K Ikeyama

Summary

Affiliation: Shiseido Research Center
Country: Japan

Publications

  1. ncbi request reprint Topical application of neuronal nitric oxide synthase inhibitor accelerates cutaneous barrier recovery and prevents epidermal hyperplasia induced by barrier disruption
    Kazuyuki Ikeyama
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 127:1713-9. 2007
  2. doi request reprint Neuronal nitric oxide synthase in epidermis is involved in cutaneous circulatory response to mechanical stimulation
    Kazuyuki Ikeyama
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 130:1158-66. 2010
  3. doi request reprint Effect of endothelial nitric oxide synthase on epidermal permeability barrier recovery after disruption
    K Ikeyama
    Shiseido Innovative Science Research and Development Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Br J Dermatol 163:915-9. 2010
  4. doi request reprint Mechanical-stimulation-evoked calcium waves in proliferating and differentiated human keratinocytes
    Moe Tsutsumi
    Shiseido Research Center, 2 12 1, Fukuura, Kanazawa Ku, Yokohama, 236 8643, Japan
    Cell Tissue Res 338:99-106. 2009
  5. ncbi request reprint Epidermal keratinocytes as the forefront of the sensory system
    Mitsuhiro Denda
    Shiseido Life Science Research Center, Yokohama, Japan
    Exp Dermatol 16:157-61. 2007
  6. doi request reprint Calcium ion propagation in cultured keratinocytes and other cells in skin in response to hydraulic pressure stimulation
    Makiko Goto
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Cell Physiol 224:229-33. 2010
  7. doi request reprint Calcium ion gradients and dynamics in cultured skin slices of rat hindpaw in response to stimulation with ATP
    Moe Tsutsumi
    Shiseido Research Center, Shiseido Co, Ltd, Yokohama, Japan
    J Invest Dermatol 129:584-9. 2009
  8. doi request reprint Expressions of rod and cone photoreceptor-like proteins in human epidermis
    Moe Tsutsumi
    Shiseido Research Center, Fukuura, Kanazawa Ku, Yokohama, Japan
    Exp Dermatol 18:567-70. 2009
  9. ncbi request reprint Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice
    Akiko Harauma
    Department of Clinical Innovative Medicine, Translational Research Center, Kyoto University Hospital, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 358:751-6. 2007

Collaborators

  • Kaori Inoue
  • M Denda
  • Hirofumi Aoki
  • Moe Tsutsumi
  • Sumiko Denda
  • Makiko Goto
  • Akiko Harauma
  • Jotaro Nakanishi
  • Shigeyoshi Fuziwara
  • Hidenori Arai
  • Kaeko Kamei
  • Ryo Takano
  • Saburo Hara
  • Toshinori Murayama
  • Masayuki Yokode
  • Toru Kita
  • Hideto Sano

Detail Information

Publications9

  1. ncbi request reprint Topical application of neuronal nitric oxide synthase inhibitor accelerates cutaneous barrier recovery and prevents epidermal hyperplasia induced by barrier disruption
    Kazuyuki Ikeyama
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 127:1713-9. 2007
    ..These results suggest that NO plays an important signaling role in cutaneous barrier homeostasis and in epidermal hyperplasia induced by barrier disruption...
  2. doi request reprint Neuronal nitric oxide synthase in epidermis is involved in cutaneous circulatory response to mechanical stimulation
    Kazuyuki Ikeyama
    Shiseido Research Center, Yokohama, Japan
    J Invest Dermatol 130:1158-66. 2010
    ..These results are consistent with the idea that NO generated by epidermal nNOS has a significant role in the cutaneous circulatory response to mechanical stimulation...
  3. doi request reprint Effect of endothelial nitric oxide synthase on epidermal permeability barrier recovery after disruption
    K Ikeyama
    Shiseido Innovative Science Research and Development Center, 2 12 1 Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    Br J Dermatol 163:915-9. 2010
    ..We previously demonstrated that neuronal nitric oxide synthase (nNOS) in epidermal keratinocytes is associated with epidermal permeability barrier homeostasis...
  4. doi request reprint Mechanical-stimulation-evoked calcium waves in proliferating and differentiated human keratinocytes
    Moe Tsutsumi
    Shiseido Research Center, 2 12 1, Fukuura, Kanazawa Ku, Yokohama, 236 8643, Japan
    Cell Tissue Res 338:99-106. 2009
    ..Thus, signaling via gap junctions might be involved in the induction of calcium waves in response to mechanical stress at the upper layer of the epidermis...
  5. ncbi request reprint Epidermal keratinocytes as the forefront of the sensory system
    Mitsuhiro Denda
    Shiseido Life Science Research Center, Yokohama, Japan
    Exp Dermatol 16:157-61. 2007
    ..e. first, keratinocytes recognize various environmental factors, and then the information is processed and conveyed to the nervous system...
  6. doi request reprint Calcium ion propagation in cultured keratinocytes and other cells in skin in response to hydraulic pressure stimulation
    Makiko Goto
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Cell Physiol 224:229-33. 2010
    ..These results suggest that differentiated keratinocytes are sensitive to external pressure and that TRP might be involved in the mechanism of their response...
  7. doi request reprint Calcium ion gradients and dynamics in cultured skin slices of rat hindpaw in response to stimulation with ATP
    Moe Tsutsumi
    Shiseido Research Center, Shiseido Co, Ltd, Yokohama, Japan
    J Invest Dermatol 129:584-9. 2009
    ..These results suggest that the response to stimulation of keratinocytes in cultured skin slices varies depending upon the location (depth) within the epidermis...
  8. doi request reprint Expressions of rod and cone photoreceptor-like proteins in human epidermis
    Moe Tsutsumi
    Shiseido Research Center, Fukuura, Kanazawa Ku, Yokohama, Japan
    Exp Dermatol 18:567-70. 2009
    ..PCR analysis confirmed the expression of rhodopsin-like and opsin-like genes in human retina and the skin. These results suggest that a series of proteins, which play a crucial role in visual perception, are expressed in human epidermis...
  9. ncbi request reprint Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice
    Akiko Harauma
    Department of Clinical Innovative Medicine, Translational Research Center, Kyoto University Hospital, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 358:751-6. 2007
    ..Aqueous extract of ML had a strong scavenging effect on 1,1-diphenyl-2-picrylhydrazyl and inhibited lipoprotein oxidation. These results confirm that ML contains anti-oxidative substances that might help prevent atherosclerosis...