Shinya Murakami

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Activation of adenosine-receptor-enhanced iNOS mRNA expression by gingival epithelial cells
    S Murakami
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Japan
    J Dent Res 81:236-40. 2002
  2. pmc Periodontal disease in a patient with Prader-Willi syndrome: a case report
    Manabu Yanagita
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Med Case Rep 5:329. 2011
  3. ncbi request reprint Regeneration of periodontal tissues by basic fibroblast growth factor
    S Murakami
    Department of Periodontology and Endodontology, Osaka University Faculty of Dentistry, Japan
    J Periodontal Res 34:425-30. 1999
  4. ncbi request reprint Recombinant human basic fibroblast growth factor (bFGF) stimulates periodontal regeneration in class II furcation defects created in beagle dogs
    S Murakami
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Periodontal Res 38:97-103. 2003
  5. doi request reprint Immunomodulation of dendritic cells differentiated in the presence of nicotine with lipopolysaccharide from Porphyromonas gingivalis
    Manabu Yanagita
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Osaka, Japan
    Eur J Oral Sci 120:408-14. 2012
  6. doi request reprint Fibroblast growth factor-2 regulates the cell function of human dental pulp cells
    Yoshio Shimabukuro
    Division of Oral Biology and Disease Control, Department of Periodontology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Endod 35:1529-35. 2009
  7. doi request reprint Fibroblast growth factor-2 regulates expression of osteopontin in periodontal ligament cells
    Yoshimitsu Terashima
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Cell Physiol 216:640-50. 2008
  8. ncbi request reprint Basic fibroblast growth factor regulates expression of heparan sulfate in human periodontal ligament cells
    Yoshio Shimabukuro
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Matrix Biol 27:232-41. 2008
  9. doi request reprint Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1β or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling
    Yoichiro Kashiwagi
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Arch Oral Biol 57:483-90. 2012
  10. pmc CD73-generated adenosine promotes osteoblast differentiation
    Masahide Takedachi
    Department of Periodontology, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Cell Physiol 227:2622-31. 2012

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Activation of adenosine-receptor-enhanced iNOS mRNA expression by gingival epithelial cells
    S Murakami
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Japan
    J Dent Res 81:236-40. 2002
    ..These results provide new evidence for the possible involvement of adenosine in the regulation of inflammatory responses by HGEC in periodontal tissues...
  2. pmc Periodontal disease in a patient with Prader-Willi syndrome: a case report
    Manabu Yanagita
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Med Case Rep 5:329. 2011
    ..The prevalence of Prader-Willi syndrome is estimated to be one in 10,000 to 25,000. However, descriptions of the oral and dental phenotype are rare...
  3. ncbi request reprint Regeneration of periodontal tissues by basic fibroblast growth factor
    S Murakami
    Department of Periodontology and Endodontology, Osaka University Faculty of Dentistry, Japan
    J Periodontal Res 34:425-30. 1999
    ....
  4. ncbi request reprint Recombinant human basic fibroblast growth factor (bFGF) stimulates periodontal regeneration in class II furcation defects created in beagle dogs
    S Murakami
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Periodontal Res 38:97-103. 2003
    ..The present results indicate that topical application of bFGF can enhance considerable periodontal regeneration in artificially created furcation class II bone defects of beagle dogs...
  5. doi request reprint Immunomodulation of dendritic cells differentiated in the presence of nicotine with lipopolysaccharide from Porphyromonas gingivalis
    Manabu Yanagita
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Osaka, Japan
    Eur J Oral Sci 120:408-14. 2012
    ..These results suggest that the presence of nicotine during differentiation of DCs modulates the immunoregulatory functions of P. gingivalis LPS-stimulated DCs...
  6. doi request reprint Fibroblast growth factor-2 regulates the cell function of human dental pulp cells
    Yoshio Shimabukuro
    Division of Oral Biology and Disease Control, Department of Periodontology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Endod 35:1529-35. 2009
    ..In this study, we examined the effects of FGF-2 on growth, migration, and differentiation of human dental pulp cells (HDPC)...
  7. doi request reprint Fibroblast growth factor-2 regulates expression of osteopontin in periodontal ligament cells
    Yoshimitsu Terashima
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Cell Physiol 216:640-50. 2008
    ..The present results indicated that FGF-2 induces unique expression of osteopontin, which may play a role different from the other bone-related proteins during the process of periodontal tissue regeneration by FGF-2...
  8. ncbi request reprint Basic fibroblast growth factor regulates expression of heparan sulfate in human periodontal ligament cells
    Yoshio Shimabukuro
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Matrix Biol 27:232-41. 2008
    ..The diversity of the expression patterns of HS proteoglycans may be associated with the FGF-2-induced biological functions of HPDL cells...
  9. doi request reprint Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1β or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling
    Yoichiro Kashiwagi
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Arch Oral Biol 57:483-90. 2012
    ....
  10. pmc CD73-generated adenosine promotes osteoblast differentiation
    Masahide Takedachi
    Department of Periodontology, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Cell Physiol 227:2622-31. 2012
    ..Collectively, our results indicate that CD73 generated adenosine positively regulates osteoblast differentiation via A(2B)AR signaling...
  11. doi request reprint Nicotine modulates the immunological function of dendritic cells through peroxisome proliferator-activated receptor-γ upregulation
    Manabu Yanagita
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Yamadaoka 1 8, Suita, Osaka 565 0871, Japan
    Cell Immunol 274:26-33. 2012
    ..These data suggest the effect of nicotine on altering DC immunogenicity by impeding Th1 immunity is partially mediated by upregulation of PPAR γ...
  12. doi request reprint Fibroblast growth factor-2 stimulates directed migration of periodontal ligament cells via PI3K/AKT signaling and CD44/hyaluronan interaction
    Yoshio Shimabukuro
    Division of Oral Biology and Disease Control, Department of Periodontology, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Cell Physiol 226:809-21. 2011
    ....
  13. ncbi request reprint Fibroblast growth factor-2 stimulates hyaluronan production by human dental pulp cells
    Yoshio Shimabukuro
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Endod 31:805-8. 2005
    ..These results provide new evidence for the involvement of FGF-2 in the regulation of HA production by HDPC possibly through HAS 1 and HAS 2...
  14. doi request reprint Nicotine inhibits mineralization of human dental pulp cells
    Manabu Yanagita
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Endod 34:1061-5. 2008
    ..These results indicate that nicotine suppresses the cytodifferentiation and mineralization of HDPCs, possibly via nAChR...
  15. ncbi request reprint Fibroblast growth factor-2 regulates the synthesis of hyaluronan by human periodontal ligament cells
    Yoshio Shimabukuro
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Cell Physiol 203:557-63. 2005
    ..These results provide new evidence for the possible involvement of FGF-2 in the regulation of HA production and its appreciable roles in not only homeostasis but also regeneration of periodontal tissues...
  16. ncbi request reprint Osteoinductive and anti-inflammatory effect of royal jelly on periodontal ligament cells
    Manabu Yanagita
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Osaka 565 0871, Japan
    Biomed Res 32:285-91. 2011
    ..These findings suggest that the osteoinductive and anti-inflammatory effects of RJ can provide benefits for the treatment and prevention of periodontal diseases...
  17. ncbi request reprint Effects of basic fibroblast growth factor on human gingival epithelial cells
    Shin ichi Takayama
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Periodontol 73:1467-73. 2002
    ..In this study, we examined FGF-2 expression in gingival epithelium and the effect of FGF-2 on proliferative responses by gingival epithelial (GE) cells...
  18. pmc The Effects of Cigarette Smoke Condensate and Nicotine on Periodontal Tissue in a Periodontitis Model Mouse
    Mikiko Kubota
    Division of Oral Biology and Disease Control, Department of Periodontology, Osaka University, Suita, Osaka, Japan
    PLoS ONE 11:e0155594. 2016
    ..The present study demonstrates that periodontal disease models are useful for elucidating the pathogenesis of cigarette smoking-related periodontal diseases. ..
  19. ncbi request reprint Human gingival epithelial cells produce chemotactic factors interleukin-8 and monocyte chemoattractant protein-1 after stimulation with Porphyromonas gingivalis via toll-like receptor 2
    Yutaka Kusumoto
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Periodontol 75:370-9. 2004
    ..In order to investigate the possible activation of HGEC by Pg through Toll-like receptors (TLRs), we analyzed the production of chemotactic factors and the activated nuclear factor-kappa B (NF-kappaB)...
  20. ncbi request reprint IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells
    Manabu Yanagita
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Japan
    Biochem Biophys Res Commun 297:329-34. 2002
    ..The enhanced NO production by IL-15 was inhibited by AMT, an iNOS-specific inhibitor. These results suggest that IL-15 is a potent regulator of iNOS expression by HGEC and involved in innate immunity in the mucosal epithelium...
  21. pmc TGF-Beta Negatively Regulates the BMP2-Dependent Early Commitment of Periodontal Ligament Cells into Hard Tissue Forming Cells
    Takanobu Kawahara
    Department of Periodontology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    PLoS ONE 10:e0125590. 2015
    ..A synthetic drug that regulates endogenous TGF-β signals may be efficacious for developing periodontal regenerative therapies. ..
  22. doi request reprint Nicotine can skew the characterization of the macrophage type-1 (MPhi1) phenotype differentiated with granulocyte-macrophage colony-stimulating factor to the MPhi2 phenotype
    Manabu Yanagita
    Department of Periodontology, Osaka University Graduate School of Dentistry, Japan
    Biochem Biophys Res Commun 388:91-5. 2009
    ..These results suggest that nicotine can change the functional characteristics of MPhi and skew the MPhi1 phenotype to MPhi2. We propose that nicotine is a potent regulator that modulates immune responses in microenvironments...
  23. pmc Action Mechanism of Fibroblast Growth Factor-2 (FGF-2) in the Promotion of Periodontal Regeneration in Beagle Dogs
    Toshie Nagayasu-Tanaka
    Pharmacology Department, Drug Research Center, Kaken Pharmaceutical Co, Ltd, Kyoto, Kyoto, Japan Department of Periodontology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    PLoS ONE 10:e0131870. 2015
    ..Therefore, these multifaceted effects of FGF-2 promote new tissue formation at the early regeneration phase, leading to enhanced formation of new bone, cementum, and PDL. ..
  24. doi request reprint Trophic factors from adipose tissue-derived multi-lineage progenitor cells promote cytodifferentiation of periodontal ligament cells
    Keigo Sawada
    Department of Periodontology, Osaka University Graduate School of Dentistry, Osaka, Japan
    Biochem Biophys Res Commun 464:299-305. 2015
    ..IGFBP6 may play crucial roles in ADMPC-induced periodontal regeneration. ..
  25. ncbi request reprint [Periodontal regeneration by FGF2]
    Shinya Murakami
    Osaka University Graduate School of Dentistry, Department of Periodontology
    Clin Calcium 17:249-55. 2007
    ..If we can generate an intelligent carrier for FGF2 in the nature of "scaffold", indications of FGF2 therapy would be dramatically increased...
  26. pmc Periodontal tissue regeneration using fibroblast growth factor-2: randomized controlled phase II clinical trial
    Masahiro Kitamura
    Osaka University Dental Hospital, Suita, Japan
    PLoS ONE 3:e2611. 2008
    ..This study aimed to clarify the activity of FGF-2 in stimulating regeneration of periodontal tissue lost by periodontitis and to evaluate the safety of such stimulation...
  27. ncbi request reprint PLAP-1/asporin, a novel negative regulator of periodontal ligament mineralization
    Satoru Yamada
    Department of Periodontology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
    J Biol Chem 282:23070-80. 2007
    ....
  28. doi request reprint Role of ferritin in the cytodifferentiation of periodontal ligament cells
    Jianxia Hou
    Department of Periodontology, Peking University School and Hospital of Stomatology, 22 Zhongguancun Nandajie, Haidian District, Beijing 100081, PR China
    Biochem Biophys Res Commun 426:643-8. 2012
    ..This is the first report to demonstrate that ferritin is predominantly expressed in PDL tissues and positively regulates the cytodifferentiation and mineralization of PDL cells...
  29. doi request reprint Randomized Placebo-Controlled and Controlled Non-Inferiority Phase III Trials Comparing Trafermin, a Recombinant Human Fibroblast Growth Factor 2, and Enamel Matrix Derivative in Periodontal Regeneration in Intrabony Defects
    Masahiro Kitamura
    Osaka University Graduate School of Dentistry, Suita, Japan
    J Bone Miner Res 31:806-14. 2016
    ..Safety problems were not identified in either study. Therefore, trafermin is an effective and safe treatment for periodontal regeneration in intrabony defect, and its efficacy was superior in rhFGF-2 compared to EMD treatments...
  30. pmc A Putative Association of a Single Nucleotide Polymorphism in GPR126 with Aggressive Periodontitis in a Japanese Population
    Jirouta Kitagaki
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    PLoS ONE 11:e0160765. 2016
    ..The GPR126 SNP rs536714306 negatively influences this homeostasis, leading to the development of AgP, suggesting that it is a candidate genetic risk factor for AgP in the Japanese population. ..
  31. doi request reprint [Present status of periodontal regeneration - FGF-2 and Teriparatide - ]
    Masahide Takedachi
    Department of Periodontology, Osaka University Graduate School of Dentistry, Japan
    Clin Calcium 22:99-104. 2012
    ..Both of the therapies have been expected to be the periodontal regeneration therapy of the next generation. In this review, we introduce the present status of these new periodontal regenerative therapies...
  32. pmc Role of mechanical stress-induced glutamate signaling-associated molecules in cytodifferentiation of periodontal ligament cells
    Chiharu Fujihara
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 285:28286-97. 2010
    ..The present data demonstrate that the glutamate signaling induced by mechanical stress positively regulates the cytodifferentiation and mineralization of PDL cells...
  33. ncbi request reprint Thrombin regulates the function of human blood dendritic cells
    Manabu Yanagita
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 364:318-24. 2007
    ..Moreover, thrombin induced HLA-DR and CD86 expression on DC and the thrombin-treated DC induced allogenic T cell proliferation. These findings indicate that thrombin plays a role in the regulation of blood DC functions...
  34. pmc Time-lapse Raman imaging of osteoblast differentiation
    Aya Hashimoto
    Department of Applied Physics, Graduate School of Engineering, Osaka University, 2 1 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Sci Rep 5:12529. 2015
    ..We expect time-lapse Raman imaging to help us to further elucidate osteoblastic mineralization mechanisms that have previously been unobservable. ..
  35. doi request reprint Effects of an ascorbic acid-derivative dentifrice in patients with gingivitis: a double-masked, randomized, controlled clinical trial
    Yoshio Shimabukuro
    Department of Periodontology, Osaka University Graduate School of Dentistry, Suita, Japan
    J Periodontol 86:27-35. 2015
    ..The aim of this study is to investigate the effect of a dentifrice containing L-ascorbic acid 2-phosphate magnesium salt (APM), a long-acting ascorbic acid derivative with antioxidant properties, on gingival inflammation...
  36. doi request reprint [Periodontal destruction and trends in periodontal treatment for patients]
    Manabu Yanagita
    Department of Periodontology, Osaka University Graduate School of Dentistry, Japan
    Clin Calcium 26:751-7. 2016
    ..Here, we review the possible mechanisms of periodontal destruction. In addition, we described future outlook of our translational research for periodontal regenerative medicine. ..
  37. pmc Examination of the Relationship between Oral Health and Arterial Sclerosis without Genetic Confounding through the Study of Older Japanese Twins
    Yuko Kurushima
    Osaka University Graduate School of Dentistry, Department of Prosthodontics, Gerodontology, and Oral Rehabilitation, Suita, Osaka, Japan
    PLoS ONE 10:e0127642. 2015
    ..The aim of this study was to evaluate oral health as a significant risk factor related to arterial sclerosis after eliminating genetic confounding through study of older Japanese twins...
  38. pmc Changes in the Distribution of Periodontal Nerve Fibers during Dentition Transition in the Cat
    Koji Miki
    Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, Osaka, Japan Department of Periodontology, Osaka University Graduate School of Dentistry, Osaka, Japan
    PLoS ONE 10:e0129826. 2015
    ..The sparse distribution of periodontal nerve fibers in deciduous dentition agrees with clinical evidence that children are less sensitive to tooth stimulation than adults. ..
  39. doi request reprint Isolation and characterization of the human immature osteoblast culture system from the alveolar bones of aged donors for bone regeneration therapy
    Makoto Aino
    Aichi Gakuin University, School of Dentistry, Department of Periodontology, Nagoya, Aichi, Japan
    Expert Opin Biol Ther 14:1731-44. 2014
    ..In this study, we developed immature human osteoblasts isolated from aged alveolar bone (HAOBs)...
  40. pmc In vivo evaluation of ocular inflammatory responses in experimental diabetes
    H Tamura
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto 606 8507, Japan
    Br J Ophthalmol 89:1052-7. 2005
    ..This study was designed to evaluate inflammatory reactions in the diabetic eye through retinal leucocyte dynamics in the inflamed eyes of diabetic rats...
  41. ncbi request reprint Analysis of transcriptional regulation of human breast aromatase by in vitro and in vivo studies
    N Harada
    Department of Biochemistry, School of Medicine, Fujita Health University, Toyoake, 470 1192, Aichi, Japan
    J Steroid Biochem Mol Biol 79:151-6. 2001
    ..These results show that this transgenic mouse is a good model animal for the study of tissue-specific regulation of human aromatase gene...
  42. ncbi request reprint Blockade of killer cells can prevent lethal acute graft-versus-host disease in a rat model
    K Akioka
    Department of Organ Transplant and Endocrine Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Transplant Proc 35:501-3. 2003
  43. doi request reprint Voided stain on paper method for analysis of mouse urination
    Y Sugino
    Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Neurourol Urodyn 27:548-52. 2008
    ..To evaluate the usefulness of a quantification method using filter paper for analyzing minute voided urine of the mouse...
  44. ncbi request reprint Nitric oxide synthase gene therapy for erectile dysfunction: comparison of plasmid, adenovirus, and adenovirus-transduced myoblast vectors
    S Tirney
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Mol Urol 5:37-43. 2001
    ..Gene therapy of NOS may open new avenues of treatment for erectile dysfunction. Control of NOS expression would be necessary to prevent priapism...
  45. ncbi request reprint Nitric oxide synthase gene transfer for erectile dysfunction in a rat model
    M B Chancellor
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    BJU Int 91:691-6. 2003
    ....
  46. ncbi request reprint A novel gene suppressed in the ventricle of carnitine-deficient juvenile visceral steatosis mice
    M Masuda
    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan
    FEBS Lett 408:221-4. 1997
    ..The CDV-1 cDNA contained an open reading frame predicting a peptide of 107 amino acids, which composed the C-terminal portion of CDV-1R peptide consisting of 414 amino acids...
  47. ncbi request reprint Histochemical localization of copper in various organs of brindled mice after copper therapy
    N Yoshimura
    Department of Pathology, Hirosaki University School of Medicine, Japan
    Pathol Int 45:10-8. 1995
    ..This suggests impaired intracellular Cu transport from cytosol to organella, which in the kidney is refractory to the Cu therapy adopted...