T Saida

Summary

Affiliation: Shinshu University
Country: Japan

Publications

  1. ncbi request reprint Histopathological characteristics of malignant melanoma affecting mucous membranes: a unifying concept of histogenesis
    Toshiaki Saida
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Pathology 36:404-13. 2004
  2. ncbi request reprint Significance of dermoscopic patterns in detecting malignant melanoma on acral volar skin: results of a multicenter study in Japan
    Toshiaki Saida
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Arch Dermatol 140:1233-8. 2004
  3. ncbi request reprint Lessons learned from studies of the development of early melanoma
    Toshiaki Saida
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Int J Clin Oncol 10:371-4. 2005
  4. ncbi request reprint Dermoscopy for acral pigmented skin lesions
    Toshiaki Saida
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Clin Dermatol 20:279-85. 2002
  5. ncbi request reprint Malignant melanoma on the sole: how to detect the early lesions efficiently
    T Saida
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Pigment Cell Res 13:135-9. 2000
  6. ncbi request reprint Recent advances in melanoma research
    T Saida
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, 390 8621, Matsumoto, Japan
    J Dermatol Sci 26:1-13. 2001
  7. pmc Mutation analysis of BRAF and KIT in circulating melanoma cells at the single cell level
    K Sakaizawa
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Br J Cancer 106:939-46. 2012
  8. doi request reprint Dermoscopy of pigmented lesions on mucocutaneous junction and mucous membrane
    J Lin
    Department of Dermatology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Br J Dermatol 161:1255-61. 2009
  9. ncbi request reprint Loss of beta-catenin expression associated with disease progression in malignant melanoma
    T Kageshita
    Department of Dermatology, Kumamoto University School of Medicine, 1 1 Honjo, Kumamoto 860 0811, Japan
    Br J Dermatol 145:210-6. 2001
  10. ncbi request reprint Growth dynamics of acquired melanocytic nevi. Higher reactivity of proliferating cell nuclear antigen in junctional and compound nevi than intradermal nevi
    Y Tokuda
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    J Am Acad Dermatol 31:220-4. 1994

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Histopathological characteristics of malignant melanoma affecting mucous membranes: a unifying concept of histogenesis
    Toshiaki Saida
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Pathology 36:404-13. 2004
    ..Particular attention was paid to elucidation of morphological characteristics of early phases of mucosal melanoma in order to contribute to effective detection of this highly malignant neoplasm in the curable stages...
  2. ncbi request reprint Significance of dermoscopic patterns in detecting malignant melanoma on acral volar skin: results of a multicenter study in Japan
    Toshiaki Saida
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Arch Dermatol 140:1233-8. 2004
    ....
  3. ncbi request reprint Lessons learned from studies of the development of early melanoma
    Toshiaki Saida
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Int J Clin Oncol 10:371-4. 2005
  4. ncbi request reprint Dermoscopy for acral pigmented skin lesions
    Toshiaki Saida
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Clin Dermatol 20:279-85. 2002
  5. ncbi request reprint Malignant melanoma on the sole: how to detect the early lesions efficiently
    T Saida
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Pigment Cell Res 13:135-9. 2000
    ..The author believes the guidelines surely work efficiently in screening early MM on the sole...
  6. ncbi request reprint Recent advances in melanoma research
    T Saida
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, 390 8621, Matsumoto, Japan
    J Dermatol Sci 26:1-13. 2001
    ..Finally, the concept of molecular classification of melanoma by gene expression profile is introduced, which possibly enables us to give the tailor-made therapy for each melanoma patient in the near future...
  7. pmc Mutation analysis of BRAF and KIT in circulating melanoma cells at the single cell level
    K Sakaizawa
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Br J Cancer 106:939-46. 2012
    ..Circulating tumour cells (CTC) are present in the peripheral blood of a significant proportion of cancer patients...
  8. doi request reprint Dermoscopy of pigmented lesions on mucocutaneous junction and mucous membrane
    J Lin
    Department of Dermatology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Br J Dermatol 161:1255-61. 2009
    ..The dermoscopic features of pigmented lesions on the mucocutaneous junction and mucous membrane are different from those on hairy skin. Differentiation between benign lesions and malignant melanomas of these sites is often difficult...
  9. ncbi request reprint Loss of beta-catenin expression associated with disease progression in malignant melanoma
    T Kageshita
    Department of Dermatology, Kumamoto University School of Medicine, 1 1 Honjo, Kumamoto 860 0811, Japan
    Br J Dermatol 145:210-6. 2001
    ..beta-catenin plays a crucial role in the function of cell adhesion molecules and also participates in growth regulatory signalling pathways that may be involved in malignant transformation...
  10. ncbi request reprint Growth dynamics of acquired melanocytic nevi. Higher reactivity of proliferating cell nuclear antigen in junctional and compound nevi than intradermal nevi
    Y Tokuda
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    J Am Acad Dermatol 31:220-4. 1994
    ..CONCLUSION: The findings of the present study are in accordance with an epidermal melanocytic origin of acquired melanocytic nevi...
  11. ncbi request reprint Effective detection of plantar malignant melanoma
    T Saida
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Int J Dermatol 32:722-5. 1993
    ..CONCLUSIONS: The present study confirmed the validity of the 7-mm criterion for the early effective detection of plantar malignant melanoma...
  12. pmc Polyclonality of BRAF mutations in primary melanoma and the selection of mutant alleles during progression
    J Lin
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Br J Cancer 104:464-8. 2011
    ..2009; 101:1423-7). Here, we tested whether similar heterogeneity of BRAF mutations exists in primary melanomas...
  13. ncbi request reprint New immunodeficient (nude-scid, beige-scid) mice as excellent recipients of human skin grafts containing intraepidermal neoplasms
    Y Takizawa
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Arch Dermatol Res 289:213-8. 1997
    ..The present study revealed that nude-scid and beige-scide mice newly produced by us provide a very useful in vivo experimental model for the investigation of carcinogenesis and tumor progression in human skin...
  14. ncbi request reprint Increased synthesis of hyaluronate enhances motility of human melanoma cells
    T Ichikawa
    Department of Dermatology, Angio Aging Division, Research Center on Aging and Adaptation, Shinshu University School of Matsumoto, Japan
    J Invest Dermatol 113:935-9. 1999
    ..These results suggest that hyaluronate may play a role in the aggressiveness of human melanoma cells...
  15. ncbi request reprint Reduced expression of actin-binding proteins, h-caldesmon and calponin h1, in the vascular smooth muscle inside melanoma lesions: an adverse prognostic factor for malignant melanoma
    Y Koganehira
    Department of Dermatology, Molecular Oncology and Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Br J Dermatol 148:971-80. 2003
    ..Objectives To clarify the characteristics of small arteries and small veins of melanoma lesions...
  16. ncbi request reprint Loricrin keratoderma: a cause of congenital ichthyosiform erythroderma and collodion baby
    K Matsumoto
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Br J Dermatol 145:657-60. 2001
    ..We conclude that loricrin gene mutation may present as congenital ichthyosiform erythroderma, and should be included in the differential diagnosis of collodion baby...
  17. ncbi request reprint Genetic and epigenetic alterations in the differential diagnosis of malignant melanoma and spitzoid lesion
    M Takata
    Department of Dermatology, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto 390 8621, Japan
    Br J Dermatol 156:1287-94. 2007
    ..The histopathological differentiation of malignant melanoma and Spitz naevus often presents diagnostic problems...
  18. ncbi request reprint Chronic obesity lymphoedematous mucinosis: three cases of pretibial mucinosis in obese patients with pitting oedema
    Y Tokuda
    Division of Dermatology, Matsumoto National Hospital, 1209 Yoshikawa Murai cho, Matsumoto, Nagano 399 8701, Japan
    Br J Dermatol 154:157-61. 2006
    ..We propose that the present cases of 'chronic obesity lymphoedematous mucinosis' belong to the clinical entity of pretibial mucinosis...
  19. ncbi request reprint Growth inhibition of human malignant melanoma transfected with the human interferon-beta gene by means of cationic liposomes
    T Kageshita
    Department of Dermatology, Kumamoto University School of Medicine, Japan
    Melanoma Res 11:337-42. 2001
    ..These data suggest that transfection of the HuIFNbeta gene using cationic liposomes is a promising candidate for gene therapy of human melanoma...
  20. ncbi request reprint Expression of lamins depends on epidermal differentiation and transformation
    M Oguchi
    Departments of Dermatology and Molecular Oncology and Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Br J Dermatol 147:853-8. 2002
    ..It has been suggested that A- and B-type lamins, proteins of the nuclear lamina, play important roles in the morphogenesis of the nucleus and cellular differentiation...
  21. ncbi request reprint Solid facial edema in a patient with rosacea
    H Uhara
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    J Dermatol 27:214-6. 2000
    ..The patient was treated with fleroxacin (100 mg/day, orally) for two weeks with a marked reduction of both solid facial edema and periorbital edema...
  22. ncbi request reprint Estrogen-receptor-alpha-positive extramammary Paget's disease treated with hormonal therapy
    M Iijima
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Dermatology 213:144-6. 2006
    ..During a follow-up period of 22 months, performance status was well maintained for 17 months. Hormonal therapy may be an alternative for selected cases of advanced extramammary Paget's disease...
  23. ncbi request reprint Docetaxel induced durable response in advanced extramammary Paget's disease: a case report
    Shinji Oguchi
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    J Dermatol 29:33-7. 2002
    ..The partial response persisted for more than 12 months and the patient was able to enjoy daily life. Docetaxel may be an effective drug for patients with advanced extramammary Paget's disease...
  24. ncbi request reprint [Melanoma]
    Toshiaki Saida
    Dept of Dermatology, Shinshu University School of Medicine
    Gan To Kagaku Ryoho 33:1386-91. 2006
    ..No effective chemotherapy or biotherapy has been established to date, however, interesting new findings were recently reported in the fields of immunotherapy and molecular targeting therapy...
  25. ncbi request reprint Repeated cationic multilamellar liposome-mediated gene transfer enhanced transduction efficiency against murine melanoma cell lines
    Misato Nobayashi
    Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    J Dermatol Sci 29:206-13. 2002
    ....
  26. ncbi request reprint Genetic alterations in melanocytic tumors
    Minoru Takata
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Dermatol Sci 43:1-10. 2006
    ..The clear differences in genetic aberration patterns have significant clinical implications in the diagnosis and treatment of melanocytic tumors...
  27. ncbi request reprint A new melanoma antigen fatty acid-binding protein 7, involved in proliferation and invasion, is a potential target for immunotherapy and molecular target therapy
    Yasufumi Goto
    Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Shinanomachi, Tokyo, Japan
    Cancer Res 66:4443-9. 2006
    ..These results showed that FABP7 is frequently expressed in melanoma, may be involved in cell proliferation and invasion, and may be a potential target for development of diagnostic and therapeutic methods...
  28. ncbi request reprint Early acral melanoma in situ: correlation between the parallel ridge pattern on dermoscopy and microscopic features
    Yasushi Ishihara
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Dermatopathol 28:21-7. 2006
    ..We propose that a finding of preferential proliferation of solitary arranged melanocytes in the crista profunda intermedia is an important clue for the histopathological diagnosis of early phases of acral melanoma...
  29. ncbi request reprint [Malignant melanoma]
    Kazuhiko Matsumoto
    Clinical Trial and Research Center, Shinshu University Hospital
    Nihon Rinsho 64:1321-6. 2006
    ..In addition, we have recently performed a phase I/IIa trial of IFNbeta gene therapy for advanced melanoma patients...
  30. ncbi request reprint Early cancers of the skin: clinical, histopathological, and molecular characteristics
    Minoru Takata
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Int J Clin Oncol 10:391-7. 2005
    ..Precise molecular analyses of early stages of skin cancers may have a strong impact on our understanding of in vivo development of cancers in other human organs...
  31. ncbi request reprint Nonpigmenting solitary fixed drug eruption caused by a Chinese traditional herbal medicine, ma huang (Ephedra Hebra), mainly containing pseudoephedrine and ephedrine
    Kazuhiko Matsumoto
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    J Am Acad Dermatol 48:628-30. 2003
    ..The causative drug was determined by closed patch test on postlesional skin as a Chinese traditional herbal medicine, ma huang (Ephedra Hebra), mainly containing pseudoephedrine and ephedrine...
  32. ncbi request reprint Establishment of a novel melanoma cell line SMYM-PRGP showing cytogenetic and biological characteristics of the radial growth phase of acral melanomas
    Hiroshi Murata
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Cancer Sci 98:958-63. 2007
    ..SMYM-PRGP is an excellent tool for investigating the development and progression of acral melanoma...
  33. ncbi request reprint [Guidelines for proper use of antineoplastic agents. Skin cancer]
    Hisashi Uhara
    Gan To Kagaku Ryoho 29:1074-80. 2002
  34. ncbi request reprint Malignant melanoma on the sole showing prominent neural differentiation and perineural infiltration
    Koichi Hayashi
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Int J Dermatol 41:247-9. 2002
  35. doi request reprint Anatomic transitions and the histopathologic features of melanocytic nevi
    Toshiaki Saida
    Arch Dermatol 144:1232-3; author reply 1233-4. 2008
  36. doi request reprint Computer-based classification of dermoscopy images of melanocytic lesions on acral volar skin
    Hitoshi Iyatomi
    Department of Electronic Informatics, Hosei University Faculty of Engineering, Koganei, Tokyo, Japan
    J Invest Dermatol 128:2049-54. 2008
    ..These also achieved good detection accuracy as indicated by their AUC values: 0.985, 0.931, and 0.890, respectively. The features used in the melanoma-nevus classifier and the parallel ridge detector have significant overlap...
  37. doi request reprint Statistical profiles of malignant melanoma and other skin cancers in Japan: 2007 update
    Kazuyuki Ishihara
    The Institute for Analysis of Prognostic Factors in Skin Cancer, 3 14 9 Tsukishima, Chuo Ku, Tokyo, 104 0052, Japan
    Int J Clin Oncol 13:33-41. 2008
    ..In the present study, patients registered from 1997 to 2001 (group C) were investigated and the data were compared with findings obtained by the subsequent follow-up of groups A and B...
  38. ncbi request reprint Urethral advancement procedure for reconstruction after excision of male parameatal melanoma in situ
    Haruaki Kato
    Department of Urology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Urol Int 74:183-4. 2005
    ..We successfully reconstructed the glans penis and external meatus by means of the urethral mobilization and advancement technique for an adult patient with a parameatal lesion of melanoma in situ...
  39. ncbi request reprint Multiple hypersonographic spots in basal cell carcinoma
    Hisashi Uhara
    Department of Dermatology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Dermatol Surg 33:1215-9. 2007
    ..Its contribution to diagnosis is generally limited, however. Recently, we observed hypersonographic spots in some cases of basal cell carcinoma...
  40. ncbi request reprint Usefulness of monoclonal antibody HIK1083 specific for gastric O-glycan in differentiating cutaneous metastasis of gastric cancer from primary sweat gland carcinoma
    Miwako Iijima
    Department of Dermatology, School of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Dermatopathol 29:452-6. 2007
    ....
  41. ncbi request reprint Eccrine porocarcinoma: clinical and pathological studies of 12 cases
    Junko Shiohara
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    J Dermatol 34:516-22. 2007
    ..Death was correlated with a pathological growth pattern and clinical lymph node metastasis. Sentinel lymph node biopsy was performed usefully in two patients...
  42. ncbi request reprint Specific dermoscopy patterns and amplifications of the cyclin D1 gene to define histopathologically unrecognizable early lesions of acral melanoma in situ
    Maki Yamaura
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    Arch Dermatol 141:1413-8. 2005
    ..To define early lesions of acral melanoma in situ that cannot be recognized histopathologically...
  43. ncbi request reprint Carbonic anhydrase II is a tumor vessel endothelium-associated antigen targeted by dendritic cell therapy
    Kenta Yoshiura
    Department of Advanced Medical Science, University of Tokyo, Japan
    Clin Cancer Res 11:8201-7. 2005
    ....
  44. ncbi request reprint Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet
    Giuseppe Argenziano
    Department of Dermatology, Second University of Naples, Italy
    J Am Acad Dermatol 48:679-93. 2003
    ..There is a need for better standardization of the dermoscopic terminology in assessing pigmented skin lesions...
  45. ncbi request reprint Number of acquired melanocytic nevi in patients with melanoma and control subjects in Japan: Nevus count is a significant risk factor for nonacral melanoma but not for acral melanoma
    Shiho Rokuhara
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    J Am Acad Dermatol 50:695-700. 2004
    ..However, there are only a few population-based studies on acquired nevi in Asian populations, and no epidemiologic study on relationship between number of acquired nevi and melanoma in Japanese populations has been reported...
  46. ncbi request reprint [Angiosarcoma]
    Toshiaki Saida
    Dept of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Gan To Kagaku Ryoho 31:351-5. 2004
    ..In this review, recent advances in the management of this neoplasm are discussed, including those in surgery, radiation, chemotherapy and biotherapy...
  47. ncbi request reprint Diagnosis and categorization of acral melanocytic lesions using teledermoscopy
    Domenico Piccolo
    Department of Dermatology, University of L Aquila, L Aquila, Italy
    J Telemed Telecare 10:346-50. 2004
    ..Teledermoscopy represents a useful tool for the diagnosis of acral melanoma and for the categorization of patterns that suggest benign or potentially malignant acral melanocytic lesions...
  48. ncbi request reprint Solitary eccrine syringofibroadenoma
    Takeshi Ichikawa
    J Dermatol 30:853-4. 2003
  49. ncbi request reprint ASC/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma
    Xin Guan
    Department of Molecular Oncology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Nagano, Japan
    Int J Cancer 107:202-8. 2003
    ..Our study shows that ASC is downregulated in melanoma, and that its suppression is partially mediated by aberrant methylation...
  50. ncbi request reprint Growth inhibition of subcutaneous mouse melanoma and induction of natural killer cells by liposome-mediated interferon-beta gene therapy
    Yasushi Ryuke
    Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Melanoma Res 13:349-56. 2003
    ..Taken together, our data suggest that cationic liposome-mediated IFNbeta gene therapy could be effective against melanoma by directly inducing cell death and stimulating NK cells...
  51. ncbi request reprint The place of lymphatic mapping and sentinel node biopsy in oncology
    Alistair J Cochran
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    Int J Clin Oncol 8:139-50. 2003
    ..They also provide unique opportunities for basic and translational research...
  52. ncbi request reprint [Inter-hospital teledermatology conference using a videophone network]
    Yoriko Yamazaki
    Department of Dermatology, Shinshu University School of Medicine
    Igaku Butsuri 23:40-3. 2003
    ..The ease with which the data can be manipulated enables us to discuss difficult cases in detail. This style of teleconference system may have benefits for dermatologists especially at rural hospitals in consultation with senior doctors...
  53. ncbi request reprint Genome profiling of melanocytic tumors using multiplex ligation-dependent probe amplification (MLPA): Its usefulness as an adjunctive diagnostic tool for melanocytic tumors
    Minoru Takata
    Department of Dermatology, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto 390 8621, Japan
    J Dermatol Sci 40:51-7. 2005
    ..The histopathology of melanocytic tumors sometimes presents diagnostic problems. Applicable parameters other than routine pathology are needed...
  54. ncbi request reprint Constitutive activation of the mitogen-activated protein kinase signaling pathway in acral melanomas
    Minoru Takata
    Department of Dermatology, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto, Japan
    J Invest Dermatol 125:318-22. 2005
    ..This provides a rational basis to include acral melanomas into the clinical trials with MAPK inhibitors...
  55. ncbi request reprint [Sentinel node navigation surgery in melanoma and non-melanoma malignant skin tumor]
    Yoshio Kiyohara
    Dermatology Division, Shizuoka Cancer Center
    Gan To Kagaku Ryoho 32:1191-4. 2005
    ..SNB should be applied for patients with Paget's carcinoma as a diagnostic method of lymphnode metastasis and to determine the indication of lymphnode dissection, and its usefulness must be analyzed in the near future...
  56. ncbi request reprint [Cutaneous toxicities]
    Kazuhiko Matsumoto
    Department of Dermatology, Shinshu University School of Medicine
    Gan To Kagaku Ryoho 35:1645-8. 2008
    ..Therefore, the presence of these cutaneous toxicities may serve as a surrogate marker of treatment efficacy and a predictor of survival...
  57. ncbi request reprint Results of a phase I clinical study using autologous tumour lysate-pulsed monocyte-derived mature dendritic cell vaccinations for stage IV malignant melanoma patients combined with low dose interleukin-2
    Hitomi Nagayama
    Division of Cell Processing, Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Melanoma Res 13:521-30. 2003
    ....
  58. doi request reprint A case of primary Epstein-Barr virus-associated cutaneous diffuse large B-cell lymphoma unassociated with iatrogenic or endogenous immune dysregulation
    Yasutaka Tokuda
    Department of Dermatology, Matsumoto National Hospital, Matsumoto, Japan
    J Cutan Pathol 35:666-71. 2008
    ..Immunostaining for viral proteins showed the patient to be positive for latent membrane protein 1 (LMP-1) and negative for Epstein-Barr virus nuclear antigen-1 (EBNA-2), indicating that a type II latency EBV infection pattern...
  59. ncbi request reprint Genetic control directed toward spontaneous IFN-alpha/IFN-beta responses and downstream IFN-gamma expression influences the pathogenesis of a murine psoriasis-like skin disease
    Fuyuko Arakura
    Department of Immunology and Infectious Diseases, Graduate School of Medicine, Shinshu University, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Immunol 179:3249-57. 2007
    ....
  60. ncbi request reprint Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University
    Cancer Sci 94:308-13. 2003
    ..This study supports the combined use of IT and IH using MCLs in patients with advanced malignancies...
  61. ncbi request reprint [Gene therapy for patients with malignant melanoma]
    Toshiaki Saida
    Department of Dermatology, Shinshu University School of Medicine
    Nihon Rinsho 63:566-71. 2005
  62. ncbi request reprint Anatomical and histopathological correlates of the dermoscopic patterns seen in melanocytic nevi on the sole: a retrospective study
    Atsushi Miyazaki
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    J Am Acad Dermatol 53:230-6. 2005
    ..Anatomical and histopathologic correlates of the unique dermoscopic patterns seen in melanocytic nevi on acral volar skin is yet to be clarified...
  63. ncbi request reprint Intratumoral injection of immature dendritic cells enhances antitumor effect of hyperthermia using magnetic nanoparticles
    Kouji Tanaka
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya, Japan
    Int J Cancer 116:624-33. 2005
    ..This study has important implications for the application of MCL-induced hyperthermia plus DC therapy in patients with advanced malignancies as a novel cancer therapy...
  64. ncbi request reprint High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi
    Nami Ichii-Nakato
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan
    J Invest Dermatol 126:2111-8. 2006
    ..Most of these nevi with wild-type BRAF had neroblastoma ras viral oncogene homolog mutations (9/14, 64.3%), suggesting different pathogenesis of medium-sized congenital nevi from acquired nevi and small congenital nevi...
  65. ncbi request reprint Calponin h1 suppresses tumor growth of Src-induced transformed 3Y1 cells in association with a decrease in angiogenesis
    Miwako Kaneko
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Jpn J Cancer Res 93:935-43. 2002
    ..These results suggest that CNh1 plays a role as tumor suppressor in SR-3Y1 mainly by decreasing VEGF expression and angiogenesis in vivo and partially through reducing cellular proliferative potential and cell motility...
  66. ncbi request reprint Lymphangitis of the foot demonstrating lymphatic drainage pathways from the sole
    Hisashi Uhara
    Department of Dermatology, Shinshu University, School of Medicine, Nagano, Japan
    J Am Acad Dermatol 47:502-4. 2002
    ..There are two main lymphatic routes from the lower extremity: the fibular route to the popliteal node and the tibial route to the distant groin node. However, little is known about lymphatics from the sole...
  67. ncbi request reprint Histogenesis of congenital and acquired melanocytic nevi: a unifying concept
    Toshiaki Saida
    Am J Dermatopathol 28:377-9. 2006
  68. ncbi request reprint Skin infiltration of juvenile myelomonocytic leukemia
    Kazuhiko Matsumoto
    Department of Dermatology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Dermatol 31:748-51. 2004
    ..JMML cells in some patients, including our case, seem to have a great affinity for the skin, and skin biopsy aids in early detection of this disease...
  69. ncbi request reprint Systemic plasmacytosis with aseptic bone necrosis and high fever
    Masao Fukuzawa
    J Dermatol 31:696-8. 2004
  70. ncbi request reprint Heat immunotherapy using magnetic nanoparticles and dendritic cells for T-lymphoma
    Kouji Tanaka
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Biosci Bioeng 100:112-5. 2005
    ..5% (1/8) in the case of mice treated by hyperthermia alone. This novel cancer therapy, which we have termed "heat immunotherapy", may be applicable to patients with advanced malignancies...
  71. ncbi request reprint Dermoscopic patterns of acral melanocytic nevi: their variations, changes, and significance
    Toshiaki Saida
    Arch Dermatol 143:1423-6. 2007