Yoichi Oikawa

Summary

Affiliation: Saiseikai Central Hospital
Country: Japan

Publications

  1. doi request reprint Insulinoma may mask the existence of Type 1 diabetes
    Y Oikawa
    Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan
    Diabet Med 29:e138-41. 2012
  2. pmc CXC chemokine ligand 10 DNA vaccination plus Complete Freund's Adjuvant reverses hyperglycemia in non-obese diabetic mice
    Yoichi Oikawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Rev Diabet Stud 7:209-24. 2010
  3. ncbi request reprint GAD-reactive T cells were mainly detected in autoimmune-related type 1 diabetic patients with HLA DR9
    Arata Itoh
    Department of Internal Medicine, Keio Univ School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1037:33-40. 2004
  4. ncbi request reprint CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice
    Toshikatsu Shigihara
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Immunol 175:8401-8. 2005
  5. doi request reprint FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patients
    Kyoko Iwase
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Autoimmunity 42:159-67. 2009
  6. ncbi request reprint Detection of GAD-reactive CD4+ cells in so-called "type 1B" diabetes
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1005:378-86. 2003
  7. ncbi request reprint Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin D receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related type 1 diabetes in the Japanese
    Yasuhiko Kanazawa
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1079:251-6. 2006
  8. doi request reprint Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes
    Yasuhiko Kanazawa
    Department of Internal Medicine, Keio University School of Medicine, Shimanomachi Shinjuku ku, Tokyo, Japan
    J Autoimmun 32:104-9. 2009
  9. ncbi request reprint Significance of serum CXCL10/IP-10 level in type 1 diabetes
    Toshikatsu Shigihara
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    J Autoimmun 26:66-71. 2006
  10. ncbi request reprint Relationship between beta cell mass of NOD donors and diabetes development of NOD-scid recipients in adoptive transfer system
    Satoru Yamada
    Department of Internal Medicine, Kitasato Institute Hospital, Tokyo, Japan
    Ann N Y Acad Sci 1005:211-4. 2003

Collaborators

Detail Information

Publications33

  1. doi request reprint Insulinoma may mask the existence of Type 1 diabetes
    Y Oikawa
    Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan
    Diabet Med 29:e138-41. 2012
    ..Usually, appropriate removal of the insulinoma results in normalization of blood glucose levels. However, we found novel cases of insulinoma, in which hyperglycaemia developed soon after resection of the insulinoma...
  2. pmc CXC chemokine ligand 10 DNA vaccination plus Complete Freund's Adjuvant reverses hyperglycemia in non-obese diabetic mice
    Yoichi Oikawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Rev Diabet Stud 7:209-24. 2010
    ..In the present study, we aimed to examine whether anti-CXCL10 plus CFA treatment can effectively reverse autoimmune diabetes development...
  3. ncbi request reprint GAD-reactive T cells were mainly detected in autoimmune-related type 1 diabetic patients with HLA DR9
    Arata Itoh
    Department of Internal Medicine, Keio Univ School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1037:33-40. 2004
    ..There was an association between T cell reactivity against GAD and HLA DR9 in Japanese type 1 diabetes...
  4. ncbi request reprint CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice
    Toshikatsu Shigihara
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Immunol 175:8401-8. 2005
    ..Therefore, CXCL10 neutralization is suggested to be useful for maintaining beta cell mass at any stage of autoimmune diabetes...
  5. doi request reprint FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patients
    Kyoko Iwase
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Autoimmunity 42:159-67. 2009
    ..The FOXP3/Scurfin gene is known to be a master gene of Tregs. Therefore, we tried to analyze the relation between the gene polymorphism and adult onset type 1 diabetes and its subtype in the Japanese population...
  6. ncbi request reprint Detection of GAD-reactive CD4+ cells in so-called "type 1B" diabetes
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1005:378-86. 2003
    ..In this study, we tried to demonstrate the existence of islet-associated antigen-specific T cells in type 1 diabetes without islet-associated autoantibody...
  7. ncbi request reprint Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin D receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related type 1 diabetes in the Japanese
    Yasuhiko Kanazawa
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1079:251-6. 2006
    ..The frequency of the CT60 GG genotype did not appear to be affected by either the VDR gene Bsm I large B polymorphism or HLA DR9...
  8. doi request reprint Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes
    Yasuhiko Kanazawa
    Department of Internal Medicine, Keio University School of Medicine, Shimanomachi Shinjuku ku, Tokyo, Japan
    J Autoimmun 32:104-9. 2009
    ..Based upon these results, we propose that anti-whole GAD65-reactive T cells have the ability to regulate the development of type 1 diabetes...
  9. ncbi request reprint Significance of serum CXCL10/IP-10 level in type 1 diabetes
    Toshikatsu Shigihara
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    J Autoimmun 26:66-71. 2006
    ..These results suggest that serum CXCL10 level may reflect accumulation of Th1 lymphocytes in pancreatic LN, and measurement of serum CXCL10 level may be useful to assess the pathophysiology of the disease course in type 1 diabetes...
  10. ncbi request reprint Relationship between beta cell mass of NOD donors and diabetes development of NOD-scid recipients in adoptive transfer system
    Satoru Yamada
    Department of Internal Medicine, Kitasato Institute Hospital, Tokyo, Japan
    Ann N Y Acad Sci 1005:211-4. 2003
    ..To clarify how the beta cell mass is reduced, we performed adoptive transfer experiments and examined the relationship between the pancreatic status of NOD donors and the time taken to transfer diabetes into NOD-scid recipients...
  11. ncbi request reprint Thiazolidinediones may not reduce diabetes incidence in type 1 diabetes
    Toshikatsu Shigihara
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1079:365-8. 2006
    ..Therefore, further research should take place before the application of thiazolidinediones to human slowly progressive insulin-dependent diabetes mellitus (SPIDDM) patients...
  12. ncbi request reprint Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity
    Yoshinori Nakagawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1005:359-61. 2003
    ..Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet-associated autoimmunity is suggested...
  13. ncbi request reprint Hyperplastic islets observed in "reversed" NOD mice treated without hematopoietic cells
    Yoshiaki Okubo
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 79:18-23. 2008
    ....
  14. ncbi request reprint CXC chemokine ligand 10 neutralization suppresses the occurrence of diabetes in nonobese diabetic mice through enhanced beta cell proliferation without affecting insulitis
    Jiro Morimoto
    Division of Endocrinology, School of Medicine, Keio University, Tokyo, Japan
    J Immunol 173:7017-24. 2004
    ..Thus, CXCL10 neutralization can be a new therapeutic target for beta cell survival, not only during the early stage of type 1 diabetes, but also after islet transplantation...
  15. ncbi request reprint Risk for future diabetes among individuals with high-normal glycemia at 40 years of age
    Yusuke Kabeya
    Department of Internal Medicine, Saiseikai Central Hospital, Japan
    Intern Med 51:2703-8. 2012
    ..The present study investigated the risk for future diabetes among individuals with high-normal glycemia (fasting plasma glucose (FPG) of 100-109 mg/dL) in an early middle-aged population...
  16. doi request reprint Pioglitazone may accelerate disease course of slowly progressive type 1 diabetes
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Diabetes Metab Res Rev 27:951-3. 2011
    ..However, the rate of progression to SPIDDM with the use of insulin-sensitizing agents is unknown. The aim of this study was to determine the effect of insulin-sensitizing agents on SPIDDM patients...
  17. ncbi request reprint Insulin-like growth factor-1 (IGF-1)-derived peptide protects against diabetes in NOD mice
    Keiichi Kodama
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Autoimmunity 37:481-7. 2004
    ..It was suggested that IGF-1 peptide 50-70 immunization can be used as a tool for prevention of type 1 diabetes...
  18. ncbi request reprint Effect of combination therapy of a rapid-acting insulin secretagogue (glinide) with premixed insulin in type 2 diabetes mellitus
    Satoru Yamada
    Department of Internal Medicine, Kitasato Institute Hospital, Tokyo
    Intern Med 46:1893-7. 2007
    ..To examine this, we added glinide once a day to twice daily injections of premixed insulin...
  19. ncbi request reprint Systemic administration of IL-18 promotes diabetes development in young nonobese diabetic mice
    Yoichi Oikawa
    Department of Internal Medicine, Keio University School of Medicine, Department of Internal Medicine, Tokyo Denryoku Hospital, Japan
    J Immunol 171:5865-75. 2003
    ....
  20. pmc Factors Associated with the Decline of Kidney Function Differ among eGFR Strata in Subjects with Type 2 Diabetes Mellitus
    Shu Meguro
    Nephrology, Endocrinology and Metabolism Division, Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Int J Endocrinol 2012:687867. 2012
    ....
  21. ncbi request reprint Associations of insulin resistance and glycemic control with the risk of kidney stones
    Yusuke Kabeya
    Department of Internal Medicine, Saiseikai Central Hospital, Japan
    Intern Med 51:699-705. 2012
    ..The associations of insulin resistance and glycemic control with the risk of kidney stones were explored...
  22. ncbi request reprint Expression levels of CXC chemokine receptors 3 are associated with clinical phenotype of type 1 diabetes
    Satoru Yamada
    Department of Internal Medicine, Kitasato Institute Hospital, 5 9 1 Shirokane, Minato ku, Tokyo 108 8642, Japan
    Ann N Y Acad Sci 1079:186-9. 2006
    ..CXCR3 expression level is associated with the onset pattern of type 1 diabetes. Further studies are needed to clarify the role of chemokines in type 1 diabetes...
  23. ncbi request reprint Proatherogenic effect of interleukin-18 is exerted with high-fat diet, but not with normal diet in spontaneously hyperlipidemic mice
    Takatoshi Imai
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 18:1090-101. 2011
    ..The purpose of this study was to reveal the effect of increased serum IL-18 within its physiological fluctuations on atherosclerosis development under different conditions of dietary fat content...
  24. ncbi request reprint Determinants of an optimal response to pioglitazone in terms of HDL-cholesterol
    Yusuke Kabeya
    Department of Internal Medicine, Saiseikai Central Hospital, Japan
    Intern Med 50:825-31. 2011
    ..In the present study, the characteristics of lipid responders were investigated...
  25. doi request reprint Eradication of Helicobactor pylori may trigger onset of type 1 diabetes: a case report
    Ai Tada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1150:208-9. 2008
    ..Although further investigation is needed to understand the pathophysiology of T1D, we would like to emphasize that clinicians should consider the risk of its development after eradication of Helicobactor pylori...
  26. doi request reprint Effect on the atherogenic marker plasminogen activator inhibitor type-1 of addition of the ACE inhibitor imidapril to angiotensin II type 1 receptor antagonist therapy in hypertensive patients with abnormal glucose metabolism: a prospective cohort study i
    Ken Yajima
    Department of Internal Medicine, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, 4 2 22 Nishikicho, Tachikawa, Tokyo 190 8531, Japan
    Clin Drug Investig 29:811-9. 2009
    ..The objective of this study was to determine whether the ACE inhibitor imidapril reduces PAI-1 levels in hypertensive patients already being treated with an ARB...
  27. ncbi request reprint Assessment of beta cell mass and oxidative peritoneal exudate cells in murine type 1 diabetes using adoptive transfer system
    Satoru Yamada
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Autoimmunity 36:63-70. 2003
    ..These results suggest that a marked reduction of beta cell mass occurs at the very late prediabetic stage, and assessment of the proportion of oxidative PEC is useful to evaluate disease activity in type 1 diabetes...
  28. doi request reprint A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse
    Ai Tada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Immunol 187:4947-53. 2011
    ..We conclude that an FT1D-like phenotype can be induced in the background of autoimmune diabetes by a mimic of viral dsRNA, and this model is useful for understanding human FT1D...
  29. pmc Association of glycemic status with impaired lung function among recipients of a health screening program: a cross-sectional study in Japanese adults
    Yusuke Kabeya
    Department of Internal Medicine, Saiseikai Central Hospital
    J Epidemiol 24:410-6. 2014
    ..We hypothesized that there are continuous and inverse associations between glycemic measures and lung function tests and examined the hypothesis in Japanese adults...
  30. ncbi request reprint NKT cell frequency in Japanese type 1 diabetes
    Yoichi Oikawa
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1005:230-2. 2003
    ..Here, we combined the data of NKT cell frequency in Ab+ and Ab- "classic" type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity...
  31. pmc The Role of the CXCL10/CXCR3 System in Type 1 Diabetes
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Rev Diabet Stud 6:81-4. 2009
    ..Thus, understanding the CXCL10/CXCR3 system may be important for finding a cure. In this short review, we discuss the role of the CXCL10/CXCR3 system in type 1 diabetes and propose relevant treatment options...
  32. pmc Improved Monitoring of the Hyperglycemic State in Type 1 Diabetes Patients by Use of the Glycoalbumin/HbA1c Ratio
    Takatoshi Imai
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Rev Diabet Stud 4:44-8. 2007
    ..However, in type 1 diabetic patients, we often find an even higher GA/HbA1c ratio of nearly 3.5. Therefore, this study was performed to examine the significance of a higher GA/HbA1c ratio...
  33. ncbi request reprint T-cell function in anti-GAD65(+)diabetes with residual beta-cell function
    Ryuji Suzuki
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Autoimmun 20:83-90. 2003
    ....