Hirokazu Yamagami

Summary

Affiliation: Osaka City University
Country: Japan

Publications

  1. pmc Trehalose 6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis induces foreign-body- and hypersensitivity-type granulomas in mice
    H Yamagami
    Department of Host Defense, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Infect Immun 69:810-5. 2001
  2. doi request reprint Usefulness of double-balloon endoscopy in the diagnosis of malignant small-bowel tumors
    Hirokazu Yamagami
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Clin Gastroenterol Hepatol 6:1202-5. 2008
  3. ncbi request reprint Signet-ring cell carcinoma of the jejunum diagnosed by double balloon enteroscopy
    Hirokazu Yamagami
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Hepatogastroenterology 55:1246-8. 2008
  4. doi request reprint Phenotypical and functional study of ghrelin and its receptor in the pathogenesis of Crohn's disease
    Shuhei Hosomi
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Inflamm Bowel Dis 14:1205-13. 2008
  5. pmc High-mobility group box 1 inhibits gastric ulcer healing through Toll-like receptor 4 and receptor for advanced glycation end products
    Yuji Nadatani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 8:e80130. 2013
  6. doi request reprint Dysregulated upregulation of T-cell immunoglobulin and mucin domain-3 on mucosal T helper 1 cells in patients with Crohn's disease
    Kenichi Morimoto
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Scand J Gastroenterol 46:701-9. 2011
  7. doi request reprint Anti-tumour necrosis factor agents reduce non-steroidal anti-inflammatory drug-induced small bowel injury in rheumatoid arthritis patients
    Toshio Watanabe
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Gut 63:409-14. 2014
  8. doi request reprint Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis
    Koji Otani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Osaka 545 8585, Japan
    Biochem Biophys Res Commun 426:342-9. 2012
  9. ncbi request reprint Dislocation of Rab13 and vasodilator-stimulated phosphoprotein in inactive colon epithelium in patients with Crohn's disease
    Mizuki Ohira
    Department of Gastroenterology, Osaka City University, Graduate School of Medicine, Osaka, Japan
    Int J Mol Med 24:829-35. 2009
  10. doi request reprint Incidence and risk factors of gastrointestinal bleeding in patients on low-dose aspirin therapy after percutaneous coronary intervention in Japan
    Yuji Nadatani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Scand J Gastroenterol 48:320-5. 2013

Collaborators

Detail Information

Publications86

  1. pmc Trehalose 6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis induces foreign-body- and hypersensitivity-type granulomas in mice
    H Yamagami
    Department of Host Defense, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Infect Immun 69:810-5. 2001
    ..Taken together with a previous report, this study shows that TDM is a pleiotropic molecule against the host and plays an important role in the pathogenesis of tuberculosis...
  2. doi request reprint Usefulness of double-balloon endoscopy in the diagnosis of malignant small-bowel tumors
    Hirokazu Yamagami
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Clin Gastroenterol Hepatol 6:1202-5. 2008
    ..This study examined the clinical features of patients with MSBT and evaluated the usefulness of DBE in the diagnosis of MSBT...
  3. ncbi request reprint Signet-ring cell carcinoma of the jejunum diagnosed by double balloon enteroscopy
    Hirokazu Yamagami
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Hepatogastroenterology 55:1246-8. 2008
    ..The endoscopic findings are important in diagnosing such lesions, and are useful in distinguishing them from other diseases...
  4. doi request reprint Phenotypical and functional study of ghrelin and its receptor in the pathogenesis of Crohn's disease
    Shuhei Hosomi
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Inflamm Bowel Dis 14:1205-13. 2008
    ..The aim of this study was to investigate the expression of ghrelin and GHSR and the function of ghrelin in inflammatory bowel disease (IBD)...
  5. pmc High-mobility group box 1 inhibits gastric ulcer healing through Toll-like receptor 4 and receptor for advanced glycation end products
    Yuji Nadatani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 8:e80130. 2013
    ..Thus, we showed that HMGB1 is a complicating factor in the gastric ulcer healing process, which acts through TLR4 and RAGE to induce excessive inflammatory responses. ..
  6. doi request reprint Dysregulated upregulation of T-cell immunoglobulin and mucin domain-3 on mucosal T helper 1 cells in patients with Crohn's disease
    Kenichi Morimoto
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Scand J Gastroenterol 46:701-9. 2011
    ..We investigated TIM-3 and galectin-9 expression in inflammatory bowel disease (IBD) patients and in healthy controls, and evaluated the immune role of the TIM-3 pathway in Crohn's disease (CD) pathogenesis...
  7. doi request reprint Anti-tumour necrosis factor agents reduce non-steroidal anti-inflammatory drug-induced small bowel injury in rheumatoid arthritis patients
    Toshio Watanabe
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Gut 63:409-14. 2014
    ..We evaluated the preventive effect of anti-TNF therapy against NSAID-induced enteropathy in rheumatoid arthritis (RA) patients...
  8. doi request reprint Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis
    Koji Otani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Osaka 545 8585, Japan
    Biochem Biophys Res Commun 426:342-9. 2012
    ..Our findings suggest that TLR9 signaling plays important roles in the suppression of H. pylori-induced gastritis in the early phase via downregulation of Th1-type cytokines modulated by IFN-α...
  9. ncbi request reprint Dislocation of Rab13 and vasodilator-stimulated phosphoprotein in inactive colon epithelium in patients with Crohn's disease
    Mizuki Ohira
    Department of Gastroenterology, Osaka City University, Graduate School of Medicine, Osaka, Japan
    Int J Mol Med 24:829-35. 2009
    ..Latent dislocation of tight junction proteins in the inactive mucosa of patients with Crohn's disease may permit the invasion of gut antigens to initiate and perpetuate altered immune response...
  10. doi request reprint Incidence and risk factors of gastrointestinal bleeding in patients on low-dose aspirin therapy after percutaneous coronary intervention in Japan
    Yuji Nadatani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Scand J Gastroenterol 48:320-5. 2013
    ..Long-term treatment with LDA has serious adverse effects, including gastrointestinal (GI) hemorrhage. Most studies have focused only on upper GI bleeding and few studies have evaluated the effect of LDA on total GI bleeding...
  11. doi request reprint High mobility group box 1 promotes small intestinal damage induced by nonsteroidal anti-inflammatory drugs through Toll-like receptor 4
    Yuji Nadatani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Pathol 181:98-110. 2012
    ..Exogenous HMGB1 aggravated the damage in TLR2- and RAGE-KO mice but did not affect the damage in TLR4-KO mice. Thus, our results suggest that HMGB1 promotes NSAID-induced small intestinal damage through TLR4-dependent signaling pathways...
  12. ncbi request reprint Cigarette smoking and its association with overlapping gastroesophageal reflux disease, functional dyspepsia, or irritable bowel syndrome
    Yasuhiro Fujiwara
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
    Intern Med 50:2443-7. 2011
    ..Several studies have shown a significant occurrence of overlap among these 3 diseases. The purpose of this study was to examine the factors associated with such disease overlap in Japanese adults...
  13. doi request reprint Gastrointestinal bleeding after percutaneous coronary intervention
    Tetsuya Tanigawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka City, Japan
    Digestion 83:153-60. 2011
    ..Further extensive studies are required to ascertain the beneficial effect of prophylactic agents for dual antiplatelet therapy following PCI...
  14. doi request reprint Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid
    Toshio Watanabe
    Dept of Gastroenterology, Osaka City Univ Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Am J Physiol Gastrointest Liver Physiol 297:G506-13. 2009
    ..These findings suggest that LcS exhibits a prophylactic effect on indomethacin-induced enteropathy by suppressing the LPS/TLR4 signaling pathway and that this probiotic effect of LcS may be mediated by L-lactic acid...
  15. doi request reprint Risk factors for severe nonsteroidal anti-inflammatory drug-induced small intestinal damage
    Toshio Watanabe
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
    Dig Liver Dis 45:390-5. 2013
    ..Few studies have assessed the risk factors associated with nonsteroidal anti-inflammatory drugs (NSAIDs)-induced small intestinal damage...
  16. doi request reprint Cytoglobin may be involved in the healing process of gastric mucosal injuries in the late phase without angiogenesis
    Fumio Tanaka
    Department of Gastroenterology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno Ku, Osaka, 545 8585, Japan
    Dig Dis Sci 58:1198-206. 2013
    ..Cytoglobin (Cygb) is the newest globin family and is upregulated during hypoxia to maintain the oxygen status. Herein, we investigated Cygb expression in both acute and chronic gastric mucosal injuries...
  17. doi request reprint Pathogenesis of proton-pump inhibitor-refractory non-erosive reflux disease according to multichannel intraluminal impedance-pH monitoring
    Yukie Kohata
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Gastroenterol Hepatol 27:58-62. 2012
    ..The purpose of this study was to clarify the usefulness of multichannel intraluminal impedance-pH (MII-pH) monitoring for PPI-refractory NERD patients and examine the pathogenesis...
  18. doi request reprint Association between left-handedness and gastrointestinal symptoms
    Yasuhiro Fujiwara
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Digestion 84:114-8. 2011
    ..The aim of this study was to determine the association between left-handedness and GI symptoms or diseases...
  19. doi request reprint Leptin promotes gastric ulcer healing via upregulation of vascular endothelial growth factor
    Tetsuya Tanigawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan ttanigawa med osaka cu ac jp
    Digestion 81:86-95. 2010
    ..Its role in gastric ulcer healing is unclear. In this study, we investigated the role of leptin in gastric ulcer healing...
  20. doi request reprint Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma
    Hiroshi Tatsuwaki
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 101:550-8. 2010
    ..These findings suggest that reduction of 15-PGDH is an independent predictor of poor survival associated with enhancement of cell proliferation in gastric adenocarcinoma...
  21. doi request reprint Proliferation of immature plasma cells in pouchitis mucosa in patients with ulcerative colitis
    Naoto Hirata
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Inflamm Bowel Dis 14:1084-90. 2008
    ..We have previously reported the specific and significant proliferation of immature plasma lineage cells in the ulcer bases and inflamed mucosa of UC. In the present study we report the results of a phenotypic study of ileal pouch mucosa...
  22. doi request reprint Evaluation of small bowel injury in patients with rheumatoid arthritis by capsule endoscopy: effects of anti-rheumatoid arthritis drugs
    Satoshi Sugimori
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Digestion 78:208-13. 2008
    ..We evaluated the incidence of small bowel injury in RA patients who were taking anti-RA drugs with or without concomitant NSAIDs by capsule endoscopy...
  23. pmc Usefulness of non-magnifying narrow-band imaging in screening of early esophageal squamous cell carcinoma: a prospective comparative study using propensity score matching
    Yasuaki Nagami
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Gastroenterol 109:845-54. 2014
    ..Here, we aimed to compare NM-NBI and chromoendoscopy with iodine staining (CE-Iodine) in terms of the diagnostic performance, and to evaluate the usefulness of NM-NBI in detecting early esophageal SCC...
  24. pmc Toll-like receptor 2 mediates ischemia-reperfusion injury of the small intestine in adult mice
    Toshio Watanabe
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 9:e110441. 2014
    ..Neutrophil depletion prevented intestinal I/R injury in wild-type mice. These findings suggest that TLR2 may mediate I/R injury of the small intestine in adult mice via induction of inflammatory mediators such as TNF-α and ICAM-1. ..
  25. doi request reprint Rebamipide inhibits indomethacin-induced small intestinal injury: possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5
    Tetsuya Tanigawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka City, Osaka 545 8585, Japan
    Eur J Pharmacol 704:64-9. 2013
    ..In conclusion, our study results suggest that rebamipide inhibits indomethacin-induced small intestinal injuries, possibly by modulating microbiota in the small intestine by upregulation of α-defensin 5...
  26. ncbi request reprint Precise endoscopic and pathologic features in a Crohn's disease case with two fistula-associated small bowel adenocarcinomas complicated by an anal canal adenocarcinoma
    Mitsue Sogawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
    Intern Med 52:445-9. 2013
    ..Accumulating endoscopic findings of CD-associated cancer and precise pathologic diagnostic findings will help to establish a suitable surveillance method...
  27. ncbi request reprint The usefulness of double-balloon enteroscopy in gastrointestinal stromal tumors of the small bowel with obscure gastrointestinal bleeding
    Masami Nakatani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
    Intern Med 51:2675-82. 2012
    ..The aim of the present study was to analyze the clinical characteristics of small bowel GISTs and the usefulness of DBE, CE and computed tomography (CT)...
  28. doi request reprint Internal hypoechoic feature by EUS as a possible predictive marker for the enlargement potential of gastric GI stromal tumors
    Miho Onishi
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Gastrointest Endosc 75:731-8. 2012
    ..There is no clinical predictor for the enlargement potential of gastric GI stromal tumors (GISTs) during the follow-up observation period...
  29. doi request reprint Role of Th-2 cytokines in the development of Barrett's esophagus in rats
    Yukie Kohata
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 7 Asahimachi, Abenoku, Osaka, 545 8585, Japan
    J Gastroenterol 46:883-93. 2011
    ..The aim of this study was to examine the role of Th-2 cytokines during the development of Barrett's esophagus, using a rat model...
  30. ncbi request reprint Evaluation of deep small bowel involvement by double-balloon enteroscopy in Crohn's disease
    Nobuhide Oshitani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Gastroenterol 101:1484-9. 2006
    ..The aim of this study was to evaluate ileal involvement, which cannot be achieved using conventional colonoscopy, by DBE in patients with Crohn's disease...
  31. doi request reprint Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life
    Makiko Kaji
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Gastroenterol Hepatol 25:1151-6. 2010
    ..The purpose of this study was to examine the prevalence of GERD, FD, and IBS, their overlap rates, and HR-QOL for each disease and each overlap compared with healthy controls in the Japanese general population...
  32. doi request reprint Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis
    Koji Otani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Biochem Biophys Res Commun 382:252-8. 2009
    ..In conclusion, IL-17A exerts anti-inflammatory effects on H. pylori-induced gastritis through suppression of Th1 differentiation...
  33. pmc Hybrid therapy with locoregional steroid injection and polyglycolic acid sheets to prevent stricture after esophageal endoscopic submucosal dissection
    Yasuaki Nagami
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Endosc Int Open 4:E1017-22. 2016
    ....
  34. doi request reprint Microbiota Plays a Key Role in Non-Steroidal Anti-Inflammatory Drug-Induced Small Intestinal Damage
    Koji Otani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Digestion 95:22-28. 2017
    ..However, to date, no established therapies and prophylactic agents are available to treat such damages. We reviewed the role of intestinal microbiota in NSAID-induced intestinal damage and identified potential therapeutic candidates...
  35. ncbi request reprint Concentration of Glial Cell Line-Derived Neurotrophic Factor Positively Correlates with Symptoms in Functional Dyspepsia
    Fumio Tanaka
    Departments of Gastroenterology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno Ku, Osaka, 545 8585, Japan
    Dig Dis Sci 61:3478-3485. 2016
    ..Enteric glial cells can produce glial cell line-derived neurotrophic factor (GDNF) to repair disrupted epithelial barrier function...
  36. doi request reprint Long-term prognosis of expanded-indication differentiated-type early gastric cancer treated with endoscopic submucosal dissection or surgery using propensity score analysis
    Shusei Fukunaga
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka
    Gastrointest Endosc . 2016
    ..This study aimed to evaluate the long-term outcomes of ESD and surgery for expanded-indication lesions of differentiated-type EGC...
  37. doi request reprint The five-year survival rate after endoscopic submucosal dissection for superficial esophageal squamous cell neoplasia
    Yasuaki Nagami
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Dig Liver Dis . 2016
    ..However, there were a few reports about the long-term outcomes of these patients due to short follow-up periods...
  38. doi request reprint Comparison of Risk Factors Between Small Intestinal Ulcerative and Vascular Lesions in Occult Versus Overt Obscure Gastrointestinal Bleeding
    Junichi Okamoto
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3, Asahimachi, Abeno Ku, Osaka, 545 8585, Japan
    Dig Dis Sci 61:533-41. 2016
    ..We evaluated the risk factors related to ulcerative and vascular lesions of the small intestine diagnosed by capsule endoscopy or balloon-assisted endoscopy in OGIB cases...
  39. doi request reprint Reduction of prostaglandin transporter predicts poor prognosis associated with angiogenesis in gastric adenocarcinoma
    Shogo Takeda
    Departments of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka City, Osaka, Japan
    J Gastroenterol Hepatol 31:376-83. 2016
    ..We investigated PGT in gastric adenocarcinoma by determining its expression pattern and examining associations of PGT with prognosis and tumor angiogenesis...
  40. doi request reprint Locoregional steroid injection prevents stricture formation after endoscopic submucosal dissection for esophageal cancer: a propensity score matching analysis
    Yasuaki Nagami
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3, Asahimachi, Abeno Ku, Osaka, 545 8585, Japan
    Surg Endosc 30:1441-9. 2016
    ..We evaluated the efficacy of prophylactic locoregional steroid injections for stricture formation caused by ESD using quasi-randomized analysis...
  41. doi request reprint Tumor necrosis factor α decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease
    Takuya Tsukahara
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Pathol 185:185-96. 2015
    ..Thus, GPR120-dependent signaling inhibited the stimulatory effects of GPR40 on GLP-2 expression, and TNF-α treatment decreased GLP-2 expression by up-regulating GPR120 expression in L cells. ..
  42. doi request reprint Endoscopic radial incision and cutting method for refractory esophageal stricture after endoscopic submucosal dissection of superficial esophageal carcinoma
    Hiroaki Minamino
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Dig Endosc 25:200-3. 2013
    ..ERIC is a safe and efficient method for treating refractory strictures after EBD caused by ESD for SEC...
  43. doi request reprint High prevalence of gastroesophageal reflux symptoms in patients with non-alcoholic fatty liver disease associated with serum levels of triglyceride and cholesterol but not simple visceral obesity
    Yoshiko Fujikawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Digestion 86:228-37. 2012
    ..However, other characteristic factors different from visceral obesity are associated with the pathogenesis of NAFLD. We investigated the prevalence of GERD symptoms in patients with NAFLD and its associated risk factors...
  44. pmc Mitochondrial disorders in NSAIDs-induced small bowel injury
    Toshio Watanabe
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    J Clin Biochem Nutr 48:117-21. 2011
    ....
  45. ncbi request reprint Mycobacterial trehalose 6,6'-dimycolate preferentially induces type 1 helper T cell responses through signal transducer and activator of transcription 4 protein
    Ryuta Oiso
    Department of Host Defense, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    Microb Pathog 39:35-43. 2005
    ..These results shed light on the molecular pathogenesis of mycobacterial disease. Taken together with previous studies, TDM is a pleiotropic molecule against the host and participates in the pathogenesis...
  46. pmc Lansoprazole, a Proton Pump Inhibitor, Suppresses Production of Tumor Necrosis Factor-alpha and Interleukin-1beta Induced by Lipopolysaccharide and Helicobacter Pylori Bacterial Components in Human Monocytic Cells via Inhibition of Activation of Nuclear F
    Tetsuya Tanigawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    J Clin Biochem Nutr 45:86-92. 2009
    ..These findings suggest that LANSO exerts anti-inflammatory effects by suppressing induction of TNF-alpha and IL-1beta via inhibition of nuclear factor (NF)-kappaB and ERK activation...
  47. ncbi request reprint [Gastric ulcer in the elderly: general concept and clinical features]
    Makiko Kubo
    Department of Gastroenterology, Osaka City University Graduate School of Medicine
    Nihon Rinsho 68:1967-72. 2010
    ..Even recently, there have been no changes in the mortality of patients with severe gastric ulcers. Management based on pathological conditions of gastric ulcers in the elderly persons is required...
  48. doi request reprint Prevalence of mid-gastrointestinal bleeding in patients with acute overt gastrointestinal bleeding: multi-center experience with 1,044 consecutive patients
    Hirotoshi Okazaki
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abenoku, Osaka 545 8585, Japan
    J Gastroenterol 44:550-5. 2009
    ..Video capsule endoscopy (VCE) and double-balloon enteroscopy (DBE) enable the detection of small intestinal lesions...
  49. ncbi request reprint A comparison between capsule endoscopy and double balloon enteroscopy using propensity score-matching analysis in patients with previous obscure gastrointestinal bleeding
    Yuki Kakiya
    a Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Scand J Gastroenterol . 2016
    ..However, the efficacy of CE over DBE in patients with previous OGIB remains unclear. This study aimed to compare, in terms of diagnostic yield, the efficacy of DBE with that of CE in patients with previous OGIB...
  50. pmc NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
    Shigehiro Itani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Sci Rep 6:39075. 2016
    ..The NLRP3 inflammasome-derived IL-1β and IL-18 may play a protective role against UC through different mechanisms...
  51. pmc Disorder of autonomic nervous system and its vulnerability to external stimulation in functional dyspepsia
    Kazunari Tominaga
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    J Clin Biochem Nutr 58:161-5. 2016
    ..Imbalanced autonomic nervous system function and vulnerability for recovery from external stimuli were observed in functional dyspepsia patients, which was associated with dyspeptic symptoms. ..
  52. pmc Double-balloon endoscopy WAS effective in diagnosing small intestinal duplication: a case report
    Yuji Nadatani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka City, Osaka 545 8585 Japan
    Springerplus 5:1598. 2016
    ..In this report, we present an adult case of ileal duplication that was revealed by double-balloon endoscopy (DBE)...
  53. ncbi request reprint Prediction of Poor Response to Modified Neuroleptanalgesia with Midazolam for Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma
    Masaki Ominami
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Digestion 94:73-81. 2016
    ..We examined the incidence and risk factors for poor response to m-NLA with midazolam and pethidine hydrochloride...
  54. doi request reprint Characteristics of Sleep Disturbances in Patients with Gastroesophageal Reflux Disease
    Narika Iwakura
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
    Intern Med 55:1511-7. 2016
    ..Conclusion GERD patients with sleep disturbances commonly experience daytime sleepiness and an impaired health-related quality of life, especially in terms of physical components. ..
  55. doi request reprint Structural changes in gastric glial cells and delayed gastric emptying as responses to early life stress and acute adulthood stress in rats
    Kazunari Tominaga
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan Electronic address
    Life Sci 148:254-9. 2016
    ..We aimed to investigate structural changes in gastric EGC and gastric emptying as responses to maternal separation and acute adulthood stress in rats to elucidate the pathophysiological roles of gastric EGC...
  56. doi request reprint Successful Treatment of Early-Diagnosed Primary Phlegmonous Gastritis
    Kunihiro Kato
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
    Intern Med 54:2863-6. 2015
    ..The results of a culture from a biopsy of the lesion indicated phlegmonous gastritis. The patient was successfully treated with an antibiotic without gastrectomy. ..
  57. doi request reprint Rectal biopsy, rather than ileal, is appropriate to confirm the diagnosis of early gastrointestinal graft-versus-host disease
    Hiroaki Minamino
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3, Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Scand J Gastroenterol 50:1428-34. 2015
    ..Therefore, an earlier accurate diagnosis of macroscopic and microscopic features using an appropriate modality improves the prognosis of patients with suspected GI-GVHD...
  58. doi request reprint Booster influenza vaccination does not improve immune response in adult inflammatory bowel disease patients treated with immunosuppressives: a randomized controlled trial
    Hiroko Matsumoto
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    J Gastroenterol 50:876-86. 2015
    ..This research was conducted is to assess the effect of booster doses of the trivalent influenza vaccine in adult inflammatory bowel disease (IBD) patients treated with anti-tumor necrosis factor (TNF)-α agents and/or immunomodulators...
  59. doi request reprint Clinical impact of ultrathin colonoscopy for Crohn's disease patients with strictures
    Kenichi Morimoto
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Gastroenterol Hepatol 30:66-70. 2015
    ..An ultrathin colonoscope (outer diameter 9.2 mm) has been developed for superior insertion performance...
  60. doi request reprint Rebamipide Alters the Esophageal Microbiome and Reduces the Incidence of Barrett's Esophagus in a Rat Model
    Yukie Kohata
    Department of Gastroenterology, Graduate School of Medicine, Osaka City University, 1 4 7 Asahimachi, Abenoku, Osaka, 545 8585, Japan
    Dig Dis Sci 60:2654-61. 2015
    ..Barrett's esophagus (BE) is characterized by a distinct Th2-predominant cytokine profile. However, antigens that shift the immune response toward the Th2 profile are unknown...
  61. doi request reprint Usefulness of baseline impedance in patients with proton pump inhibitor-refractory nonerosive reflux disease
    Yukie Kohata
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Gastroenterol Hepatol 30:36-40. 2015
    ..The aim of this study was to examine the usefulness of baseline impedance in PPI-refractory NERD patients...
  62. ncbi request reprint Primary small intestinal mucosa-associated lymphoid tissue lymphoma diagnosed by balloon-assisted enteroscopy
    Yuji Nadatani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
    Intern Med 53:2671-4. 2014
    ..The present case suggests that in MALT lymphoma, intestinal wall fragility may lead to perforation even though the lesion may appear to be a superficial ulcer on endoscopy. ..
  63. doi request reprint Role of small intestinal bacterial overgrowth in severe small intestinal damage in chronic non-steroidal anti-inflammatory drug users
    Motoko Muraki
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Scand J Gastroenterol 49:267-73. 2014
    ..CONCLUSION. SIBO might have a role in the development of severe small intestinal damage in chronic NSAID users...
  64. doi request reprint Activation of the MyD88 signaling pathway inhibits ischemia-reperfusion injury in the small intestine
    Toshio Watanabe
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka Japan
    Am J Physiol Gastrointest Liver Physiol 303:G324-34. 2012
    ..These findings suggest that the MyD88 signaling pathway may inhibit I/R injury in the small intestine by inducing COX-2 expression...
  65. doi request reprint A prospective, single-blind trial comparing wireless capsule endoscopy and double-balloon enteroscopy in patients with obscure gastrointestinal bleeding
    Natsuhiko Kameda
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Gastroenterol 43:434-40. 2008
    ..However, which of the two is superior is unclear. We therefore prospectively compared the clinical efficacy of CE and DBE...
  66. ncbi request reprint Usefulness of magnetic resonance imaging for detection of asymptomatic osteonecrosis of the femoral head in patients with inflammatory bowel disease on long-term corticosteroid treatment
    Noriko Kamata
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Scand J Gastroenterol 43:308-13. 2008
    ..The aim of this study was to assess the usefulness of magnetic resonance imaging in diagnosing early osteonecrotic change and to determine whether corticosteroid administration is related to the development of osteonecrosis...
  67. pmc Rebamipide, a mucoprotective drug, inhibits NSAIDs-induced gastric mucosal injury: possible involvement of the downregulation of 15-hydroxyprostaglandin dehydrogenase
    Tetsuya Tanigawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka City, Osaka 545 8585, Japan
    J Clin Biochem Nutr 48:149-53. 2011
    ....
  68. pmc Bile acids induce cdx2 expression through the farnesoid x receptor in gastric epithelial cells
    Yingji Xu
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    J Clin Biochem Nutr 46:81-6. 2010
    ..The effects of CDCA and GW4064 on expression of Cdx2 and MUC2 were abolished by guggulsterone. These findings suggest that bile acids may induce gastric intestinal metaplasia and carcinogenesis through the FXR...
  69. pmc Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome
    Koji Otani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine 1 4 3 Asahimachi, Abeno Ku, Osaka, Japan
    Sci Rep 6:32587. 2016
    ..These results demonstrate that colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. ..
  70. doi request reprint Efficacy of concomitant elemental diet therapy in scheduled infliximab therapy in patients with Crohn's disease to prevent loss of response
    Noriko Kamata
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    Dig Dis Sci 60:1382-8. 2015
    ..Elemental diet (ED) therapy has been established as a nutrition therapy for CD in Japan. ED therapy can reduce antigen exposure and is both efficacious and safe...
  71. doi request reprint Effects of esomeprazole on sleep in patients with gastroesophageal reflux disease as assessed on actigraphy
    Keiko Hiramoto
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
    Intern Med 54:559-65. 2015
    ..The aim of this study was to examine the effects of esomeprazole treatment on GERD symptoms and sleep parameters assessed using actigraphs and questionnaires...
  72. ncbi request reprint [Portal venous gas complicated with Crohn's disease. A report of a case]
    Kyoko Fujii
    Department of Gastroenterology, Osaka City University Graduate School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 100:42-7. 2003
  73. pmc Long-Term Benefits of Smoking Cessation on Gastroesophageal Reflux Disease and Health-Related Quality of Life
    Yukie Kohata
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 11:e0147860. 2016
    ..Varenicline, a nicotinic receptor partial agonist, is used to aid smoking cessation. The purpose of this study was to prospectively examine the long-term benefits of smoking cessation on GERD and health-related quality of life (HR-QOL)...
  74. pmc Acid reflux directly causes sleep disturbances in rat with chronic esophagitis
    Kenichi Nakahara
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 9:e106969. 2014
    ..This study aimed to investigate the association between GERD and sleep, and the effect of PPI on sleep by using a rat model of chronic acid reflux esophagitis...
  75. ncbi request reprint The production of interferon-gamma-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity
    Atsushi Noguchi
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Gastroenterol 42:947-56. 2007
    ..To clarify which types of cells produce interferon-gamma-inducible protein 10 (IP-10) and whether IP-10 is associated with the development of ulcerative colitis (UC), we investigated IP-10 production in UC patients...
  76. ncbi request reprint Differential expression of vasoactive intestinal peptide receptor 1 expression in inflammatory bowel disease
    Tomomi Yukawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Int J Mol Med 20:161-7. 2007
    ..The differential expression of VIPR1 in ulcerative colitis and Crohn's disease mucosa suggests that the VIP system plays different roles in the pathogenesis of IBD...
  77. doi request reprint Infliximab and/or immunomodulators inhibit immune responses to trivalent influenza vaccination in adults with inflammatory bowel disease
    Yoshie Hagihara
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
    J Crohns Colitis 8:223-33. 2014
    ..The purpose of this study was to evaluate the influence of immunosuppressive therapy on the immune response to the trivalent influenza vaccine in adult patients with inflammatory bowel disease...
  78. ncbi request reprint [Post infectious irritable bowel syndrome experimental model]
    Nobuhide Oshitani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine
    Nihon Rinsho 64:1437-40. 2006
    ..Pathogenesis of irritable bowel syndrome may be further subdivided by the results of experimental models, and a novel therapeutic approach is expected from such experimental models...
  79. doi request reprint Endoscopic differential diagnosis between ulcerative colitis-associated neoplasia and sporadic neoplasia in surveillance colonoscopy using narrow band imaging
    Kenji Watanabe
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Dig Endosc 23:143-9. 2011
    ..Optimization of surveillance colonoscopy, including development of novel methods, should be addressed in the near future...
  80. doi request reprint The prevalence of adverse events associated with double-balloon enteroscopy from a single-centre dataset in Japan
    Sayoko Nakayama
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
    Dig Liver Dis 46:706-9. 2014
    ..There are few comprehensive reports detailing the prevalence of major adverse events associated with a double-balloon enteroscopy procedure...
  81. pmc Pre-illness isoflavone consumption and disease risk of ulcerative colitis: a multicenter case-control study in Japan
    Satoko Ohfuji
    Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan
    PLoS ONE 9:e110270. 2014
    ..We examined the association between pre-illness isoflavone consumption and the risk of UC...
  82. ncbi request reprint [Rumination syndrome in an adult with normal intelligence]
    Takashi Sugawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 103:631-5. 2006
    ..Since patients with rumination syndrome are often misdiagnosed and receive unnecessary treatment, awareness of it by physicians is important...
  83. ncbi request reprint A murine model of granulomatous colitis with mesenteric lymphadenitis induced by mycobacterial cord factor
    Mitsue Sogawa
    Department of Anatomy, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Virchows Arch 442:151-8. 2003
    ..The CF-induced colonic granulomas associated with mesenteric lymphadenitis will be useful for investigating human granulomatous colitis...
  84. ncbi request reprint Three cases of primary sclerosing cholangitis associated with ulcerative colitis; diagnostic usefulness of magnetic resonance cholangiopancreatography
    Nobuhide Oshitani
    Third Department of Internal Medicine, Osaka City University Medical School, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Hepatogastroenterology 49:317-21. 2002
    ..Primary sclerosing cholangitis is often accompanied by inflammatory bowel disease in western countries. However, the incidence of primary sclerosing cholangitis in patients with ulcerative colitis appears to be much lower in Japan...
  85. doi request reprint A questionnaire-based survey on the prescription of non-steroidal anti-inflammatory drugs by physicians in East Asian countries in 2007
    Tetsuo Arakawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abenoku, Osaka, Japan
    Digestion 79:177-85. 2009
    ..Nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin are widely used clinically but increase the risk of gastrointestinal (GI) complications...