Hisae Sumi

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc High expression of α-synuclein in damaged mitochondria with PLA2G6 dysfunction
    Hisae Sumi-Akamaru
    Department of Neurology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Japan
    Acta Neuropathol Commun 4:27. 2016
  2. ncbi request reprint Inverse correlation between the formation of mitochondria-derived vacuoles and Lewy-body-like hyaline inclusions in G93A superoxide-dismutase-transgenic mice
    Hisae Sumi
    Department of Neurology D 4, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, 565 0871, Osaka, Japan
    Acta Neuropathol 112:52-63. 2006
  3. doi request reprint Nuclear TAR DNA binding protein 43 expression in spinal cord neurons correlates with the clinical course in amyotrophic lateral sclerosis
    Hisae Sumi
    Department of Neurology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Japan
    J Neuropathol Exp Neurol 68:37-47. 2009
  4. ncbi request reprint Benefit of valproic acid in suppressing disease progression of ALS model mice
    Fuminobu Sugai
    Department of Neurology D 4, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Eur J Neurosci 20:3179-83. 2004
  5. ncbi request reprint Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD 40: relevance to Parkinson's disease
    Tatsusada Okuno
    Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurosci Res 81:874-82. 2005
  6. doi request reprint Pioglitazone promotes peripheral nerve remyelination after crush injury through CD36 upregulation
    Masaki Eto
    Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Peripher Nerv Syst 13:242-8. 2008
  7. pmc Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson's disease patients
    Katsuya Araki
    Department of Neurology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Sci Rep 5:17625. 2015
  8. doi request reprint Adult-onset multiple acyl CoA dehydrogenation deficiency associated with an abnormal isoenzyme pattern of serum lactate dehydrogenase
    Fuminobu Sugai
    Department of Neurology, Otemae Hospital, Chuo Ku, Osaka, Japan
    Neuromuscul Disord 22:159-61. 2012
  9. ncbi request reprint Hepatoma-derived growth factor is a neurotrophic factor harbored in the nucleus
    Zhiwei Zhou
    Department of Neurology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    J Biol Chem 279:27320-6. 2004

Collaborators

Detail Information

Publications9

  1. pmc High expression of α-synuclein in damaged mitochondria with PLA2G6 dysfunction
    Hisae Sumi-Akamaru
    Department of Neurology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Japan
    Acta Neuropathol Commun 4:27. 2016
    ..The strong affinity of αSyn for damaged mitochondrial membranes may promote membrane stabilization of mitochondria and neuronal survival in neurons. ..
  2. ncbi request reprint Inverse correlation between the formation of mitochondria-derived vacuoles and Lewy-body-like hyaline inclusions in G93A superoxide-dismutase-transgenic mice
    Hisae Sumi
    Department of Neurology D 4, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, 565 0871, Osaka, Japan
    Acta Neuropathol 112:52-63. 2006
    ..Taken together, the present findings suggest that the mitochondria-derived vacuoles might prevent the formation of LBHIs by sequestering mutated SOD1 from the cytoplasm...
  3. doi request reprint Nuclear TAR DNA binding protein 43 expression in spinal cord neurons correlates with the clinical course in amyotrophic lateral sclerosis
    Hisae Sumi
    Department of Neurology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Japan
    J Neuropathol Exp Neurol 68:37-47. 2009
    ....
  4. ncbi request reprint Benefit of valproic acid in suppressing disease progression of ALS model mice
    Fuminobu Sugai
    Department of Neurology D 4, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Eur J Neurosci 20:3179-83. 2004
    ..Considering the long usage of VPA for epileptic patients with good tolerance and safety, these data strongly support the clinical application of VPA for ALS treatment...
  5. ncbi request reprint Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD 40: relevance to Parkinson's disease
    Tatsusada Okuno
    Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurosci Res 81:874-82. 2005
    ..Together these data suggest that up-regulated iNOS and COX-2 via the CD 40 pathway may lead to dopaminergic neuron loss and may participate in the neuroinflammaory pathway of PD...
  6. doi request reprint Pioglitazone promotes peripheral nerve remyelination after crush injury through CD36 upregulation
    Masaki Eto
    Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Peripher Nerv Syst 13:242-8. 2008
    ..These results indicate that PIO promotes peripheral nerve remyelination possibly through CD36. It may be possible to apply PIO to the remedy against demyelinating neuropathies...
  7. pmc Synchrotron FTIR micro-spectroscopy for structural analysis of Lewy bodies in the brain of Parkinson's disease patients
    Katsuya Araki
    Department of Neurology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Sci Rep 5:17625. 2015
    ..Also, 2D infrared mapping of LBs revealed that the content of the β-sheet structure is higher in the halo than in the core, and the core contains a large amount of proteins and lipids. ..
  8. doi request reprint Adult-onset multiple acyl CoA dehydrogenation deficiency associated with an abnormal isoenzyme pattern of serum lactate dehydrogenase
    Fuminobu Sugai
    Department of Neurology, Otemae Hospital, Chuo Ku, Osaka, Japan
    Neuromuscul Disord 22:159-61. 2012
    ..4%), LDH-2 (34.9%), LDH-5 (6.9%) and LDH-1/LDH-2 ratio (1.0). The abnormal LDH isoenzyme pattern may be one feature of adult-onset MADD selectively affecting type I muscle fibers with relatively high LDH-1 content...
  9. ncbi request reprint Hepatoma-derived growth factor is a neurotrophic factor harbored in the nucleus
    Zhiwei Zhou
    Department of Neurology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    J Biol Chem 279:27320-6. 2004
    ....