Takeshi Kusafuka

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint P53 gene mutations in pleuropulmonary blastomas
    Takeshi Kusafuka
    Department of Pediatric Surgery, Osaka University Medical School, Suita, Japan
    Pediatr Hematol Oncol 19:117-28. 2002
  2. ncbi request reprint Novel germ-line deletion of SNF5/INI1/SMARCB1 gene in neonate presenting with congenital malignant rhabdoid tumor of kidney and brain primitive neuroectodermal tumor
    Takeshi Kusafuka
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Genes Chromosomes Cancer 40:133-9. 2004
  3. ncbi request reprint Codon 45 of the beta-catenin gene, a specific mutational target site of Wilms' tumor
    Takeshi Kusafuka
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Mol Med 10:395-9. 2002
  4. ncbi request reprint Silencing of MYCN by RNA interference induces growth inhibition, apoptotic activity and cell differentiation in a neuroblastoma cell line with MYCN amplification
    Keigo Nara
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Oncol 30:1189-96. 2007
  5. ncbi request reprint Detection of a novel alteration of the Axin gene in various pediatric neoplasms
    Jiangyong Miao
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Oncol Rep 10:1943-6. 2003
  6. ncbi request reprint Artificially accumulated beta-catenin inhibits proliferation and induces neurite extension of neuroblastoma cell line NB-1 via up-regulation of trkA
    Surasak Sangkhathat
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Oncol Rep 16:1197-203. 2006
  7. ncbi request reprint In vitro RNA interference against beta-catenin inhibits the proliferation of pediatric hepatic tumors
    Surasak Sangkhathat
    Department of Pediatric Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Int J Oncol 28:715-22. 2006
  8. ncbi request reprint Mutation of beta-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis
    Jiangyong Miao
    Department of Pediatric Surgery, Osaka University Medical School, Suita, Osaka, Japan
    Int J Mol Med 11:461-4. 2003
  9. doi request reprint Usefulness of power Doppler ultrasonography and superparamagnetic iron oxide enhanced magnetic resonance imaging for diagnosis of focal nodular hyperplasia of the liver after treatment of neuroblastoma
    Kiminobu Sugito
    Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan
    Pediatr Hematol Oncol 27:250-6. 2010
  10. doi request reprint Allogeneic hematopoietic stem cell transplantation against recurrent rhabdomyosarcoma
    Hideaki Ohta
    Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan
    J Pediatr Hematol Oncol 33:e35-8. 2011

Detail Information

Publications23

  1. ncbi request reprint P53 gene mutations in pleuropulmonary blastomas
    Takeshi Kusafuka
    Department of Pediatric Surgery, Osaka University Medical School, Suita, Japan
    Pediatr Hematol Oncol 19:117-28. 2002
    ..The results raise the possibility that p53 inactivation can occur as a nonrandom genetic change involving the pathogenesis and outcome of PPB. Further studies in a larger series are necessary to clarify these matters...
  2. ncbi request reprint Novel germ-line deletion of SNF5/INI1/SMARCB1 gene in neonate presenting with congenital malignant rhabdoid tumor of kidney and brain primitive neuroectodermal tumor
    Takeshi Kusafuka
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Genes Chromosomes Cancer 40:133-9. 2004
    ..Additional large somatic deletions resulted in total inactivation of the gene in both tumors. Our patient provides evidence for an important role of SNF5/INI1germ-line mutation in predisposing patients to multiple rhabdoid tumors...
  3. ncbi request reprint Codon 45 of the beta-catenin gene, a specific mutational target site of Wilms' tumor
    Takeshi Kusafuka
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan
    Int J Mol Med 10:395-9. 2002
    ....
  4. ncbi request reprint Silencing of MYCN by RNA interference induces growth inhibition, apoptotic activity and cell differentiation in a neuroblastoma cell line with MYCN amplification
    Keigo Nara
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Oncol 30:1189-96. 2007
    ..Using RNAi method, the knock-down of MYCN expression induced growth-inhibition, apoptotic activity and cell differentiation in MYCN-amplified NB-1 cell line...
  5. ncbi request reprint Detection of a novel alteration of the Axin gene in various pediatric neoplasms
    Jiangyong Miao
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Oncol Rep 10:1943-6. 2003
    ..Our results indicated that a tumor-associated mutation of the Axin gene is generally a rare event in our series of pediatric neoplasms...
  6. ncbi request reprint Artificially accumulated beta-catenin inhibits proliferation and induces neurite extension of neuroblastoma cell line NB-1 via up-regulation of trkA
    Surasak Sangkhathat
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Oncol Rep 16:1197-203. 2006
    ....
  7. ncbi request reprint In vitro RNA interference against beta-catenin inhibits the proliferation of pediatric hepatic tumors
    Surasak Sangkhathat
    Department of Pediatric Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Int J Oncol 28:715-22. 2006
    ..Our data indicate that beta-catenin can be considered a specific target for gene therapy in pediatric hepatic tumors with mutations and overexpression of this gene...
  8. ncbi request reprint Mutation of beta-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis
    Jiangyong Miao
    Department of Pediatric Surgery, Osaka University Medical School, Suita, Osaka, Japan
    Int J Mol Med 11:461-4. 2003
    ..Our observations suggest that, in some SCTs of the pancreas presented in the pediatric age group, mutated beta-catenin has an important oncogenic effect...
  9. doi request reprint Usefulness of power Doppler ultrasonography and superparamagnetic iron oxide enhanced magnetic resonance imaging for diagnosis of focal nodular hyperplasia of the liver after treatment of neuroblastoma
    Kiminobu Sugito
    Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan
    Pediatr Hematol Oncol 27:250-6. 2010
    ....
  10. doi request reprint Allogeneic hematopoietic stem cell transplantation against recurrent rhabdomyosarcoma
    Hideaki Ohta
    Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan
    J Pediatr Hematol Oncol 33:e35-8. 2011
    ..A graft-versus-tumor effect through allogeneic immune cells might produce a beneficial effect for high-risk RMS...
  11. ncbi request reprint Hotspot mutations of BRAF gene are not associated with pediatric solid neoplasms
    Jiangyong Miao
    The Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Oncol Rep 12:1269-72. 2004
    ..The current study represents the first genetic analysis of the BRAF gene in pediatric solid tumors. Our data suggest that mutations of BRAF gene as a mechanism of tumorigenesis is unlikely to be associated with most childhood neoplasms...
  12. ncbi request reprint Renal cell carcinoma in a pediatric patient with an inherited mitochondrial mutation
    Surasak Sangkhathat
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871 Japan
    Pediatr Surg Int 21:745-8. 2005
    ..With this information, we speculated a role of mitochondria mutation in the pathogenesis of this cancer...
  13. doi request reprint A case series of children with high-risk metastatic neuroblastoma treated with a novel treatment strategy consisting of postponed primary surgery until the end of systemic chemotherapy including high-dose chemotherapy
    Yoshiko Hashii
    Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan
    Pediatr Hematol Oncol 25:439-50. 2008
    ..Eleven consecutive pediatric neuroblastoma patients were treated according to this strategy. Seven of 11 patients remained in complete remission for 21-171 months. This treatment strategy seems feasible and a further study is warranted...
  14. ncbi request reprint Vaginal reconstruction in a patient with rhabdomyosarcoma previously treated by total vaginectomy
    Takeshi Kusafuka
    Department of Pediatric Surgery, Osaka University Medical School, Suita, Osaka, Japan
    J Pediatr Surg 37:1365-7. 2002
    ..Because continuity from the vaginal introitus to the uterus was established, fertility can be expected for this patient...
  15. ncbi request reprint Mutation analysis of the BCL10 gene in childhood solid malignancies
    Jiangyong Miao
    Department of Pediatric Surgery, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Med Pediatr Oncol 39:543-6. 2002
    ..Furthermore, abnormalities of chromosome 1 where the BCL10 gene is located are a common feature in pediatric solid tumors. Therefore, we analyzed 95 pediatric solid cancers for genomic BCL10 mutations...
  16. ncbi request reprint Living-related liver transplantation with removal of inferior vena cava for unresectable hepatoblastoma
    Toshimichi Hasegawa
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    Pediatr Transplant 10:521-4. 2006
    ..Because the collaterals were well developed, the patient tolerated the procedure well. The serum AFP level decreased from 186 699 to 8 ng/mL in 11 months after LTx without local recurrence or distant metastasis...
  17. ncbi request reprint Intraoperative radiation therapy for advanced neuroblastoma: the problem of securing the IORT field
    Kiminobu Sugito
    Department of Pediatric Surgery, Nihon University School of Medicine, 30 1, Ohyaguchi Kamimachi, Itabashi ku, Tokyo, 173 8610, Japan
    Pediatr Surg Int 23:1203-7. 2007
    ..However, there is a problem of securing the IORT field. For local control, it is necessary to add an external beam radiation after IORT when it is difficult to secure the IORT field...
  18. doi request reprint Mesenchymal hamartoma of the liver originating in the caudate lobe with t(11;19)(q13;q13.4): report of a case
    Kiminobu Sugito
    Department of Pediatric Surgery, Nihon University School of Medicine, 30 1 Ohyaguchi kamimachi, Itabashi ku, Tokyo, 173 8610, Japan
    Surg Today 40:83-7. 2010
    ..It is similar to the seven cases previously reported, in that one of the breakpoints involves the chromosome band 19q13.3 or 19q13.4, but it is the first report of an abnormality originating in the caudate lobe...
  19. ncbi request reprint Axin, the main component of the Wnt signaling pathway, is not mutated in kidney tumors in children
    Jiangyong Miao
    Department of Pediatric Surgery, Osaka University Medical School, Suita, Japan
    Int J Mol Med 9:377-9. 2002
    ..Our results indicated that mutations of Axin gene as a mechanism of tumorigenesis are not associated with pediatric renal tumors including Wilms' tumors...
  20. ncbi request reprint Novel mutation of Endothelin-B receptor gene in Waardenburg-Hirschsprung disease
    Surasak Sangkhathat
    Department of Pediatric Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Pediatr Surg Int 21:960-3. 2005
    ..Moreover, the non-penetrance of heterozygotes in our pedigree, which differs from other reports, demonstrates the high pleiotropic effect of EDNRB mutations in human...
  21. ncbi request reprint Mutations and polymorphisms of Hirschsprung disease candidate genes in Thai patients
    Surasak Sangkhathat
    Pediatric Surgery Unit, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hadyai, Songkhla, 90110, Thailand
    J Hum Genet 51:1126-32. 2006
    ..The GG/GG genotype construct was associated with RSD and with males. The study also detected a variant allele of RET S836S which has never been reported in Asian cohorts...
  22. ncbi request reprint Effect of FTY720 and ex vivo graft irradiation in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1
    Kiminobu Sugito
    Division of Pediatric Surgery, Department of Surgery, Nihon University School of Medicine, 30 1 Ohyaguchi kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Surg Today 38:38-41. 2008
    ....
  23. ncbi request reprint Epigenetic differences between Wilms' tumours in white and east-Asian children
    Ryuji Fukuzawa
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Lancet 363:446-51. 2004
    ..We investigated whether the difference in incidence of Wilms' tumour between children of east-Asian descent and white children is due to variations in proportion of tumours with loss of IGF2 imprinting (IGF2 LOI)...