Takuya Tashiro

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi request reprint Structure-activity relationship studies of novel glycosphingolipids that stimulate natural killer T-cells
    Takuya Tashiro
    Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Saitama, Japan
    Biosci Biotechnol Biochem 76:1055-67. 2012
  2. doi request reprint RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 with a sulfonamide linkage: their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines
    Takuya Tashiro
    Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Bioorg Med Chem 16:8896-906. 2008
  3. doi request reprint Synthesis and biological activity of hydroxylated analogues of KRN7000 (α-galactosylceramide)
    Masao Shiozaki
    Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Wako Shi, Saitama, Japan
    Carbohydr Res 370:46-66. 2013
  4. doi request reprint Induction of Th1-biased cytokine production by alpha-carba-GalCer, a neoglycolipid ligand for NKT cells
    Takuya Tashiro
    Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Japan
    Int Immunol 22:319-28. 2010
  5. doi request reprint RCAI-61 and related 6'-modified analogs of KRN7000: their synthesis and bioactivity for mouse lymphocytes to produce interferon-γ in vivo
    Takuya Tashiro
    Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Bioorg Med Chem 21:3066-79. 2013
  6. doi request reprint Synthesis and biological activity of ester and ether analogues of alpha-galactosylceramide (KRN7000)
    Masao Shiozaki
    Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Carbohydr Res 345:1663-84. 2010
  7. doi request reprint RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines
    Takuya Tashiro
    Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Bioorg Med Chem 20:4540-8. 2012
  8. doi request reprint Synthesis of RCAI-172 (C6 epimer of RCAI-147) and its biological activity
    Masao Shiozaki
    Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan Electronic address
    Bioorg Med Chem 22:827-33. 2014
  9. doi request reprint RCAI-37, 56, 59, 60, 92, 101, and 102, cyclitol and carbasugar analogs of KRN7000: their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines
    Takuya Tashiro
    Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Bioorg Med Chem 17:6360-73. 2009
  10. doi request reprint Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Valpha14-Jalpha18 TCRalpha gene
    Hiroshi Watarai
    Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
    Blood 115:230-7. 2010

Detail Information

Publications13

  1. ncbi request reprint Structure-activity relationship studies of novel glycosphingolipids that stimulate natural killer T-cells
    Takuya Tashiro
    Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Saitama, Japan
    Biosci Biotechnol Biochem 76:1055-67. 2012
    ..Some of them show potent bioactivities and have the potential of being utilized as therapeutic agents. In this review, structure-activity relationship studies of novel glycolipids which stimulate NKT cells efficiently are summarized...
  2. doi request reprint RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 with a sulfonamide linkage: their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines
    Takuya Tashiro
    Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Bioorg Med Chem 16:8896-906. 2008
    ..According to their bioassay, these sulfonamide analogs were shown to be the stimulants of mouse NKT cells to induce the production of Th2-biased cytokines in vitro, while RCAI-38 did not induce any cytokine production...
  3. doi request reprint Synthesis and biological activity of hydroxylated analogues of KRN7000 (α-galactosylceramide)
    Masao Shiozaki
    Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Wako Shi, Saitama, Japan
    Carbohydr Res 370:46-66. 2013
    ..It was recognized that two compounds (†)RCAI-147/-160 showed good suppression of EAE symptoms...
  4. doi request reprint Induction of Th1-biased cytokine production by alpha-carba-GalCer, a neoglycolipid ligand for NKT cells
    Takuya Tashiro
    Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Japan
    Int Immunol 22:319-28. 2010
    ..Modulation of the sugar moiety in glycolipids might therefore provide optimal therapeutic reagents for protective immune responses against tumor or pathogens...
  5. doi request reprint RCAI-61 and related 6'-modified analogs of KRN7000: their synthesis and bioactivity for mouse lymphocytes to produce interferon-γ in vivo
    Takuya Tashiro
    Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Bioorg Med Chem 21:3066-79. 2013
    ....
  6. doi request reprint Synthesis and biological activity of ester and ether analogues of alpha-galactosylceramide (KRN7000)
    Masao Shiozaki
    Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Carbohydr Res 345:1663-84. 2010
    ..Ester analogues 30a, 31a, and 61 showed activity for IFNgamma and IL-4 production of iNKT cells, while ether (31b) and 4-methoxy ester (76) analogues of alpha-galactosylceramide were not active for iNKT cells...
  7. doi request reprint RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines
    Takuya Tashiro
    Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Bioorg Med Chem 20:4540-8. 2012
    ..The hexadecyl ureido analog [RCAI-84 (2)] was comparable to KRN7000 in its bioactivity. The octylureido [RCAI-107 (3)], 5-phenylpentylureido [RCAI-108 (5)], and thioureido [RCAI-91 (6)] analogs were almost inactive...
  8. doi request reprint Synthesis of RCAI-172 (C6 epimer of RCAI-147) and its biological activity
    Masao Shiozaki
    Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan Electronic address
    Bioorg Med Chem 22:827-33. 2014
    ..There exist seven chiral centers in the aglycon part of RCAI-172, and even though the change of configuration is just one position (C6-OH), the effect on both Th1/Th2 response and EAE test is fairly large. ..
  9. doi request reprint RCAI-37, 56, 59, 60, 92, 101, and 102, cyclitol and carbasugar analogs of KRN7000: their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines
    Takuya Tashiro
    Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Bioorg Med Chem 17:6360-73. 2009
    ..RCAI-60 (4, carbafucose analog) and RCAI-101 (6, 6-O-methylated 3) showed strong bioactivity, on the other hands, RCAI-37 (1, myo-inositol analog) and 102 (2, neo-inositol analog) induced little cytokine production...
  10. doi request reprint Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Valpha14-Jalpha18 TCRalpha gene
    Hiroshi Watarai
    Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
    Blood 115:230-7. 2010
    ..The cloned ES culture system offers a new opportunity for the elucidation of the molecular events on NKT-cell development and for the establishment of NKT-cell therapy...
  11. ncbi request reprint Synthesis of sphingolipids with an ω-esterified long acyl chain, ceramide components of the human epidermis
    Takuya Tashiro
    Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biosci Biotechnol Biochem 76:1715-20. 2012
    ..We synthesized these ceramides by employing olefin cross metathesis as the key reaction for constructing their ω-hydroxytriacontanoyl part (13)...
  12. ncbi request reprint Syntheses of 2-Isopropyl-4,5-dihydrothiazole and 6-Hydroxy-6-methyl-3-heptanone, pheromone components of the male mouse, Mus musculus
    Takuya Tashiro
    Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Saitama, Japan
    Biosci Biotechnol Biochem 72:2398-402. 2008
    ..Syntheses of 2-isopropyl-4,5-dihydrothiazole and 6-hydroxy-6-methyl-3-heptanone, pheromone components of the male mouse, Mus musculus, were achieved to provide sufficient amounts of samples for biological studies...
  13. ncbi request reprint RCAI-8, 9, 18, 19, and 49-52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines
    Ken ichi Fuhshuku
    Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Bioorg Med Chem 16:950-64. 2008
    ..RCAI-18 was shown to be a potent inducer of cytokine production by mouse NKT cells, while RCAI-51 was a moderately active inducer...