Tomohide Tsukahara

Summary

Affiliation: Sapporo Medical University
Country: Japan

Publications

  1. doi request reprint Peptide vaccination therapy: Towards the next generation
    Tomohide Tsukahara
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo, Japan
    Pathol Int 66:547-553. 2016
  2. pmc Specific targeting of a naturally presented osteosarcoma antigen, papillomavirus binding factor peptide, using an artificial monoclonal antibody
    Tomohide Tsukahara
    From the Department of Pathology
    J Biol Chem 289:22035-47. 2014
  3. pmc Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas
    M Murase
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Br J Cancer 101:1425-32. 2009
  4. pmc NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
    Tomohide Tsukahara
    Department of Pathology, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Diagn Pathol 7:114. 2012
  5. doi request reprint Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma
    Tomohide Tsukahara
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Cancer Sci 100:47-53. 2009
  6. pmc HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Transl Med 7:44. 2009
  7. doi request reprint Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical Unviersity School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Japan
    Cancer Sci 99:368-75. 2008
  8. ncbi request reprint Clonal T-cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A*0206
    Shigeharu Kimura
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, 060 8543, Japan
    J Orthop Res 26:271-8. 2008
  9. ncbi request reprint Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor
    Tomohide Tsukahara
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Res 64:5442-8. 2004
  10. ncbi request reprint Prognostic significance of HLA class I expression in osteosarcoma defined by anti-pan HLA class I monoclonal antibody, EMR8-5
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Sci 97:1374-80. 2006

Collaborators

Detail Information

Publications49

  1. doi request reprint Peptide vaccination therapy: Towards the next generation
    Tomohide Tsukahara
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo, Japan
    Pathol Int 66:547-553. 2016
    ....
  2. pmc Specific targeting of a naturally presented osteosarcoma antigen, papillomavirus binding factor peptide, using an artificial monoclonal antibody
    Tomohide Tsukahara
    From the Department of Pathology
    J Biol Chem 289:22035-47. 2014
    ..In conclusion, scFv clone D12 might be useful to select candidate patients for PBF A2.2 peptide-based immunotherapy and develop antibody-based immunotherapy...
  3. pmc Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas
    M Murase
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Br J Cancer 101:1425-32. 2009
    ..In this study, we identified and characterised side population (SP) cells that showed drug-resistant features in human bone sarcoma cell lines...
  4. pmc NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
    Tomohide Tsukahara
    Department of Pathology, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Diagn Pathol 7:114. 2012
    ..We finally diagnosed this case as extranodal NK/T-cell lymphoma (nasal type). Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8050621197741854...
  5. doi request reprint Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma
    Tomohide Tsukahara
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Cancer Sci 100:47-53. 2009
    ....
  6. pmc HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Transl Med 7:44. 2009
    ..However, clinical application of PBF-based immunotherapy requires identification of naturally presented CTL epitopes in osteosarcoma cells in the context of more common HLA molecules such as HLA-A2...
  7. doi request reprint Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical Unviersity School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Japan
    Cancer Sci 99:368-75. 2008
    ..These findings suggested prognostic significance and immunodominancy of PBF in patients with osteosarcoma. PBF is the candidate target for immunotherapy in patients with osteosarcoma...
  8. ncbi request reprint Clonal T-cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A*0206
    Shigeharu Kimura
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, 060 8543, Japan
    J Orthop Res 26:271-8. 2008
    ..These findings suggest that CTL2004-c6 and CTL2004-c17 recognize autologous tumor-rejection antigens presented by HLA-A*0206, which may have been expressed by tumor cells that had been eradicated by the host's immunosurveillance system...
  9. ncbi request reprint Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor
    Tomohide Tsukahara
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Res 64:5442-8. 2004
    ..These findings suggest that PBF is a shared tumor-associated antigen, which may serve as a source of peptides applicable to peptide-based immunotherapy for osteosarcoma and other malignant tumors...
  10. ncbi request reprint Prognostic significance of HLA class I expression in osteosarcoma defined by anti-pan HLA class I monoclonal antibody, EMR8-5
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Sci 97:1374-80. 2006
    ..These findings suggest that the class I-restricted cytotoxic T lymphocyte pathway plays a major role in immune surveillance of patients with osteosarcoma...
  11. pmc Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells
    Akari Takahashi
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan Cancer Diagnosis Laboratory, Japan Science and Technology Agency Innovation Plaza Hokkaido, Japan Science and Technology Agency, Kita ku, Sapporo, Japan
    PLoS ONE 8:e69095. 2013
    ....
  12. ncbi request reprint Improved generation of HLA class I/peptide tetramers
    Yuriko Sato
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Japan
    J Immunol Methods 271:177-84. 2002
    ..Consequently, by using mutant HLA-A*2402/peptide tetramers, CTL precursors (CTLp) that specifically recognize antigenic peptide derived from the X;18 chromosomal translocations of synovial sarcoma were detected in patients' PBL...
  13. ncbi request reprint Recognition by cellular and humoral autologous immunity in a human osteosarcoma cell line
    Yuki Nabeta
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, 060 8543, Sapporo, Japan
    J Orthop Sci 8:554-9. 2003
    ..In conclusion, our results demonstrated the presence of host cellular and humoral immune responses to autologous osteosarcoma cells. This offered the opportunity to identify osteosarcoma antigens recognized by autologous immunity...
  14. doi request reprint SYT-SSX breakpoint peptide vaccines in patients with synovial sarcoma: a study from the Japanese Musculoskeletal Oncology Group
    Satoshi Kawaguchi
    Departments of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Japan
    Cancer Sci 103:1625-30. 2012
    ..Of note, one patient showed transient shrinkage of a metastatic lesion. The response of the patients to the B protocols is encouraging and warrants further investigation...
  15. ncbi request reprint Crisscross CTL induction by SYT-SSX junction peptide and its HLA-A*2402 anchor substitute
    Kazunori Ida
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Immunol 173:1436-43. 2004
    ....
  16. doi request reprint Autologous CTL response against cancer stem-like cells/cancer-initiating cells of bone malignant fibrous histiocytoma
    Masanobu Kano
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Sci 102:1443-7. 2011
    ..Thus, CTL-based immunotherapy could target CSC of bone sarcoma to help prevent tumor recurrence...
  17. ncbi request reprint HLA-restricted specific tumor cytolysis by autologous T-lymphocytes infiltrating metastatic bone malignant fibrous histiocytoma of lymph node
    Tomohide Tsukahara
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543 Japan
    J Orthop Res 24:94-101. 2006
    ..The present autologous cell lines provide the basis for identification of novel tumor-associated antigens and may be helpful in the establishment of immunotherapy for patients with MFH of the bone...
  18. doi request reprint Molecular pathological approaches to human tumor immunology
    Noriyuki Sato
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo Japan
    Pathol Int 59:205-17. 2009
    ..Finally, the type of basic and clinical tumor immunology research highly required currently, and in the very near future, are described...
  19. ncbi request reprint Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family, Livin/ML-IAP in lung cancer
    Hiroyuki Hariu
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17 Chuo ku, Sapporo 060 8556, Japan
    Clin Cancer Res 11:1000-9. 2005
    ..Our data suggest that Livin/ML-IAP may be an excellent target antigen in immunotherapy for lung cancer and Livin7 peptide may serve as a potent peptide vaccine for HLA-A*2402(+)/Livin(+) lung cancer patients...
  20. doi request reprint Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-α-mediated oxidative folding in murine tumor cells
    Toshimitsu Kajiwara
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Eur J Immunol 46:2842-2851. 2016
    ....
  21. doi request reprint ECRG4 is a negative regulator of caspase-8-mediated apoptosis in human T-leukemia cells
    Junichi Matsuzaki
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Carcinogenesis 33:996-1003. 2012
    ..Since ECRG4 expression is downregulated in activated T cells, our results suggest that ECRG4 is a novel antiapoptotic gene which is involved in the negative regulation of caspase-8-mediated apoptosis in T cells...
  22. pmc Phase I vaccination trial of SYT-SSX junction peptide in patients with disseminated synovial sarcoma
    Satoshi Kawaguchi
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Transl Med 3:1. 2005
    ..Modification of both the peptide itself and the related protocol is required to further improve the therapeutic efficacy...
  23. pmc Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells
    Rena Morita
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Sci 105:389-95. 2014
    ..Taken together, the results indicate that DNAJB8 is expressed and has role in CRC CSC/CIC and that DNAJB8 is a novel target of CRC CSC/CIC-targeting immunotherapy. ..
  24. doi request reprint MAPK13 is preferentially expressed in gynecological cancer stem cells and has a role in the tumor-initiation
    Kazuyo Yasuda
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Biochem Biophys Res Commun 472:643-7. 2016
    ..These results indicate that MAPK13 is expressed in gynecological CSCs/CICs and has roles in the maintenance of CSCs/CICs and tumor-initiating ability, and MAPK13 might be a novel molecular target for treatment-resistant CSCs/CICs. ..
  25. doi request reprint Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients
    Hidekazu Kameshima
    Departments of Surgery Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Sci 102:1181-7. 2011
    ....
  26. pmc Establishment and Analysis of Cancer Stem-Like and Non-Cancer Stem-Like Clone Cells from the Human Colon Cancer Cell Line SW480
    Akari Takaya
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, 060 8556, Japan
    PLoS ONE 11:e0158903. 2016
    ..SP clone cells and MP clone cells are a very stable in vitro CSC/CIC-enriched and non-CSC/CIC model for further analysis. ..
  27. pmc Cancer-associated oxidoreductase ERO1-α drives the production of VEGF via oxidative protein folding and regulating the mRNA level
    Tsutomu Tanaka
    Department of Pathology, Sapporo Medical University, S1W17, Chuo Ku, Sapporo 060 8556, Japan
    Br J Cancer 114:1227-34. 2016
    ..Therefore, to clarify the mechanism, we investigated the effect of ERO1-α on a tumour from the point of view of angiogenesis...
  28. doi request reprint CpG-A stimulates Hsp72 secretion from plasmacytoid dendritic cells, facilitating cross-presentation
    Tsutomu Tanaka
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan United Graduate School of Veterinary Sciences, Yamaguchi University, Yamaguchi, Japan
    Immunol Lett 167:34-40. 2015
    ..Our experiments therefore suggest a mechanism for orchestration of immune responses by stimulation of pDCs with CpG-A. ..
  29. pmc High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in the novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma
    Makoto Emori
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    PLoS ONE 8:e84187. 2013
    ..009). In conclusion, CD109 might be a CSC/CIC marker in epithelioid sarcoma. Moreover, CD109 is a promising prognostic biomarker and a molecular target of cancer therapy for sarcomas including ES. ..
  30. pmc Identification of a novel human memory T-cell population with the characteristics of stem-like chemo-resistance
    Kenji Murata
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Oncoimmunology 5:e1165376. 2016
    ..Regulation of TYM might be very attractive for peptide vaccination, adoptive cell-transfer therapy and hematopoietic stem cell transplantation. ..
  31. doi request reprint The future of immunotherapy for sarcoma
    Tomohide Tsukahara
    a Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Expert Opin Biol Ther 16:1049-57. 2016
    ..However, the prognosis for non-responders to chemotherapy is still poor and immunotherapy is now focused on again...
  32. doi request reprint A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner
    Norie Ito
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan Department of Neurology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Biochem Biophys Res Commun 474:626-33. 2016
    ....
  33. doi request reprint Olfactory Receptor Family 7 Subfamily C Member 1 Is a Novel Marker of Colon Cancer-Initiating Cells and Is a Potent Target of Immunotherapy
    Rena Morita
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Clin Cancer Res 22:3298-309. 2016
    ..Cancer immunotherapy is a novel approach to target cancer. In this study, we aimed to establish novel CIC-targeting immunotherapy...
  34. doi request reprint Prognostic impact of CD109 expression in myxofibrosarcoma
    Makoto Emori
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan
    J Surg Oncol 111:975-9. 2015
    ..Myxofibrosarcoma is one of the most common soft-tissue sarcomas found in elderly patients. This study aimed to elucidate the impact of CD109 expression in myxofibrosarcoma on prognosis and recurrence...
  35. doi request reprint Cancer-Associated Oxidase ERO1-α Regulates the Expression of MHC Class I Molecule via Oxidative Folding
    Kazuharu Kukita
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan and Department of Surgery, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Immunol 194:4988-96. 2015
    ..Thus, the cancer-associated ERO1-α regulates the expression of the MHC class I molecule via oxidative folding. ..
  36. ncbi request reprint [Peptide vaccination therapy for bone and soft tissue sarcoma]
    Makoto Emori
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine
    Nihon Rinsho 69:1670-3. 2011
    ..Therefore, the use of the vaccination therapy as an adjuvant to chemotherapy for the treatment of refractory tumors may be a promising tool...
  37. doi request reprint Immunotherapeutic benefit of α-interferon (IFNα) in survivin2B-derived peptide vaccination for advanced pancreatic cancer patients
    Hidekazu Kameshima
    Department of Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Sci 104:124-9. 2013
    ..This trial was registered with the UMIN Clinical Trials Registry, no. UMIN000000905...
  38. pmc Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes
    Akari Takahashi
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo, Japan
    Cell Stress Chaperones 17:757-63. 2012
    ..These results suggest that heat shock enhances effector phase of the adaptive immune system and promotes eradication of microbe and tumor cells...
  39. pmc A quest for therapeutic antigens in bone and soft tissue sarcoma
    Satoshi Kawaguchi
    Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Transl Med 3:31. 2005
    ..Here we summarize current progress in the immunotherapy of bone and soft tissue sarcomas including the strategies utilized to identify tumor-associated antigens, and the design of clinical trials...
  40. pmc Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress
    Hiroshi Saijo
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, 060 8556, Japan
    Oncotarget 7:50043-50056. 2016
    ..These findings indicate that lung cancer cells have plasticity under a condition of oxidative stress and that HOAX5 has a critical role in dedifferentiation...
  41. doi request reprint Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal
    Yoshitaka Michifuri
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan Department of Oral Surgery, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Biochem Biophys Res Commun 439:96-102. 2013
    ..Taken together, the results indicate that the expression of SPRR1B is upregulated in oral CSCs/CICs and that SPRR1B has a role in cell growth by suppression of RASSF4...
  42. ncbi request reprint Overexpression of papillomavirus binding factor in Ewing's sarcoma family of tumors conferring poor prognosis
    Hiroki Yabe
    Department of Orthopaedic Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
    Oncol Rep 19:129-34. 2008
    ..PBF may also serve as a putative target antigen in immunotherapy for patients with ESFT that have a poor prognosis and PBF overexpression...
  43. pmc Immune responses to human cancer stem-like cells/cancer-initiating cells
    Yoshihiko Hirohashi
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Cancer Sci 107:12-7. 2016
    ..In this review article, we discuss CSC/CIC recognition by CTL, regulation of immune systems by CSC/CIC, TAA expression in CSC/CIC, and the advantages of CSC/CIC-targeting immunotherapy. ..
  44. pmc Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells
    Tsutomu Tanaka
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan United Graduate School of Veterinary Sciences, Yamaguchi University, Yamaguchi, Japan
    Cancer Sci 106:18-24. 2015
    ..Our data indicate that targeting of the antigen to a "static" early endosome by Hsp90 is essential for efficient cross-presentation...
  45. ncbi request reprint Detection and induction of CTLs specific for SYT-SSX-derived peptides in HLA-A24(+) patients with synovial sarcoma
    Yuriko Sato
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Japan
    J Immunol 169:1611-8. 2002
    ..The identification of SYT-SSX peptides may offer an opportunity to design peptide-based immunotherapeutic approaches for HLA-A24(+) patients with synovial sarcoma...
  46. doi request reprint A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma
    Shintaro Sugita
    Departments of Surgical Pathology Pathology Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo Departments of Diagnostic Pathology Hematology and Medical Oncology, Japan Labour Health and Welfare Organization, Kanto Rosai Hospital, Kanagawa, Japan
    Am J Surg Pathol 38:1571-6. 2014
    ..These findings have important implications for the differential diagnosis of SRCS. ..
  47. doi request reprint Diagnostic utility of NCOA2 fluorescence in situ hybridization and Stat6 immunohistochemistry staining for soft tissue angiofibroma and morphologically similar fibrovascular tumors
    Shintaro Sugita
    Department of Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Hum Pathol 45:1588-96. 2014
    ..The NCOA2 FISH technique is a practical method for confirming STA diagnosis. The combination of NCOA2 FISH and Stat6 IHC proved effective for the differential diagnosis of STA, even when using small biopsy specimens. ..
  48. doi request reprint Cancer immunotherapy and immunological memory
    Kenji Murata
    Department of Pathology, Sapporo Medical University School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 39:18-22. 2016
    ..Here we introduce this novel population and describe the fundamentals of immunological memory in cancer immunotherapy. ..
  49. ncbi request reprint Simultaneous radial closing wedge and ulnar shortening osteotomies for distal radius malunion
    Takuro Wada
    Department of Orthopaedic Surgery, Sapporo Medical University, School of Medicine, South 1 West 16, Sapporo 060 8543, Japan
    J Hand Surg Am 29:264-72. 2004
    ..We report the functional and radiographic outcomes of 5 patients treated for symptomatic distal radius malunion with simultaneous radial closing wedge and ulnar shortening osteotomies...