Shin ichiro Fujii

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi request reprint Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs
    Shin ichiro Fujii
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    Nat Immunol 3:867-74. 2002
  2. pmc Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells
    Kang Liu
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 202:1507-16. 2005
  3. ncbi request reprint Regulatory balance between the immune response of tumor antigen-specific T-cell receptor gene-transduced CD8 T cells and the suppressive effects of tolerogenic dendritic cells
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology RCAI, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Cancer Sci 96:897-902. 2005
  4. pmc Glycolipid alpha-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Turumi ku, Yokohama, Kanagawa 230 0045, Japan
    Proc Natl Acad Sci U S A 103:11252-7. 2006
  5. ncbi request reprint Evaluation of the function of human invariant NKT cells from cancer patients using alpha-galactosylceramide-loaded murine dendritic cells
    Kanako Shimizu
    Research Unit for Cellular Immunotherapy, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    J Immunol 177:3484-92. 2006
  6. pmc Cross-presentation of glycolipid from tumor cells loaded with alpha-galactosylceramide leads to potent and long-lived T cell mediated immunity via dendritic cells
    Kanako Shimizu
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology, Institute of Physical and Chemical Research, Tsurumi ku, Yokohama City, Kanagawa, 230 0045, Japan
    J Exp Med 204:2641-53. 2007
  7. doi request reprint Exploiting dendritic cells and natural killer T cells in immunotherapy against malignancies
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology, The Institute of Physical and Chemical Research, Yokohama RIKEN, 1 7 22, Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045 Japan
    Trends Immunol 29:242-9. 2008
  8. ncbi request reprint Application of natural killer T-cells to posttransplantation immunotherapy
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa, Japan
    Int J Hematol 81:1-5. 2005
  9. doi request reprint Dendritic cell-based cancer immunotherapies
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology, Institute of Physical and Chemical Research, Yokohama RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Arch Immunol Ther Exp (Warsz) 57:189-98. 2009
  10. doi request reprint Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, The Institute of Physical and Chemical Research RIKEN, Research Center for Allergy and Immunology, Yokohama, Japan
    Blood 113:4262-72. 2009

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs
    Shin ichiro Fujii
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    Nat Immunol 3:867-74. 2002
    ....
  2. pmc Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells
    Kang Liu
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 202:1507-16. 2005
    ..Therefore, the access of dying tumor cells to DCs that are maturing to activated NKT cells efficiently induces long-lived adaptive resistance...
  3. ncbi request reprint Regulatory balance between the immune response of tumor antigen-specific T-cell receptor gene-transduced CD8 T cells and the suppressive effects of tolerogenic dendritic cells
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology RCAI, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Cancer Sci 96:897-902. 2005
    ....
  4. pmc Glycolipid alpha-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Turumi ku, Yokohama, Kanagawa 230 0045, Japan
    Proc Natl Acad Sci U S A 103:11252-7. 2006
    ..Therefore, alpha-C-GalCer represents a glycolipid that binds more stably to dendritic cells and acts as a more effective link between innate and adaptive immunity in vivo...
  5. ncbi request reprint Evaluation of the function of human invariant NKT cells from cancer patients using alpha-galactosylceramide-loaded murine dendritic cells
    Kanako Shimizu
    Research Unit for Cellular Immunotherapy, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    J Immunol 177:3484-92. 2006
    ..This new approach should be available for evaluating the functions of NKT cells and APCs in cancer patients...
  6. pmc Cross-presentation of glycolipid from tumor cells loaded with alpha-galactosylceramide leads to potent and long-lived T cell mediated immunity via dendritic cells
    Kanako Shimizu
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology, Institute of Physical and Chemical Research, Tsurumi ku, Yokohama City, Kanagawa, 230 0045, Japan
    J Exp Med 204:2641-53. 2007
    ..Therefore, several immunogenic features of DCs are engaged by the CD1d-mediated cross-presentation of glycolipid-loaded tumor cells, leading to particularly strong and long-lived adaptive immunity...
  7. doi request reprint Exploiting dendritic cells and natural killer T cells in immunotherapy against malignancies
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology, The Institute of Physical and Chemical Research, Yokohama RIKEN, 1 7 22, Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045 Japan
    Trends Immunol 29:242-9. 2008
    ..The characterization and manipulation of DC function in tumor-bearing hosts will provide new insights into mechanisms of tumor immunology and lead to the development of successful clinical strategies...
  8. ncbi request reprint Application of natural killer T-cells to posttransplantation immunotherapy
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa, Japan
    Int J Hematol 81:1-5. 2005
    ..Control and modification of NKT cell function may play an important role in regulating GVHD/GVL effects...
  9. doi request reprint Dendritic cell-based cancer immunotherapies
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology, Institute of Physical and Chemical Research, Yokohama RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Arch Immunol Ther Exp (Warsz) 57:189-98. 2009
    ..Current DC vaccination strategies utilize a number of methods to recapitulate the cascade of events that culminate in a protective antitumor immune response...
  10. doi request reprint Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, The Institute of Physical and Chemical Research RIKEN, Research Center for Allergy and Immunology, Yokohama, Japan
    Blood 113:4262-72. 2009
    ....
  11. ncbi request reprint Tumor cells loaded with alpha-galactosylceramide induce innate NKT and NK cell-dependent resistance to tumor implantation in mice
    Kanako Shimizu
    Research Unit for Cellular Immunotherapy, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Immunol 178:2853-61. 2007
    ..Taken together, these results indicate that tumor/Gal are effective APCs for innate NKT and NK cell responses, and that these innate immune responses are able to resist the establishment of metastases in vivo...
  12. ncbi request reprint Innate Valpha14(+) natural killer T cells mature dendritic cells, leading to strong adaptive immunity
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology RCAI, RIKEN, Yokohama, Kanagawa, Japan
    Immunol Rev 220:183-98. 2007
    ..These findings help explain tumor protection via alpha-GalCer and urge development of the DC-NKT axis to provide innate and adaptive immunity to human cancers...
  13. doi request reprint Invariant NKT cells induce plasmacytoid dendritic cell (DC) cross-talk with conventional DCs for efficient memory CD8+ T cell induction
    Kanako Shimizu
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology, The Institute of Physical and Chemical Research, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    J Immunol 190:5609-19. 2013
    ..These findings reveal a previously unknown pathway of intercellular collaboration for the generation of tumor-specific CD8(+) memory T cells that can be exploited for strategic vaccination in the setting of tumor immunotherapy...
  14. pmc Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells
    Hiroshi Watarai
    RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    J Clin Invest 120:2610-8. 2010
    ..These studies demonstrate the feasibility of expanding functionally competent NKT cells via an iPSC phase, an approach that may be adapted for NKT cell-targeted therapy in humans...
  15. doi request reprint DC therapy induces long-term NK reactivity to tumors via host DC
    Kanako Shimizu
    Research Unit for Cellular Immunotherapy, The Institute of Physical and Chemical Research, RIKEN, Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    Eur J Immunol 39:457-68. 2009
    ....
  16. doi request reprint Induction of Th1-biased cytokine production by alpha-carba-GalCer, a neoglycolipid ligand for NKT cells
    Takuya Tashiro
    Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Japan
    Int Immunol 22:319-28. 2010
    ..Modulation of the sugar moiety in glycolipids might therefore provide optimal therapeutic reagents for protective immune responses against tumor or pathogens...
  17. doi request reprint Human leukemic cells loaded with alpha-galactosylceramide (alpha-GalCer) activate murine NKT cells in situ
    Kanako Shimizu
    Research Unit for Cellular Immunotherapy and Research Unit for Therapeutic Model, Institute of Physical and Chemical Research RIKEN, Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    Int J Hematol 92:152-60. 2010
    ..This method could be utilized to develop future immunotherapies in which NKT cells are targeted for activation...
  18. doi request reprint Efficient Regeneration of Human Vα24+ Invariant Natural Killer T Cells and Their Anti-Tumor Activity In Vivo
    Daisuke Yamada
    Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Science IMS, Yokohama, Japan
    Stem Cells 34:2852-2860. 2016
    ..This study thus provides a first proof of concept for the clinical application of human iPS-Vα24+ iNKT cells for cancer immunotherapy. Stem Cells 2016;34:2852-2860...
  19. ncbi request reprint Valpha14 NKT cell-mediated anti-tumor responses and their clinical application
    Ken ichiro Seino
    Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Suehiro cho 1 7 22, Tsurumi, 230 0045 Yokohama, Kanagawa, Japan
    Springer Semin Immunopathol 27:65-74. 2005
    ..In this review, we summarize the Valpha14 NKT cell-mediated cellular cascade in the anti-tumor response in mice and discuss potential clinical applications of alpha-GalCer-pulsed DC therapy...
  20. doi request reprint Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells
    Kanako Shimizu
    Research Unit for Cellular Immunotherapy, The Institute of Physical and Chemical Research RIKEN, Research Center for Allergy and Immunology RCAI, Yokohama, Japan
    Cancer Res 73:62-73. 2013
    ..Our results support the clinical development of aAVCs to harness innate and adaptive immunity for effective cancer immunotherapy...
  21. doi request reprint Induced pluripotency as a potential path towards iNKT cell-mediated cancer immunotherapy
    Hiroshi Watarai
    RIKEN Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
    Int J Hematol 95:624-31. 2012
    ....
  22. doi request reprint Prolonged antitumor NK cell reactivity elicited by CXCL10-expressing dendritic cells licensed by CD40L+ CD4+ memory T cells
    Kanako Shimizu
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology, The Institute of Physical and Chemical Research RIKEN, Yokohama, Kanagawa 230 0045, Japan
    J Immunol 186:5927-37. 2011
    ..These findings suggest that DC vaccination can sustain long-term innate NK cell immunity but requires the participation of the adaptive immune system...
  23. doi request reprint Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Valpha14-Jalpha18 TCRalpha gene
    Hiroshi Watarai
    Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
    Blood 115:230-7. 2010
    ..The cloned ES culture system offers a new opportunity for the elucidation of the molecular events on NKT-cell development and for the establishment of NKT-cell therapy...
  24. doi request reprint Systemic DC Activation Modulates the Tumor Microenvironment and Shapes the Long-Lived Tumor-Specific Memory Mediated by CD8+ T Cells
    Kanako Shimizu
    Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Science, Yokohama, Kanagawa, Japan
    Cancer Res 76:3756-66. 2016
    ..The findings of this study help to inform a next-generation platform for the generation of efficacious cancer vaccines. Cancer Res; 76(13); 3756-66. ©2016 AACR. ..
  25. ncbi request reprint An adjuvant role of in situ dendritic cells (DCs) in linking innate and adaptive immunity
    Kanako Shimizu
    Research Unit for Therapeutic Model, The Institute of Physical and Chemical Research, RIKEN, Japan
    Front Biosci 13:6193-201. 2008
    ..It is therefore crucial to determine optimal conditions for antigen delivery to DCs in an environment suited to maximally stimulate the immune system...
  26. pmc In vivo dendritic cell targeting cellular vaccine induces CD4+ Tfh cell-dependent antibody against influenza virus
    Satoru Yamasaki
    Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Science, Yokohama, Kanagawa, Japan
    Sci Rep 6:35173. 2016
    ..Thus, the in vivo DC targeting therapy by aAVC would be useful for protection against viral infection...
  27. pmc Transfer of mRNA Encoding Invariant NKT Cell Receptors Imparts Glycolipid Specific Responses to T Cells and γδT Cells
    Kanako Shimizu
    Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Science, Yokohama, Kanagawa, Japan
    PLoS ONE 10:e0131477. 2015
    ..The transfection of NKT cell TCR has the potential to be a new approach to tumor immunotherapy in patients with various types of cancer. ..
  28. doi request reprint Adoptive cytotoxic T lymphocyte therapy triggers a counter-regulatory immunosuppressive mechanism via recruitment of myeloid-derived suppressor cells
    Akihiro Hosoi
    Department of Immunotherapeutics, The University of Tokyo Hospital, Tokyo, Japan Medinet Co, Ltd, Yokohama, Japan
    Int J Cancer 134:1810-22. 2014
    ..Thus, ACT triggered counter-regulatory immunosuppressive mechanism via recruitment of MDSCs. Our results suggest that strategies to regulate the treatment-induced recruitment of these MDSCs would improve the efficacy of immunotherapy. ..
  29. doi request reprint Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells
    Raul Vizcardo
    Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Cell Stem Cell 12:31-6. 2013
    ..The present study therefore illustrates an approach for cloning and expanding functional antigen-specific CD8(+) T cells that might be applicable in cell-based therapy of cancer...
  30. ncbi request reprint [Immunological evaluation for CML and its possibility for an immunotherapy]
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology, RIKEN
    Nihon Rinsho Meneki Gakkai Kaishi 32:231-41. 2009
    ..Development of such immunotherapeutic strategies would be a promising approach to treat the imatinib-treated CML-CP patients...
  31. pmc The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways
    Fumihiko Ishikawa
    Research Unit for Human Disease Model, Rikagaku Kenkyusho RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Blood 110:3591-660. 2007
    ..We propose that human DCs use unique and flexible developmental programs that cannot be categorized into the conventional myeloid or lymphoid pathway...
  32. doi request reprint CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens
    Kenichi Asano
    Laboratory for Innate Cellular Immunity, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Immunity 34:85-95. 2011
    ..Thus, we have identified CD169(+) macrophages as lymph node-resident APCs dominating early activation of tumor antigen-specific CD8(+) T cells...
  33. pmc Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein
    Shin ichiro Fujii
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021 6399, USA
    J Exp Med 198:267-79. 2003
    ..Therefore a single dose of alphaGalCer i.v. rapidly stimulates the full maturation of DCs in situ, and this accounts for the induction of combined Th1 CD4+ and CD8+ T cell immunity to a coadministered protein...
  34. ncbi request reprint Detection and activation of human Valpha24+ natural killer T cells using alpha-galactosyl ceramide-pulsed dendritic cells
    Shin ichiro Fujii
    Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, New York, NY 10021, USA
    J Immunol Methods 272:147-59. 2003
    ..These data help to establish the conditions for loading DCs with alpha-GalCer for immune therapeutic targeting of NKT cells, and provide a new simple assay to monitor NKT function in humans...
  35. ncbi request reprint [NKT cell-mediated immunotherapy for hematological malignancies]
    Shin ichiro Fujii
    Rinsho Ketsueki 48:188-99. 2007
  36. ncbi request reprint Severe and selective deficiency of interferon-gamma-producing invariant natural killer T cells in patients with myelodysplastic syndromes
    Shin ichiro Fujii
    Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, New York, NY 10021, USA
    Br J Haematol 122:617-22. 2003
    ..This severe and selective deficiency of an important immune regulatory cell may contribute to the pathogenesis of MDS...
  37. ncbi request reprint Malignant counterpart of myeloid dendritic cell (DC) belonging to acute myelogenous leukemia (AML) exhibits a dichotomous immunoregulatory potential
    Shin ichiro Fujii
    The Center for Bone Marrow Transplantation and Immunotherapy, Institute for Clinical Research, Kumamoto National Hospital, Japan
    J Leukoc Biol 73:82-90. 2003
    ..Taken together, DC-like leukemia uniquely influences immune surveillance in contradictory ways, some of which may be involved in the mechanism of immune escape...
  38. pmc A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma
    Madhav V Dhodapkar
    Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 197:1667-76. 2003
    ....
  39. pmc Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity
    CHRISTIAN MUNZ
    Laboratory of Viral Immunobiology, Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 202:203-7. 2005
    ..Here, we comment on the evidence that these pathways are TLR independent and have the potential to respond to infection, malignancy, and immunotherapy...
  40. pmc In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination
    Laura C Bonifaz
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:815-24. 2004
    ....
  41. pmc The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation
    Shin ichiro Fujii
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:1607-18. 2004
    ....
  42. ncbi request reprint A phase I study of in vitro expanded natural killer T cells in patients with advanced and recurrent non-small cell lung cancer
    Shinichiro Motohashi
    Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Clin Cancer Res 12:6079-86. 2006
    ..We did a phase I study with autologous activated Valpha24 NKT cell therapy...
  43. ncbi request reprint The innate functions of dendritic cells in peripheral lymphoid tissues
    Ralph M Steinman
    Laboratories of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Ave, New York, NY 10021 6399, USA
    Adv Exp Med Biol 560:83-97. 2005