A Shinohara

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi Rad52 forms ring structures and co-operates with RPA in single-strand DNA annealing
    A Shinohara
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Japan
    Genes Cells 3:145-56. 1998
  2. ncbi Stimulation by Rad52 of yeast Rad51-mediated recombination
    A Shinohara
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Japan
    Nature 391:404-7. 1998
  3. pmc Tid1/Rdh54 promotes colocalization of rad51 and dmc1 during meiotic recombination
    M Shinohara
    Department of Biology, Graduate School of Science, Osaka University, 1 1 Machikaneyma, Toyonaka, Osaka 560 0043, Japan
    Proc Natl Acad Sci U S A 97:10814-9. 2000
  4. pmc Characterization of the roles of the Saccharomyces cerevisiae RAD54 gene and a homologue of RAD54, RDH54/TID1, in mitosis and meiosis
    M Shinohara
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Japan
    Genetics 147:1545-56. 1997
  5. ncbi Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA
    A Shinohara
    Department of Biology, Faculty of Science, Osaka University, Japan
    Nat Genet 4:239-43. 1993
  6. ncbi Saccharomyces cerevisiae recA homologues RAD51 and DMC1 have both distinct and overlapping roles in meiotic recombination
    A Shinohara
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Japan
    Genes Cells 2:615-29. 1997
  7. ncbi Roles of RecA homologues Rad51 and Dmc1 during meiotic recombination
    A Shinohara
    Institute for Protein Research, Osaka University, Suita, Osaka, Japan
    Cytogenet Genome Res 107:201-7. 2004
  8. ncbi Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein
    A Shinohara
    Department of Biology, Faculty of Science, Osaka University, Japan
    Cell 69:457-70. 1992
  9. ncbi RAD51 homologues in Xenopus laevis: two distinct genes are highly expressed in ovary and testis
    K Maeshima
    Department of Molecular Protozoology, Osaka University, Japan
    Gene 160:195-200. 1995
  10. doi Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination
    Michael N Conrad
    Program in Molecular, Cell and Developmental Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Cell 133:1175-87. 2008

Collaborators

  • H Ogawa
  • D K Bishop
  • K Morimatsu
  • S Matsuda
  • T Ohta
  • T Horii
  • Ying Huang
  • Masao S Sasaki
  • Seung K Kim
  • Ciaran G Morrison
  • Michael E Dresser
  • Tatsuya Hirano
  • M Shinohara
  • Michael N Conrad
  • S L Gasior
  • Y Yokoyama
  • T Otsuki
  • J M Kim
  • A Iwamatsu
  • K Mizuno
  • E L Hong
  • J A Conchello
  • H Kosaka
  • Chih Ying Lee
  • Gene Chao
  • M Takata
  • Z M Yuan
  • T Katagiri
  • R Mizuta
  • K Ozawa
  • M Hibi
  • T Yamashita
  • H Endo
  • K Ikeda
  • T Tamaya
  • X Wan
  • J M Liu
  • F Maraboeuf
  • Y Takahashi
  • M Takahashi
  • Y Furukawa
  • T Shirogane
  • J M Buerstedde
  • K Maeshima
  • R Wang
  • N Kamada
  • Y Kora
  • E Sonoda
  • Y Yamaguchi-Iwai
  • Y Miki
  • S Takeda
  • T Ishiko
  • H Utsumi
  • S Kharbanda
  • D Kufe
  • Y Nakamura
  • T Utsugisawa
  • A K Wong
  • P Sung
  • S Nakada
  • H Saito
  • R Weichselbaum
  • M Hashimoto
  • E Shita-Yamaguchi
  • M Lalande
  • N A Jenkins
  • J M LaSalle
  • F W Alt
  • H Shinagawa
  • N Copeland
  • H L Cheng
  • O Bezzubova
  • R G Mueller

Detail Information

Publications21

  1. ncbi Rad52 forms ring structures and co-operates with RPA in single-strand DNA annealing
    A Shinohara
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Japan
    Genes Cells 3:145-56. 1998
    ..Very little has been discovered about the biochemical roles and structure of the Rad52 protein...
  2. ncbi Stimulation by Rad52 of yeast Rad51-mediated recombination
    A Shinohara
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Japan
    Nature 391:404-7. 1998
    ..We conclude that this binding is crucial in recombination and that it facilitates the formation of Rad51 nucleoprotein filaments...
  3. pmc Tid1/Rdh54 promotes colocalization of rad51 and dmc1 during meiotic recombination
    M Shinohara
    Department of Biology, Graduate School of Science, Osaka University, 1 1 Machikaneyma, Toyonaka, Osaka 560 0043, Japan
    Proc Natl Acad Sci U S A 97:10814-9. 2000
    ....
  4. pmc Characterization of the roles of the Saccharomyces cerevisiae RAD54 gene and a homologue of RAD54, RDH54/TID1, in mitosis and meiosis
    M Shinohara
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Japan
    Genetics 147:1545-56. 1997
    ..These results suggest that one of the differences between the late stages of mitotic recombination and meiotic recombination might be specified by differential dependency on the Rad54 and Rdh54/Tid1 proteins...
  5. ncbi Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA
    A Shinohara
    Department of Biology, Faculty of Science, Osaka University, Japan
    Nat Genet 4:239-43. 1993
    ..The rad51 homologues fail to complement the DNA repair defect of rad51 mutants of S. cerevisiae. The mouse gene is located in the F1 region of chromosome 2 and the human gene maps to chromosome 15...
  6. ncbi Saccharomyces cerevisiae recA homologues RAD51 and DMC1 have both distinct and overlapping roles in meiotic recombination
    A Shinohara
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Japan
    Genes Cells 2:615-29. 1997
    ..Mutant analysis has shown that both proteins are required for normal meiotic recombination, for timely and efficient formation of synaptonemal complex and for normal progression out from meiotic prophase...
  7. ncbi Roles of RecA homologues Rad51 and Dmc1 during meiotic recombination
    A Shinohara
    Institute for Protein Research, Osaka University, Suita, Osaka, Japan
    Cytogenet Genome Res 107:201-7. 2004
    ..It is largely unknown how the two RecAs cooperate during meiotic recombination. In this review, recent advances on our knowledge about the roles of Rad51 and Dmc1 during meiosis are summarized and discussed...
  8. ncbi Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein
    A Shinohara
    Department of Biology, Faculty of Science, Osaka University, Japan
    Cell 69:457-70. 1992
    ..Rad51 protein is also homologous to a meiosis-specific Dmc1 protein of S. cerevisiae...
  9. ncbi RAD51 homologues in Xenopus laevis: two distinct genes are highly expressed in ovary and testis
    K Maeshima
    Department of Molecular Protozoology, Osaka University, Japan
    Gene 160:195-200. 1995
    ..The structural similarities of the XRAD51 proteins to RecA in E. coli and Rad51 in yeasts or vertebrates are discussed...
  10. doi Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination
    Michael N Conrad
    Program in Molecular, Cell and Developmental Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Cell 133:1175-87. 2008
    ..Together with recombination defects described for ndj1, our observations suggest that RPMs and SCs balance the disruption and stabilization of recombinational interactions, respectively, to regulate crossing over...
  11. ncbi Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex
    T Otsuki
    Department of Hematology, Jichi Medical School, Yakushiji 3311 1, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    Hum Mol Genet 10:2651-60. 2001
    ....
  12. ncbi Saccharomyces cerevisiae Dmc1 protein promotes renaturation of single-strand DNA (ssDNA) and assimilation of ssDNA into homologous super-coiled duplex DNA
    E L Hong
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 276:41906-12. 2001
    ..In addition, Dmc1 catalyzes strand assimilation of ssDNA oligonucleotides into homologous supercoiled duplex DNA in a reaction promoted by ATP or the non-hydrolyzable ATP analogue AMP-PNP...
  13. ncbi Effect of ions and nucleotides on the interactions of yeast Rad51 protein with single-stranded oligonucleotides
    J M Kim
    Department of Chemistry, College of Natural Sciences, Yeungnam University, Kyoungsan City, Kyoung-buk, 712-749 Republic of Korea
    J Biochem 129:469-75. 2001
    ..These features may be linked to the lower activity of Rad51 and the fact that Rad51 activity does not require the hydrolysis of ATP...
  14. pmc A chicken RAD51 homologue is expressed at high levels in lymphoid and reproductive organs
    O Bezzubova
    Basel Institute for Immunology, Switzerland
    Nucleic Acids Res 21:1577-80. 1993
    ..High expression of the chicken Rad51 gene was found within the organs of lymphoid and germ cell development suggesting its involvement in lymphoid and meiotic recombination...
  15. pmc Rad52 associates with RPA and functions with rad55 and rad57 to assemble meiotic recombination complexes
    S L Gasior
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637 USA
    Genes Dev 12:2208-21. 1998
    ..DSBs are not sufficient for the appearance of Rad51 foci; Rad52, Rad55, and Rad57 are also required supporting a model in which these three proteins promote meiotic recombination by promoting the assembly of strand exchange complexes...
  16. pmc RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein
    R Mizuta
    Howard Hughes Medical Institute, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:6927-32. 1997
    ..To detect RAD51 interactions in vivo, we developed a transient nuclear focus assay that was used to demonstrate a complete colocalization of RAB22 with RAD51 in large nuclear foci...
  17. ncbi Multiple possible sites of BRCA2 interacting with DNA repair protein RAD51
    T Katagiri
    Department of Human Genome Analysis, Japanese Foundation for Cancer Research, Tokyo, Japan
    Genes Chromosomes Cancer 21:217-22. 1998
    ....
  18. pmc Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
    M Takata
    Department of Molecular Immunology and Allergology, Kyoto University Medical School, Konoe Yoshida, Sakyo ku, Kyoto 606 8315, Japan
    EMBO J 17:5497-508. 1998
    ..These observations provide the first genetic evidence that both repair pathways play a role in maintaining chromosomal DNA during the cell cycle...
  19. ncbi Regulation of Pim-1 by Hsp90
    K Mizuno
    Division of Molecular Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Biochem Biophys Res Commun 281:663-9. 2001
    ..These results indicate that Hsp90 is coordinately regulated with Pim-1 and is involved in the stabilization and function of Pim-1...
  20. ncbi Alternatively spliced variant deleting exons 7 and 8 of the human telomerase reverse transcriptase gene is dominantly expressed in the uterus
    Y Yokoyama
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu, 500 8705, Japan
    Mol Hum Reprod 7:853-7. 2001
    ..These results suggest that regulation of splicing in the transcript encoding the hTERT reverse transcriptase domain is associated with telomerase activation in uterine tissues...
  21. ncbi Regulation of Rad51 function by c-Abl in response to DNA damage
    Z M Yuan
    Division of Cancer Pharmacology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:3799-802. 1998
    ..These findings represent the first demonstration that Rad51 is regulated by phosphorylation and support a functional role for c-Abl in regulating Rad51-dependent recombination in the response to DNA damage...