Hironori Nakagami

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc The mechanism of white and brown adipocyte differentiation
    Hironori Nakagami
    Division of Vascular Medicine and Epigenetics, Osaka University United Graduate School of Child Development, Osaka, Japan
    Diabetes Metab J 37:85-90. 2013
  2. ncbi request reprint Potential effect of angiotensin II receptor blockade in adipose tissue and bone
    Hironori Nakagami
    Division of Vascular Medicine and Epigenetics, Osaka University United Graduate School of Child Development, 2 1 Yamada oka, Suita 565 0871, Japan
    Curr Pharm Des 19:3049-53. 2013
  3. pmc Modification of a novel angiogenic peptide, AG30, for the development of novel therapeutic agents
    Hironori Nakagami
    Division of Gene Therapy Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Cell Mol Med 16:1629-39. 2012
  4. ncbi request reprint Obesity and gastrointestinal hormones-dual effect of angiotensin II receptor blockade and a partial agonist of PPAR-γ
    Hironori Nakagami
    Division of Gene Therapy Science, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, Japan
    Curr Vasc Pharmacol 9:162-6. 2011
  5. ncbi request reprint New concept of vascular calcification and metabolism
    Hironori Nakagami
    Division of Gene Therapy Science, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Vasc Pharmacol 9:124-7. 2011
  6. ncbi request reprint Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells
    Hironori Nakagami
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 25:2542-7. 2005
  7. doi request reprint Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension
    Hironori Nakagami
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Hypertens Res 30:1239-46. 2007
  8. ncbi request reprint Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy
    Hironori Nakagami
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita 565 0871, Osaka, Japan
    J Atheroscler Thromb 13:77-81. 2006
  9. doi request reprint FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1
    Hiroki Hayashi
    Division of Gene Therapy Science, Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    Arterioscler Thromb Vasc Biol 29:909-14. 2009
  10. pmc Development of a novel antimicrobial peptide, AG-30, with angiogenic properties
    Tomoyuki Nishikawa
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Cell Mol Med 13:535-46. 2009

Detail Information

Publications80

  1. pmc The mechanism of white and brown adipocyte differentiation
    Hironori Nakagami
    Division of Vascular Medicine and Epigenetics, Osaka University United Graduate School of Child Development, Osaka, Japan
    Diabetes Metab J 37:85-90. 2013
    ..This review based on our recent research, seeks to highlight the adipocyte differentiation...
  2. ncbi request reprint Potential effect of angiotensin II receptor blockade in adipose tissue and bone
    Hironori Nakagami
    Division of Vascular Medicine and Epigenetics, Osaka University United Graduate School of Child Development, 2 1 Yamada oka, Suita 565 0871, Japan
    Curr Pharm Des 19:3049-53. 2013
    ..To treat the subgroups of hypertensive patients with osteoporosis RAS can be considered a novel target...
  3. pmc Modification of a novel angiogenic peptide, AG30, for the development of novel therapeutic agents
    Hironori Nakagami
    Division of Gene Therapy Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Cell Mol Med 16:1629-39. 2012
    ..Therefore, we propose the use of AG30/5C as a wound-healing drug with antibacterial and angiogenic actions...
  4. ncbi request reprint Obesity and gastrointestinal hormones-dual effect of angiotensin II receptor blockade and a partial agonist of PPAR-γ
    Hironori Nakagami
    Division of Gene Therapy Science, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, Japan
    Curr Vasc Pharmacol 9:162-6. 2011
    ..These favorable characteristics of telmisartan might be due to its action as a partial agonist of PPAR-γ, beyond its blood pressure-lowering effect, through Ang II blockade, which may be called "metabosartan"...
  5. ncbi request reprint New concept of vascular calcification and metabolism
    Hironori Nakagami
    Division of Gene Therapy Science, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Vasc Pharmacol 9:124-7. 2011
    ..Based on these findings, we speculate that ezetimibe might prevent aortic intima calcification, which may give us the benefits to decrease vascular events...
  6. ncbi request reprint Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells
    Hironori Nakagami
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 25:2542-7. 2005
    ..The delivery of autologous progenitor cells into ischemic tissue of patients is emerging as a novel therapeutic option. Here, we report the potential impact of cultured adipose tissue-derived cells (ADSC) on angiogenic cell therapy...
  7. doi request reprint Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension
    Hironori Nakagami
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Hypertens Res 30:1239-46. 2007
    ..Our results suggest that the polymorphism of myospryn is associated with left ventricular hypertrophy, and an association between a Z-disc protein and cardiac adaptation in response to pressure overload...
  8. ncbi request reprint Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy
    Hironori Nakagami
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita 565 0871, Osaka, Japan
    J Atheroscler Thromb 13:77-81. 2006
    ..These adipose tissue-derived cells have potential in angiogenic cell therapy for ischemic disease, and might be applied for regenerative cell therapy instead of bone marrow cells in the near future...
  9. doi request reprint FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1
    Hiroki Hayashi
    Division of Gene Therapy Science, Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    Arterioscler Thromb Vasc Biol 29:909-14. 2009
    ..The goal of this study is to clear the mechanism of antiangiogenic signaling of FHL-2 in endothelial cells (ECs)...
  10. pmc Development of a novel antimicrobial peptide, AG-30, with angiogenic properties
    Tomoyuki Nishikawa
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Cell Mol Med 13:535-46. 2009
    ..These data suggest that the novel peptide, AG-30, may have therapeutic potential for ischaemic diseases...
  11. ncbi request reprint Involvement of gamma-secretase in postnatal angiogenesis
    Hiroki Hayashi
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 363:584-90. 2007
    ....
  12. pmc Decrease in blood pressure and regression of cardiovascular complications by angiotensin II vaccine in mice
    Futoshi Nakagami
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 8:e60493. 2013
    ..Taken together, these data indicate that vaccines targeting Ang II might be effective to decrease high BP and prevent cardiovascular complications without severe side effects...
  13. ncbi request reprint Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis
    Yukihiro Saito
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Circulation 114:1177-84. 2006
    ..Treatment for this disabling condition remains limited and largely ineffective. The goal of the present study was to investigate the therapeutic efficacy of hepatocyte growth factor (HGF) in animal models of lymphedema...
  14. doi request reprint Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification
    Mariana Kiomy Osako
    Division of Clinical Gene Therapy, Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Japan
    Circ Res 107:466-75. 2010
    ..The role of these proteins in vasculature, as well as the contribution of estrogen to vascular calcification, is poorly understood...
  15. pmc Therapeutic vaccine against DPP4 improves glucose metabolism in mice
    Zhengda Pang
    Departments of Geriatric Medicine and Nephrology and Clinical Gene Therapy, Graduate School of Medicine and Division of Vascular Medicine and Epigenetics, United Graduate School of Child Development, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 111:E1256-63. 2014
    ..Additionally, no significant immune-mediated damage was detected in cells and tissues where DPP4 is expressed. Thus, this DPP4 vaccine may provide a therapeutic alternative for patients with diabetes. ..
  16. doi request reprint Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of the N-type calcium channel
    Hideo Shimizu
    Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Hypertens Res 35:77-81. 2012
    ..These pleiotropic effects of antihypertensive drugs such as cilnidipine and carvedilol might provide additional benefits in the treatment of hypertensive postmenopausal women...
  17. pmc Potential role of CYLD (Cylindromatosis) as a deubiquitinating enzyme in vascular cells
    Yoichi Takami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Pathol 172:818-29. 2008
    ..In conclusion, these data demonstrate that the deubiquitinating enzyme CYLD may inhibit inflammation and proliferation in vascular cells and may represent a novel target for the treatment or prevention of atherosclerosis...
  18. ncbi request reprint Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action
    Rie Hanayama
    Division of Clinical Gene Therapy, Osaka University, Graduate School of Medicine, Osaka 565 0871, Japan
    Int J Mol Med 23:581-8. 2009
    ....
  19. ncbi request reprint Lack of association between the hepatocyte growth factor receptor, c-met, and the anti-apoptotic action of bag-1 in endothelial cells
    Hironori Nakagami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Japan
    Hypertens Res 27:359-65. 2004
    ..Taken together, these results indicate that over-expression of bag-1 has an anti-apoptotic effect on endothelial cells independent of HGF signaling...
  20. doi request reprint Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats
    Hideo Shimizu
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertens Res 32:786-90. 2009
    ..Thus, ACE inhibitors prevented osteoporosis, probably because of the inhibition of RAS, but not of nitric oxide. Overall, ACE inhibitors attenuated osteoporosis in a hypertensive rat model through the blockade of RAS...
  21. ncbi request reprint Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation
    Yoichi Takami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    Arterioscler Thromb Vasc Biol 27:2184-90. 2007
    ..Therefore, the goal of present study was to clarify the role of the UCHL1 gene in vascular remodeling by evaluating nuclear factor-kappaB (NF-kappaB) inactivation in ECs and vascular smooth muscle cells (VSMCs)...
  22. doi request reprint New treatment of periodontal diseases by using NF-kappaB decoy oligodeoxynucleotides via prevention of bone resorption and promotion of wound healing
    Hideo Shimizu
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Antioxid Redox Signal 11:2065-75. 2009
    ..Targeting of NF-kappaB might be a potential therapy in various bone metabolic diseases...
  23. doi request reprint Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet
    Hironori Nakagami
    Division of Vascular Medicine and Epigenetics, Osaka University United Graduate School of Child Development, Osaka 565 0871, Japan
    Mol Med Rep 5:37-40. 2012
    ..In hypertensive patients with metabolic syndrome, nifedipine may provide additional benefits, beyond its blood pressure-lowering effects, to prevent NASH and fatty liver disease...
  24. ncbi request reprint No influence of tumor growth by intramuscular injection of hepatocyte growth factor plasmid DNA: safety evaluation of therapeutic angiogenesis gene therapy in mice
    Atsushi Matsuki
    Division of Gene Therapy Science, Biomedical Research Center, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 315:59-65. 2004
    ..Although recombinant HGF stimulated the growth of A431 cells in vitro, temporally and locally HGF elevation in hindlimb had no effect on tumor growth in mice...
  25. pmc Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis
    Masaki Mori
    Division of Gene Therapy Science and Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Mol Biol Cell 20:3115-24. 2009
    ..Thus, zyxin reorganizes actin fibers and enhances cell motility in response to TGF-beta1, thereby regulating EMT...
  26. doi request reprint Estrogen attenuates vascular remodeling in Lp(a) transgenic mice
    Futoshi Nakagami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Japan
    Atherosclerosis 211:41-7. 2010
    ..Thus, it is mandatory to develop novel therapy to prevent atherosclerosis in high Lp(a) concentration. Here, we focused on the effect of estrogen on Lp(a) level and Lp(a)-induced vascular remodeling...
  27. doi request reprint Angiotensin II accelerates osteoporosis by activating osteoclasts
    Hideo Shimizu
    Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    FASEB J 22:2465-75. 2008
    ..Overall, Ang II accelerates osteoporosis by activating osteoclasts via RANKL induction. Blockade of Ang II might become a novel therapeutic approach to prevent osteoporosis in hypertensive patients...
  28. doi request reprint Role of central nervous system periostin in cerebral ischemia
    Munehisa Shimamura
    Department of Clinical Gene Therapy, Osaka University, Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Stroke 43:1108-14. 2012
    ..Here, we investigated the expression and role of periostin in the ischemic brain...
  29. doi request reprint Cross-talk of receptor activator of nuclear factor-κB ligand signaling with renin-angiotensin system in vascular calcification
    Mariana Kiomy Osako
    Division of Vascular Medicine and Epigenetics, United Graduate School of Child Development, Osaka University, Suita, Japan
    Arterioscler Thromb Vasc Biol 33:1287-96. 2013
    ..The present study elucidates the cross-talk between renin-angiotensin II system and receptor activator of nuclear factor-κB ligand (RANKL) system in vascular calcification...
  30. doi request reprint Long-term expression of periostin during the chronic stage of ischemic stroke in mice
    Munehisa Shimamura
    Division of Vascular Medicine and Epigenetics, Department of Child Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka, Japan
    Hypertens Res 37:494-9. 2014
    ..As periostin was expressed in various cells, such as reactive astrocytes/microglia, fibroblasts and neuronal progenitor cells, periostin might be associated with pathophysiology in post-ischemic inflammation and neurogenesis. ..
  31. doi request reprint Vascular protective effects of ezetimibe in ApoE-deficient mice
    Hironori Nakagami
    Division of Gene Therapy Science, Osaka University Graduate School of Medicine, Japan
    Atherosclerosis 203:51-8. 2009
    ..Overall, ezetimibe significantly prevented atherosclerosis through not only lipid-lowering effects, but also other direct and/or indirect vascular protective actions in ApoE-deficient mice...
  32. doi request reprint Variation in OSBPL10 is associated with dyslipidemia
    Hiroshi Koriyama
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
    Hypertens Res 33:511-4. 2010
    ..003), with an odds ratio of 0.35 (95% confidence interval=0.17-0.76). Overall, the rs2290532 (D254N) polymorphism in OSBPL10 may predispose individuals with this SNP to hyper-LDL cholesterolemia...
  33. pmc OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice
    Munehisa Shimamura
    Division of Vascular Medicine and Epigenetics, Osaka University United Graduate School of Child Development, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 111:8191-6. 2014
    ..Thus, the OPG/RANKL/RANK axis plays critical roles in controlling inflammation in ischemic brains. ..
  34. doi request reprint Long-Term Reduction of High Blood Pressure by Angiotensin II DNA Vaccine in Spontaneously Hypertensive Rats
    Hiroshi Koriyama
    From the Division of Vascular Medicine and Epigenetics, Osaka University United Graduate School of Child Development, Suita, Osaka, Japan H K, H N, M K O, M S, H K Departments of Clinical Gene Therapy F N, M K, T K, R M and Geriatric Medicine and Nephrology F N, H R, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertension 66:167-74. 2015
    ..Future development of DNA vaccine to treat hypertension may provide a new therapeutic option to treat hypertension. ..
  35. doi request reprint HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function
    Hiroki Hayashi
    Division of Gene Therapy Science, United Graduate School of Child Development, Osaka University, Osaka, Japan
    FASEB J 26:2306-17. 2012
    ..In summary, HIG1 is a novel modulator of the mitochondrial γ-secretase complex, and may play a role in the maintenance of normal mitochondrial function...
  36. doi request reprint Do angiotensin receptor blockers protect against Alzheimer's disease?
    Hitomi Kurinami
    Division of Vascular Medicine and Epigenetics, Department of Child Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Suita, Japan
    Drugs Aging 30:367-72. 2013
    ....
  37. pmc Unique remodeling processes after vascular injury in intracranial arteries: analysis using a novel mouse model
    Munehisa Shimamura
    Division of Vascular Medicine and Epigenetics, Department of Child Development, United Graduate School of Child Development, Osaka University Office for University Industry Collaboration, Osaka, Japan
    J Cereb Blood Flow Metab 33:1153-9. 2013
    ..These pathophysiologic differences might be associated with unfavorable outcomes in percutaneous transluminal angioplasty and stenting in intracranial arteries. ..
  38. ncbi request reprint Therapeutic effect of ribbon-type nuclear factor-κB decoy oligonucleotides in a rat model of inflammatory bowel disease
    Kazunari Ozaki
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    Curr Gene Ther 12:484-92. 2012
    ....
  39. ncbi request reprint Development of high-throughput functional screening of therapeutic genes, using a hemagglutinating virus of Japan envelope vector
    Tomoyuki Nishikawa
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Hum Gene Ther 17:470-5. 2006
    ..Similarly, two growth-inhibiting genes were identified, the effects of which were similar to angiostatin. Overall, this novel system will help advance our understanding of cell biology and promote the utility of human gene therapy...
  40. ncbi request reprint Prevention and regression of non-alcoholic steatohepatitis (NASH) in a rat model by metabosartan, telmisartan
    Hironori Nakagami
    Department of Gene Therapy Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Mol Med 26:477-81. 2010
    ..These favorable characteristics of telmisartan as a partial agonist of PPAR-gamma may provide a benefit in the treatment of metabolic syndrome beyond its blood pressure-lowering effect...
  41. ncbi request reprint N141I mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression
    Masaki Mori
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita 565 0871, Japan
    Life Sci 70:2567-80. 2002
    ..Our study demonstrated that mutant PS-2 induces apoptosis accompanied by increased caspase-3-like activity and decreased bcl-2 expression in neuronal cells after serum-deprivation...
  42. doi request reprint The dipeptidyl peptidase-4 inhibitor teneligliptin improved endothelial dysfunction and insulin resistance in the SHR/NDmcr-cp rat model of metabolic syndrome
    Hironori Nakagami
    Division of Vascular Medicine and Epigenetics, Osaka University United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan
    Hypertens Res 37:629-35. 2014
    ....
  43. doi request reprint [Hypertension, CKD and bone metabolism]
    Hironori Nakagami
    Division of Vascular Medicine and Epigenetics, Osaka University, United Graduate School of Child Development
    Clin Calcium 21:685-9. 2011
    ..Moreover, excess P can increase FGF23 expression and decrease activated vitamin D, which also resulted in progression of osteoporosis. Both "Hypertension" and "Chronic Kidney Disease (CKD) " are inducible factor to osteoporosis...
  44. ncbi request reprint Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis
    Hironori Nakagami
    Division of Clinical Gene Therapy, Osaka University Graduate School of Medical, 2 2 Yamada oka, Suita 565 0871, Japan
    Curr Diabetes Rev 1:59-63. 2005
    ..These pleiotropic effects of statins can be expected to improve endothelial dysfunction through nitric oxide production and/or an anti-oxidant effect in diabetic patients...
  45. ncbi request reprint Hypoxia-induced renal epithelial cell death through caspase-dependent pathway: role of Bcl-2, Bcl-xL and Bax in tubular injury
    Kei Yamamoto
    Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    Int J Mol Med 14:633-40. 2004
    ..In addition, the present results demonstrate that translocation of Bax from the cytosol to the mitochondrial membrane occurred under hypoxia, thereby leading to pathological tissue destruction...
  46. ncbi request reprint Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population
    Hiroshi Koriyama
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Japan
    J Atheroscler Thromb 17:1054-62. 2010
    ..However, little is known about the genetic basis of PAD. To elucidate this, we performed a two-staged genome-wide association study in Japanese individuals...
  47. doi request reprint Differential response of vascular hepatocyte growth factor concentration and lipid accumulation between telmisartan and losartan in ApoE-deficient mice
    Hironori Nakagami
    Department of Gene Therapy Science, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Mol Med Report 1:657-61. 2008
    ..These favorable characteristics of telmisartan might be due to its action as a partial agonist of PPARγ, beyond its blood pressure-lowering effect, through Ang II blockade...
  48. pmc A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke
    Hitomi Kurinami
    Department of Health Development and Medicine, Osaka University Graduate School of Medicine, Japan
    Sci Rep 6:38062. 2016
    ..These findings suggested that MHP1 was a partial agonist of RANKL, and administration of MHP1 attenuated ischemic injury by decreasing inflammation. MHP1 could be a novel therapeutic agent for treating ischemic stroke...
  49. ncbi request reprint Model of vasculogenesis from embryonic stem cells for vascular research and regenerative medicine
    Hironori Nakagami
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Japan
    Hypertension 48:112-9. 2006
    ..In the future, a human ES-based tissue model would be an optional tool for the screening of pharmaceutical drugs for vascular disease...
  50. ncbi request reprint Increase in nuclease resistance and incorporation of NF-kappaB decoy oligodeoxynucleotides by modification of the 3'-terminus
    Mariana Kiomy Osako
    Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, Japan
    J Gene Med 9:812-9. 2007
    ..To decrease non-specific binding and degradation from the 3'-terminus of ODN, we designed partially annealed ODN by binding the extremities of two single strands, resulting in a ribbon-shaped ODN, so called ribbon-type decoy ODN (R-ODN)...
  51. doi request reprint Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway
    Gerardo Rodriguez-Araujo
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Cell Mol Life Sci 70:1123-33. 2013
    ..This function of SNCA represents a new mechanistic insight that creates novel avenues of research with respect to the process of glucose regulation...
  52. pmc Inhibition of neointima formation through DNA vaccination for apolipoprotein(a): a new therapeutic strategy for lipoprotein(a)
    Mariko Kyutoku
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 2 Yamada Oka Suita, Japan
    Sci Rep 3:1600. 2013
    ....
  53. pmc Systemic administration of ribbon-type decoy oligodeoxynucleotide against nuclear factor κB and ets prevents abdominal aortic aneurysm in rat model
    Takashi Miyake
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Mol Ther 19:181-7. 2011
    ..Further modification of the decoy strategy would provide a means of less invasive molecular therapy for human AAA...
  54. pmc The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells
    Makiko Takeichi
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 8:e57829. 2013
    ..These results provide new insights into the regulatory mechanisms that control the epicardial EMT...
  55. ncbi request reprint Development of nucleic acid drugs for neurological disorders
    Munehisa Shimamura
    Division of Vascular Medicine and Epigenetics, Department of Child Development, United Graduate School of Child Development, Osaka University, Japan
    Curr Top Med Chem 12:1621-9. 2012
    ..In this review, we discuss the potential and problems of nucleic acid drugs in neurological disorders...
  56. doi request reprint Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells
    Daiki Morimoto
    Department of Orthopedics, Osaka University Graduate School of Medicine, Yamadaoka 2 2, Suita, Osaka 565 0871, Japan
    J Bone Miner Metab 28:418-23. 2010
    ..Our findings suggest that poly(P) have the potent role of differentiating hMSCs into osteoblastic cells at the early and later stages of osteoblastic differentiation...
  57. ncbi request reprint Hepatocyte growth factor as potential cardiovascular therapy
    Hironori Nakagami
    Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Expert Rev Cardiovasc Ther 3:513-9. 2005
    ..Randomized placebo-controlled clinical trials of alternative dosing regimens of gene therapy will be required to define the efficiency of this therapy...
  58. doi request reprint Effect of angiotensin II receptor blocker, olmesartan, on turnover of bone metabolism in bedridden elderly hypertensive women with disuse syndrome
    Motokuni Aoki
    Graduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan
    Geriatr Gerontol Int 15:1064-72. 2015
    ..In the present study, we investigated the effects of a calcium channel blocker (CCB) and an angiotensin II receptor blocker (ARB) on bone metabolism in elderly bedridden women with hypertension and disuse syndrome...
  59. pmc Essential role for miR-196a in brown adipogenesis of white fat progenitor cells
    Masaki Mori
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    PLoS Biol 10:e1001314. 2012
    ..The miR-196a-Hoxc8-C/EBPβ signaling pathway may be a therapeutic target for inducing brown adipogenesis to combat obesity and type 2 diabetes...
  60. doi request reprint [Hypertension and osteoporosis]
    Hironori Nakagami
    Division of Vascular Medicine and Epigenetics, Osaka University United Graduate School of Child Development, Japan
    Clin Calcium 23:497-503. 2013
    ..Recently, it has been reported that angiotensin receptor blockade clinically decreased the incidence of bone fracture. Renin-angiotensin system might be common molecule to regulate both hypertension and osteoporosis...
  61. ncbi request reprint Novel drug delivery system by surface modified magnetic nanoparticles
    Shin Ichi Takeda
    Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University, Osaka 565 0871, Japan
    J Nanosci Nanotechnol 6:3269-76. 2006
    ..Overall, magnetic nanoparticles with different surface modification enhance the association with plasmid DNA and cell surface as well as HVJ-E, which potentially help to improve the drug delivery system...
  62. ncbi request reprint Anti-oxidant gene therapy by NF kappa B decoy oligodeoxynucleotide
    Hironori Nakagami
    Division of Clinical Gene Therapy, Osaka University Graduate School of MedicIine, Suita, Japan
    Curr Pharm Biotechnol 7:95-100. 2006
    ..Indeed, the modified decoy ODNs possess increased nuclease resistance and are transported more efficiently into cells. Although there are still unresolved issues, decoy ODN drugs should become a reality...
  63. ncbi request reprint Hepatocyte growth factor prevents endothelial cell death through inhibition of bax translocation from cytosol to mitochondrial membrane
    Hironori Nakagami
    Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes 51:2604-11. 2002
    ..HGF may be an important factor in the maintenance of endothelial function...
  64. ncbi request reprint Therapeutic vaccines for hypertension and dyslipidemia
    Hironori Nakagami
    Division of Vascular Medicine and Epigenetics, Osaka University United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, and Fukui University
    Int Heart J 55:96-100. 2014
    ..In particular, helper T cells may activate B cells that produce antibodies against our specific antigen. In this review, we will explain our concept of therapeutic vaccines based on our recent data...
  65. pmc Novel anti-microbial peptide SR-0379 accelerates wound healing via the PI3 kinase/Akt/mTOR pathway
    Hideki Tomioka
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, Japan AnGesMG, Inc, 7 7 15 Saito Bio Incubator, Ibaraki, Osaka, Japan
    PLoS ONE 9:e92597. 2014
    ..These results indicate that SR-0379 may have the potential for drug development in wound repair, even under especially critical colonization conditions. ..
  66. ncbi request reprint NF-kappaB is a key mediator of cerebral aneurysm formation
    Tomohiro Aoki
    Department of Neurosurgery, Kyoto University, Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Circulation 116:2830-40. 2007
    ..We examined the role of nuclear factor-kappaB (NF-kappaB) in the pathogenesis of CA formation in this study...
  67. ncbi request reprint [Endothelial cell growth inhibitory gene]
    Hironori Nakagami
    Division of Gene Therapy Science, Osaka University Graduate School of Medicine
    Nihon Rinsho 64:428-31. 2006
  68. pmc Gene therapy and cell-based therapies for therapeutic angiogenesis in peripheral artery disease
    Munehisa Shimamura
    Division of Vascular Medicine and Epigenetics, Department of Child Development, United Graduate School of Child Development, Osaka University, Kanazawa University, and Hamamatsu University School of Medicine, 2 1 Yamadaoka, Suita 565 0817, Osaka, Japan
    Biomed Res Int 2013:186215. 2013
    ..Furthermore, the development of efficient gene transfer systems and effective methods for keeping transplanted cells healthy will make these novel therapies more effective and ease the symptoms of CLI. ..
  69. ncbi request reprint Modification of decoy oligodeoxynucleotides to achieve the stability and therapeutic efficacy
    Mariana Kiomy Osako
    Division of Vascular Medicine and Epigenetics, United Graduate School of Child Development, Osaka University, Osaka, Japan
    Curr Top Med Chem 12:1603-7. 2012
    ....
  70. ncbi request reprint Nucleic acid drugs for preventing restenosis after coronary revascularization
    Takashi Miyake
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Curr Top Med Chem 12:1613-20. 2012
    ..This review focuses on the potential of recent ODN-based gene therapy for the treatment of heart disease, especially restenosis after revascularization...
  71. ncbi request reprint [Gene therapy for anti-aging medicine]
    Hironori Nakagami
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University
    Nihon Rinsho 67:1407-11. 2009
    ..Recent reports suggest that HGF has an anti-inflammatory action and attenuated cellular senescence. Thus, HGF gene therapy might be an anti-aging therapy in cardiovascular diseases...
  72. ncbi request reprint Tumor necrosis factor-alpha inhibits growth factor-mediated cell proliferation through SHP-1 activation in endothelial cells
    Hironori Nakagami
    Department of Medical Biochemistry, Ehime University Medical School, Ehime, Japan
    Arterioscler Thromb Vasc Biol 22:238-42. 2002
    ..Taken together, our results suggested that TNF-alpha inhibited growth factor-mediated cell proliferation through SHP-1 activation...
  73. ncbi request reprint NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy
    Hironori Nakagami
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    J Mol Cell Cardiol 35:851-9. 2003
    ..These findings indicate that the generation of O(2)(-). contributes to oxidant-induced hypertrophic response and suggest that antioxidant therapy may have beneficial effects in cardiac hypertrophy...
  74. ncbi request reprint ACE inhibitor improves insulin resistance in diabetic mouse via bradykinin and NO
    Tetsuya Shiuchi
    Department of Medical Biochemistry, Ehime University School of Medicine, Ehime, Japan
    Hypertension 40:329-34. 2002
    ....
  75. ncbi request reprint Estrogen activates phosphatases and antagonizes growth-promoting effect of angiotensin II
    Yuko Takeda-Matsubara
    Department of Medical Biochemistry Ehime University School of Medicine, Ehime, Japan
    Hypertension 39:41-5. 2002
    ..Taken together, our results suggest a novel mechanism of vasoprotection by which estrogen antagonizes the effect of the AT(1) receptor via the activation and induction of phosphatases through nongenomic as well as genomic signaling...
  76. pmc Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4
    Fan Xiang
    Vascular Medicine Research Unit, Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Am J Physiol Heart Circ Physiol 290:H1997-2006. 2006
    ..Our findings demonstrate that CHF1/Hey2 functions as an antihypertrophic gene, possibly through inhibition of a GATA4-dependent hypertrophic program...
  77. pmc Statins and myocardial hypertrophy
    Hironori Nakagami
    Vascular Medicine Research, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Coron Artery Dis 15:247-50. 2004
    ....
  78. ncbi request reprint Role of angiotensin II-regulated apoptosis through distinct AT1 and AT2 receptors in neointimal formation
    Jun Suzuki
    Department of Medical Biochemistry, Ehime University School of Medicine, Ehime, Japan
    Circulation 106:847-53. 2002
    ..In this study, we tested the hypothesis that AT2 exerts an antiproliferative effect by inducing apoptosis, thereby antagonizing AT1a in vascular remodeling...
  79. pmc Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2
    Yasuhiko Sakata
    Vascular Medicine Research, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:16197-202. 2002
    ..These mice provide a useful model for the study of the ontogeny and natural history of ventricular septal defects and cardiomyopathy...
  80. ncbi request reprint Fluvastatin enhances the inhibitory effects of a selective angiotensin II type 1 receptor blocker, valsartan, on vascular neointimal formation
    Masatsugu Horiuchi
    Department of Medical Biochemistry, Ehime University School of Medicine, Ehime, Japan
    Circulation 107:106-12. 2003
    ....