Kenichi Koike

Summary

Affiliation: Shinshu University
Country: Japan

Publications

  1. doi request reprint Recent advances in the pathogenesis and management of juvenile myelomonocytic leukaemia
    Kenichi Koike
    Department of Paediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Br J Haematol 141:567-75. 2008
  2. ncbi request reprint [Medical support for Belarus after Chernobyl accident using a telemedicine system]
    Kenichi Koike
    Department of Pediatrics, Shinshu University Hospital, Matsumoto, Japan
    Igaku Butsuri 23:44-50. 2003
  3. ncbi request reprint Serum levels of free light chain before and after chemotherapy in primary systemic AL amyloidosis
    Masayuki Matsuda
    Third Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Intern Med 44:428-33. 2005
  4. ncbi request reprint VAD with or without subsequent high-dose melphalan followed by autologous stem cell support in AL amyloidosis: Japanese experience and criteria for patient selection
    Takahisa Gono
    Third Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Amyloid 11:245-56. 2004
  5. ncbi request reprint High-dose melphalan followed by autologous stem cell support in primary systemic AL amyloidosis with multiple organ involvement
    Yasuhiro Shimojima
    Third Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Intern Med 44:484-9. 2005
  6. doi request reprint Intrathecal donor lymphocyte infusion for isolated leukemia relapse in the central nervous system following allogeneic stem cell transplantation: a case report and literature review
    Ryu Yanagisawa
    Department of Pediatrics, Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto, 390 8621, Japan
    Int J Hematol 103:107-11. 2016
  7. doi request reprint Critical illness polyneuropathy and myopathy caused by Bacillus cereus sepsis in acute lymphoblastic leukemia
    Koichi Hirabayashi
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    J Pediatr Hematol Oncol 34:e110-3. 2012
  8. ncbi request reprint Evaluation of intensive chemotherapy in AL amyloidosis: usefulness of flow cytometric analysis of plasma cells in bone marrow
    Masayuki Matsuda
    Third Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto
    Amyloid 10:250-6. 2003
  9. doi request reprint Genetic analysis of TP53 in childhood myelodysplastic syndrome and juvenile myelomonocytic leukemia
    Shoji Saito
    Department of Pediatrics, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Leuk Res 35:1578-84. 2011
  10. doi request reprint Analysis of KRAS and NRAS Gene Mutations in Arab Asian Children With Acute Leukemia: High Frequency of RAS Mutations in Acute Lymphoblastic Leukemia
    Lika a Fasih Y Al-Kzayer
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Pediatr Blood Cancer 62:2157-61. 2015

Detail Information

Publications99

  1. doi request reprint Recent advances in the pathogenesis and management of juvenile myelomonocytic leukaemia
    Kenichi Koike
    Department of Paediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Br J Haematol 141:567-75. 2008
    ..We also review molecularly targeted therapeutics that interfere with the disrupted activation of the RAS signal transduction pathway...
  2. ncbi request reprint [Medical support for Belarus after Chernobyl accident using a telemedicine system]
    Kenichi Koike
    Department of Pediatrics, Shinshu University Hospital, Matsumoto, Japan
    Igaku Butsuri 23:44-50. 2003
    ..The system consists of a TV conference system, a digital microscopic imaging system and a high-definition image server/viewer network system (DICOM). The detailed case conference is possible among three areas of physicians...
  3. ncbi request reprint Serum levels of free light chain before and after chemotherapy in primary systemic AL amyloidosis
    Masayuki Matsuda
    Third Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Intern Med 44:428-33. 2005
    ..To investigate whether FLCs are useful as a diagnostic and therapeutic marker in Japanese patients with primary systemic AL amyloidosis, we determined these values in serum before and after chemotherapy...
  4. ncbi request reprint VAD with or without subsequent high-dose melphalan followed by autologous stem cell support in AL amyloidosis: Japanese experience and criteria for patient selection
    Takahisa Gono
    Third Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Amyloid 11:245-56. 2004
    ..In patients who cannot tolerate high-dose melphalan, VAD alone is a potent therapeutic option, although there are possible harmful effects on the heart and peripheral nerve...
  5. ncbi request reprint High-dose melphalan followed by autologous stem cell support in primary systemic AL amyloidosis with multiple organ involvement
    Yasuhiro Shimojima
    Third Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Intern Med 44:484-9. 2005
    ..When amyloidosis-related dysfunction is seen in multiple organs, this intensive chemotherapy might be a possible therapeutic option, although several modifications in the regimen and careful management are necessary...
  6. doi request reprint Intrathecal donor lymphocyte infusion for isolated leukemia relapse in the central nervous system following allogeneic stem cell transplantation: a case report and literature review
    Ryu Yanagisawa
    Department of Pediatrics, Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto, 390 8621, Japan
    Int J Hematol 103:107-11. 2016
    ..However, we suggest that IDLI remains a feasible and safe option, as no GVHD or other adverse effects occurred, even in the HLA-haploidentical setting. We will make further efforts to increase the efficacy...
  7. doi request reprint Critical illness polyneuropathy and myopathy caused by Bacillus cereus sepsis in acute lymphoblastic leukemia
    Koichi Hirabayashi
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    J Pediatr Hematol Oncol 34:e110-3. 2012
    ..He was discharged 1 year after the initiation of chemotherapy, and remission has been maintained without inconvenience to daily living activities for 3 years since disease onset...
  8. ncbi request reprint Evaluation of intensive chemotherapy in AL amyloidosis: usefulness of flow cytometric analysis of plasma cells in bone marrow
    Masayuki Matsuda
    Third Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto
    Amyloid 10:250-6. 2003
    ....
  9. doi request reprint Genetic analysis of TP53 in childhood myelodysplastic syndrome and juvenile myelomonocytic leukemia
    Shoji Saito
    Department of Pediatrics, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Leuk Res 35:1578-84. 2011
    ..His poor outcome might be associated with resistance to chemotherapy/radiation of a minor clone with both TP53 gene alteration and MLL duplication that already existed at onset...
  10. doi request reprint Analysis of KRAS and NRAS Gene Mutations in Arab Asian Children With Acute Leukemia: High Frequency of RAS Mutations in Acute Lymphoblastic Leukemia
    Lika a Fasih Y Al-Kzayer
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Pediatr Blood Cancer 62:2157-61. 2015
    ....
  11. doi request reprint Successful cord blood transplantation after repeated transfusions of unmobilized neutrophils in addition to antifungal treatment in an infant with chronic granulomatous disease complicated by invasive pulmonary aspergillosis
    Tomonari Shigemura
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan Division of Hematology, Oncology, and Immunology, Nagano Children s Hospital, Azumino, Japan Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan Division of Transfusion Medicine, Cell Processing Center, Shinshu University Hospital Department of Infection and Host Defense, Shinshu University, Graduate School of Medicine, Matsumoto, Japan
    Transfusion 54:516-21. 2014
    ..The management of life-threatening Aspergillus infections in CGD is particularly difficult because some infections cannot be eradicated with standard antifungal treatments and, hence, result in death...
  12. ncbi request reprint STI571 inhibits growth and adhesion of human mast cells in culture
    Kouichi Takeuchi
    Department of Pediatrics, Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto, 390 8621, Japan
    J Leukoc Biol 74:1026-34. 2003
    ..Our results may provide a fundamental insight for the clinical application of STI571 in allergic disorders...
  13. doi request reprint Ela2 mutations and clinical manifestations in familial congenital neutropenia
    Masaaki Shiohara
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    J Pediatr Hematol Oncol 31:319-24. 2009
    ..The contents of the neutrophil-specific granule proteins cathelicidin antimicrobial peptide and neutrophil gelatinase-associated lipocalin were also analyzed in SCN...
  14. ncbi request reprint Long-term follow-up of plasma cells in bone marrow and serum free light chains in primary systemic AL amyloidosis
    Takuhiro Yoshida
    Department of Internal Medicine Neurology and Rheumatology, Shinshu University School of Medicine, Matsumoto
    Intern Med 47:1783-90. 2008
    ..To prospectively investigate the production of M-protein and plasma cells in bone marrow before and after chemotherapy, we performed flow cytometry and analysis of serum free light chains (FLCs)...
  15. doi request reprint Usefulness of allogeneic hematopoietic stem cell transplantation in first complete remission for pediatric blastic plasmacytoid dendritic cell neoplasm with skin involvement: a case report and review of literature
    Kazuo Sakashita
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Pediatr Blood Cancer 60:E140-2. 2013
    ..Accordingly, it is important to determine whether allogeneic hematopoietic stem cell transplantation should be applied to first complete remission in the patients with poor prognosis...
  16. doi request reprint Increased pretransplant QT dispersion as a risk factor for the development of cardiac complications during and after preparative conditioning for pediatric allogeneic hematopoietic stem cell transplantation
    Noriko Motoki
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto Department of Pediatrics, Nagano National Hospital, Ueda, Japan
    Pediatr Transplant 14:986-92. 2010
    ..Increases in QTD and QTcD during the pretreatment period may be risk factors for the development of cardiac complications during and after conditioning for pediatric HSCT...
  17. doi request reprint Low toxicity of a conditioning with 8-Gy total body irradiation, fludarabine and cyclophosphamide as preparative regimen for allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies
    Ryu Yanagisawa
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Pediatr Transplant 13:737-45. 2009
    ..The intermediate-dose TBI-based conditioning regimen may confer successful engraftment combined with minimized RRT, although its efficacy should be further evaluated...
  18. pmc Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD116 on CD34(+) cells of juvenile myelomonocytic leukemia
    Yozo Nakazawa
    Department of Pediatrics, Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto, 390 8621, Japan
    J Hematol Oncol 9:27. 2016
    ..We investigated adoptive immunotherapy using GMR-targeted chimeric antigen receptor (CAR) for JMML...
  19. doi request reprint Cardiovascular Remodeling and Dysfunction Across a Range of Growth Restriction Severity in Small for Gestational Age Infants - Implications for Fetal Programming
    Yohei Akazawa
    Department of Pediatrics, Shinshu University School of Medicine
    Circ J 80:2212-20. 2016
    ..The purpose of this study was to clarify cardiovascular structure and function in small for gestational age (SGA) infants across a range of intrauterine growth restriction (IUGR) severity...
  20. doi request reprint Analysis of class I and II aberrations in Iraqi childhood acute myeloid leukemia using filter paper cards
    Lika a Fasih Y Al-Kzayer
    Department of Pediatrics, Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto, 390 8621, Nagano, Japan
    Ann Hematol 93:949-55. 2014
    ..Acute promyelocytic leukemia (APL) was frequent among Iraqi pediatric AML. It is likely that molecular diagnosis using FTA cards in underdeveloped countries could guide doctors towards an appropriate treatment strategy. ..
  21. doi request reprint Effect of the mutant microphthalmia-associated transcription factor found in Tietz syndrome on the in vitro development of mast cells
    Tomonari Shigemura
    Department of Pediatrics, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    J Pediatr Hematol Oncol 32:442-7. 2010
    ..These findings suggest that MITF does not play a critical role in MC development in humans...
  22. doi request reprint Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia
    Kazuyuki Matsuda
    Department of Laboratory Medicine, Shinshu University Hospital, 3 1 1 Asahi, Matsumoto, Japan
    Br J Haematol 148:593-9. 2010
    ..Considering the negative correlation between mutant DNA level in neonatal blood spots and age at diagnosis, JMML patients with a larger tumour burden at birth appeared to show earlier onset...
  23. ncbi request reprint Development of two cytogenetically abnormal clones from multipotential hematopoietic stem cells in a patient with juvenile myelomonocytic leukemia
    Satoshi Matsuzaki
    Department of Pediatrics, Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto, 390 8621 Nagano, Japan
    Leuk Res 29:1069-72. 2005
    ..The two karyotypically abnormal clones might have developed from multipotential hematopoietic stem cells with the potential to differentiate into myeloid and B-lymphoid lineages, but not T-lymphoid lineage...
  24. doi request reprint Clinical and laboratory outcomes after umbilical cord blood transplantation in a patient with mucolipidosis II alpha/beta
    Takumi Shibazaki
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Med Genet A 170:1278-82. 2016
    ..Although HSCT effects on the clinical manifestations were limited, laboratory data including plasma lysosomal enzyme activities and serum levels of immunoglobulin showed improvement...
  25. doi request reprint Loss of Mismatched HLA on the Leukemic Blasts of Patients With Relapsed Lymphoid Malignancies Following Bone Marrow Transplantation From Related Donors With HLA Class II Mismatches in the Graft Versus Host Direction
    Koichi Hirabayashi
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Pediatr Blood Cancer 63:709-11. 2016
    ..HLA class II loss may be a triggering event for ALL relapse after partially HLA-mismatched-related HSCT. In addition, HLA typing of relapsed leukemic blasts could be vital in the selection of retransplant donors. ..
  26. doi request reprint Successful treatment for West syndrome with severe combined immunodeficiency
    Mitsuo Motobayashi
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Brain Dev 37:140-4. 2015
    ..Immune-modulating therapies along with the administration of TPM effectively treated this severe epileptic syndrome in our patient...
  27. pmc Reduced-toxicity myeloablative conditioning consisting of 8-Gy total body irradiation, cyclophosphamide and fludarabine for pediatric hematological malignancies
    Koichi Hirabayashi
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Sci Rep 4:6942. 2014
    ..Our RTMAC regimen would be less toxic and offers a high probability of survival for children with hematological malignancies. ..
  28. doi request reprint Serial monitoring of Mucorales DNA load in serum samples of a patient with disseminated mucormycosis after allogeneic bone marrow transplantation
    Tomonari Shigemura
    Department of Pediatrics, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, 390 8621, Japan
    Int J Hematol 100:206-9. 2014
    ..This specific, noninvasive, and highly quantitative assay may be useful for the early diagnosis of mucormycosis and prediction of disease progression...
  29. doi request reprint Prophylactic treatment for hypertension and seizure in a case of allogeneic hematopoietic stem cell transplantation after posterior reversible encephalopathy syndrome
    Tetsuhiro Fukuyama
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Pediatr Transplant 15:E169-73. 2011
    ..Prophylactic treatment for hypertension with nicardipine in conjunction with close monitoring of the magnesium level and the use of valproic acid might be an effective management approach to prevent post-transplant PRES...
  30. ncbi request reprint Analysis of histone modification around the CpG island region of the p15 gene in acute myeloblastic leukemia
    Mina Ogawa
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Leuk Res 31:611-21. 2007
    ..These results suggest perturbed modifications of histone H3 around the p15 CpG island region in AML...
  31. doi request reprint Urinary excretion of ganciclovir contributes to improvement of adenovirus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation
    Yozo Nakazawa
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Pediatr Transplant 13:632-5. 2009
    ..This appeared to result partly from a high concentration of GCV in urine. GCV may be effective for AdV-induced HC without definitive disseminated infection...
  32. doi request reprint Frequent coexistence of RAS mutations in RUNX1-mutated acute myeloid leukemia in Arab Asian children
    Lika a Fasih Y Al-Kzayer
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Pediatr Blood Cancer 61:1980-5. 2014
    ..However, its contribution to the development of childhood leukemia remains unclear. In the present study, we analyzed point mutations of RUNX1 gene in children and adolescents with acute myeloid leukemia (AML) from Iraq and Jordan...
  33. doi request reprint Risk factors for diabetes mellitus and impaired glucose tolerance following allogeneic hematopoietic stem cell transplantation in pediatric patients with hematological malignancies
    Kanae Hirabayashi
    Department of Pediatrics, Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto, 390 8621, Japan
    Int J Hematol 99:477-86. 2014
    ..In multivariate analysis, an age of ≥6 years at the time of HSCT was significantly associated with the development of DM + IGT. Additionally, careful follow-up is necessary, even for NGT patients...
  34. doi request reprint Successful treatment of fulminant Wilson's disease without liver transplantation
    Mitsuo Motobayashi
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Pediatr Int 56:429-32. 2014
    ..Based on the therapeutic modalities in these five cases, non-surgical treatment (blood purification and copper chelate agents) may be able to avoid LTx in fulminant WD even with very high RWPI, although preparation for LTx is necessary. ..
  35. ncbi request reprint IgM AL amyloidosis due to B cell lymphoproliferative disorder: efficacy of high-dose melphalan followed by autologous stem cell transplantation
    Takahisa Gono
    Third Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Amyloid 11:130-5. 2004
    ..Myeloablative therapies, such as high-dose melphalan, should definitely be considered as a treatment option for AL amyloidosis, irrespective of the type of precursor immunoglobulin...
  36. doi request reprint Factor H gene variants in Japanese: its relation to atypical hemolytic uremic syndrome
    Saki Mukai
    Department of Laboratory Medicine, Shinshu University Hospital, Japan
    Mol Immunol 49:48-55. 2011
    ..Our results suggested that although FH1 mutations relates to the development of Japanese aHUS in accordance with other ethnic studies, other factor may be required for factor H polymorphism to be a risk factor of Japanese aHUS...
  37. ncbi request reprint The clinical characteristics of vitamin D deficiency in childhood: a systematic literature review of Japanese patients
    Yohei Akazawa
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    J Pediatr Endocrinol Metab 23:675-84. 2010
    ..It would be useful to find and make early interventions in cases of children at a high-risk of vitamin D deficiency...
  38. doi request reprint Polymyxin-direct hemoperfusion for sepsis-induced multiple organ failure
    Koichi Hirabayashi
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Pediatr Blood Cancer 55:202-5. 2010
    ..Serum levels of these cytokines and bioactive substances decreased after blood purification therapy, which correlated with the improvement of clinical symptoms...
  39. doi request reprint Detection of T-cell receptor gene rearrangement in children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis using the BIOMED-2 multiplex polymerase chain reaction combined with GeneScan analysis
    Kazuyuki Matsuda
    Department of Laboratory Medicine, Shinshu University Hospital, Asahi, Matsumoto, Japan
    Clin Chim Acta 412:1554-8. 2011
    ..In this study, we used BIOMED-2 multiplex PCR and GeneScan analysis to evaluate TCR gene rearrangement in childhood EBV-HLH...
  40. doi request reprint High incidence of meropenem resistance among alpha-hemolytic streptococci in children with cancer
    Masako Abe
    Department of Pediatrics, Shinshu University School of Medicine, Japan
    Pediatr Int 51:103-6. 2009
    ..Infections caused by antibiotics-resistant Gram-positive bacteria have been reported from many pediatric hematology-oncology centers...
  41. doi request reprint Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia
    Nao Yoshida
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Pediatr Res 65:334-40. 2009
    ..001). All patients who died after relapse had PTPN11 mutation. These results suggest that JMML with PTPN11 mutation might be a distinct subgroup with specific clinical characteristics and poor outcome...
  42. doi request reprint Nonocclusive Mesenteric Ischemia after Chemotherapy in an Adolescent Patient with a History of Three Allogeneic Hematopoietic Stem Cell Transplantations for Acute Lymphoblastic Leukemia
    Koichi Hirabayashi
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan Electronic address
    Pediatr neonatol . 2014
    ..Nonocclusive mesenteric ischemia should be considered during the differential diagnosis of intestinal complications after chemotherapy, even in pediatric and adolescent patients...
  43. doi request reprint Dramatic Improvement in the Multifocal Positron Emission Tomography Findings of a Young Adult with Chronic Granulomatous Disease Following Allogeneic Hematopoietic Stem Cell Transplantation
    Tomonari Shigemura
    Department of Pediatrics, Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto, 390 8621, Japan
    J Clin Immunol 35:84-6. 2015
    ..Monitoring the activity of multiple pre-existing lesions with PET scan may be beneficial to adolescent and young adult CGD-patients undergoing allogeneic HSCT...
  44. pmc Successful treatment of arrhythmia-induced cardiomyopathy in an infant with tuberous sclerosis complex
    Noriko Motoki
    Department of Pediatrics, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto, 390 8621, Japan
    BMC Pediatr 16:16. 2016
    ..However, despite being clinically silent, these lesions can provoke arrhythmias and heart failure (Pediatrics 118:1146-1151, 2006; Eur J Pediatr 153:155-7, 1994)...
  45. ncbi request reprint Regulation of mast cell development
    Masaaki Shiohara
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Chem Immunol Allergy 87:1-21. 2005
    ....
  46. doi request reprint Distinct response in maintenance of human naive and memory B cells via IL-21 receptor and TCL1/Akt pathways
    Haruo Nagumo
    Department of Infection and Host Defense, Shinshu University, Asahi, Matsumoto, Nagano, Japan
    Cell Immunol 256:56-63. 2009
    ..This study suggests that naive and memory B cells are regulated by several distinct molecules, and the IL-21R and TCL1/Akt pathways might play crucial roles in naïve B cells for their maintenance...
  47. ncbi request reprint A possible role for the production of multiple HLA antibodies in fatal platelet transfusion refractoriness after peripheral blood progenitor cell transplantation from the mother in a patient with relapsed leukemia
    Yozo Nakazawa
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Transfusion 47:326-34. 2007
    ..There has been controversy over whether HLA alloimmunization is a risk factor for platelet (PLT) transfusion refractoriness (PTR) in hematopoietic peripheral blood progenitor cell transplantation (HPBPCT)...
  48. doi request reprint Exfoliative toxin A staphylococcal scalded skin syndrome in preterm infants
    Ken Saida
    Department of Pediatrics Shinshu, University School of Medicine, 3 1 1 Asahi, Matsumoto, 390 8621, Japan
    Eur J Pediatr 174:551-5. 2015
    ....
  49. doi request reprint Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin B
    Tomonari Shigemura
    Department of Pediatrics, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Int J Infect Dis 29:200-2. 2014
    ..The quantification of Mucorales DNA in CSF may be useful for evaluating cerebral mucormycosis...
  50. doi request reprint Safety and tolerability of allogeneic dendritic cell vaccination with induction of Wilms tumor 1-specific T cells in a pediatric donor and pediatric patient with relapsed leukemia: a case report and review of the literature
    Shoji Saito
    Center for Advanced Cell Therapy, Shinshu University Hospital, Matsumoto, Japan Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Cytotherapy 17:330-5. 2015
    ..WT1-specific immune responses were detected after vaccination by both WT1-tetramer analysis and enzyme-linked immunosorbent spot assay. This strategy may be safe, tolerable and even feasible for patients with a relapse after HSCT. ..
  51. doi request reprint An increase in circulating B cell-activating factor in childhood-onset ocular myasthenia gravis
    Mitsuo Motobayashi
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Pediatr Neurol 52:404-9. 2015
    ..The pathophysiology of childhood-onset ocular myasthenia gravis remains unclear. We investigated serum B cell-activating factor levels and other immunological parameters in child patients with ocular myasthenia gravis...
  52. pmc Anti-leukemic potency of piggyBac-mediated CD19-specific T cells against refractory Philadelphia chromosome-positive acute lymphoblastic leukemia
    Shoji Saito
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Cytotherapy 16:1257-69. 2014
    ....
  53. ncbi request reprint A complex karyotype, including a three-way translocation generating a NUP98-HOXD13 transcript, in an infant with acute myeloid leukemia
    Eiko Hidaka
    Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan
    Cancer Genet Cytogenet 176:137-43. 2007
    ..The NUP98-HOXD13 fusion transcript created by t(2;11;9)(q31;p15;q22) may play an important role in the leukemogenesis in this case...
  54. doi request reprint Replaced platelet concentrates containing a new additive solution, M-sol: safety and efficacy for pediatric patients
    Ryu Yanagisawa
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan Division of Blood Transfusion, Shinshu University Hospital, Matsumoto, Japan Hokkaido Red Cross Blood Center, Sapporo, Japan Department of Pediatrics, Asahikawa Medical University School of Medicine, Asahikawa, Japan
    Transfusion 53:2053-60. 2013
    ..Replacing P-PCs with PCs containing M-sol (M-sol-R-PCs) is expected to prevent ATRs. However, this has not yet been verified by sufficient clinical evidence...
  55. doi request reprint Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia
    Sayoko Doisaki
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Blood 120:1485-8. 2012
    ..These patients are the first reported to have somatic mosaicism for oncogenic NRAS mutations. The clinical course of these patients suggests that NRAS mosaicism may be associated with a mild disease phenotype in JMML...
  56. doi request reprint Telecommunication system for children undergoing stem cell transplantation
    Kazumi Higuchi
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Pediatr Int 53:1002-9. 2011
    ..To reduce the psychological distress of such children, a Web-based telecommunications system was developed...
  57. doi request reprint Neurodevelopmental features in 2q23.1 microdeletion syndrome: report of a new patient with intractable seizures and review of literature
    Mitsuo Motobayashi
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Med Genet A 158:861-8. 2012
    ....
  58. doi request reprint Cryptic insertion into 11q23 of MLLT10 not involved in t(1;15;11;10)(p36;q11;q23;q24) in infant acute biphenotypic leukemia
    Kazuyuki Matsuda
    Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan
    Cancer Genet Cytogenet 190:113-20. 2009
    ..Furthermore, the level of MRD had already increased before hematologic relapse. The identification and characterization of MLL rearrangement at the genomic DNA level may be useful for MRD quantification...
  59. ncbi request reprint Effective combination therapy using interferon-gamma and interleukin-2 for disseminated Mycobacterium avium complex infection in a pediatric patient with AIDS
    Yukio Sekiguchi
    Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Clin Infect Dis 41:e104-6. 2005
    ..Use of a combination of interferon-gamma and interferon-2 resulted in a remarkable improvement in the patient's condition, accompanied by an increase in circulating CD4+ T cells...
  60. ncbi request reprint Granulocyte-macrophage colony-stimulating factor induces de novo methylation of the p15 CpG island in hematopoietic cells
    Xiao Yan Zhao
    Department of Pediatrics, Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto 390 8621, Japan
    Cytokine 31:203-12. 2005
    ..No new methylated alleles appeared in the coexistence of the DNMT and HDAC inhibitors. Taken together, GM-CSF may be able to induce de novo methylation of the p15 gene, using HDAC(s) as well as DNMT(s)...
  61. doi request reprint Anakinra improves sensory deafness in a Japanese patient with Muckle-Wells syndrome, possibly by inhibiting the cryopyrin inflammasome
    Takashi Yamazaki
    Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Arthritis Rheum 58:864-8. 2008
    ..Thus, our case suggests that anakinra possibly affects the cryopyrin inflammasome and markedly improves the clinical and laboratory manifestations of MWS...
  62. pmc Rapidly progressive Kaposi's Sarcoma in an Iraqi boy received Valproic acid: a case report and review of literature
    Lika a Fasih Y Al-Kzayer
    Department of Paediatrics, Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto, Nagano, 390 8621, Japan
    BMC Pediatr 16:111. 2016
    ..To our knowledge, this is the first paediatric KS case report from Iraq. Our patient was showing an unusual aggressive course of the disease while receiving Valproic acid (VPA) of the potential immune-suppressive effect...
  63. ncbi request reprint Impact of Decreased Serum Insulin-Like Growth Factor-1 Levels on Central Aortic Compliance in Small-for-Gestational-Age Infants
    Yohei Akazawa
    Department of Paediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Neonatology 111:30-36. 2017
    ..Intrauterine growth restriction is associated with arterial hypertension in adulthood; however, the underlying mechanism is unclear...
  64. doi request reprint Reversible cerebral vasoconstriction syndrome and posterior reversible encephalopathy syndrome in a boy with Loeys-Dietz syndrome
    Yohei Akazawa
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Med Genet A 167:2435-9. 2015
    ..Endothelial dysfunction, associated with impaired TGF-β signaling, might have been attributable to the development of RCVS and PRES...
  65. doi request reprint Neurologically normal development of a patient with severe methionine adenosyltransferase I/III deficiency after continuing dietary methionine restriction
    Koichi Hirabayashi
    Department of Pediatrics, Ina Central Hospital, Ina, Japan Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan Electronic address
    Gene 530:104-8. 2013
    ..There is not much information on established standard therapy for patients with severe methionine adenosyltransferase (MAT) I/III deficiency...
  66. ncbi request reprint Long-term epidemiologic longitudinal study on the effect of vaccines on public inoculation
    Itsuo Matsuoka
    Shinshu University Graduate School of Medicine, Matsumoto, Japan
    Turk J Pediatr 54:376-81. 2012
    ..Although localized to a particular region, our results show that it is important to increase the immunization rate of vaccines for large-scale protection against viral infections through public programs...
  67. ncbi request reprint Superoxide dismutase (SOD) as a potential inhibitory mediator of inflammation via neutrophil apoptosis
    Kozo Yasui
    Department of Pediatrics, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto, 390 8621, Japan
    Free Radic Res 39:755-62. 2005
    ..SOD may be a potential inhibitory mediator of neutrophil-mediated inflammation...
  68. ncbi request reprint Specific autoantibodies to platelet glycoproteins in Epstein-Barr virus-associated immune thrombocytopenia
    Miyuki Tanaka
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Int J Hematol 78:168-70. 2003
    ..In addition, we present our findings on the effectiveness of intravenous immunoglobulin therapy for immune thrombocytopenia associated with Epstein-Barr virus...
  69. ncbi request reprint Novel compound heterozygous mutation of the MC2R gene in a patient with familial glucocorticoid deficiency
    Hiroki Matsuura
    Department of Paediatrics, Shinshu University School ofMedicine, Matsumoto, Japan
    J Pediatr Endocrinol Metab 19:1167-70. 2006
    ..This is the first report of FGD associated with a compound heterozygous mutation of C21Y and R146H in the MC2R gene...
  70. doi request reprint Bilateral perisylvian polymicrogyria, periventricular nodular heterotopia, and left ventricular noncompaction in a girl with 10.5-11.1 Mb terminal deletion of 1p36
    Shoji Saito
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Am J Med Genet A 146:2891-7. 2008
    ..An atypically large deletion in this patient might be the basis for the development of these features and the severe clinical course...
  71. ncbi request reprint Association between serum uric acid levels and cardiometabolic risk factors among Japanese junior high school students
    Minoru Hongo
    Department of Cardiovascular Medicine, Shinshu University School of Health Sciences, Matsumoto, Japan
    Circ J 74:1570-7. 2010
    ....
  72. doi request reprint A case of Bardet-Biedl syndrome complicated with intracranial hypertension in a Japanese child
    Ken Saida
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Brain Dev 36:721-4. 2014
    ..Her papilledema improved following administration of acetazolamide. This is the first report of a case of BBS complicated with intracranial hypertension and its treatment...
  73. ncbi request reprint IL-9 enhances the growth of human mast cell progenitors under stimulation with stem cell factor
    Shigeyuki Matsuzawa
    Department of Pediatrics, School of Medicine, Graduate School of Medicine, Shinshu University, Matsumoto, Japan
    J Immunol 170:3461-7. 2003
    ..Taken together, IL-9 appears to act as a potent enhancer for the SCF-dependent growth of mast cell progenitors in humans, particularly asthmatic patients...
  74. ncbi request reprint Late-onset cases of familial hemophagocytic lymphohistiocytosis with missense perforin gene mutations
    Ikuyo Ueda
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Hematol 82:427-32. 2007
    ..None had homozygous nonsense mutations. Our data suggest that nonsense perforin gene mutations yield early onset and missense mutations late onset in FHL2 cases...
  75. ncbi request reprint Successful unrelated cord blood transplantation using a reduced-intensity conditioning regimen in a 6-month-old infant with congenital neutropenia complicated by severe pneumonia
    Yozo Nakazawa
    Department of Pediatrics, Reconstructive Medicine and Tissue Engineering, Shinshu University School of Medicine, Matsumoto, Japan
    Int J Hematol 80:287-90. 2004
    ..The patient gradually caught up on growth and development after the CBT. Unrelated CBT using a reduced-intensity conditioning regimen may be an effective treatment for congenital neutropenia...
  76. ncbi request reprint CD30+ anaplastic large cell lymphoma complicated by pyoderma gangrenosum with increased levels of serum cytokines
    Shoji Saito
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Eur J Haematol 77:251-4. 2006
    ..An association between PG and increased cytokine levels was suggested. Even in children, dermatosis of PG should receive prompt careful evaluation for underlying hematological malignancy...
  77. doi request reprint Right-to-left shunting in the ductus arteriosus is induced readily by intense crying and rapid postural change in neonates with meconium-stained amniotic fluid
    Atsushi Baba
    Departments of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Pediatr Crit Care Med 13:60-5. 2012
    ....
  78. doi request reprint Genetic evaluation of childhood acute lymphoblastic leukemia in Iraq using FTA cards
    Lika a Fasih Y Al-Kzayer
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Pediatr Blood Cancer 59:461-7. 2012
    ....
  79. ncbi request reprint ARF tumor suppressor induces mitochondria-dependent apoptosis by modulation of mitochondrial Bcl-2 family proteins
    Yozo Nakazawa
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano 390 8621, Japan
    J Biol Chem 278:27888-95. 2003
    ..Additionally, ARF seems to down-regulate Bcl-2 in a p53-dependent manner while up-regulating Bax/Bim via a p53-independent pathway...
  80. doi request reprint Reflex seizures induced by micturition and defecation, successfully treated with clobazam and phenytoin
    Tsukasa Higuchi
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Epileptic Disord 13:166-71. 2011
    ....
  81. ncbi request reprint Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group
    Eiichi Ishii
    Department of Pediatrics, Saga University, Nabeshima, Saga, Japan
    Pediatr Blood Cancer 47:268-72. 2006
    ..We analyzed the features and outcome of neonatal leukemia in Japan to establish an appropriate treatment strategy for this rare disorder...
  82. ncbi request reprint ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils
    Masaaki Shiohara
    Department of Pediatrics, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto 390 8621, Japan
    Biochem Biophys Res Commun 293:1314-8. 2002
    ..These findings suggest that up-regulation of ASC is closely associated with inflammation and apoptosis in neutrophils...
  83. pmc Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus
    Koichiro Yamada
    Department of Microbiology and Immunology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano, 390 8621, Japan
    Retrovirology 6:79. 2009
    ..Therefore, the descriptions of the location and the integration frequency of the HIR presented here may help us to better understand vector-induced leukemogenesis...
  84. ncbi request reprint Effect of parathyroid hormone administration in a patient with severe hypoparathyroidism caused by gain-of-function mutation of calcium-sensing receptor
    Masaaki Shiohara
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Endocr J 53:797-802. 2006
    ..These results indicate that PTH therapy could be effective in correcting serum and urine calcium and the phosphate levels in hypoparathyroidism caused by activating mutation of CaR...
  85. ncbi request reprint Gastroduodenal lesions in primary AL amyloidosis
    Takahisa Gono
    Shinshu University School of Medicine, Matsumoto, Japan, Nantan Hospital, Yagi, Japan
    Gastrointest Endosc 56:563. 2002
  86. ncbi request reprint [Fanconi's pancytopenia syndrome]
    Tsukasa Higuchi
    Department of Pediatrics, Shinshu University School of Medicine
    Nihon Rinsho . 2006
  87. ncbi request reprint Synergism between stem cell factor and granulocyte-macrophage colony-stimulating factor on cell proliferation by induction of cyclins
    Takehiko Kamijo
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano 390 8621, Japan
    Cytokine 19:267-75. 2002
    ....
  88. ncbi request reprint Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations
    Kazuyuki Matsuda
    Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan
    Blood 109:5477-80. 2007
    ..Additionally, numbers of circulating granulocyte-macrophage progenitors were significantly reduced during the clinical course. Thus, some patients with JMML with specific RAS mutations may have spontaneously improving disease...
  89. ncbi request reprint Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions
    Eiichi Ishii
    Department of Pediatrics, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Blood 105:3442-8. 2005
    ..These results suggest an association between the type of genetic mutation in FHL cases and the magnitude of CTL cytolytic activity and age at onset...
  90. ncbi request reprint HLA-identical sibling peripheral blood stem cell transplantation in children and adolescents
    Tsutomu Watanabe
    Department of Pediatrics, University of Tokushima School of Medicine, Japan
    Biol Blood Marrow Transplant 8:26-31. 2002
    ..For high-risk malignancies, whether or not a graft-versus-leukemia effect prevents relapse needs to be clarified in future comparative studies with BMT...
  91. ncbi request reprint Serologic analysis of three cases of neonatal alloimmune thrombocytopenia associated with HLA antibodies
    Satoshi Saito
    Department of Legal Medicine, Shinshu University School of Medicine, Matumoto, Japan
    Transfusion 43:908-17. 2003
    ..Cases in which NAIT has been caused by HLA antibodies are relatively rare. In this study, three cases of NAIT associated with HLA antibodies that occurred in a 1-year period are reported...
  92. ncbi request reprint Nephrotic syndrome due to primary AL amyloidosis, successfully treated with VAD and subsequent high-dose melphalan followed by autologous peripheral blood stem cell transplantation
    Takahisa Gono
    Third Department of Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621
    Intern Med 42:72-7. 2003
    ..To avoid the progression of primary AL amyloidosis, intensive chemotherapy should be actively used when the general status and vital organ functions are well preserved...
  93. ncbi request reprint Viral infections in juvenile myelomonocytic leukemia: prevalence and clinical implications
    Atsushi Manabe
    Department of Pediatric Hematology Oncology, Institute of Medical Science, University of Tokyo, Japan
    J Pediatr Hematol Oncol 26:636-41. 2004
    ..The authors therefore measured the cellular expression of the MxA protein, a reliable marker of viral infection, at diagnosis in children with JMML to estimate the prevalence of such infections...
  94. ncbi request reprint Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome
    Gang Xu
    Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki, Aomori, 036 8563 Japan
    Blood 102:2960-8. 2003
    ..These results indicate that expression of GATA-1 with a defective N-terminal activation domain contributes to the expansion of TMD blast cells and that other genetic changes contribute to the development of AMKL in Down syndrome...
  95. ncbi request reprint Treatment of neurodegenerative CNS disease in Langerhans cell histiocytosis with a combination of intravenous immunoglobulin and chemotherapy
    Shinsaku Imashuku
    Division of Pediatrics, Takasago seibu Hospital, Takasago, Japan
    Pediatr Blood Cancer 50:308-11. 2008
    ..In rare cases, patients with Langerhans cell histiocytosis (LCH) develop neurodegenerative CNS disease (ND-CNS-LCH). Management of ND-CNS-LCH has not been established...
  96. ncbi request reprint Acquisition of loss of the wild-type NRAS locus with aggressive disease progression in a patient with juvenile myelomonocytic leukemia and a heterozygous NRAS mutation
    Kazuyuki Matsuda
    Haematologica 92:1576-8. 2007
    ..According to microsatellite and FISH analyses, the post-BC homozygous mutation might result from the loss of the wild-type NRAS locus through mitotic recombination...
  97. ncbi request reprint Bilineage acute leukemia of T-lymphoid and myeloid lineages
    Norimoto Kobayashi
    Haematologica 89:1139-41. 2004
    ..Comparative analyses of genetic markers and proliferative/differentiative potential show the possibility of malignant transformation of a T-lineage stem cell with the potential to differentiate into the myeloid lineage...
  98. doi request reprint Neurodegenerative central nervous system disease as late sequelae of Langerhans cell histiocytosis. Report from the Japan LCH Study Group
    Shinsaku Imashuku
    Division of Pediatrics, Takasago seibu Hospital, 1 10 41 Nakasuji, Takasago, Hyogo Prefecture, Japan 676 0812
    Haematologica 93:615-8. 2008
    ....
  99. ncbi request reprint Allogeneic haematopoietic cell transplantation from alternative donors with a conditioning regimen of low-dose irradiation, fludarabine and cyclophosphamide in Fanconi anaemia
    Hiromasa Yabe
    Specialized Clinical Science, Pediatrics, Tokai University School of Medicine, Isehara, Japan
    Br J Haematol 134:208-12. 2006
    ..The 1-year overall survival was 96.3% (95% CI, 89-100). This conditioning regimen exerted an immunosuppressive effect that enabled durable engraftment in alternative donor HCT without severe toxicity...