Shinji Takai

Summary

Affiliation: Osaka Medical College
Country: Japan

Publications

  1. ncbi request reprint Tissue angiotensin II generating system by angiotensin-converting enzyme and chymase
    Mizuo Miyazaki
    Department of Pharmacology, Osaka Medical College, Japan
    J Pharmacol Sci 100:391-7. 2006
  2. doi request reprint Comparison of the relative importance of vascular and plasma drug concentrations to the hypotensive effect of telmisartan in rats
    Shinji Takai
    Department of Innovative Medicine, Osaka Medical College, Takatsuki, Japan
    J Renin Angiotensin Aldosterone Syst 17:1470320316633895. 2016
  3. ncbi request reprint Chymase inhibition attenuates monocrotaline-induced sinusoidal obstruction syndrome in hamsters
    S Masubuchi
    Department of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki 569 8686, Japan
    Curr Med Chem 20:2723-9. 2013
  4. pmc Powerful vascular protection by combining cilnidipine with valsartan in stroke-prone, spontaneously hypertensive rats
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan
    Hypertens Res 36:342-8. 2013
  5. ncbi request reprint Multiple mechanisms for the action of chymase inhibitors
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City, Osaka 569 8686, Japan
    J Pharmacol Sci 118:311-6. 2012
  6. ncbi request reprint Antinociceptive effects of angiotensin-converting enzyme inhibitors and an angiotensin II receptor antagonist in mice
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Life Sci 59:PL331-6. 1996
  7. ncbi request reprint Characterization of chymase from human vascular tissues
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Clin Chim Acta 265:13-20. 1997
  8. ncbi request reprint 12-Hydroxyeicosatetraenoic acid directly potentiates angiotensin II-induced vascular contraction
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Eur J Pharmacol 358:161-4. 1998
  9. ncbi request reprint Chymase processes big-endothelin-2 to endothelin-2-(1-31) that induces contractile responses in the isolated monkey trachea
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Eur J Pharmacol 358:229-33. 1998
  10. ncbi request reprint Effects of a new 12-lipoxygenase inhibitor, daphnodorin A, on angiotensin II-induced vascular contraction in hamster
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Prostaglandins Leukot Essent Fatty Acids 60:135-8. 1999

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Tissue angiotensin II generating system by angiotensin-converting enzyme and chymase
    Mizuo Miyazaki
    Department of Pharmacology, Osaka Medical College, Japan
    J Pharmacol Sci 100:391-7. 2006
    ..It is essential to understand not only the intracellular mechanisms of Ang II but also the process of Ang II productions in each disease to show accurate indications of the effectiveness of ACE inhibitor, ARB, and chymase inhibitor...
  2. doi request reprint Comparison of the relative importance of vascular and plasma drug concentrations to the hypotensive effect of telmisartan in rats
    Shinji Takai
    Department of Innovative Medicine, Osaka Medical College, Takatsuki, Japan
    J Renin Angiotensin Aldosterone Syst 17:1470320316633895. 2016
    ....
  3. ncbi request reprint Chymase inhibition attenuates monocrotaline-induced sinusoidal obstruction syndrome in hamsters
    S Masubuchi
    Department of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki 569 8686, Japan
    Curr Med Chem 20:2723-9. 2013
    ..In conclusion, chymase inhibition by TY-51469 may prevent the accelerating of severity in monocrotaline-induced SOS in hamsters...
  4. pmc Powerful vascular protection by combining cilnidipine with valsartan in stroke-prone, spontaneously hypertensive rats
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan
    Hypertens Res 36:342-8. 2013
    ..Thus, valsartan and cilnidipine combination therapy might have a powerful protective effect in the vascular tissues via increases in the angiotensin-(1-7)/angiotensin II ratio in plasma...
  5. ncbi request reprint Multiple mechanisms for the action of chymase inhibitors
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City, Osaka 569 8686, Japan
    J Pharmacol Sci 118:311-6. 2012
    ..Thus, chymase inhibitors may be useful for preventing damage to various organs via multiple mechanisms without lowering blood pressure...
  6. ncbi request reprint Antinociceptive effects of angiotensin-converting enzyme inhibitors and an angiotensin II receptor antagonist in mice
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Life Sci 59:PL331-6. 1996
    ..These results suggest that brain endogenous angiotensin II is likely to be involved in central nociceptive mechanisms by its antagonistic interaction with endogenous opioid system...
  7. ncbi request reprint Characterization of chymase from human vascular tissues
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Clin Chim Acta 265:13-20. 1997
    ..The N-terminal sequence was identical to the sequence for human skin/heart chymase. Thus, the chymostatin-sensitive angiotensin II-generating enzyme in human vascular tissues is identified as chymase...
  8. ncbi request reprint 12-Hydroxyeicosatetraenoic acid directly potentiates angiotensin II-induced vascular contraction
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Eur J Pharmacol 358:161-4. 1998
    ..We demonstrated clearly that 12-HETE directly potentiates the angiotensin II-induced contraction...
  9. ncbi request reprint Chymase processes big-endothelin-2 to endothelin-2-(1-31) that induces contractile responses in the isolated monkey trachea
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Eur J Pharmacol 358:229-33. 1998
    ..These results suggest that the contractile response of big-endothelin-2 is predominantly dependent on the conversion of big-endothelin-2 to endothelin-2-(1-31) by chymase...
  10. ncbi request reprint Effects of a new 12-lipoxygenase inhibitor, daphnodorin A, on angiotensin II-induced vascular contraction in hamster
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Prostaglandins Leukot Essent Fatty Acids 60:135-8. 1999
    ..These results suggest that daphnodorin A, but not daphnodorin B, may suppress angiotensin II-induced vascular contractile responses through the inhibition of 12-lipoxygenase...
  11. ncbi request reprint Effects of daphnodorin A, daphnodorin B and daphnodorin C on human chymase-dependent angiotensin II formation
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Life Sci 64:1889-96. 1999
    ....
  12. ncbi request reprint Chymase-dependent angiotensin II formation in human vascular tissue
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan
    Circulation 100:654-8. 1999
    ..We studied whether chymase bound to heparin, resembling an in vivo form, could contribute to Ang II formation in the presence of natural protease inhibitors...
  13. ncbi request reprint A new method for simultaneous measurements of mast cell proteases in human vascular tissue
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Clin Exp Pharmacol Physiol 27:700-4. 2000
    ..2 mol/L KCl. The present study demonstrates a new method for the simultaneous measurement of proteases derived from mast cells in humans...
  14. ncbi request reprint Cilostazol suppresses intimal formation in dog grafted veins with reduction of angiotensin II-forming enzymes
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 569 8686, Japan
    Eur J Pharmacol 411:301-4. 2001
    ..7% by treatment of cilostazol, and the activities of angiotensin II-forming enzymes were suppressed significantly. The inhibitory effect of cilostazol in intimal formation may be dependent on inhibition of angiotensin II-forming enzymes...
  15. ncbi request reprint Different angiotensin II-forming pathways in human and rat vascular tissues
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, 569 8686, Osaka, Japan
    Clin Chim Acta 305:191-5. 2001
    ..These findings suggest clearly that human vascular tissues contain two angiotensin II-forming enzymes, angiotensin-converting enzyme and chymase, but rat vascular tissues have no chymase-dependent angiotensin II-forming pathway...
  16. ncbi request reprint 12-Hydroxyeicosatetraenoic acid potentiates angiotensin II-induced pressor response in rats
    S Takai
    Department of Pharmacology, Osaka Medical College, Osaka 569 8686, Takatsuki City, Japan
    Eur J Pharmacol 418:R1-2. 2001
    ..5, 6.8 and 4.8 mm Hg, respectively. The significant pressor response was observed at 10 and 20 min after the administration. In this study, we clearly demonstrated that 12-HETE potentiated the angiotensin II-induced pressor response...
  17. ncbi request reprint An orally active chymase inhibitor, BCEAB, suppresses heart chymase activity in the hamster
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Japan
    Jpn J Pharmacol 86:124-6. 2001
    ..0% and 26.9% 3 h after oral administration of 100 and 300 mg of BCEAB/kg of body weight, respectively. In conclusion, BCEAB is a useful chymase inhibitor for studying the role of chymase in vivo...
  18. ncbi request reprint Oral administration of a specific chymase inhibitor, NK3201, inhibits vascular proliferation in grafted vein
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Japan
    Life Sci 69:1725-32. 2001
    ..In this study, we demonstrate for the first time that oral administration of a specific chymase inhibitor, NK3201, appears useful for preventing vascular proliferation...
  19. ncbi request reprint Beneficial effect of trandolapril on the lifespan of a severe hypertensive model
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Hypertens Res 24:559-64. 2001
    ..These data demonstrate that trandolapril extends the lifespan of this severe hypertensive model, even in cases in which the blood pressure cannot be lowered...
  20. ncbi request reprint Effect of chymase inhibitor on vascular proliferation
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan
    Jpn J Pharmacol 90:223-7. 2002
    ..Chymase plays an important role in the development of vascular proliferation via the induction of local angiotensin II formation in injured vessels...
  21. ncbi request reprint A novel chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[,4-dioxo-1-phenyl-7-(2-pyridyloxy)]2-heptyl]acetamide (NK3201), suppressed intimal hyperplasia after balloon injury
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan
    J Pharmacol Exp Ther 304:841-4. 2003
    ..06 and 0.24 +/- 0.04 mm2, respectively, and this difference was significant. In this study, we demonstrated for the first time that a chymase inhibitor prevented the development of intimal hyperplasia in the balloon-injured arteries...
  22. ncbi request reprint Mechanisms of angiotensin II type 1 receptor blocker for anti-atherosclerotic effect in monkeys fed a high-cholesterol diet
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan
    J Hypertens 21:361-9. 2003
    ....
  23. ncbi request reprint [Role of chymase in vascular diseases and the efficacy of chymase inhibitor]
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Japan
    Nihon Yakurigaku Zasshi 122:111-20. 2003
    ..These reports indicate that local angiotensin II production by chymase is involved only in the injured vessels. Therefore, a chymase inhibitor may be useful for preventing vascular disorders without affecting blood pressure...
  24. ncbi request reprint Application of a chymase inhibitor, NK3201, for prevention of vascular proliferation
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City, Osaka 569 8686, Japan
    Cardiovasc Drug Rev 21:185-98. 2003
    ..Therefore, NK3201 may be useful for preventing vascular proliferation without affecting blood pressure...
  25. ncbi request reprint Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki 569 8686, Japan
    Hypertens Res 27:213-9. 2004
    ..ACE activities in vascular tissues and the heart may be important targets in terms of the ability of ACE inhibitors to lower blood pressure or inhibit cardiac hypertrophy, respectively...
  26. ncbi request reprint A single treatment with a specific chymase inhibitor, TY-51184, prevents vascular proliferation in canine grafted veins
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Osaka, Japan
    J Pharmacol Sci 94:443-8. 2004
    ..In this study, we demonstrated that a single treatment with a specific chymase inhibitor, TY-51184, could prevent the vascular proliferation in canine grafted veins...
  27. ncbi request reprint Comparative effects of candesartan and amlodipine in a monkey atherosclerotic model
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Hypertens Res 27:517-22. 2004
    ..Therefore, a blockade of angiotensin II action rather than a hypotensive effect may play an important role in preventing the development of atherosclerosis in primates...
  28. ncbi request reprint A novel therapeutic strategy against vascular disorders with chymase inhibitor
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Japan
    Curr Vasc Pharmacol 1:217-24. 2003
    ..Therefore, chymase inhibitors may be useful for preventing vascular disoders without affecting blood pressure...
  29. ncbi request reprint Chymase as a novel target for the prevention of vascular diseases
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City, Osaka 569 8686, Japan
    Trends Pharmacol Sci 25:518-22. 2004
    ..We propose that chymase is a novel target for preventing vascular diseases...
  30. ncbi request reprint Therapeutic applications of chymase inhibitors in cardiovascular diseases and fibrosis
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City, Osaka 569 8686, Japan
    Eur J Pharmacol 501:1-8. 2004
    ..Therefore, chymase inhibitors may be useful for preventing cardiovascular diseases and fibrosis via inhibition of angiotensin II formation and transforming growth factor-beta activation...
  31. ncbi request reprint The regressive effect of an angiotensin II receptor blocker on formed fatty streaks in monkeys fed a high-cholesterol diet
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan
    J Hypertens 23:1879-86. 2005
    ....
  32. ncbi request reprint Eplerenone inhibits atherosclerosis in nonhuman primates
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 569 8686, Japan
    Hypertension 46:1135-9. 2005
    ..In conclusion, eplerenone may strengthen the endothelium-dependent relaxation and suppress angiotensin-converting enzyme activity in the vasculature, thus preventing the development of atherosclerosis in nonhuman primates...
  33. ncbi request reprint Significance of angiotensin II receptor blocker lipophilicities and their protective effect against vascular remodeling
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Hypertens Res 28:593-600. 2005
    ..In conclusion, a highly lipophilic ARB, telmisartan, may be useful for preventing NAD(P)H oxidase activity, and thereby for conferring vascular protection...
  34. ncbi request reprint Effect of olmesartan medoxomil on atherosclerosis: clinical implications of the emerging evidence
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Osaka, Japan
    Am J Cardiovasc Drugs 6:363-6. 2006
    ..Thus, olmesartan medoxomil, which rapidly reduces inflammatory markers, may have a beneficial antiatherosclerotic effect...
  35. ncbi request reprint Inhibition of matrix metalloproteinase-9 activity by lisinopril after myocardial infarction in hamsters
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 589 8686, Japan
    Eur J Pharmacol 568:231-3. 2007
    ..Angiotensin-converting enzyme inhibitors might directly inhibit matrix metalloproteinase-9 activity...
  36. ncbi request reprint Significance of matrix metalloproteinase-9 in cardiac dysfunction during the very acute phase after myocardial infarction in hamsters
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City 589 8686, Japan
    Eur J Pharmacol 572:57-60. 2007
    ..Matrix metalloproteinase-9 might play a crucial role in cardiac dysfunction and left-ventricular dilatation during the very acute phase after myocardial infarction...
  37. doi request reprint Inhibition of vascular angiotensin-converting enzyme by telmisartan via the peroxisome proliferator-activated receptor gamma agonistic property in rats
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Hypertens Res 30:1231-7. 2007
    ..In conclusion, the partial PPARgamma agonist telmisartan might inhibit vascular ACE activity, and result in the prevention of oxidative stress and endothelial dysfunction more effectively than non-agonistic valsartan...
  38. ncbi request reprint Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Daigaku machi 2 7, Takatsuki City, Osaka, Japan
    J Pharmacol Sci 110:459-65. 2009
    ..Furthermore, there were significantly more pancreatic islets in the TY-51469 group than in the placebo group. In conclusion, chymase inhibition might protect against pancreatic islet disorganization...
  39. doi request reprint Significance of angiotensin II receptor blockers with high affinity to angiotensin II type 1 receptors for vascular protection in rats
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku cho, Takatsuki City, Osaka, Japan
    Hypertens Res 32:853-60. 2009
    ..Thus, heterogeneity in binding affinity to AT(1) receptors among ARBs may result in different degrees of vascular protection and lifespan extension...
  40. ncbi request reprint Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    J Atheroscler Thromb 16:480-9. 2009
    ..We evaluated the effect of DGLA on atherosclerosis in apoE-deficient mice and studied the mechanism of the anti-atherosclerotic effect...
  41. doi request reprint Combination therapy with irbesartan and efonidipine for attenuation of proteinuria in Dahl salt-sensitive rats
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan
    Hypertens Res 33:953-9. 2010
    ..Values for these parameters were reduced to control levels in the irbesartan+efonidipine-treated group. Combination therapy with ARB and T- and L-type CCB might produce a powerful renal protective effect...
  42. ncbi request reprint Chymase as an important target for preventing complications of metabolic syndrome
    S Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan
    Curr Med Chem 17:3223-9. 2010
    ..In this review, we propose the significance of chymase as a target to prevent complications of metabolic syndrome...
  43. ncbi request reprint New approaches to blockade of the renin-angiotensin-aldosterone system: chymase as an important target to prevent organ damage
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Japan
    J Pharmacol Sci 113:301-9. 2010
    ..In this review, we propose the possible use of chymase inhibitors as agents to prevent organ damage...
  44. doi request reprint Candesartan and amlodipine combination therapy provides powerful vascular protection in stroke-prone spontaneously hypertensive rats
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku cho, Takatsuki City, Osaka, Japan
    Hypertens Res 34:245-52. 2011
    ..Thus, candesartan and amlodipine combination therapy could have a powerful protective effect in vascular tissues via the reduction of oxidative stress...
  45. doi request reprint Targets of chymase inhibitors
    Shinji Takai
    Osaka Medical College, Department of Pharmacology, Daigaku machi 2 7, Takatsuki City, Osaka 569 8686, Japan
    Expert Opin Ther Targets 15:519-27. 2011
    ..Therefore, diseases related to angiotensin II TGF-β, and MMP-9 could potentially be treated with chymase inhibitors...
  46. ncbi request reprint Irbesartan prevents metabolic syndrome in rats via activation of peroxisome proliferator-activated receptor γ
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Osaka, Japan
    J Pharmacol Sci 116:309-15. 2011
    ..These findings suggest that through PPARγ stimulation along with angiotensin II inhibition, irbesartan may be an optimal treatment option in the prevention of metabolic syndrome as well as hypertension...
  47. doi request reprint Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice
    Nao Inoue
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City, Osaka 569 8686, Japan
    Atherosclerosis 204:359-64. 2009
    ..The purpose of this study was to determine whether chymase is involved in angiotensin (Ang) II-induced AAA development in apolipoprotein E (apoE)-deficient mice...
  48. doi request reprint Involvement of angiotensin II-dependent vascular endothelial growth factor gene expression via NADPH oxidase in the retina in a type 2 diabetic rat model
    Masanori Fukumoto
    Department of Pharmacology, Osaka Medical College, Osaka, Japan
    Curr Eye Res 33:885-91. 2008
    ..In SDT rats, the plasma glucose level and angiotensin-converting enzyme (ACE) levels were measured, and effects of angiotensin II receptor blocker (ARB) and angiotensin II were also studied...
  49. ncbi request reprint Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis
    Denan Jin
    Department of Pharmacology, Osaka Medical College, Japan
    J Pharmacol Sci 109:275-84. 2009
    ....
  50. ncbi request reprint Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient mice
    Nao Inoue
    Department of Pharmacology, Osaka Medical College, Osaka 569 8686, Japan
    J Atheroscler Thromb 16:164-71. 2009
    ..The involvement of vascular Ang II-forming enzymes in the progression of AAA was studied...
  51. ncbi request reprint Role of chymase-dependent angiotensin II formation in regulating blood pressure in spontaneously hypertensive rats
    Kazuyoshi Kirimura
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Hypertens Res 28:457-64. 2005
    ..These results indicated that chymase-dependent angiotensin II did not regulate blood pressure in SHR in the present study...
  52. ncbi request reprint Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma
    Shinji Takai
    Department of Pharmacology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, Japan
    Life Sci 81:585-91. 2007
    ..SB203580, an inhibitor of p38 MAPK, suppressed the TPA-induced HSP27 phosphorylation. Our results strongly suggest that activation of PKCdelta regulates the phosphorylation of HSP27 via p38 MAPK in human HCC...
  53. doi request reprint Rho-kinase inhibitors decrease TGF-beta-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts
    Masashi Kuno
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
    Biochem Pharmacol 77:196-203. 2009
    ..Taken together, our results strongly suggest that Rho-kinase regulates TGF-beta-stimulated VEGF synthesis via SAPK/JNK activation in osteoblasts...
  54. ncbi request reprint (-)-Epigallocatechin gallate attenuates the induction of HSP27 stimulated by sphingosine 1-phosphate via suppression of phosphatidylinositol 3-kinase/Akt pathway in osteoblasts
    Hideo Natsume
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Int J Mol Med 24:197-203. 2009
    ..These results strongly suggest that EGCG suppresses the induction of HSP27 stimulated by sphingosine 1-phosphate via attenuation of, not the p38 MAP kinase pathway, but of the phosphatidylinositol 3-kinase/Akt pathway in osteoblasts...
  55. ncbi request reprint Effect of chymase inhibition on the arteriovenous fistula stenosis in dogs
    Denan Jin
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    J Am Soc Nephrol 16:1024-34. 2005
    ....
  56. doi request reprint Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular signal-regulated kinase
    Rie Matsushima-Nishiwaki
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Biol Chem 283:18852-60. 2008
    ..These findings strongly suggest that the control of the phosphorylated heat shock protein 27 levels could be a new therapeutic strategy especially to counter the recurrence of hepatocellular carcinoma...
  57. ncbi request reprint The effects of chymase on matrix metalloproteinase-2 activation in neointimal hyperplasia after balloon injury in dogs
    Kanta Kishi
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Hypertens Res 30:77-83. 2007
    ..These results suggest that chymase inhibitors can prevent the development of intimal hyperplasia via the inhibition of matrix metalloproteinase-2 activation in balloon-injured arteries...
  58. ncbi request reprint alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB
    En Shu
    Department of Pharmacology, Gifu University Graduate School of Medicine, Japan
    Arch Biochem Biophys 438:111-8. 2005
    ..Our results indicate that PDGF-BB induces phosphorylation of alphaB-crystallin via p38 MAP kinase during myocardial infarction...
  59. ncbi request reprint The significance of chymase in the progression of abdominal aortic aneurysms in dogs
    Keiichi Furubayashi
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Hypertens Res 30:349-57. 2007
    ..Thus, chymase inhibition may become a useful strategy for preventing abdominal aortic aneurysms...
  60. ncbi request reprint Roles of chymase in stenosis occurring after polytetrafluoroethylene graft implantations
    Denan Jin
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City, Osaka 569 8686, Japan
    Life Sci 81:1291-300. 2007
    ....
  61. pmc (-)-Epigallocatechin gallate reduces platelet-derived growth factor-BB-stimulated interleukin-6 synthesis in osteoblasts: suppression of SAPK/JNK
    Shinji Takai
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
    Mediators Inflamm 2008:291808. 2008
    ..These results strongly suggest that EGCG inhibits the PDGF-BB-stimulated synthesis of IL-6 via suppression of SAPK/JNK pathway in osteoblasts...
  62. doi request reprint Effects of gelatin hydrogel containing chymase inhibitor on scarring in a canine filtration surgery model
    Shota Kojima
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan
    Invest Ophthalmol Vis Sci 52:7672-80. 2011
    ..To investigate the effects of gelatin hydrogel (GH) containing a chymase inhibitor (CI) on intraocular pressure (IOP) and conjunctival scarring in a canine model of glaucoma surgery...
  63. doi request reprint Chymase plays an important role in left ventricular remodeling induced by intermittent hypoxia in mice
    Chika Matsumoto
    Department of Internal Medicine III, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan
    Hypertension 54:164-71. 2009
    ..These changes were all suppressed by NK3201 treatment. Therefore, chymase might play an important role in intermittent hypoxia-induced left ventricular remodeling, which is independent of the systemic blood pressure...
  64. ncbi request reprint Possible roles of angiotensin II-forming enzymes, angiotensin converting enzyme and chymase-like enzyme, in the human aneurysmal aorta
    Koutaro Tsunemi
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Hypertens Res 25:817-22. 2002
    ..01), while differences in ACE activity were not observed. Our results suggest that increases in local Ang II formation induced by chymase-like enzymes may play important roles in the pathogenesis of aneurysmal formation...
  65. ncbi request reprint Impact of chymase inhibitor on cardiac function and survival after myocardial infarction
    Denan Jin
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City, Osaka 569 8686, Japan
    Cardiovasc Res 60:413-20. 2003
    ....
  66. ncbi request reprint A specific chymase inhibitor, NK3201, suppresses bleomycin-induced pulmonary fibrosis in hamsters
    Masato Sakaguchi
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 589 8686, Japan
    Eur J Pharmacol 493:173-6. 2004
    ..The ratio of fibrotic area to total area in NK3201-treated hamsters was significantly decreased to 54.0% of the ratio in placebo-treated hamsters. Therefore, NK3201 may be useful in the prevention of pulmonary fibrosis...
  67. ncbi request reprint A specific chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide (NK3201), suppresses development of abdominal aortic aneurysm in hamsters
    Koutaro Tsunemi
    Thoracic and Cardiovascular Surgery, Osaka Medical College, Takatsuki City, Osaka 569 8686, Japan
    J Pharmacol Exp Ther 309:879-83. 2004
    ..NK3201 significantly reduced the chymase activity in the placebo-treated group. Here, we demonstrated for the first time that a chymase inhibitor prevented the development of abdominal aortic aneurysm in a hamster experimental model...
  68. ncbi request reprint Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts
    Junichi Yamauchi
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Int J Mol Med 23:267-72. 2009
    ..These results strongly suggest that tacrolimus enhances FGF-2-stimulated VEGF release via up-regulation of SAPK/JNK through modulating p70 S6 kinase in osteoblasts...
  69. ncbi request reprint Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats
    Kanta Kishi
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Japan
    Pediatr Res 60:77-82. 2006
    ..Thus, angiotensin II-forming chymase may play a role in the proliferation of the medial layer in the lung arterioles of monocrotaline-induced pulmonary hypertensive rats...
  70. ncbi request reprint Mast cell chymase in the ischemic kidney of severe unilateral renovascular hypertension
    Takashi Morikawa
    Department of Internal Medicine, Osaka City General Hospital, Osaka, Japan
    Am J Kidney Dis 45:e45-50. 2005
    ..This is the first report of an increase in chymase activity in the interstitium of an ischemic kidney and renal artery and vein in a patient with RVH and atherosclerosis...
  71. ncbi request reprint Beneficial effects of angiotensin-converting enzyme inhibition in adriamycin-induced cardiomyopathy in hamsters
    Kenichi Okumura
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Japan
    Jpn J Pharmacol 88:183-8. 2002
    ....
  72. ncbi request reprint Lengthy suppression of vascular proliferation by a chymase inhibitor in dog grafted veins
    Koutaro Tsunemi
    Departments of Pharmacology and Thoracic and Cardiovascular Surgery, Osaka Medical College, Osaka, Japan
    J Thorac Cardiovasc Surg 124:621-5. 2002
  73. ncbi request reprint Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models
    Mizuo Miyazaki
    Department of Pharmacology, Osaka Medical College, 2 7, Daigakumachi, Takatsuki City, Osaka 569 8686, Japan
    Pharmacol Ther 112:668-76. 2006
    ..We propose that chymase inhibitors are effective in the prevention of multiple cardiovascular disorders, especially at the local event level without any effect on the systemic blood pressure...
  74. ncbi request reprint [Anti-atherosclerotic effect]
    Shinji Takai
    Department of Pharmacology, Osaka Medical College
    Nihon Rinsho 64:518-23. 2006
  75. doi request reprint Evidence for abundant presence of chymase-positive mast cells in the kidneys of patients with immunoglobulin A nephropathy: effect of combination therapy with prednisolone and angiotensin II receptor blocker valsartan
    Yoshio Konishi
    Department of Internal Medicine, Osaka City General Hospital, and Department of Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hypertens Res 31:1517-24. 2008
    ..Combination therapy using prednisolone and valsartan may lead to improvements in intra-renal circulation and to interference in the recruitment of chymase-positive mast cells...
  76. ncbi request reprint Beneficial effects of cardiac chymase inhibition during the acute phase of myocardial infarction
    Denan Jin
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City, Osaka 569 8686, Japan
    Life Sci 71:437-46. 2002
    ..1%, n = 18; BCEAB, 27.8%, n = 18; P < 0.05). These findings demonstrated for the first time that cardiac chymase participates directly in the pathophysiologic state after MI in hamsters...
  77. ncbi request reprint Oral administration of a novel chymase inhibitor, NK3201, prevents peritoneal adhesion formation in hamsters
    Yukiko Okamoto
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Japan
    Jpn J Pharmacol 90:94-6. 2002
    ..01). Oral administration of NK3201 may be a useful drug for prevention of peritoneal adhesion formation...
  78. ncbi request reprint Chymase and angiotensin converting enzyme activities in a hamster model of glaucoma filtering surgery
    Hitoshi Sakaguchi
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Curr Eye Res 24:325-31. 2002
    ..In this work, we created sclerocorneal wounds in hamster eyes and measured the levels of ACE and chymase activities in the eye during the wound healing process...
  79. ncbi request reprint A novel chymase inhibitor, 4-[1-([bis-(4-methyl-phenyl)-methyl]-carbamoyl)3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), suppressed cardiac fibrosis in cardiomyopathic hamsters
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan
    J Pharmacol Exp Ther 305:17-23. 2003
    ..Therefore, the activation of transforming growth factor-beta by chymase may play an important role in the progression of cardiac fibrosis and cardiac dysfunction in cardiomyopathy...
  80. ncbi request reprint An antiarrhythmic effect of a chymase inhibitor after myocardial infarction
    Denan Jin
    Department of Pharmacology, Osaka Medical College, Japan
    J Pharmacol Exp Ther 309:490-7. 2004
    ..An antiarrhythmic effect of chymase inhibitors may contribute to reductions in the mortality rate during the acute phase after MI...
  81. ncbi request reprint Significance of chymase inhibition for prevention of adhesion formation
    Yukiko Okamoto
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City, Osaka 589 8686, Japan
    Eur J Pharmacol 484:357-9. 2004
    ..80+/-0.20; chymase inhibitor, 1.60+/-0.31). Thus, chymase inhibitors may be a novel strategy to prevent adhesion formation...
  82. ncbi request reprint Role of chymase on growth of cultured canine Tenon's capsule fibroblasts and scarring in a canine conjunctival flap model
    Midori Maruichi
    Department of Pharmacology, Osaka Medical College, 2 7 Diagaku machi, Takatsuki City, Osaka 569 8686, Japan
    Exp Eye Res 79:111-8. 2004
    ..6% compared with that in placebo-treated treated eyes. In conclusion, chymase stimulates proliferation of fibroblasts derived from canine Tenon's capsule and chymase may play an important role in scarring after glaucoma surgery...
  83. ncbi request reprint Usefulness of serum mast cell-specific chymase levels for postmortem diagnosis of anaphylaxis
    Hajime Nishio
    Department of Legal Medicine, Osaka Medical College, Takatsuki 569 8686, Japan
    Int J Legal Med 119:331-4. 2005
    ..826, p=0.011). Furthermore, chymase was shown to be quite stable in serum. These results showed that measurement of serum chymase levels might be an additional tool for postmortem diagnosis of anaphylaxis...
  84. ncbi request reprint Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice
    Kuniharu Matsuno
    Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Circulation 112:2677-85. 2005
    ..To clarify the role of Nox1 in Ang II-mediated hypertension, we generated Nox1-deficient (-/Y) mice...
  85. ncbi request reprint [Tumor suppressive effect]
    Shinji Takai
    Department of Pharmacology, Osaka Medical College
    Nihon Rinsho 64:512-7. 2006
  86. ncbi request reprint Prediction of interaction mode between a typical ACE inhibitor and MMP-9 active site
    Daisuke Yamamoto
    Biomedical Computation Center, Osaka Medical College, 2 7 Daigakuchou, Takatsuki, Osaka, Japan
    Biochem Biophys Res Commun 354:981-4. 2007
    ..These findings showed that ACE inhibitors could become important seeds for cardiovascular protection and the development of MMP inhibitors...
  87. ncbi request reprint Pharmacological implications of MMP-9 inhibition by ACE inhibitors
    Daisuke Yamamoto
    Biomedical Computation Center, Osaka Medical College, 2 7 Daigakuchou, Takatuski, Osaka 569 8686, Japan
    Curr Med Chem 16:1349-54. 2009
    ..Research of the molecular interaction between MMP-9 active sites and ACE inhibitors appears to be an important key in the development of effective MMP-9 inhibitors for cardiovascular protection...
  88. ncbi request reprint Impact of the renin-angiotensin-aldosterone-system on cardiovascular and renal complications in diabetes mellitus
    Tetsuya Hayashi
    Department of Internal Medicine III, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, Osaka 569 8686, Japan
    Curr Vasc Pharmacol 8:189-97. 2010
    ..This review presents the available information about the role of the RAAS in the cardiovascular and renal complications of diabetes...
  89. doi request reprint Inhibitory profiles of captopril on matrix metalloproteinase-9 activity
    Daisuke Yamamoto
    Biomedical Computation Center, Osaka Medical College, 2 7 Daigakuchou, Takatsuki, Osaka 569 8686, Japan
    Eur J Pharmacol 588:277-9. 2008
    ..Molecular models showed that captopril directly bound to the MMP-9 active center. Compared with the other ACE inhibitors, the compact structure of captopril seemed to make the inhibitory profiles on the MMP-9 active site...
  90. ncbi request reprint Inhibition of matrix metalloproteinase-9 activity by trandolapril after middle cerebral artery occlusion in rats
    Hidekazu Tanaka
    Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan
    Hypertens Res 30:469-75. 2007
    ..Thus, the inhibition of MMP-9 by trandolapril might be part of the mechanism that prevents cerebral damage after cerebral ischemia...
  91. ncbi request reprint Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9
    Daisuke Yamamoto
    Biomedical Computation Center, Osaka Medical College, 2 7 Daigakuchou, Takatsuki, Osaka 569 8686, Japan
    J Mol Cell Cardiol 43:670-6. 2007
    ..These findings show that imidapril inhibits MMP-9 directly like lisinopril and its hydrophobic interactions with the S1 site of MMP-9 would be important for enhancing inhibitory activity...
  92. doi request reprint Significance of chymase-dependent matrix metalloproteinase-9 activation on indomethacin-induced small intestinal damages in rats
    Kazuki Kakimoto
    Second Department of Internal Medicine, Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 569 8686, Japan
    J Pharmacol Exp Ther 332:684-9. 2010
    ..The area of small intestinal damage was also significantly ameliorated by TY-51469 treatment. These findings suggest that chymase-dependent MMP-9 activation has a significant role in indomethacin-induced small intestinal damage in rats...
  93. ncbi request reprint Chymase inhibitor suppresses adhesion formation in a hamster experimental model
    Yukiko Okamoto
    Department of Pharmacology, Osaka Medical College, Osaka 589 8686, Takatsuki City, Japan
    Eur J Pharmacol 435:265-7. 2002
    ..22; P<0.01). This specific chymase inhibitor, Suc-Val-Pro-Phe(p) (OPh)2, significantly suppressed the scores for adhesion formation in a hamster experimental model. Thus, chymase may play an important role in the adhesion formation...
  94. ncbi request reprint Increased local angiotensin II formation in aneurysmal aorta
    Masayoshi Nishimoto
    Department of Pharmacology, Osaka Medical College, 2 7 Daigaku cho, Takatsuki City, Osaka 569 8686, Japan
    Life Sci 71:2195-205. 2002
    ..Angiotensin II-forming enzymes, chymase and ACE, were significantly increased in the aneurysmal aorta, and increased angiotensin II may be associated with the development of aneurysmal formations...
  95. ncbi request reprint Trandolapril reduces infarction area after middle cerebral artery occlusion in rats
    Ken Okamoto
    Department of Pharmacology, Osaka Medical College, Takatsuki, Japan
    Hypertens Res 25:583-8. 2002
    ..4 +/- 2.3%, respectively, and the difference between these values was significant. These results demonstrate that inhibition of the increased brain ACE activity in infarct lesions can reduce the infarction area after MCA occlusion...
  96. pmc Suppression of basic fibroblast growth factor-induced angiogenesis by a specific chymase inhibitor, BCEAB, through the chymase-angiotensin-dependent pathway in hamster sponge granulomas
    Michiko Muramatsu
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Japan
    Br J Pharmacol 137:554-60. 2002
    ..These results suggest that the significance of chymase in bFGF-induced angiogenesis was confirmed, and a novel inhibitor, BCEAB, strongly suppresses the bFGF-induced angiogenesis through the chymase-angiotensin II-VEGF dependent pathway...
  97. ncbi request reprint Chymase inhibitor, BCEAB, suppressed peritoneal adhesion formation in hamster
    Yukiko Okamoto
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Japan
    J Surg Res 107:219-22. 2002
    ..To clarify the role of chymase produced from mast cells in adhesion formation, we investigated the preventive effect of a specific chymase inhibitor, BCEAB, on adhesion formation in a hamster experimental model...
  98. ncbi request reprint Development of the chymase inhibitor as an anti-tissue-remodeling drug: myocardial infarction and some other possibilities
    Yoshikazu Sukenaga
    Research and Development Division, Pharmaceuticals Group, Nippon Kayaku Co, Ltd, Tokyo, Japan
    Jpn J Pharmacol 90:218-22. 2002
    ..Our recent data indicated chymase participation in bladder fibrosis, like interstitial cystitis. Therefore, the orally active chymase inhibitor NK3201 may have protective effects on tissue remodeling in several diseases...
  99. ncbi request reprint Attenuation of adhesion formation after cardiac surgery with a chymase inhibitor in a hamster model
    Yoshiharu Soga
    Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Japan
    J Thorac Cardiovasc Surg 127:72-8. 2004
    ..However, the role of chymase in cardiac adhesion formation has not yet been elucidated. We have assessed whether a specific chymase inhibitor, Suc-Val-Pro-Phe(p) (OPh)(2), prevents postoperative cardiac adhesions in hamsters...
  100. ncbi request reprint Granulocyte colony-stimulating factor-mobilized circulating c-Kit+/Flk-1+ progenitor cells regenerate endothelium and inhibit neointimal hyperplasia after vascular injury
    Michitaka Takamiya
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602 8566, Japan
    Arterioscler Thromb Vasc Biol 26:751-7. 2006
    ....
  101. ncbi request reprint Thiamine attenuates the hypertension and metabolic abnormalities in CD36-defective SHR: uncoupling of glucose oxidation from cellular entry accompanied with enhanced protein O-GlcNAcylation in CD36 deficiency
    Takao Tanaka
    Third Division, Department of Internal Medicine, Osaka Medical College, Osaka, Japan
    Mol Cell Biochem 299:23-35. 2007
    ..Therefore, we attempted to activate glucose oxidation with the repletion of thiamine, a coenzyme for multiple steps of glucose metabolism...