Yu Nakagawa

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. doi request reprint Mannose-binding geometry of pradimicin A
    Yu Nakagawa
    Synthetic Cellular Chemistry Laboratory, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Chemistry 19:10516-25. 2013
  2. doi request reprint Mapping of the primary mannose binding site of pradimicin A
    Yu Nakagawa
    Synthetic Cellular Chemistry Laboratory, RIKEN Advanced Science Institute, Wako, Saitama 351 0198, Japan
    J Am Chem Soc 133:17485-93. 2011
  3. doi request reprint Solid-state NMR analysis of calcium and d-mannose binding of BMY-28864, a water-soluble analogue of pradimicin A
    Yu Nakagawa
    Synthetic Cellular Chemistry Laboratory, RIKEN Advanced Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Bioorg Med Chem Lett 22:1040-3. 2012
  4. ncbi request reprint Artificial analogs of naturally occurring tumor promoters as biochemical tools and therapeutic leads
    Yu Nakagawa
    Synthetic Cellular Chemistry Laboratory, RIKEN Advanced Science Institute, Wako, Saitama, Japan
    Biosci Biotechnol Biochem 76:1262-74. 2012
  5. doi request reprint Pradimicin A, a D-mannose-binding antibiotic, binds pyranosides of L-fucose and L-galactose in a calcium-sensitive manner
    Yu Nakagawa
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan Synthetic Cellular Chemistry Laboratory, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan Electronic address
    Bioorg Med Chem Lett 25:2963-6. 2015
  6. doi request reprint Molecular architecture and therapeutic potential of lectin mimics
    Yu Nakagawa
    Synthetic Cellular Chemistry Laboratory, RIKEN Advanced Science Institute, Wako, Saitama, Japan
    Adv Carbohydr Chem Biochem 68:1-58. 2012

Detail Information

Publications6

  1. doi request reprint Mannose-binding geometry of pradimicin A
    Yu Nakagawa
    Synthetic Cellular Chemistry Laboratory, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Chemistry 19:10516-25. 2013
    ..The present study provides new insights into the molecular basis of Man recognition and glycan specificity of PRM-A. ..
  2. doi request reprint Mapping of the primary mannose binding site of pradimicin A
    Yu Nakagawa
    Synthetic Cellular Chemistry Laboratory, RIKEN Advanced Science Institute, Wako, Saitama 351 0198, Japan
    J Am Chem Soc 133:17485-93. 2011
    ..Interestingly, the proposed Man binding site of PRM-A seems to resemble the typical architecture of artificial carbohydrate receptors...
  3. doi request reprint Solid-state NMR analysis of calcium and d-mannose binding of BMY-28864, a water-soluble analogue of pradimicin A
    Yu Nakagawa
    Synthetic Cellular Chemistry Laboratory, RIKEN Advanced Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Bioorg Med Chem Lett 22:1040-3. 2012
    ..These results collectively indicate that the mode of binding of Ca(2+) ion and Man is nearly identical between PRM-A and 1...
  4. ncbi request reprint Artificial analogs of naturally occurring tumor promoters as biochemical tools and therapeutic leads
    Yu Nakagawa
    Synthetic Cellular Chemistry Laboratory, RIKEN Advanced Science Institute, Wako, Saitama, Japan
    Biosci Biotechnol Biochem 76:1262-74. 2012
    ..This review focuses on artificial analogs of phorbol esters, teleocidins, and aplysiatoxins, and discusses their potential as biochemical tools and therapeutic leads...
  5. doi request reprint Pradimicin A, a D-mannose-binding antibiotic, binds pyranosides of L-fucose and L-galactose in a calcium-sensitive manner
    Yu Nakagawa
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan Synthetic Cellular Chemistry Laboratory, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan Electronic address
    Bioorg Med Chem Lett 25:2963-6. 2015
    ..These results collectively indicate that PRM-A binds pyranosides of L-Fuc and L-Gal when Ca(2+) concentration is not excessive to trap these sugars by chelation but sufficient to form the [PRM-A/Ca(2+)] complex...
  6. doi request reprint Molecular architecture and therapeutic potential of lectin mimics
    Yu Nakagawa
    Synthetic Cellular Chemistry Laboratory, RIKEN Advanced Science Institute, Wako, Saitama, Japan
    Adv Carbohydr Chem Biochem 68:1-58. 2012
    ..Their molecular basis of carbohydrate recognition and therapeutic potential are also discussed...