Affiliation: RIKEN Brain Science Institute
- Molecular chaperone-mediated tau protein metabolism counteracts the formation of granular tau oligomers in human brainN Sahara
Laboratory for Alzheimer s Disease, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
J Neurosci Res 85:3098-108. 2007..This is expressed pathologically as an early sign of NFT formation. The molecular basis of chaperone-mediated protection against neurodegeneration might lead to the development of therapeutics for tauopathies. (c) 2007 Wiley-Liss, Inc...
- Tau oligomerization: a role for tau aggregation intermediates linked to neurodegenerationN Sahara
Laboratory for Alzheimer s Disease, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
Curr Alzheimer Res 5:591-8. 2008..Here, we review the latest developments in tracking the structural changes of tau protein and discuss the utility improving our understanding of tau aggregation pathway leading to human tauopathies...