Hideaki Kikuta

Summary

Affiliation: Pediatric Clinic
Country: Japan

Publications

  1. pmc Immunofluorescence assay for detection of human metapneumovirus-specific antibodies by use of baculovirus-expressed fusion protein
    Nobuhisa Ishiguro
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo 060 8638, Japan
    Clin Diagn Lab Immunol 12:202-5. 2005
  2. ncbi request reprint Development of a rapid chromatographic immunoassay for detection of human metapneumovirus using monoclonal antibodies against nucleoprotein of hMPV
    Hideaki Kikuta
    Pediatric Clinic, Touei Hospital, Sapporo, Japan
    Hybridoma (Larchmt) 26:17-21. 2007
  3. pmc Comparison of a lateral-flow immunochromatography assay with real-time reverse transcription-PCR for detection of human metapneumovirus
    Hideaki Kikuta
    Pediatric Clinic, Touei Hospital, N 41, E 16, Higashi ku, Sapporo 007 0841, Japan
    J Clin Microbiol 46:928-32. 2008
  4. ncbi request reprint Efficacy of antibiotic prophylaxis for intrafamilial transmission of group A beta-hemolytic streptococci
    Hideaki Kikuta
    Pediatric Clinic, Touei Hospital, Sapporo, Japan
    Pediatr Infect Dis J 26:139-41. 2007
  5. ncbi request reprint [Human metapneumovirus]
    Hideaki Kikuta
    Touei Hospital, Pediatric Clinic, Higashi ku, Sapporo
    Uirusu 56:173-81. 2006
  6. ncbi request reprint Production and characterization of neutralizing monoclonal antibodies against human metapneumovirus F protein
    Xiaoming Ma
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hybridoma (Larchmt) 24:201-5. 2005
  7. ncbi request reprint Comparison of the seroprevalence of human metapneumovirus and human respiratory syncytial virus
    Takashi Ebihara
    Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
    J Med Virol 72:304-6. 2004
  8. pmc Human metapneumovirus infection in Japanese children
    Takashi Ebihara
    Department of Pediatrics, Hokkaido University School of Medicine, Kohnan Hospital, Sapporo, Japan
    J Clin Microbiol 42:126-32. 2004
  9. doi request reprint Detection of four genetic subgroup-specific antibodies to human metapneumovirus attachment (G) protein in human serum
    Rika Endo
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Gen Virol 89:1970-7. 2008
  10. pmc Detection of human bocaviruses 1 to 4 from nasopharyngeal swab samples collected from patients with respiratory tract infections
    Naoko Koseki
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Clin Microbiol 50:2118-21. 2012

Collaborators

Detail Information

Publications44

  1. pmc Immunofluorescence assay for detection of human metapneumovirus-specific antibodies by use of baculovirus-expressed fusion protein
    Nobuhisa Ishiguro
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo 060 8638, Japan
    Clin Diagn Lab Immunol 12:202-5. 2005
    ..The Bac-F IFA is a more reliable, sensitive, and specific method for the detection of hMPV antibodies than is the hMPV IFA...
  2. ncbi request reprint Development of a rapid chromatographic immunoassay for detection of human metapneumovirus using monoclonal antibodies against nucleoprotein of hMPV
    Hideaki Kikuta
    Pediatric Clinic, Touei Hospital, Sapporo, Japan
    Hybridoma (Larchmt) 26:17-21. 2007
    ..The assay had good specificity and sufficient sensitivity to detect hMPV. Therefore, the assay may be a rapid and useful test for diagnosis of hMPV infections...
  3. pmc Comparison of a lateral-flow immunochromatography assay with real-time reverse transcription-PCR for detection of human metapneumovirus
    Hideaki Kikuta
    Pediatric Clinic, Touei Hospital, N 41, E 16, Higashi ku, Sapporo 007 0841, Japan
    J Clin Microbiol 46:928-32. 2008
    ..5% specificity). Although the sensitivity of the IC assay is lower than that of real-time RT-PCR, the IC assay is a rapid and useful test for the diagnosis of hMPV infections in children...
  4. ncbi request reprint Efficacy of antibiotic prophylaxis for intrafamilial transmission of group A beta-hemolytic streptococci
    Hideaki Kikuta
    Pediatric Clinic, Touei Hospital, Sapporo, Japan
    Pediatr Infect Dis J 26:139-41. 2007
    ..The role of chemoprophylaxis for household contacts of patients with acute streptococcal disease is uncertain...
  5. ncbi request reprint [Human metapneumovirus]
    Hideaki Kikuta
    Touei Hospital, Pediatric Clinic, Higashi ku, Sapporo
    Uirusu 56:173-81. 2006
    ..Reinfection with hMPV frequently occurs in children, implying that the host immune response induced by natural infection provides incomplete protection. The RT-PCR test is the most sensitive test for detection of hMPV...
  6. ncbi request reprint Production and characterization of neutralizing monoclonal antibodies against human metapneumovirus F protein
    Xiaoming Ma
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hybridoma (Larchmt) 24:201-5. 2005
    ..Production of MAbs to the hMPV F protein is critical for development of diagnostic techniques, vaccine research, and studies on viral pathogenesis...
  7. ncbi request reprint Comparison of the seroprevalence of human metapneumovirus and human respiratory syncytial virus
    Takashi Ebihara
    Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
    J Med Virol 72:304-6. 2004
    ..60%, P < 0.025), and the difference was particularly notable between the ages of 4 months and 1 year (11% vs. 48%, P = 0.006). The results suggest that primary infection with hMPV occurs somewhat later than that with hRSV...
  8. pmc Human metapneumovirus infection in Japanese children
    Takashi Ebihara
    Department of Pediatrics, Hokkaido University School of Medicine, Kohnan Hospital, Sapporo, Japan
    J Clin Microbiol 42:126-32. 2004
    ..The RT-PCR test is the most sensitive test for detection of hMPV, and a serological test may be useful to differentiate between primary infection and reinfection with hMPV...
  9. doi request reprint Detection of four genetic subgroup-specific antibodies to human metapneumovirus attachment (G) protein in human serum
    Rika Endo
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Gen Virol 89:1970-7. 2008
    ..This assay may be useful for the study of immune responses of humans to different hMPV strains, especially for clarifying the risk of reinfection with hMPV...
  10. pmc Detection of human bocaviruses 1 to 4 from nasopharyngeal swab samples collected from patients with respiratory tract infections
    Naoko Koseki
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Clin Microbiol 50:2118-21. 2012
    ..6%), 3 (0.4%), and 5 (0.6%) of 850 nasopharyngeal swab samples collected from children with respiratory tract infections, respectively. Out of the 145 HBoV1-4-positive samples, 62 (42.8%) were codetected with other respiratory viruses...
  11. ncbi request reprint Detection of antibodies against human metapneumovirus by Western blot using recombinant nucleocapsid and matrix proteins
    Nobuhisa Ishiguro
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Med Virol 78:1091-5. 2006
    ..Therefore, Western blot using N and M proteins provide a useful tool for analysis of immune responses to hMPV...
  12. ncbi request reprint Seroprevalence of human metapneumovirus in Japan
    Takashi Ebihara
    Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
    J Med Virol 70:281-3. 2003
    ..All of the children had been exposed to human metapneumovirus by the age of 10 years. The results show that human metapneumovirus is circulating in the Japanese population and is a ubiquitous virus acquired early in life...
  13. doi request reprint Detection of KI polyomavirus and WU polyomavirus DNA by real-time polymerase chain reaction in nasopharyngeal swabs and in normal lung and lung adenocarcinoma tissues
    Shinobu Teramoto
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Microbiol Immunol 55:525-30. 2011
    ..KIPyV was detected in one of 30 specimens of lung tissue (3.3%). Neither of the viruses was detected in 30 samples of lung adenocarcinoma tissue...
  14. ncbi request reprint Possible involvement in oncogenesis of a single base mutation in an internal ribosome entry site of Epstein-Barr nuclear antigen 1 mRNA
    Rika Endo
    Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
    J Med Virol 72:630-4. 2004
    ....
  15. ncbi request reprint [Diagnosis of EBV infection]
    Hideaki Kikuta
    Touei Hospital, Pediatric Clinic
    Nihon Rinsho 64:617-20. 2006
  16. ncbi request reprint Detection of human coronavirus NL63 in young children with bronchiolitis
    Takashi Ebihara
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    J Med Virol 75:463-5. 2005
    ..Three (2.5%) of the 118 samples were positive for HCoV-NL63 by reverse transcription-polymerase chain reaction tests. HCoV-NL63 may be one of the causative agents of bronchiolitis in young children...
  17. ncbi request reprint Latency pattern of Epstein-Barr virus and methylation status in Epstein-Barr virus-associated hemophagocytic syndrome
    Mikio Yoshioka
    Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
    J Med Virol 70:410-9. 2003
    ..The methylation status in Cp and phenotype of EBV-infected cells may be critical differences in EBV-associated hemophagocytic syndrome and infectious mononucleosis...
  18. pmc Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A beta-Hemolytic Streptococcus pharyngitis in Children
    Hideaki Kikuta
    Pediatric Clinic, Touei Hospital, N 41, E 16, Higashi ku, Sapporo 007 0841, Japan
    Int J Pediatr 2009:863608. 2009
    ..There was no statistical difference between the two groups. A 5-day course of oral cephalosporins is not always recommended for treatment of GABHS pharyngitis in children who have repeated episodes of pharyngitis...
  19. doi request reprint Comparison of the clinical effectiveness of zanamivir and laninamivir octanoate for children with influenza A(H3N2) and B in the 2011-2012 season
    Naoko Koseki
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Influenza Other Respir Viruses 8:151-8. 2014
    ..To evaluate the clinical effectiveness of the two inhaled neuraminidase inhibitors (NAIs), zanamivir (ZN) and laninamivir octate (LO), for influenza A(H3N2) and B virus infections...
  20. ncbi request reprint Relationship between gene polymorphisms of mannose-binding lectin (MBL) and two molecular forms of MBL
    Itaru Terai
    Institute of Medical Science, Health Sciences University of Hokkaido, Sapporo, Japan
    Eur J Immunol 33:2755-63. 2003
    ..An apparent MBL deficiency does not in fact representa deficiency in MBL molecules but rather the presence of circulating oligomeric mutant MBL with impaired function...
  21. ncbi request reprint Protein-losing cytomegalovirus gastritis in a patient with Stevens-Johnson syndrome
    Mikio Yoshioka
    Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
    Digestion 65:234-7. 2002
    ..The possible mechanism by which cytomegalovirus gastritis occurred in the present case and effective diagnostic procedures are discussed...
  22. ncbi request reprint Nitric oxide synthesis in ornithine transcarbamylase deficiency: possible involvement of low no synthesis in clinical manifestations of urea cycle defect
    Hironori Nagasaka
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Pediatr 145:259-62. 2004
    ..The patients were found to have low NO synthesis, suggesting that the low NO synthesis contributes to the clinical manifestations of urea cycle defect...
  23. ncbi request reprint Decreased affinity of mosaic-structure recombinant penicillin-binding protein 2 for oral cephalosporins in Neisseria gonorrhoeae
    Susumu Ochiai
    Research and Development Department, Mitsubishi Kagaku Bio Clinical Laboratories, Inc, 3 30 1 Shimura, Itabashi ku, Tokyo 174 8555, Japan
    J Antimicrob Chemother 60:54-60. 2007
    ..The aim of this study was to determine the affinity of mosaic PBP 2 for cephalosporins in N. gonorrhoeae...
  24. ncbi request reprint Human rhinovirus 87 identified as human enterovirus 68 by VP4-based molecular diagnosis
    Hiroaki Ishiko
    Research and Development Department, Mitsubishi Kagaku Bio Clinical Laboratories, Tokyo, Japan
    Intervirology 45:136-41. 2002
    ..HRV-87 showed the second highest homology (76.8%) with EV-70, another member of the human EV-D, in a sample of 66 human EVs and 12 HRVs. Therefore, HRV-87 should be reclassified into the cluster containing human EV-68...
  25. ncbi request reprint TT virus infection during childhood
    Hitoshi Ohto
    Division of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima City, Japan
    Transfusion 42:892-8. 2002
    ..TT virus (TTV) is widespread in the general population, however, the mode of its transmission and the mechanism of maintaining it in the general population are unclear...
  26. doi request reprint Molecular epidemiology of norovirus gastroenteritis in Soma, Japan, 2001-2003
    Noriko Onishi
    Department of Pediatrics, Fukushima Medical University School of Medicine, and Public Soma General Hospital, Fukushima, Japan
    Pediatr Int 50:65-9. 2008
    ..The aim of the present paper was to investigate the molecular epidemiology of norovirus gastroenteritis in Japan using polymerase chain reaction (PCR) and subsequent phylogenetic analysis...
  27. pmc Rapid detection of the mosaic structure of the Neisseria gonorrhoeae penA Gene, which is associated with decreased susceptibilities to oral cephalosporins
    Susumu Ochiai
    Advanced Medicine Development Department, R and D and Business Development Segment, Mitsubishi Chemical Medience Corporation, 3 30 1 Shimura, Itabashi ku, Tokyo 174 8555, Japan
    J Clin Microbiol 46:1804-10. 2008
    ..This real-time PCR assay for the detection of mosaic PBP 2 of N. gonorrhoeae is thus useful in the prediction of decreased susceptibilities to oral cephalosporins...
  28. pmc Novel human adenovirus causing nosocomial epidemic keratoconjunctivitis
    Hiroaki Ishiko
    Host Defense Laboratory, Mitsubishi Chemical Medience Corporation, Shimura 3 30 1, Itabashi ku, Tokyo 174 8555, Japan
    J Clin Microbiol 46:2002-8. 2008
    ..2% identity. The sequences of the loop 2 and fiber knob regions from the representative strain, Kobe-H, were dissimilar in all prototype strains of 51 serotypes. We believe that this virus is a novel serotype of HAdV that causes EKC...
  29. pmc Epidemic keratoconjunctivitis due to the novel hexon-chimeric-intermediate 22,37/H8 human adenovirus
    Koki Aoki
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Clin Microbiol 46:3259-69. 2008
    ..However, the nucleotide sequence of the fiber gene was identical to that of the HAdV-8 prototype strain. 22 We propose that this virus is a new hexon-chimeric intermediate HAdV-22,37/H8, and may be an etiological agent of EKC...
  30. ncbi request reprint Application of polymerase chain reaction and subsequent phylogenetic analysis to the diagnosis of enteroviral infection in the central nervous system
    Mitsuaki Hosoya
    Department of Paediatrics, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukusima 960 1295, Japan
    J Clin Virol 25:S27-38. 2002
    ..Enteroviral infections of the central nervous system (CNS) are often difficult to diagnose, even if consistent conventional laboratory methodologies are used...
  31. pmc High genetic diversity of the attachment (G) protein of human metapneumovirus
    Nobuhisa Ishiguro
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo 060 8638, Japan
    J Clin Microbiol 42:3406-14. 2004
    ..Clarification of the antigenic diversity of G is important for epidemiological analysis and for establishment of strategies to prevent hMPV infection...
  32. ncbi request reprint Production and release of infectious hepatitis C virus from human liver cell cultures in the three-dimensional radial-flow bioreactor
    Hideki Aizaki
    Department of Virology II, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
    Virology 314:16-25. 2003
    ..It will also accelerate research into the pathogenicity of HCV, as well as the development of prophylactic agents and new therapy...
  33. pmc Five new genome types of adenovirus type 37 caused epidemic keratoconjunctivitis in Sapporo, Japan, for more than 10 years
    Toshihide Ariga
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo, Hokkaido 060 8638, Japan
    J Clin Microbiol 43:726-32. 2005
    ..We conclude that mutations in the adenovirus genome occurred chronologically and that certain mutations were correlated with the epidemics of adenoviral keratoconjunctivitis...
  34. ncbi request reprint Tolerability and efficacy of N-chlorotaurine in epidemic keratoconjunctivitis--a double-blind, randomized, phase-2 clinical trial
    Barbara Teuchner
    Department of Ophthalmology, Innsbruck Medical University, Innsbruck, Austria
    J Ocul Pharmacol Ther 21:157-65. 2005
    ..N-chlorotaurine was well-tolerated, shortened the duration of illness, and seems to be a useful causative therapeutic approach in severe epidemic keratoconjunctivitis...
  35. ncbi request reprint Characterization of the hepatitis C virus RNA replication complex associated with lipid rafts
    Hideki Aizaki
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Virology 324:450-61. 2004
    ..Depletion of cellular cholesterol selectively reduced HCV RNA replication. These findings provide further insights into the mechanism of HCV replication in vivo...
  36. pmc Detection of human bocavirus in Japanese children with lower respiratory tract infections
    Xiaoming Ma
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo 060 8638, Japan
    J Clin Microbiol 44:1132-4. 2006
    ..7%) collected from children with lower respiratory tract infections. HBoV may be one of the causative agents of lower respiratory tract infections in young children...
  37. ncbi request reprint Phylogenetic analysis of wild-type 1 polioviruses isolated during the final period of transmission in Turkey
    Etem Ozkaya
    Virology Department, Refik Saydam National Hygiene Center, Cemal Gursel Cad 16, Sihhiye 06100, Ankara, Turkey
    J Gen Virol 85:1591-5. 2004
    ..This finding serves as a reference for future poliovirus surveillance both in Turkey and worldwide...
  38. ncbi request reprint Molecular diagnosis of human enteroviruses by phylogeny-based classification by use of the VP4 sequence
    Hiroaki Ishiko
    Research and Development Department, Mitsubishi Kagaku Bio Clinical Laboratories, Tokyo 174 8555, Japan
    J Infect Dis 185:744-54. 2002
    ..VP4-based classification appears to be an effective tool for the molecular epidemiology study of EVs...
  39. ncbi request reprint Genetic diversity of enterovirus 71 associated with hand, foot and mouth disease epidemics in Japan from 1983 to 2003
    Mitsuaki Hosoya
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pediatr Infect Dis J 25:691-4. 2006
    ..The surveillance data indicate that EV71 infection follows an epidemic mode of transmission, causing large outbreaks and then becoming quiescent for a few years...
  40. pmc Genetic diversity of coxsackievirus A16 associated with hand, foot, and mouth disease epidemics in Japan from 1983 to 2003
    Mitsuaki Hosoya
    Department of Pediatrics, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima 960 1295, Japan
    J Clin Microbiol 45:112-20. 2007
    ..We concluded that repeated outbreaks of CV-A16-related HFMD in Japan were caused, in part, by the introduction of genetically changed CV-A16 strains, which might be transmitted overseas...
  41. ncbi request reprint Molecular epidemiology of adenoviral conjunctivitis in Hanoi, Vietnam
    Xue Hai Jin
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Ophthalmol 142:1064-6. 2006
    ..To investigate the serotypes of adenovirus causing conjunctivitis in Hanoi, Vietnam...
  42. ncbi request reprint Anti-adenoviral effect of anti-HIV agents in vitro in serotypes inducing keratoconjunctivitis
    Eiichi Uchio
    Department of Ophthalmology, Fukuoka University School of Medicine, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Graefes Arch Clin Exp Ophthalmol 245:1319-25. 2007
    ..We evaluated the anti-adenoviral effect of anti-HIV (human immunodeficiency virus) agents in this study...
  43. pmc Quantitative detection and rapid identification of human adenoviruses
    Rika Miura-Ochiai
    Research and Development Department, Mitsubishi Kagaku Bio Clinical Laboratories, Inc, Shimura 3 30 1, Itabashi ku, Tokyo 174 8555, Japan
    J Clin Microbiol 45:958-67. 2007
    ..LightCycler PCR followed by phylogenetic analysis provides an effective tool for the rapid identification of hAdVs and for studying molecular epidemiology...
  44. pmc Seroepidemiology of human bocavirus in Hokkaido prefecture, Japan
    Rika Endo
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo 060 8638, Japan
    J Clin Microbiol 45:3218-23. 2007
    ..These results suggest that HBoV is a ubiquitous virus acquired early in life and that HBoV might play a role in the course of lower respiratory tract infections...