Hiroki Toyoda

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc Enhanced quantal release of excitatory transmitter in anterior cingulate cortex of adult mice with chronic pain
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada
    Mol Pain 5:4. 2009
  2. pmc Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment
    Fanny W F Shum
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, University of Toronto, Toronto, Canada
    Learn Mem 14:304-12. 2007
  3. pmc Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 2:e167. 2007
  4. ncbi request reprint Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiation
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Dev Neurobiol 67:498-509. 2007
  5. ncbi request reprint Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain
    Ming Gao Zhao
    Department of Physiology, Faculty of Medicine, and Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 26:8923-30. 2006
  6. doi request reprint Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV
    Long Jun Wu
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Eur J Neurosci 27:1923-32. 2008
  7. ncbi request reprint Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario, Canada
    J Cell Physiol 211:336-43. 2007
  8. ncbi request reprint Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:11107-16. 2005
  9. pmc Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 3:36. 2007
  10. pmc Interplay of amygdala and cingulate plasticity in emotional fear
    Hiroki Toyoda
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Neural Plast 2011:813749. 2011

Detail Information

Publications21

  1. pmc Enhanced quantal release of excitatory transmitter in anterior cingulate cortex of adult mice with chronic pain
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada
    Mol Pain 5:4. 2009
    ....
  2. pmc Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment
    Fanny W F Shum
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, University of Toronto, Toronto, Canada
    Learn Mem 14:304-12. 2007
    ..Our findings suggest that exposure to EE alters physiological properties within the ACC which results in enhanced responses to inflammation...
  3. pmc Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 2:e167. 2007
    ..Our results suggest that GluR5 is a key regulator of inhibitory circuits in the amygdala and highlight the potential use of GluR5-specific drugs in the treatment of pathological anxiety...
  4. ncbi request reprint Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiation
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Dev Neurobiol 67:498-509. 2007
    ..Our results demonstrate that the GluR1 subunit is essential for synaptic plasticity in the ACC and may play critical roles under physiological and pathological conditions...
  5. ncbi request reprint Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain
    Ming Gao Zhao
    Department of Physiology, Faculty of Medicine, and Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 26:8923-30. 2006
    ..Our findings provide strong evidence that presynaptic alterations caused by peripheral inflammation contribute to memory impairments after injury...
  6. doi request reprint Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV
    Long Jun Wu
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Eur J Neurosci 27:1923-32. 2008
    ..Our results provide strong evidence that forebrain CaMKIV contributes to trace fear memory by enhancing synaptic potentiation in the ACC...
  7. ncbi request reprint Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario, Canada
    J Cell Physiol 211:336-43. 2007
    ....
  8. ncbi request reprint Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:11107-16. 2005
    ..Our results demonstrate that the upregulation of NR2B receptors in the ACC contributes to behavioral sensitization caused by inflammation...
  9. pmc Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 3:36. 2007
    ..Thus, our study suggests that the MAPK signaling pathway is involved in the induction of cingulate LTP and plays a critical role in physiological conditions...
  10. pmc Interplay of amygdala and cingulate plasticity in emotional fear
    Hiroki Toyoda
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Neural Plast 2011:813749. 2011
    ....
  11. ncbi request reprint Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome
    Ming Gao Zhao
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:7385-92. 2005
    ..This suggests that synaptic plasticity in the ACC and amygdala of FMR1 KO mice plays an important role in the expression of behavioral phenotypes similar to the symptoms of fragile X syndrome...
  12. pmc Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa
    Hui Xu
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 2:29. 2006
    ..GluR5-containing KARs are thus important for spinal sensory transmission/modulation in the spinal cord...
  13. doi request reprint FMRP acts as a key messenger for dopamine modulation in the forebrain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON M5S1A8, Canada
    Neuron 59:634-47. 2008
    ..Our study has identified FMRP as a key messenger for DA modulation in the forebrain and may provide insights into the cellular and molecular mechanisms underlying fragile X syndrome...
  14. pmc Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Ontario, Canada
    Mol Pain 5:46. 2009
    ..Our results demonstrate that AMPA receptor subunit GluA1 is a key mechanism for the expression of ACC LTP and inflammation-induced long-term plastic changes in the ACC...
  15. ncbi request reprint Evidence for a role of CaMKIV in the development of opioid analgesic tolerance
    Shanelle W Ko
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Medical Sciences Building Rm3342, Toronto, Canada, M5S 1A8
    Eur J Neurosci 23:2158-68. 2006
    ..Our results provide novel evidence for the role of CaMKIV in the development of opioid analgesic tolerance but not physical dependence...
  16. ncbi request reprint Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Eur J Neurosci 22:485-94. 2005
    ..Furthermore, our studies provide direct physiological evidence that both NR2A and NR2B subunits are involved in the induction of LTD in the ACC...
  17. ncbi request reprint Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, University of Toronto, Medical Sciences Bldg, Rm 3342, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 94:1805-13. 2005
    ..Our results show that KA receptors contribute to synaptic transmission in adult ACC pyramidal neurons and provide a synaptic basis for the physiology and pathology of KA receptors in ACC-related functions...
  18. ncbi request reprint Genetic evidence for adenylyl cyclase 1 as a target for preventing neuronal excitotoxicity mediated by N-methyl-D-aspartate receptors
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 282:1507-17. 2007
    ..Our findings provide direct evidence that AC1 plays an important role in neuronal excitotoxicity and may serve as a therapeutic target for preventing excitotoxicity in stroke and neurodegenerative diseases...
  19. pmc Calcium/calmodulin-dependent kinase IV contributes to translation-dependent early synaptic potentiation in the anterior cingulate cortex of adult mice
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Mol Brain 3:27. 2010
    ..Our results reveal in the first time a transcription- and translation-dependent component of early synaptic LTP in adult ACC synapses, and demonstrate that CaMKIV enhances early synaptic potentiation by activating new protein synthesis...
  20. ncbi request reprint NMDA receptor-dependent long-term depression in the anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Rev Neurosci 17:403-13. 2006
    ..Here, we review recent studies and present new experimental data on the roles of NMDA receptors during synaptic depression in the ACC. Furthermore, we consider the physiological and pathological significance of LTD in the ACC...
  21. ncbi request reprint Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice
    Shanelle Ko
    Department of Physiology, Faculty of Medicine, and Centre for the Study of Pain, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurosci 25:977-84. 2005
    ..Selectively targeting different KAR subtypes may provide a useful strategy for treating persistent pain and fear-related mental disorders...