Kiyoshi Kawabata

Summary

Affiliation: Sankyo Co
Country: Japan

Publications

  1. ncbi request reprint Enantioselective determination of azelnidipine in human plasma using liquid chromatography-tandem mass spectrometry
    Kiyoshi Kawabata
    Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 852:389-97. 2007
  2. ncbi request reprint Quantitative determination of pravastatin and R-416, its main metabolite in human plasma, by liquid chromatography-tandem mass spectrometry
    Kiyoshi Kawabata
    Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co, Ltd, 1 2 58, Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 816:73-9. 2005
  3. ncbi request reprint Simultaneous determination of azelnidipine and two metabolites in human plasma using liquid chromatography-tandem mass spectrometry
    Kiyoshi Kawabata
    Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co Ltd, 1 2 58, Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 844:45-52. 2006
  4. doi request reprint Quantitative determination of clopidogrel active metabolite in human plasma by LC-MS/MS
    Makoto Takahashi
    Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    J Pharm Biomed Anal 48:1219-24. 2008
  5. ncbi request reprint Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics
    Yohei Nishizato
    Division of Pharmaceutical Sciences, Department of Clinical Pharmacokinetics, Graduate School, Kyushu University, Fukuoka, Japan
    Clin Pharmacol Ther 73:554-65. 2003
  6. ncbi request reprint Determination of the active and inactive metabolites of prasugrel in human plasma by liquid chromatography/tandem mass spectrometry
    Nagy A Farid
    Lilly Research Laboratories, Lilly Corporate Center, DC 0714, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Rapid Commun Mass Spectrom 21:169-79. 2007
  7. doi request reprint Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism
    Suttasinee Suwannakul
    Department of Clinical Pharmacokinetics, Kyushu University, Higashi ku, Fukuoka, 812 8582, Japan
    J Hum Genet 53:899-904. 2008

Collaborators

  • Atsushi Kurihara
  • Nagy A Farid
  • Suttasinee Suwannakul
  • Makoto Takahashi
  • Miyuki Kimura
  • Ichiro Ieiri
  • Shin Irie
  • Yuichi Sugiyama
  • Hiroyuki Kusuhara
  • Shun Higuchi
  • Takeshi Hirota
  • Yohei Nishizato
  • Henrianna Pang
  • Akinori Urae
  • Hiroshi Takane
  • Hiroshi Suzuki
  • Yoko Urasaki
  • Kenji Otsubo

Detail Information

Publications7

  1. ncbi request reprint Enantioselective determination of azelnidipine in human plasma using liquid chromatography-tandem mass spectrometry
    Kiyoshi Kawabata
    Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 852:389-97. 2007
    ..Furthermore, the method described above was used to separately measure the concentrations of the azelnidipine enantiomers in plasma samples collected from healthy subjects who had received a single oral dose of 16 mg of azelnidipine...
  2. ncbi request reprint Quantitative determination of pravastatin and R-416, its main metabolite in human plasma, by liquid chromatography-tandem mass spectrometry
    Kiyoshi Kawabata
    Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co, Ltd, 1 2 58, Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 816:73-9. 2005
    ..This assay method was successfully used to evaluate the pravastatin and R-416 levels in healthy volunteers following oral administration of Mevalotin...
  3. ncbi request reprint Simultaneous determination of azelnidipine and two metabolites in human plasma using liquid chromatography-tandem mass spectrometry
    Kiyoshi Kawabata
    Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co Ltd, 1 2 58, Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 844:45-52. 2006
    ..Furthermore, the method developed was successfully applied to pharmacokinetic studies on azelnidipine, M-1 and M-2 after an oral dose of 16mg CALBLOCK tablets (2mgx8mg tablets) to healthy volunteers...
  4. doi request reprint Quantitative determination of clopidogrel active metabolite in human plasma by LC-MS/MS
    Makoto Takahashi
    Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, Tokyo 140 8710, Japan
    J Pharm Biomed Anal 48:1219-24. 2008
    ..The derivatized MP-AM was stable in human plasma for 4 months at -80 degrees C. The validated method was successfully used to analyze clinical samples and determine the pharmacokinetics of clopidogrel AM...
  5. ncbi request reprint Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics
    Yohei Nishizato
    Division of Pharmaceutical Sciences, Department of Clinical Pharmacokinetics, Graduate School, Kyushu University, Fukuoka, Japan
    Clin Pharmacol Ther 73:554-65. 2003
    ....
  6. ncbi request reprint Determination of the active and inactive metabolites of prasugrel in human plasma by liquid chromatography/tandem mass spectrometry
    Nagy A Farid
    Lilly Research Laboratories, Lilly Corporate Center, DC 0714, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Rapid Commun Mass Spectrom 21:169-79. 2007
    ..These methods have been applied to determine the concentrations of the active and inactive metabolites of prasugrel in human plasma...
  7. doi request reprint Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism
    Suttasinee Suwannakul
    Department of Clinical Pharmacokinetics, Kyushu University, Higashi ku, Fukuoka, 812 8582, Japan
    J Hum Genet 53:899-904. 2008
    ....