Yoshiyuki Nagai

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi request reprint [Establishment and progress of Sendai virus engineering]
    Yoshiyuki Nagai
    Tanpakushitsu Kakusan Koso 51:27-37. 2006
  2. pmc Studies on the paramyxovirus accessory genes by reverse genetics in the Sendai virus-mouse system
    Takemasa Sakaguchi
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 84:439-51. 2008
  3. ncbi request reprint Primary replication of a recombinant Sendai virus vector in macaques
    Munehide Kano
    AIDS Research Centre, Department of Viral Diseases and Vaccine Control, Division of Experimental Animal Research, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    J Gen Virol 83:1377-86. 2002
  4. pmc Characterization of the amino acid residues of sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation
    Atsushi Kato
    Department of Virology 3, National Institute of Infectious Diseases, Musashi Murayama, Tokyo 208 0011, Japan
    J Virol 78:7443-54. 2004
  5. pmc A new Sendai virus vector deficient in the matrix gene does not form virus particles and shows extensive cell-to-cell spreading
    Makoto Inoue
    DNAVEC Research Inc, Tsukuba shi, Ibaraki 305 0856, Japan
    J Virol 77:6419-29. 2003
  6. ncbi request reprint Virus multiplication and induction of apoptosis by Sendai virus: role of the C proteins
    A Hajime Koyama
    Department of Virology, The University of Tokushima Graduate School of Medicine, Tokushima 770 8503, Japan
    Microbes Infect 5:373-8. 2003
  7. ncbi request reprint Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice
    Katsuhiro Kiyotani
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Virology 359:82-91. 2007
  8. pmc Importance of the anti-interferon capacity of Sendai virus C protein for pathogenicity in mice
    Atsushi Kato
    Department of Virology 3, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashi Murayama, Tokyo 208 0011, Japan
    J Virol 81:3264-71. 2007
  9. pmc The long noncoding region of the human parainfluenza virus type 1 f gene contributes to the read-through transcription at the m-f gene junction
    Tatiana Bousse
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 76:8244-51. 2002
  10. ncbi request reprint Loss of virus-specific CD4(+) T cells with increases in viral loads in the chronic phase after vaccine-based partial control of primary simian immunodeficiency virus replication in macaques
    Wen hui Lun
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Gen Virol 85:1955-63. 2004

Collaborators

Detail Information

Publications47

  1. ncbi request reprint [Establishment and progress of Sendai virus engineering]
    Yoshiyuki Nagai
    Tanpakushitsu Kakusan Koso 51:27-37. 2006
  2. pmc Studies on the paramyxovirus accessory genes by reverse genetics in the Sendai virus-mouse system
    Takemasa Sakaguchi
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 84:439-51. 2008
    ..These achievements appear to have facilitated a scientific trend where the accessory genes are a focus of active investigation in studies on other paramyxoviruses and opened up a new common ground shared between virology and immunology...
  3. ncbi request reprint Primary replication of a recombinant Sendai virus vector in macaques
    Munehide Kano
    AIDS Research Centre, Department of Viral Diseases and Vaccine Control, Division of Experimental Animal Research, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    J Gen Virol 83:1377-86. 2002
    ..None of the SeV-immunized macaques displayed appreciable clinical manifestations. These results support the idea that this system may be used safely in primates, including humans...
  4. pmc Characterization of the amino acid residues of sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation
    Atsushi Kato
    Department of Virology 3, National Institute of Infectious Diseases, Musashi Murayama, Tokyo 208 0011, Japan
    J Virol 78:7443-54. 2004
    ..Thus, amino acid sequence requirements differ greatly between IFN antagonism and RNA synthesis inhibition. In addition, we confirmed that another SeV accessory protein, V, does not antagonize IFN...
  5. pmc A new Sendai virus vector deficient in the matrix gene does not form virus particles and shows extensive cell-to-cell spreading
    Makoto Inoue
    DNAVEC Research Inc, Tsukuba shi, Ibaraki 305 0856, Japan
    J Virol 77:6419-29. 2003
    ..Thus, SeV/DeltaM is a novel type of vector with the characteristic features of loss of virus particle formation and gain of cell-to-cell spreading via a mechanism dependent on the activation of the fusion protein...
  6. ncbi request reprint Virus multiplication and induction of apoptosis by Sendai virus: role of the C proteins
    A Hajime Koyama
    Department of Virology, The University of Tokushima Graduate School of Medicine, Tokushima 770 8503, Japan
    Microbes Infect 5:373-8. 2003
    ..Apparently, the antiapoptotic activity of the C proteins supports virus multiplication in the infected cells...
  7. ncbi request reprint Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice
    Katsuhiro Kiyotani
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Virology 359:82-91. 2007
    ..These results indicate that SeV V protein counteracts IRF-3-mediated innate antiviral immunity for efficient virus replication and pathogenesis in mice, but it is not IFN...
  8. pmc Importance of the anti-interferon capacity of Sendai virus C protein for pathogenicity in mice
    Atsushi Kato
    Department of Virology 3, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashi Murayama, Tokyo 208 0011, Japan
    J Virol 81:3264-71. 2007
    ..Conversely, the results show that the innate immunity contributed to elimination of SeV in early stages of infection in the absence of anti-IFN capacity...
  9. pmc The long noncoding region of the human parainfluenza virus type 1 f gene contributes to the read-through transcription at the m-f gene junction
    Tatiana Bousse
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 76:8244-51. 2002
    ..These phenotypes seem to be responsible for the extended survival of mice infected with rSVhMFjCG...
  10. ncbi request reprint Loss of virus-specific CD4(+) T cells with increases in viral loads in the chronic phase after vaccine-based partial control of primary simian immunodeficiency virus replication in macaques
    Wen hui Lun
    AIDS Research Center, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    J Gen Virol 85:1955-63. 2004
    ....
  11. ncbi request reprint [The program of Founding Research Centers for Emerging and Reemerging Infectious Diseases: the present status and future prospects]
    Yoshiko Okamoto
    Center of Research Network for Infectious Diseases, RIKEN Yurakucho Denki Bldg North 7th fl 1 7 1 Yuraku cho, Chiyoda ku Tokyo 100 0006, Japan
    Uirusu 57:207-15. 2007
    ..By referring to these networks as models, Japan's program should be implemented over the long run but not be based on a short-time perspective. Thus, secure funding is a major issue...
  12. ncbi request reprint Recombinant Sendai viruses expressing different levels of a foreign reporter gene
    Tsuyoshi Tokusumi
    DNAVEC Research Inc, Tsukuba shi, Ibaraki, Japan
    Virus Res 86:33-8. 2002
    ..This suggests the potential for matching therapeutic gene expression level to individual therapy programs by changing the position of the foreign gene when SeVs are used as vectors for human gene therapy...
  13. pmc The amino-terminal half of Sendai virus C protein is not responsible for either counteracting the antiviral action of interferons or down-regulating viral RNA synthesis
    Atsushi Kato
    Department of Viral Diseases and Vaccine Control, National Institute of Infectious Diseases, Musashi Murayama, Tokyo 208 0011, Japan
    J Virol 76:7114-24. 2002
    ..These data indicated that the activities of the C protein to counteract the antiviral action of IFNs and to down-regulate viral RNA synthesis were not encoded within a region of at least 98 amino acids in its amino-terminal half...
  14. pmc AIP1/Alix is a binding partner of Sendai virus C protein and facilitates virus budding
    Takemasa Sakaguchi
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Virol 79:8933-41. 2005
    ..The results of this study suggest that AIP1/Alix plays a role in efficient SeV budding and that the SeV C protein facilitates virus budding through interaction with AIP1/Alix...
  15. ncbi request reprint Induction of Gag-specific T-cell responses by therapeutic immunization with a Gag-expressing Sendai virus vector in macaques chronically infected with simian-human immunodeficiency virus
    Moriaki Kato
    Department of Microbiology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Vaccine 23:3166-73. 2005
    ....
  16. ncbi request reprint [Round table discussion on highly pathogenic H5N1 avian influenza]
    Yoshiyuki Nagai
    Uirusu 54:123-41. 2004
  17. ncbi request reprint Recombinant Sendai virus vectors deleted in both the matrix and the fusion genes: efficient gene transfer with preferable properties
    Makoto Inoue
    DNAVEC Research Inc, 1 25 11 Kannondai, Tsukuba shi, Ibaraki 305 0856, Japan
    J Gene Med 6:1069-81. 2004
    ..In order to improve this vector, both the matrix (M) and fusion (F) genes were deleted from its genome...
  18. pmc Molecular epidemiology of echoviruses 11 and 13, based on an environmental surveillance conducted in Toyama Prefecture, 2002-2003
    Masae Iwai
    Department of Virology, Toyama Institute of Health, Nakataikouyama, Kosugi Machi, Imizu shi, Toyama 939 0363, Japan
    Appl Environ Microbiol 72:6381-7. 2006
    ....
  19. pmc Influence of glycosylation on the efficacy of an Env-based vaccine against simian immunodeficiency virus SIVmac239 in a macaque AIDS model
    Kazuyasu Mori
    AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Virol 79:10386-96. 2005
    ..This study demonstrated that the prime-boost Env vaccine was effective against homologous SIVmac239 challenge. Changes in glycosylation affected both cell-mediated and humoral immune responses and vaccine efficacy...
  20. ncbi request reprint The Japan Thrombosis Registry for Atrial Fibrillation, Coronary or Cerebrovascular Events (J-TRACE): a nation-wide, prospective large cohort study; the study design
    Hideki Origasa
    Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Circ J 72:991-7. 2008
    ....
  21. ncbi request reprint Epidemiology and molecular analysis of group A streptococci from patients involved in food-borne disease outbreaks in Japan between 1996 and 2003
    Daisuke Tanaka
    Department of Bacteriology, Toyama Institute of Health, Imizu, Toyama 939 0363, Japan
    Jpn J Infect Dis 59:202-3. 2006
  22. doi request reprint Abrogation of AIDS vaccine-induced cytotoxic T-lymphocyte efficacy in vivo due to a change in viral epitope flanking sequences
    Chikaya Moriya
    International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Microbes Infect 10:285-92. 2008
    ..Our results suggest that even vaccine-induced CTL efficacy can be abrogated by a single amino acid change in viral epitope flanking region, underlining the influence of viral epitope flanking sequences on CTL-based AIDS vaccine efficacy...
  23. ncbi request reprint Naked Sendai virus vector lacking all of the envelope-related genes: reduced cytopathogenicity and immunogenicity
    Mariko Yoshizaki
    DNAVEC Corporation, 1 25 11 Kannondai, Tsukuba shi, Ibaraki 305 0856, Japan
    J Gene Med 8:1151-9. 2006
    ..We improved the vector by deleting all of the envelope-related genes from the SeV genome and thus reducing its immunogenicity...
  24. pmc Genetic features of clinical isolates of Streptococcus dysgalactiae subsp. equisimilis possessing Lancefield's group A antigen
    Daisuke Tanaka
    Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama 930 8555, Japan
    J Clin Microbiol 46:1526-9. 2008
    ..The results indicate that a conserved clone has persisted and spread within Japan, and two different emm types were observed within members of this clone...
  25. doi request reprint Comparison between Sendai virus and adenovirus vectors to transduce HIV-1 genes into human dendritic cells
    Noriaki Hosoya
    Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan
    J Med Virol 80:373-82. 2008
    ..Our data suggest that SeV could be one of the reliable vectors for immuno-genetherapy for HIV-1 infected patients...
  26. ncbi request reprint Genotyping of Clostridium perfringens isolates collected from food poisoning outbreaks and healthy individuals in Japan based on the cpe locus
    Daisuke Tanaka
    Toyama Institute of Health, Toyama 939 0363, Japan
    Jpn J Infect Dis 60:68-9. 2007
  27. ncbi request reprint Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials
    Masafumi Kitakaze
    Cardiovascular Division of Medicine, National Cardiovascular Centre, Suita, Osaka, Japan
    Lancet 370:1483-93. 2007
    ..Patients who have acute myocardial infarction remain at major risk of cardiovascular events. We aimed to assess the effects of either human atrial natriuretic peptide or nicorandil on infarct size and cardiovascular outcome...
  28. pmc Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial
    Tetsuro Matano
    Department of Microbiology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Exp Med 199:1709-18. 2004
    ..Our results indicate that vaccine induction of highly effective CTLs can result in the containment of replication of a highly pathogenic immunodeficiency virus...
  29. ncbi request reprint Molecular epidemiology of group A streptococci T serotype 1
    Daisuke Tanaka
    Department of Bacteriology, Toyama Institute of Health, Toyama 939 0363, Japan
    Jpn J Infect Dis 55:89-90. 2002
  30. ncbi request reprint Recombinant Sendai virus-mediated gene transfer into adult rat retinal tissue: efficient gene transfer by brief exposure
    Yasuhiro Ikeda
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Exp Eye Res 75:39-48. 2002
    ..This work represents the first report of SeV-mediated gene transfer to ocular tissue, and identifies recombinant SeV as a new tool for studies of retinal gene transfer and gene therapy...
  31. ncbi request reprint An improved method for recovery of F-defective Sendai virus expressing foreign genes from cloned cDNA
    Takahiro Hirata
    DNAVEC Research Inc, 1 25 11 Kannondai, Tsukuba shi, Ibaraki 305 0856, Japan
    J Virol Methods 104:125-33. 2002
    ..This system may provide the basis for constructing recombinant F-defective Sendai virus for preventing and treating human diseases in the form of vaccines and vectors for gene therapy...
  32. ncbi request reprint Induction of HIV-1-specific neutralizing antibodies in mice vaccinated with a recombinant Sendai virus vector
    Munehide Kano
    AIDS Research Center, National Institute of Infectious Diseases, Tokyo 208 0011, Japan
    Jpn J Infect Dis 55:59-60. 2002
  33. ncbi request reprint Fibroblast growth factor-2 determines severity of joint disease in adjuvant-induced arthritis in rats
    Akihisa Yamashita
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 168:450-7. 2002
    ..FGF-2 may prove to be a possible therapeutic target to treat subjects with RA...
  34. ncbi request reprint Angiogenic gene therapy for experimental critical limb ischemia: acceleration of limb loss by overexpression of vascular endothelial growth factor 165 but not of fibroblast growth factor-2
    Ichiro Masaki
    Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circ Res 90:966-73. 2002
    ..The therapeutic effect of FGF-2, associated with the harmonized angiogenic effects seen with endogenous VEGF, provides important insights into therapeutic angiogenesis...
  35. pmc Interference between D30N and L90M in selection and development of protease inhibitor-resistant human immunodeficiency virus type 1
    Wataru Sugiura
    AIDS Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo 2080011, Japan
    Antimicrob Agents Chemother 46:708-15. 2002
    ..In contrast, D30N/L90M demonstrated severe impairment. Thus, the concept of mutual antagonism of the two mutations was substantiated biochemically and functionally...
  36. ncbi request reprint The nasal epithelium as a factory for systemic protein delivery
    Uta Griesenbach
    Department of Gene Therapy, Imperial College School of Medicine at the National Heart and Lung Institute, London, SM5 1RU, UK
    Mol Ther 5:98-103. 2002
    ..The combination of a high-efficiency gene transfer agent (SeV) and sites that can be assessed noninvasively (nose or lung) may circumvent several current challenges to gene therapy...
  37. ncbi request reprint Rapid phenotypic assay for human immunodeficiency virus type 1 protease using in vitro translation
    Mutsunori Iga
    Department of Internal Medicine II, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1601, Japan
    J Virol Methods 106:25-37. 2002
    ..This simple and rapid method may be useful for phenotyping of drug-resistant HIV-1 protease as well as for screening new inhibitors of HIV-1 protease...
  38. pmc An efficient and versatile mammalian viral vector system for major histocompatibility complex class I/peptide complexes
    Ai Kawana-Tachikawa
    Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Virol 76:11982-8. 2002
    ..Our system can be used not only to detect but also to stimulate antigen-specific cellular immune responses...
  39. pmc Recombinant Sendai virus expressing the G glycoprotein of respiratory syncytial virus (RSV) elicits immune protection against RSV
    Toru Takimoto
    St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Virol 78:6043-7. 2004
    ..RSV G-recombinant SV is thus a promising live virus vaccine candidate for RSV...
  40. ncbi request reprint A CCR2-V64I polymorphism affects stability of CCR2A isoform
    Emi E Nakayama
    Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    AIDS 18:729-38. 2004
    ..The aim of the present study is to elucidate the molecular mechanism underlying the effect of this allele...
  41. ncbi request reprint Comparison of risk factors in acute myocardial infarction and unstable angina pectoris in patients < or =66 versus >66 years of age
    Shiro Hoshida
    Osaka Rosai Hospital, Sakai, Japan
    Am J Cardiol 93:608-10. 2004
    ....
  42. pmc Impaired processing and presentation of cytotoxic-T-lymphocyte (CTL) epitopes are major escape mechanisms from CTL immune pressure in human immunodeficiency virus type 1 infection
    Yoshiyuki Yokomaku
    AIDS Research Center, National Institute of Infectious Diseases, University of Tokyo, Tokyo, Japan
    J Virol 78:1324-32. 2004
    ..We emphasize the importance of testing HIV-1 variants in an endogenous expression system...
  43. ncbi request reprint Masking of the contribution of V protein to Sendai virus pathogenesis in an infection model with a highly virulent field isolate
    Takemasa Sakaguchi
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Virology 313:581-7. 2003
    ..The V protein therefore seems to be potentially functional in the highly virulent Hamamatsu strain and to be prominent if virus replication is restricted...
  44. pmc Protective efficacy of an AIDS vaccine, a single DNA priming followed by a single booster with a recombinant replication-defective Sendai virus vector, in a macaque AIDS model
    Akiko Takeda
    Department of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    J Virol 77:9710-5. 2003
    ..6PD infections...
  45. ncbi request reprint No significant enhancement of protection by Tat-expressing Sendai viral vector-booster in a macaque AIDS model
    Tetsuro Matano
    Department of Microbiology, Graduate School of Medicine, The University of Tokyo, Japan
    AIDS 17:1392-4. 2003
  46. pmc Nontransmissible virus-like particle formation by F-deficient sendai virus is temperature sensitive and reduced by mutations in M and HN proteins
    Makoto Inoue
    DNAVEC Research Inc, Tsukuba shi, Ibaraki 305 0856, Japan
    J Virol 77:3238-46. 2003
    ..The absence of F protein in SeV/deltaF and the additional mutations in M and HN in SeV/M(ts)HN(ts)deltaF probably weaken the ability to transport M protein to the plasma membrane, leading to the diminished formation of NTVLP...
  47. pmc Alteration of Sendai virus morphogenesis and nucleocapsid incorporation due to mutation of cysteine residues of the matrix protein
    Takemasa Sakaguchi
    Department of Bacteriology, Hiroshima University School of Medicine, Hiroshima 734 8551, Japan
    J Virol 76:1682-90. 2002
    ..Cysteine-dependent conformation of the M protein was not due to disulfide bond formation, since the cysteines were shown to be free throughout the viral life cycle...