Makoto Miyamoto

Summary

Affiliation: Pharmaceutical Research Division
Country: Japan

Publications

  1. ncbi request reprint Visual electrophysiological features of two naturally occurring mouse models with retinal dysfunction
    Makoto Miyamoto
    Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Osaka, Japan
    Curr Eye Res 31:329-35. 2006
  2. doi request reprint Detection of cell-free, liver-specific mRNAs in peripheral blood from rats with hepatotoxicity: a potential toxicological biomarker for safety evaluation
    Makoto Miyamoto
    Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Yodogawa ku, Osaka 532 8686, Japan
    Toxicol Sci 106:538-45. 2008
  3. doi request reprint A nonsense mutation in Gnat1, encoding the alpha subunit of rod transducin, in spontaneous mouse models of retinal dysfunction
    Makoto Miyamoto
    Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 2 17 85 Jusohonmachi, Yodogawa ku, Osaka 532 8686, Japan
    Exp Eye Res 90:63-9. 2010
  4. doi request reprint IRD1 and IRD2 mice, naturally occurring models of hereditary retinal dysfunction, show late-onset and progressive retinal degeneration
    Makoto Miyamoto
    Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Jusohonmachi 2 chome, Osaka, Japan
    Curr Eye Res 35:137-45. 2010
  5. doi request reprint Albumin and apolipoprotein H mRNAs in human plasma as potential clinical biomarkers of liver injury: analyses of plasma liver-specific mRNAs in patients with liver injury
    Shingo Okubo
    a Drug Safety Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan and
    Biomarkers 21:353-62. 2016
  6. doi request reprint Identification of novel liver-specific mRNAs in plasma for biomarkers of drug-induced liver injury and quantitative evaluation in rats treated with various hepatotoxic compounds
    Shingo Okubo
    Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
    Toxicol Sci 132:21-31. 2013

Collaborators

  • Takao Ando
  • Shingo Okubo
  • Kenji Takami
  • Kiyoshi Ashida
  • Dai Ito
  • Tetsuro Urushidani
  • Hiroshi Yamada
  • Atsushi Ono
  • Yasuo Ohno
  • Noriyuki Nakatsu
  • Masayuki Kanki

Detail Information

Publications6

  1. ncbi request reprint Visual electrophysiological features of two naturally occurring mouse models with retinal dysfunction
    Makoto Miyamoto
    Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Osaka, Japan
    Curr Eye Res 31:329-35. 2006
    ..The purpose of this study was to describe the features of retinal dysfunction in both mutant mice...
  2. doi request reprint Detection of cell-free, liver-specific mRNAs in peripheral blood from rats with hepatotoxicity: a potential toxicological biomarker for safety evaluation
    Makoto Miyamoto
    Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Yodogawa ku, Osaka 532 8686, Japan
    Toxicol Sci 106:538-45. 2008
    ..It is believed that the detection of cell-free organ/tissue-specific mRNA in peripheral blood is a promising approach in the survey of toxicological biomarkers...
  3. doi request reprint A nonsense mutation in Gnat1, encoding the alpha subunit of rod transducin, in spontaneous mouse models of retinal dysfunction
    Makoto Miyamoto
    Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 2 17 85 Jusohonmachi, Yodogawa ku, Osaka 532 8686, Japan
    Exp Eye Res 90:63-9. 2010
    ..Thus our results showed that IRD1 and IRD2 mice harbor a nonsense mutation in the Gnat1 gene, resulting in the absence or suppressed expression of the Tralpha protein, which is the likely cause of rod dysfunction in both mutants...
  4. doi request reprint IRD1 and IRD2 mice, naturally occurring models of hereditary retinal dysfunction, show late-onset and progressive retinal degeneration
    Makoto Miyamoto
    Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Jusohonmachi 2 chome, Osaka, Japan
    Curr Eye Res 35:137-45. 2010
    ..To elucidate whether Institute for Cancer Research (ICR) derived retinal dysfunction (IRD) 1 and IRD2 mice, spontaneous mouse models of rod-cone and rod dysfunction, respectively, develop age-related retinal degeneration...
  5. doi request reprint Albumin and apolipoprotein H mRNAs in human plasma as potential clinical biomarkers of liver injury: analyses of plasma liver-specific mRNAs in patients with liver injury
    Shingo Okubo
    a Drug Safety Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan and
    Biomarkers 21:353-62. 2016
    ..Plasma liver-specific mRNAs are useful biomarkers of hepatotoxicity in rats...
  6. doi request reprint Identification of novel liver-specific mRNAs in plasma for biomarkers of drug-induced liver injury and quantitative evaluation in rats treated with various hepatotoxic compounds
    Shingo Okubo
    Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
    Toxicol Sci 132:21-31. 2013
    ..These results strongly support the reliability and usefulness of the four circulating liver-specific mRNAs as biomarkers for DILI...