Tomomi Michiue

Summary

Affiliation: Osaka City University
Country: Japan

Publications

  1. doi request reprint Evaluation of Postmortem Drug Concentrations in Bile Compared with Blood and Urine in Forensic Autopsy Cases
    Mariko Tominaga
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan Forensic Autopsy Section, Medico Legal Consultation and Postmortem Investigation Support Center MLCPI SC, c o Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    J Anal Toxicol 40:367-73. 2016
  2. doi request reprint Cardiac dilatation index as an indicator of terminal central congestion evaluated using postmortem CT and forensic autopsy data
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan Forensic Autopsy Section, Medico Legal Consultation and Postmortem Investigation Support Center MLCPI SC, c o Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan Electronic address
    Forensic Sci Int 263:152-7. 2016
  3. doi request reprint Contribution of forensic autopsy to scene reconstruction in mass fire casualties: a case of alleged arson on a floor consisting of small compartments in a building
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan Forensic Autopsy Section, Medico legal Consultation and Postmortem Investigation Support Center, c o Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan Electronic address
    Leg Med (Tokyo) 17:43-7. 2015
  4. doi request reprint Forensic pathological evaluation of postmortem pulmonary CT high-density areas in serial autopsy cases of sudden cardiac death
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan Forensic Autopsy Section, Medico Legal Consultation and Postmortem Investigation Support Center MLCPI SC, c o Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan Electronic address
    Forensic Sci Int 232:199-205. 2013
  5. doi request reprint Postmortem CT investigation of air/gas distribution in the lungs and gastrointestinal tracts of newborn infants: a serial case study with regard to still- and live birth
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Forensic Sci Int 226:74-80. 2013
  6. doi request reprint Postmortem serum levels of amylase and gamma glutamyl transferase (GGT) as markers of systemic tissue damage in forensic autopsy
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 15:79-84. 2013
  7. doi request reprint Quantitative analysis of pulmonary pathophysiology using postmortem computed tomography with regard to the cause of death
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Forensic Sci Int 220:232-8. 2012
  8. doi request reprint Forensic pathological evaluation of injury severity and fatal outcome in traffic accidents: five illustrative autopsy cases of clinically unexpected death
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Forensic Sci Med Pathol 4:153-8. 2008
  9. doi request reprint Pathological and biochemical analysis of the pathophysiology of fatal electrocution in five autopsy cases
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S549-52. 2009
  10. doi request reprint Cardiothoracic ratio in postmortem chest radiography with regard to the cause of death
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 12:73-8. 2010

Collaborators

Detail Information

Publications87

  1. doi request reprint Evaluation of Postmortem Drug Concentrations in Bile Compared with Blood and Urine in Forensic Autopsy Cases
    Mariko Tominaga
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan Forensic Autopsy Section, Medico Legal Consultation and Postmortem Investigation Support Center MLCPI SC, c o Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    J Anal Toxicol 40:367-73. 2016
    ....
  2. doi request reprint Cardiac dilatation index as an indicator of terminal central congestion evaluated using postmortem CT and forensic autopsy data
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan Forensic Autopsy Section, Medico Legal Consultation and Postmortem Investigation Support Center MLCPI SC, c o Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan Electronic address
    Forensic Sci Int 263:152-7. 2016
    ....
  3. doi request reprint Contribution of forensic autopsy to scene reconstruction in mass fire casualties: a case of alleged arson on a floor consisting of small compartments in a building
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan Forensic Autopsy Section, Medico legal Consultation and Postmortem Investigation Support Center, c o Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan Electronic address
    Leg Med (Tokyo) 17:43-7. 2015
    ..These observations contribute to evidence-based reconstruction of the fire disaster, and suggest how deaths could have been prevented by appropriate disaster measures. ..
  4. doi request reprint Forensic pathological evaluation of postmortem pulmonary CT high-density areas in serial autopsy cases of sudden cardiac death
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan Forensic Autopsy Section, Medico Legal Consultation and Postmortem Investigation Support Center MLCPI SC, c o Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan Electronic address
    Forensic Sci Int 232:199-205. 2013
    ....
  5. doi request reprint Postmortem CT investigation of air/gas distribution in the lungs and gastrointestinal tracts of newborn infants: a serial case study with regard to still- and live birth
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Forensic Sci Int 226:74-80. 2013
    ..The combined use of PM-CT is useful to demonstrate air/gas distributions in the lungs and gastrointestinal tract for interpretation of spontaneous breathing after birth in newborn fatalities...
  6. doi request reprint Postmortem serum levels of amylase and gamma glutamyl transferase (GGT) as markers of systemic tissue damage in forensic autopsy
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 15:79-84. 2013
    ....
  7. doi request reprint Quantitative analysis of pulmonary pathophysiology using postmortem computed tomography with regard to the cause of death
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Forensic Sci Int 220:232-8. 2012
    ..Mode HU represents the major alveolar status, while the mean HU reflects the whole lung air contents. CT data analysis is useful for quantitative evaluation of pulmonary pathology as a supplementary procedure...
  8. doi request reprint Forensic pathological evaluation of injury severity and fatal outcome in traffic accidents: five illustrative autopsy cases of clinically unexpected death
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Forensic Sci Med Pathol 4:153-8. 2008
    ....
  9. doi request reprint Pathological and biochemical analysis of the pathophysiology of fatal electrocution in five autopsy cases
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S549-52. 2009
    ..The present study suggested that the mode of death due to electrocution might be closely related to the macromorphology of electrical marks...
  10. doi request reprint Cardiothoracic ratio in postmortem chest radiography with regard to the cause of death
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 12:73-8. 2010
    ..This also suggests the potential usefulness of postmortem CT and MRI for analysis of terminal cardiac function...
  11. doi request reprint Quantitative analysis of single-stranded DNA immunoreactivity as a marker of neuronal apoptosis in hippocampus with regard to the causes of death in medicolegal autopsy
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 11:S168-70. 2009
    ..These findings suggested that the analyses of ssDNA-immunohistochemistry in the hippocampus may be useful for evaluating neuronal damage in various causes of death...
  12. doi request reprint Single-stranded DNA as an immunohistochemical marker of neuronal damage in human brain: an analysis of autopsy material with regard to the cause of death
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Forensic Sci Int 178:185-91. 2008
    ..The neuronal positivity was usually lower for drowning and acute ischemic disease. Topographical analysis of ssDNA-positive neurons may contribute to investigating the cause of brain damage and survival period after a fatal insult...
  13. ncbi request reprint Postmortem cardiac troponin I and creatine kinase MB levels in the blood and pericardial fluid as markers of myocardial damage in medicolegal autopsy
    Bao Li Zhu
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 9:241-50. 2007
    ....
  14. ncbi request reprint Postmortem cardiac troponin T levels in the blood and pericardial fluid. Part 1. Analysis with special regard to traumatic causes of death
    Bao Li Zhu
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 8:86-93. 2006
    ....
  15. ncbi request reprint Differences in postmortem urea nitrogen, creatinine and uric acid levels between blood and pericardial fluid in acute death
    Bao Li Zhu
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 9:115-22. 2007
    ..Similar findings were often observed for other acute and subacute deaths. These findings suggest that a comparison between blood and pericardial nitrogenous compounds would be useful for investigating the cause and process of death...
  16. doi request reprint Evaluation of postmortem calcium and magnesium levels in the pericardial fluid with regard to the cause of death in medicolegal autopsy
    Dong Ri Li
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S276-8. 2009
    ..These findings suggest that postmortem pericardial Ca and Mg can be used to investigate the cause of death, especially for saltwater drowning, hypothermia and hyperthermia...
  17. doi request reprint Analysis of postmortem biochemical findings with regard to the lung weight in drowning
    Hitoshi Maeda
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 11:S269-72. 2009
    ..These findings suggest that analyses of serum and pericardial markers in relation to lung weight are useful for evaluating the composition and amount of aspirated medium when investigating drowning death...
  18. doi request reprint Postmortem catecholamine levels in pericardial and cerebrospinal fluids with regard to the cause of death in medicolegal autopsy
    Takaki Ishikawa
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Forensic Sci Int 228:52-60. 2013
    ....
  19. ncbi request reprint Possible factors contributing to the postmortem lung weight in fire fatalities
    Bao Li Zhu
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 7:139-43. 2005
    ..In addition, elderly females appear to be most susceptible among fire casualties, and extreme cardiomegaly may also be a potential fatal risk factor...
  20. ncbi request reprint Postmortem serum catecholamine levels in relation to the cause of death
    Bao Li Zhu
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Forensic Sci Int 173:122-9. 2007
    ..These findings differed markedly from clinical observations and suggest that the postmortem serum catecholamine levels may reflect the magnitude of physical stress responses during the process of death in individual cases...
  21. doi request reprint Postmortem serum nitrogen compounds and C-reactive protein levels with special regard to investigation of fatal hyperthermia
    Hitoshi Maeda
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Forensic Sci Med Pathol 4:175-80. 2008
    ..These serum markers may be practically useful for postmortem investigation of death due to hyperthermia (heat stroke), for which specific pathological and toxicological evidence may not be available...
  22. doi request reprint Evaluation of postmortem S100B levels in the cerebrospinal fluid with regard to the cause of death in medicolegal autopsy
    Dong Ri Li
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S273-5. 2009
    ..A CSF S100B level of >2000 ng/ml in the early postmortem period might be considered a biochemical sign of fatally severe brain damage...
  23. ncbi request reprint Postmortem cardiac troponin T levels in the blood and pericardial fluid. Part 2: analysis for application in the diagnosis of sudden cardiac death with regard to pathology
    Bao Li Zhu
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 8:94-101. 2006
    ....
  24. doi request reprint Comparative evaluation of postmortem serum concentrations of neopterin and C-reactive protein
    Takaki Ishikawa
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Forensic Sci Int 179:135-43. 2008
    ..Combined analyses of neopterin and CRP may be useful to investigate viral infections and delayed traumatic death involving SIRS to support pathological findings...
  25. doi request reprint Potential risk factors for sudden cardiac death: an analysis of medicolegal autopsy cases
    Hitoshi Maeda
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S263-5. 2009
    ..These findings suggest different risk factors or etiologies, including active atherosclerosis, latent renal failure, dehydration and cardiac hypertrophy, for sudden deaths due to these heart diseases...
  26. doi request reprint Immunohistochemical distribution of basic fibroblast growth factor (bFGF) in medicolegal autopsy
    Qi Wang
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S161-4. 2009
    ..These findings suggested that bFGF expression in the lung, liver, kidney and brain varies depending on the cause of death, and is useful for investigating deaths...
  27. ncbi request reprint [Five fatalities due to inhalation of "asphyxiant gases": pathophysiological analysis in autopsy cases]
    Bao Li Zhu
    Department of Legal Medicine, Osaka City University Medical School
    Chudoku Kenkyu 18:77-81. 2005
    ....
  28. doi request reprint Comprehensive evaluation of pericardial biochemical markers in death investigation
    Osamu Kawamoto
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Forensic Sci Int 224:73-9. 2013
    ..These observations suggest the usefulness of pericardial biomarkers for investigating the cause and process of death to reinforce pathological and toxicological findings...
  29. doi request reprint Postmortem mRNA quantification for investigation of infantile death: a comparison with adult cases
    Dong Zhao
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S286-9. 2009
    ..These findings indicate a similar death process due to pulmonary infection and asphyxiation in infants; thus, it may be difficult to distinguish these causes of death...
  30. doi request reprint Postmortem analyses of gaseous and volatile substances in pericardial fluid and bone marrow aspirate
    Mariko Tominaga
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    J Anal Toxicol 37:147-51. 2013
    ..The inclusion of these materials in routine analysis may be also useful to investigate pharmacokinetics and toxicokinetics in the death process and the influence of postmortem redistribution/diffusion...
  31. ncbi request reprint Quantitative analysis of ubiquitin-immunoreactivity in the midbrain periaqueductal gray matter with regard to the causes of death in forensic autopsy
    Li Quan
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 7:151-6. 2005
    ....
  32. ncbi request reprint [Influence of inhaling carbon monoxide-containing gas in fire fatalities--an investigation of forensic autopsy cases]
    Bao Li Zhu
    Department of Legal Medicine, Osaka City University Medical School
    Chudoku Kenkyu 20:37-44. 2007
    ....
  33. doi request reprint Molecular pathology of natriuretic peptides in the myocardium with special regard to fatal intoxication, hypothermia, and hyperthermia
    Jian Hua Chen
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka, 545 8585, Japan
    Int J Legal Med 126:747-56. 2012
    ..These findings suggest terminal high cardiac strain in methamphetamine intoxication, decreased cardiac strain in sedative-hypnotic intoxication and hyperthermia (heatstroke), and persistent congestion in hypothermia (cold exposure)...
  34. doi request reprint Immunohistochemical distribution of chromogranin A in medicolegal autopsy materials
    Chiemi Yoshida
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 11:S231-3. 2009
    ..These findings suggest that hypothalamic CgA immunopositivity can be used as a marker for investigating individual differences in stress responses during the death process. Further investigation of other causes of death is needed...
  35. doi request reprint Evaluation of pulmonary GLUT1 and VEGF mRNA levels in relation to lung weight in medicolegal autopsy cases
    Dong Zhao
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S290-3. 2009
    ..Different mechanisms might be involved in non-cardiogenic or neurogenic pulmonary congestion and edema for ICH/brain contusions and subdural hematoma...
  36. doi request reprint Tissue-specific differences in mRNA quantification of glucose transporter 1 and vascular endothelial growth factor with special regard to death investigations of fatal injuries
    Dong Zhao
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Forensic Sci Int 177:176-83. 2008
    ..Tissue-specific differences in mRNA quantification of GLUT1 and VEGF shed light on tissue ischemia/hypoxia and subsequent tissue-dependent pathophysiological changes leading to death after injury...
  37. ncbi request reprint Immunohistochemical distribution of S-100 protein in the cerebral cortex with regard to the cause of death in forensic autopsy
    Dong Ri Li
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 8:78-85. 2006
    ..These observations suggest that astrocytes are more rapidly and severely injured than neurons during fatal brain damage, thereby causing an elevation in the serum S100B level...
  38. ncbi request reprint Immunohistochemical investigation of ubiquitin and myoglobin in the kidney in medicolegal autopsy cases
    Takaki Ishikawa
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8558, Japan
    Forensic Sci Int 171:136-41. 2007
    ..Concomitant increases in the tubular Mb- and Ub-positivities were characteristic to deaths from injury and hypothermia. These findings suggest that Ub may serve as a sensitive indicator of the fatal influence of traumas...
  39. ncbi request reprint [Immunohistochemical distribution of single-stranded DNA in the brain in medico-legal autopsy cases of carbon monoxide intoxication]
    Tomomi Michiue
    Department of Legal Medicine, Osaka City University Medical School
    Chudoku Kenkyu 21:63-8. 2008
    ..These findings suggest that CO causes selective neuronal damage in the pallidum...
  40. doi request reprint Evaluation of human brain damage in fatalities due to extreme environmental temperature by quantification of basic fibroblast growth factor (bFGF), glial fibrillary acidic protein (GFAP), S100β and single-stranded DNA (ssDNA) immunoreactivities
    Qi Wang
    Department of Legal Medicine, Osaka City University Medical School, Abeno, Osaka, Japan
    Forensic Sci Int 219:259-64. 2012
    ..These markers may be useful for evaluating brain damage and responses in fatalities due to extreme environmental temperatures...
  41. doi request reprint Postmortem serum levels of pulmonary surfactant-associated proteins A and D with regard to the cause of death in medicolegal autopsy
    Li Quan
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S301-3. 2009
    ..These findings suggest that comparative analysis of serum SP-D and SP-A is useful for investigating primary or secondary pulmonary alveolar damage in the death process...
  42. doi request reprint Forensic molecular pathology of violent deaths
    Hitoshi Maeda
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Forensic Sci Int 203:83-92. 2010
    ....
  43. doi request reprint Immunohistochemistry of von Willebrand factor in the lungs with regard to the cause of death in forensic autopsy
    Li Quan
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 11:S294-6. 2009
    ..8%) than in cases with a higher COHb level of >60% (n=3/12, 25.0%). These findings suggest that Cap-vWF positivity is closely related to the death process involving pulmonary microvascular injury...
  44. ncbi request reprint Postmortem pericardial natriuretic peptides as markers of cardiac function in medico-legal autopsies
    Bao Li Zhu
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka, 545 8585, Japan
    Int J Legal Med 121:28-35. 2007
    ..These observations suggest that elevations in the postmortem pericardial ANP and BNP may mainly depend on acute atrial overload and subacute or chronic cardiac failure, respectively, and may be reduced by advanced myocardial damage...
  45. doi request reprint Molecular pathology of pulmonary edema in forensic autopsy cases with special regard to fatal hyperthermia and hypothermia
    Qi Wang
    Department of Legal Medicine, Osaka City University Medical School, Osaka, Japan
    Forensic Sci Int 228:137-41. 2013
    ..Systematic analysis of gene expressions using real-time PCR might be a useful procedure in forensic death investigation...
  46. ncbi request reprint Evaluation of postmortem serum calcium and magnesium levels in relation to the causes of death in forensic autopsy
    Bao Li Zhu
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Forensic Sci Int 155:18-23. 2005
    ..These markers may be useful especially for diagnosis and differentiation of salt- and freshwater drownings and may be also helpful to determine the causes of death involving skeletal muscle damage, including burns and MA intoxication...
  47. doi request reprint Postmortem biochemistry and immunohistochemistry of adrenocorticotropic hormone with special regard to fatal hypothermia
    Takaki Ishikawa
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Forensic Sci Int 179:147-51. 2008
    ..The serum level was maintained despite a low CSF level and pituitary immunopositivity for fatal hypothermia, while the serum and CSF levels as well as pituitary immunopositivity were decreased for hyperthermia...
  48. ncbi request reprint Ubiquitin-immunoreactive structures in the midbrain of methamphetamine abusers
    Li Quan
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 7:144-50. 2005
    ..These findings suggest dysfunction of the nigral dopaminergic neurons and PGM neurons in the midbrain in MA abuse, which may account for the clinical symptoms...
  49. ncbi request reprint Forensic pathological investigation of myocardial hypoxia-inducible factor-1 alpha, erythropoietin and vascular endothelial growth factor in cardiac death
    Bao Li Zhu
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 10:11-9. 2008
    ....
  50. doi request reprint Intrapulmonary aquaporin-5 expression as a possible biomarker for discriminating smothering and choking from sudden cardiac death: a pilot study
    Qi Wang
    Department of Legal Medicine, Osaka City University Medical School, Osaka, Japan
    Forensic Sci Int 220:154-7. 2012
    ..These observations indicate a partial difference in pulmonary molecular pathology among these causes of death, suggesting a procedure for possible discrimination of smothering and choking from sudden cardiac death...
  51. doi request reprint Quantitative immunohistochemical analysis of human brain basic fibroblast growth factor, glial fibrillary acidic protein and single-stranded DNA expressions following traumatic brain injury
    Qi Wang
    Department of Legal Medicine, Osaka City University Medical School, Osaka, Japan
    Forensic Sci Int 221:142-51. 2012
    ..These observations suggest that the combined use of bFGF, GFAP and ssDNA immunohistochemistry can be used to evaluate the severity of damage and response of brain after TBI...
  52. doi request reprint Evaluation of postmortem serum and cerebrospinal fluid levels of thyroid-stimulating hormone with special regard to fatal hypothermia
    Takaki Ishikawa
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S228-30. 2009
    ..These observations suggest that a decrease in serum and CSF TSH levels in hypothermia is related to hypothalamic adenohypophyseal dysfunction...
  53. doi request reprint Postmortem biochemistry and immunohistochemistry of chromogranin A as a stress marker with special regard to fatal hypothermia and hyperthermia
    Chiemi Yoshida
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka, 545 8585, Japan
    Int J Legal Med 125:11-20. 2011
    ..These observations suggest characteristic neuroendocrinal activation in fatal cases of hypo- and hyperthermia and also intoxication. CgA may be a useful biochemical and immunohistochemical marker for investigating these causes of death...
  54. doi request reprint Postmortem analyses of drugs in pericardial fluid and bone marrow aspirate
    Mariko Tominaga
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi, Abeno, Japan
    J Anal Toxicol 37:423-9. 2013
    ..These observations suggest that PCF and BMA are useful materials to be included in the forensic toxicological routine when blood samples are not available, as well as to investigate pharmaco-/toxicokinetics and postmortem redistribution...
  55. doi request reprint Death following the ingestion of detergent: an autopsy case with special regard to the histochemical findings
    Osamu Kawamoto
    Department of Legal Medecine, Osaka City University Medical School, Asahi machi, 1 4 3, Abeno, Osaka, 545 8585, Japan
    Forensic Sci Med Pathol 9:208-13. 2013
    ..These findings were in keeping with death from ingestion of detergent and demonstrated the importance of preventing accidents such as this in healthcare facilities for elderly people...
  56. ncbi request reprint Ubiquitin immunoreactivity in the midbrain as a marker of stress to motor nervous systems in fatal injury
    Li Quan
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 7:157-63. 2005
    ....
  57. ncbi request reprint Quantitative RT-PCR assays of hypoxia-inducible factor-1alpha, erythropoietin and vascular endothelial growth factor mRNA transcripts in the kidneys with regard to the cause of death in medicolegal autopsy
    Dong Zhao
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 8:258-63. 2006
    ..Quantitative assays of renal HIF-1alpha, EPO and VEGF mRNA transcripts are potentially useful for investigating the pathophysiology of death, and VEGF mRNA may be especially useful as an indication of acute circulatory failure...
  58. doi request reprint Pathophysiology of sudden cardiac death as demonstrated by molecular pathology of natriuretic peptides in the myocardium
    Jian Hua Chen
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Forensic Sci Int 223:342-8. 2012
    ....
  59. doi request reprint Morphological analysis of astrocytes in the hippocampus in mechanical asphyxiation
    Dong Ri Li
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8558, Japan
    Leg Med (Tokyo) 12:63-7. 2010
    ..These findings suggest that hippocampal astrocyte injury is caused by cerebral hypoxia accompanied by congestion, especially in mechanical asphyxia due to neck compression...
  60. doi request reprint Postmortem lung weight with regard to survival time
    Jian Hua Chen
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S238-40. 2009
    ..These findings suggest that an increase in lung weight due to progressive congestion and edema and a heavier lung weight may indicate a longer survival time...
  61. doi request reprint Analyses of cardiac blood cells and serum proteins with regard to cause of death in forensic autopsy cases
    Li Quan
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S297-300. 2009
    ..These findings suggest that analyses of blood cells and proteins are useful for investigating the cause of death...
  62. doi request reprint Morphological and functional alterations in the adenohypophysis in cases of brain death
    Takaki Ishikawa
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 11:S234-7. 2009
    ..These results indicate that the pituitary is partially preserved after brain death...
  63. doi request reprint Molecular pathology of pulmonary edema after injury in forensic autopsy cases
    Qi Wang
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585, Osaka, Japan
    Int J Legal Med 126:875-82. 2012
    ....
  64. doi request reprint Molecular pathology of pulmonary surfactants and cytokines in drowning compared with other asphyxiation and fatal hypothermia
    Takako Miyazato
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka, 545 8585, Japan
    Int J Legal Med 126:581-7. 2012
    ..These mRNA expressions can be used as markers of pulmonary injury to assist in investigations of the pathophysiology of drowning and fatal hypothermia in combination with other biochemical and biological markers...
  65. doi request reprint Postmortem quantitative mRNA analyses of death investigation in forensic pathology: an overview and prospects
    Dong Zhao
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S43-5. 2009
    ....
  66. ncbi request reprint Histopathological changes of the hippocampus neurons in brain injury
    Dong Ri Li
    Department of Legal Medicine, Osaka City University Medical School, Osaka, Japan
    Histol Histopathol 24:1113-20. 2009
    ..These findings suggest possible induction of GFAP or a related protein in hippocampus neurons depending on the severity of brain swelling following head injury...
  67. doi request reprint Postmortem serotonin levels in cerebrospinal and pericardial fluids with regard to the cause of death in medicolegal autopsy
    Li Quan
    Department of Legal Medicine, Osaka City University Medical School, Abeno, Osaka, Japan
    Leg Med (Tokyo) 13:75-8. 2011
    ..These findings suggest elevations in CSF and PCF 5-HT levels due to systemic toxic or hyperthermic neuronal dysfunction, and systemic stress responses to trauma without CNS involvement...
  68. ncbi request reprint Evaluation of postmortem urea nitrogen, creatinine and uric acid levels in pericardial fluid in forensic autopsy
    Bao Li Zhu
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 7:287-92. 2005
    ..These observations suggested the stability of UN, Cr and UA in the pericardial fluid within 48 h postmortem and their usefulness for the pathophysiological investigation of death involving azotemia...
  69. ncbi request reprint Postmortem serum protein S100B levels with regard to the cause of death involving brain damage in medicolegal autopsy cases
    Dong Ri Li
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 8:71-7. 2006
    ....
  70. ncbi request reprint Postmortem serum endotoxin level in relation to the causes of death
    Bao Li Zhu
    Department of Legal Medicine, Osaka City University Medical School, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 7:103-9. 2005
    ....
  71. doi request reprint Difference in molecular pathology of natriuretic peptides in the myocardium between acute asphyxial and cardiac deaths
    Jian Hua Chen
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 14:177-82. 2012
    ..These observations suggest a difference between primary heart failure in sudden cardiac death and terminal cardiac dysfunction secondary to fatal asphyxiation or drowning...
  72. doi request reprint Combined analyses of creatine kinase MB, cardiac troponin I and myoglobin in pericardial and cerebrospinal fluids to investigate myocardial and skeletal muscle injury in medicolegal autopsy cases
    Qi Wang
    Department of Legal Medicine, Osaka City University Medical School, Abeno, Japan
    Leg Med (Tokyo) 13:226-32. 2011
    ....
  73. doi request reprint An autopsy case of an infant with Joubert syndrome who died unexpectedly and a review of the literature
    Takaki Ishikawa
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka, 545 8585, Japan
    Forensic Sci Int 179:e67-73. 2008
    ..These findings, together with a review of previous clinical case reports, suggest that Joubert syndrome should be considered as a predisposition to sudden unexpected death in infants mainly due to aspiration or complicated infection...
  74. doi request reprint Analysis of cardiac troponins and creatine kinase MB in cerebrospinal fluid in medicolegal autopsy cases
    Hitoshi Maeda
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 11:S266-8. 2009
    ..These findings suggest that CSF levels of cTnT and cTnI are useful for investigating the progress and duration of myocardial damage in the death process. CKMB may be used as a marker of persistent hypoxic myocardial damage before death...
  75. ncbi request reprint Evaluation of post-mortem ethanol concentrations in pericardial fluid and bone marrow aspirate
    Hitoshi Maeda
    Department of Legal Medicine, Osaka City University Medical School, Abeno, Japan
    Forensic Sci Int 161:141-3. 2006
    ..These findings suggest that pericardial fluid and bone marrow aspirate can be used as an alternative material when adequate blood specimens are not available...
  76. doi request reprint An autopsy case of internal jugular vein thrombophlebitis involving sepsis following blunt neck injury
    Takaki Ishikawa
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    J Forensic Leg Med 15:114-7. 2008
    ..These findings suggest sepsis as the cause of death, induced by infected internal jugular vein thrombophlebitis following blunt neck injury involving impaired skin barrier...
  77. doi request reprint Suicidal vehicle-assisted ligature strangulation resulting in complete decapitation: an autopsy report and a review of the literature
    Dong Zhao
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 10:310-5. 2008
    ....
  78. doi request reprint Immunohistochemistry of catecholamines in the hypothalamic-pituitary-adrenal system with special regard to fatal hypothermia and hyperthermia
    Takaki Ishikawa
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 12:121-7. 2010
    ..591, p<0.01). These observations suggest a characteristic immunohistochemical pattern of systemic stress response to fatal hypothermia and hyperthermia, involving the hypothalamus and adrenal medulla...
  79. doi request reprint Evaluation of human brain damage in fire fatality by quantification of basic fibroblast growth factor (bFGF), glial fibrillary acidic protein (GFAP) and single-stranded DNA (ssDNA) immunoreactivities
    Qi Wang
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Forensic Sci Int 211:19-26. 2011
    ....
  80. ncbi request reprint Postmortem stability of pituitary hormones in the human adenohypophysis
    Takaki Ishikawa
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 8:34-8. 2006
    ..These findings suggest the usefulness of immunohistochemical investigation of the adenohypophysis for estimating the time of death and endocrinologic evaluation in decomposed cadavers...
  81. doi request reprint Cerebellar contusions as a possible cause of traumatic basal subarachnoid hemorrhage: a case report
    Jian Hua Chen
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 12:97-9. 2010
    ..The site of impact to the neck suggested the cerebellar contusions to be a coup injury due to hard blows...
  82. doi request reprint Undiagnosed late-onset chylothorax accompanied by fatal acute pulmonary thromboembolism after surgical treatment of lung cancer: an autopsy case and review of the literature
    Takaki Ishikawa
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 12:35-8. 2010
    ....
  83. doi request reprint Unexpected sudden death due to intracranial chordoma: an autopsy case
    Dong Ri Li
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Forensic Sci Int 200:e15-8. 2010
    ..The brainstem is one of the most vulnerable regions in the brain, and careful examination of this region is important for forensic pathologists...
  84. ncbi request reprint Age-dependent increase of clusterin in the human pituitary gland
    Takaki Ishikawa
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Leg Med (Tokyo) 8:28-33. 2006
    ..These findings indicate an age-dependent accumulation of clusterin in the pituitary gland, which may be related to the aging of endocrine systems...
  85. ncbi request reprint Quantitative morphometry of granular 'dot-like' ubiquitin-immunoreactivity in the crus cerebri in asphyxiation and fire fatalities
    Li Quan
    Department of Legal Medicine, Osaka City University Medical School, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 7:81-8. 2005
    ....
  86. doi request reprint Fatal facial-intracranial impalement injury in an accidental fall from a height: an autopsy case report with a review of the literature
    Qi Wang
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, Osaka 545 8585, Japan
    Forensic Sci Int 200:e21-4. 2010
    ..Furthermore, the present case suggested the difficulty of clinical diagnosis even using CT; thus, a forensic autopsy was necessary to determine the manner and cause of death...
  87. doi request reprint Significance of postmortem biochemistry in determining the cause of death
    Hitoshi Maeda
    Department of Legal Medicine, Osaka City University Medical School, Asahi machi 1 4 3, Abeno, 545 8585 Osaka, Japan
    Leg Med (Tokyo) 11:S46-9. 2009
    ..The application of these procedures may depend on the concept of medicolegal autopsy, and it is essential to establish postmortem databases through routine casework...