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Int J Clin Oncol 11:90-107. 2006
    ..In this review, we summarize these unique mechanisms and review the results of clinical trials of antiangiogenic therapy for these cancers, discussing prospects and problems relating to antiangiogenic therapy...