Takashi Omura

Summary

Affiliation: Osaka City University
Country: Japan

Publications

  1. ncbi request reprint Myocardial ischemia activates the JAK-STAT pathway through angiotensin II signaling in in vivo myocardium of rats
    T Omura
    First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    J Mol Cell Cardiol 33:307-16. 2001
  2. ncbi request reprint Involvement of c-Jun NH2 terminal kinase and p38MAPK in rapamycin-mediated inhibition of neointimal formation in rat carotid arteries
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan
    J Cardiovasc Pharmacol 46:519-25. 2005
  3. ncbi request reprint Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Mol Cell Cardiol 38:583-92. 2005
  4. ncbi request reprint Core protein of hepatitis C virus induces cardiomyopathy
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Circ Res 96:148-50. 2005
  5. ncbi request reprint Involvement of apoptosis signal-regulating kinase-1 on angiotensin II-induced monocyte chemoattractant protein-1 expression
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Arterioscler Thromb Vasc Biol 24:270-5. 2004
  6. ncbi request reprint Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan
    Hypertension 39:81-6. 2002
  7. ncbi request reprint The long-acting Ca2+-channel blocker azelnidipine prevents left ventricular remodeling after myocardial infarction
    Daisuke Nishiya
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Asahimachi, Osaka, Japan
    J Pharmacol Sci 103:391-7. 2007
  8. ncbi request reprint Effects of aldosterone receptor antagonist and angiotensin II type I receptor blocker on cardiac transcriptional factors and mRNA expression in rats with myocardial infarction
    Ryo Matsumoto
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Japan
    Circ J 68:376-82. 2004
  9. ncbi request reprint Effects of granulocyte-colony stimulating factor on cardiac remodeling after myocardial infarction
    Yasuhiro Takagi
    Department of Internal Medicine and Cardiology, Osaka City University, Graduate School of Medicine, 1 4 3, Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Osaka City Med J 51:43-50. 2005
  10. ncbi request reprint Angiotensin blockade inhibits osteopontin expression in non-infarcted myocardium after myocardial infarction
    Takanori Kusuyama
    Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine, Japan
    J Pharmacol Sci 98:283-9. 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Myocardial ischemia activates the JAK-STAT pathway through angiotensin II signaling in in vivo myocardium of rats
    T Omura
    First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    J Mol Cell Cardiol 33:307-16. 2001
    ....
  2. ncbi request reprint Involvement of c-Jun NH2 terminal kinase and p38MAPK in rapamycin-mediated inhibition of neointimal formation in rat carotid arteries
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan
    J Cardiovasc Pharmacol 46:519-25. 2005
    ..Therefore, we examined the effects of rapamycin on MAPK and transcriptional factors in cultured human coronary artery smooth muscle cells (CASMC) and in balloon-injured rat carotid arteries...
  3. ncbi request reprint Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Mol Cell Cardiol 38:583-92. 2005
    ..In conclusion, G-protein-coupled receptor agonist-induced PAI-1 expression is partially mediated through JNK activation...
  4. ncbi request reprint Core protein of hepatitis C virus induces cardiomyopathy
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Circ Res 96:148-50. 2005
    ..These histological changes are just consistent with cardiomyopathy. In conclusion, the HCV-core protein directly plays an important role in the development of cardiomyopathy...
  5. ncbi request reprint Involvement of apoptosis signal-regulating kinase-1 on angiotensin II-induced monocyte chemoattractant protein-1 expression
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Arterioscler Thromb Vasc Biol 24:270-5. 2004
    ..To elucidate these molecular mechanisms, angiotensin II-induced expression of MCP-1 was examined in cultured rat neonatal ventricular cardiomyocytes and fibroblasts by adenovirus gene transfer...
  6. ncbi request reprint Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan
    Hypertension 39:81-6. 2002
    ..In conclusion, we provide the first evidence that DNJun inhibits cardiomyocyte hypertrophy through inhibition of AP-1 transcriptional activity...
  7. ncbi request reprint The long-acting Ca2+-channel blocker azelnidipine prevents left ventricular remodeling after myocardial infarction
    Daisuke Nishiya
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Asahimachi, Osaka, Japan
    J Pharmacol Sci 103:391-7. 2007
    ..3 +/- 0.8, respectively). In conclusion, azelnidipine can prevent LV remodeling and improve systolic and diastolic function after MI. Administration of long-acting Ca(2+)-channel blockers after MI is an effective strategy for treating MI...
  8. ncbi request reprint Effects of aldosterone receptor antagonist and angiotensin II type I receptor blocker on cardiac transcriptional factors and mRNA expression in rats with myocardial infarction
    Ryo Matsumoto
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Japan
    Circ J 68:376-82. 2004
    ....
  9. ncbi request reprint Effects of granulocyte-colony stimulating factor on cardiac remodeling after myocardial infarction
    Yasuhiro Takagi
    Department of Internal Medicine and Cardiology, Osaka City University, Graduate School of Medicine, 1 4 3, Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Osaka City Med J 51:43-50. 2005
    ..However, the effects of G-CSF on MI are still controversial and the molecular mechanism of G-CSF treatment for repair of the infarcted heart is not fully understood...
  10. ncbi request reprint Angiotensin blockade inhibits osteopontin expression in non-infarcted myocardium after myocardial infarction
    Takanori Kusuyama
    Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine, Japan
    J Pharmacol Sci 98:283-9. 2005
    ..Both ACEI and ARB significantly prevented cardiac fibrosis and osteopontin expression. In conclusion, angiotensin blockade inhibits osteopontin expression in non-infarcted myocardium and prevents cardiac remodeling after MI...
  11. ncbi request reprint Beneficial effects of combination of ACE inhibitor and angiotensin II type 1 receptor blocker on cardiac remodeling in rat myocardial infarction
    Yasuhiro Nakamura
    Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Cardiovasc Res 57:48-54. 2003
    ..In this study, we compared the effects of an ACE inhibitor (temocapril), an ARB (CS-866), and their combination on cardiac remodeling after MI...
  12. ncbi request reprint Effects of erythropoietin on cardiac remodeling after myocardial infarction
    Daisuke Nishiya
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Asahimachi, Japan
    J Pharmacol Sci 101:31-9. 2006
    ..In conclusion, when administered after MI, EPO prevents cardiac remodeling and improves ventricular function with enhanced angiogenesis and reduced apoptosis...
  13. ncbi request reprint Vascular endothelial growth factor-expressing mesenchymal stem cell transplantation for the treatment of acute myocardial infarction
    Ryo Matsumoto
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan
    Arterioscler Thromb Vasc Biol 25:1168-73. 2005
    ..We hypothesized that transplantation of VEGF-expressing MSCs could effectively treat acute myocardial infarction (MI) by providing enhanced cardioprotection, followed by angiogenic effects in salvaging ischemic myocardium...
  14. ncbi request reprint Granulocyte-colony stimulating factor augments neovascularization induced by bone marrow transplantation in rat hindlimb ischemia
    Yasuhiro Takagi
    Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medical Sciences, Osaka, Japan
    J Pharmacol Sci 99:45-51. 2005
    ..In conclusion, G-CSF was found to augment neovascularization in rat hindlimb ischemia. Combined use of G-CSF treatment and BMT may be a useful strategy for therapeutic neovascularization in ischemic tissues...
  15. ncbi request reprint Effects of cellular cardiomyoplasty on ventricular remodeling assessed by Doppler echocardiography and topographic immunohistochemistry
    Minoru Yoshiyama
    Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Japan
    Circ J 68:580-6. 2004
    ....
  16. ncbi request reprint Cardioprotective effect of SEA0400, a selective inhibitor of the Na(+)/Ca(2+) exchanger, on myocardial ischemia-reperfusion injury in rats
    Minoru Yoshiyama
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan
    J Pharmacol Sci 95:196-202. 2004
    ..This study demonstrates that the NCX is an important mechanism for cell death in myocardial ischemia and reperfusion in rats. SEA0400 may prove to be a promising new drug in the clinical treatment of myocardial ischemia and reperfusion...
  17. ncbi request reprint Effects of treatment for diabetes mellitus on circulating vascular progenitor cells
    Takanori Kusuyama
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Japan
    J Pharmacol Sci 102:96-102. 2006
    ..DM reduces the number of circulating EPCs and SMPCs according to its severity, and treatment of DM significantly increases the number of EPCs and SMPCs, which may be involved in angiogenesis and atherosclerosis in diabetes...
  18. ncbi request reprint Transmitral inflow pattern assessed by Doppler echocardiography in angiotensin II type 1A receptor knockout mice with myocardial infarction
    Yasuhiro Nakamura
    Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Circ J 66:192-6. 2002
    ..05). mRNA expressions of ANP, BNP, collagen I and collagen III in the non-infarcted LV and RV of KO-MI were significantly lower than WT-MI. In conclusion, transmitral inflow abnormalities in KO-MI were attenuated compared with WT-MI...
  19. ncbi request reprint Important role of apoptosis signal-regulating kinase 1 in ischemia-induced angiogenesis
    Yasukatsu Izumi
    Department of Pharmacology, Osaka City University Medical School, Japan
    Arterioscler Thromb Vasc Biol 25:1877-83. 2005
    ..We first examined the role of apoptosis signal-regulating kinase 1 (ASK1), one of mitogen-activated protein kinase kinase kinases, in ischemia-induced angiogenesis...
  20. ncbi request reprint The effects of HMG-CoA reductase inhibitor on vascular progenitor cells
    Takanori Kusuyama
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Japan
    J Pharmacol Sci 101:344-9. 2006
    ..Our findings suggest a previously unreported mechanism of the effect of statin therapy on vascular progenitor cells...
  21. ncbi request reprint Additive improvement of left ventricular remodeling by aldosterone receptor blockade with eplerenone and angiotensin II type 1 receptor antagonist in rats with myocardial infarction
    Minoru Yoshiyama
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Graduate School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Nihon Yakurigaku Zasshi 124:83-9. 2004
    ..Combination therapy with an candesartan substantially potentiates this effect by a complementary prevention of LV fibrosis, cardiac hypertrophy, and molecular alterations...
  22. ncbi request reprint Effects of FK506 on acute allograft rejection in transplanted rat heart: the role of mitogen-activated protein kinases, AP-1 and NF-kappaB
    Takanobu Aoyama
    Second Department of Surgery, Osaka City University Medical School, Japan
    Osaka City Med J 49:1-10. 2003
    ..These results suggest that the signal transduction pathways may play important roles in acute allograft rejection in rat cardiac transplantation...
  23. ncbi request reprint Left ventricular remodeling after myocardial infarction in antecedent hypertensive patients
    Minoru Yoshiyama
    Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Hypertens Res 28:293-9. 2005
    ..The results demonstrated that antecedent hypertension interacts with ventricular cavity dilatation after MI...
  24. ncbi request reprint Activation of mitogen-activated protein kinases, activator protein-1, and nuclear factor-kappaB during acute rejection after heterotopic heart transplantation in rats
    Hidekazu Hirai
    Department of Cardiovascular Surgery, Osaka City University, Graduate School of Medicine, Japan
    Osaka City Med J 52:9-19. 2006
    ..This study aimed to determine whether MAPKs and transcriptional factors such as activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) were involved in acute rejection after cardiac transplantation...
  25. ncbi request reprint Nipradilol can prevent left ventricular systolic and diastolic dysfunction after myocardial infarction in rats
    Satoru Izutani
    Department of Internal Medicine, Graduate School of Medicine, Osaka City University, Japan
    Circ J 66:289-93. 2002
    ..In conclusions, nipradilol prevents the cardiac remodeling that is accompanied by systolic and diastolic dysfunction, and inhibits abnormal myocardial gene expression after MI...