H Koyama

Summary

Affiliation: Osaka City University
Country: Japan

Publications

  1. ncbi Preferential stiffening of central over peripheral arteries in type 2 diabetes
    Eiji Kimoto
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
    Diabetes 52:448-52. 2003
  2. ncbi The association of plasma adiponectin level with carotid arterial stiffness
    Takahiro Araki
    Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Metabolism 55:587-92. 2006
  3. pmc Endogenous Secretory RAGE as a Novel Biomarker for Metabolic Syndrome and Cardiovascular Diseases
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Biomark Insights 2:331-9. 2007
  4. pmc Serum C-reactive protein and thioredoxin levels in subjects with mildly reduced glomerular filtration rate
    Shoko Tsuchikura
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    BMC Nephrol 11:7. 2010
  5. ncbi Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Circulation 108:524-9. 2003
  6. ncbi Low circulating endogenous secretory receptor for AGEs predicts cardiovascular mortality in patients with end-stage renal disease
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Arterioscler Thromb Vasc Biol 27:147-53. 2007
  7. pmc RAGE and soluble RAGE: potential therapeutic targets for cardiovascular diseases
    Hidenori Koyama
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Mol Med 13:625-35. 2007
  8. ncbi Platelet in progression of atherosclerosis: a potential target in diabetic patients
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Curr Diabetes Rev 1:159-65. 2005
  9. ncbi Plasma level of endogenous secretory RAGE is associated with components of the metabolic syndrome and atherosclerosis
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Arterioscler Thromb Vasc Biol 25:2587-93. 2005
  10. doi AGEs/RAGE in CKD: irreversible metabolic memory road toward CVD?
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Eur J Clin Invest 40:623-35. 2010

Collaborators

Detail Information

Publications70

  1. ncbi Preferential stiffening of central over peripheral arteries in type 2 diabetes
    Eiji Kimoto
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
    Diabetes 52:448-52. 2003
    ..In contrast, sex was associated with PWV of the peripheral arteries. Thus, type 2 diabetes had greater impact on PWV of the central arteries, and different factors were involved in PWV among different arterial regions...
  2. ncbi The association of plasma adiponectin level with carotid arterial stiffness
    Takahiro Araki
    Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Metabolism 55:587-92. 2006
    ....
  3. pmc Endogenous Secretory RAGE as a Novel Biomarker for Metabolic Syndrome and Cardiovascular Diseases
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Biomark Insights 2:331-9. 2007
    ..These findings suggest that plasma esRAGE may act as a protective factor against and a novel biomarker for the occurrence of metabolic syndrome and cardiovascular diseases...
  4. pmc Serum C-reactive protein and thioredoxin levels in subjects with mildly reduced glomerular filtration rate
    Shoko Tsuchikura
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    BMC Nephrol 11:7. 2010
    ..We compared the levels of serum biomarkers for inflammation and oxidative stress between subjects with normal and mildly reduced glomerular filtration rate (GFR)...
  5. ncbi Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Circulation 108:524-9. 2003
    ..In the present study, we examine the relation between platelet P-selectin expression and atherosclerotic parameters in 517 subjects...
  6. ncbi Low circulating endogenous secretory receptor for AGEs predicts cardiovascular mortality in patients with end-stage renal disease
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Arterioscler Thromb Vasc Biol 27:147-53. 2007
    ..Here, we evaluated if plasma esRAGE is a predictor of cardiovascular mortality in a cohort of 206 (171 nondiabetic) patients with end-stage renal diseases (ESRD)...
  7. pmc RAGE and soluble RAGE: potential therapeutic targets for cardiovascular diseases
    Hidenori Koyama
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Mol Med 13:625-35. 2007
    ..In this review, we summarize recent findings regarding pathophysiological roles in cardiovascular disease of RAGE and soluble RAGE and discuss their potential usefulness as therapeutic targets and biomarkers for the disease...
  8. ncbi Platelet in progression of atherosclerosis: a potential target in diabetic patients
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Curr Diabetes Rev 1:159-65. 2005
    ..This review will focus on altered platelet function in diabetic patients, and its implications in the progression of atherosclerosis...
  9. ncbi Plasma level of endogenous secretory RAGE is associated with components of the metabolic syndrome and atherosclerosis
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Arterioscler Thromb Vasc Biol 25:2587-93. 2005
    ..Here, we measured plasma esRAGE level with a recently developed enzyme-linked immunosorbent assay (ELISA) and examined its association with atherosclerosis in age- and gender-matched 203 type 2 diabetic and 134 nondiabetic subjects...
  10. doi AGEs/RAGE in CKD: irreversible metabolic memory road toward CVD?
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Eur J Clin Invest 40:623-35. 2010
    ....
  11. ncbi Molecular pathways of cyclic nucleotide-induced inhibition of arterial smooth muscle cell proliferation
    H Koyama
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Cell Physiol 186:1-10. 2001
    ..This review summarizes our knowledge of the signaling pathways regulated by cyclic nucleotides in arterial smooth muscle cells...
  12. pmc Fatigue is a predictor for cardiovascular outcomes in patients undergoing hemodialysis
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Clin J Am Soc Nephrol 5:659-66. 2010
    ..This study was designed to examine whether fatigue symptoms or fatigue's underlying components are a predictor for cardiovascular diseases in high-risk subjects with ESRD...
  13. ncbi Arterial wall stiffness is associated with peripheral circulation in patients with type 2 diabetes
    Akane Kizu
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Atherosclerosis 170:87-91. 2003
    ..Thus, arterial wall stiffness of femoral artery appears to be a major determinant of peripheral circulation in patients with type 2 diabetes...
  14. ncbi Short-term aerobic exercise improves arterial stiffness in type 2 diabetes
    Hisayo Yokoyama
    Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Diabetes Res Clin Pract 65:85-93. 2004
    ..To investigate whether: (1) aerobic exercise decreases arterial stiffness and (2) reduction in arterial stiffness is associated with improvement in insulin resistance in type 2 diabetes...
  15. ncbi Arterial wall thickness is associated with insulin resistance in type 2 diabetic patients
    Shigehiko Fujiwara
    Metabolism, Endocrinology and Molecular Medicine, Department of Internal Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 10:246-52. 2003
    ..0001, respectively). In conclusion, insulin resistance is associated with both CA-IMT and FA-IMT in type 2 diabetic patients, suggesting that it is an independent risk factor for the development of atherosclerosis in type 2 diabetes...
  16. ncbi Association between plasma angiopoietin-like protein 3 and arterial wall thickness in healthy subjects
    Sawako Hatsuda
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Vasc Res 44:61-6. 2007
    ..We evaluated the possible association between plasma ANGPTL3 level and carotid artery intima-media thickness (CA-IMT) and femoral artery intima-media thickness (FA-IMT) in healthy human subjects...
  17. doi Poor glycemic control is a significant predictor of cardiovascular events in chronic hemodialysis patients with diabetes
    Yoshihiro Tsujimoto
    Inoue Hospital, Osaka, Japan
    Ther Apher Dial 13:358-65. 2009
    ..0046, respectively). In diabetic hemodialysis patients, poor glycemic control is a significant, independent predictor of the emergence of CVD, indicating the importance of careful management of glycemic control in hemodialysis patients...
  18. doi Fetuin-A and atherosclerotic calcified plaque in patients with type 2 diabetes mellitus
    Masanori Emoto
    The Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Metabolism 59:873-8. 2010
    ..753; 95% confidence interval, 0.608-0.933; P = .010). These results suggest that fetuin-A may inhibit the calcification of atherosclerotic plaques independently of the dialyzed condition...
  19. ncbi Mönckeberg's medial sclerosis and inorganic phosphate in uremia
    A Shioi
    Department of Cardiovascular Medicine, Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Kidney Dis 38:S47-9. 2001
    ..As a possible etiologic factor inducing these two responses, hyperphosphatemia among various metabolic disturbances recognized in uremia may play an important role in the development of MMS in uremia...
  20. ncbi The K469E polymorphism of the intercellular adhesion molecule-1 gene is associated with plasma fibrinogen level in type 2 diabetes
    Hisayo Yokoyama
    Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Metabolism 54:381-6. 2005
    ....
  21. ncbi Inflammation and bone resorption as independent factors of accelerated arterial wall thickening in patients with rheumatoid arthritis
    Mayumi Nagata-Sakurai
    Osaka City University Graduate School of Medicine, Osaka, Japan
    Arthritis Rheum 48:3061-7. 2003
    ..The present longitudinal study was performed to determine whether the change in arterial thickness was accelerated in RA patients and to determine which factor was important in the progression of arterial wall changes...
  22. ncbi Platelet activation is associated with hypoadiponectinemia and carotid atherosclerosis
    Takuhito Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Atherosclerosis 188:190-5. 2006
    ..423), serum adiponectin levels (r = -0.289) and age (r = -0.184) were the three independent determinants. Thus, our data unveil novel link between hypoadiponectinemia and platelet activation...
  23. ncbi Mechanism of atherosclerotic calcification
    A Shioi
    Department of Cardiovascular Medicine, Osaka City University Medical School, Japan
    Z Kardiol 89:75-9. 2000
    ..Therefore, the phenotypic changes of VSMCs in atherosclerotic plaque may contribute to the development of atherosclerotic calcification...
  24. ncbi Platelet-monocyte aggregates are independently associated with occurrence of carotid plaques in type 2 diabetic patients
    Takuhito Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 12:344-52. 2005
    ..Thus, an increase in platelet-monocyte aggregation in type 2 diabetic patients appears to be involved in the pathophysiology of carotid atherosclerosis...
  25. doi Fetuin-A is associated with calcified coronary artery disease
    Katsuhito Mori
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Coron Artery Dis 21:281-5. 2010
    ..As diabetes and uremia make the role of fetuin-A in cardiovascular disease uncertain, we investigated the association between fetuin-A and calcified coronary artery disease in participants without diabetes and renal dysfunction...
  26. ncbi Effect of adiponectin on carotid arterial stiffness in type 2 diabetic patients treated with pioglitazone and metformin
    Takahiro Araki
    Metabolism, Endocrinology, and Molecular Medicine, Department of Internal Medicine, Osaka City University Graduate Medical School, Osaka 545 8585, Japan
    Metabolism 55:996-1001. 2006
    ....
  27. doi Central versus peripheral arterial stiffness in association with coronary, cerebral and peripheral arterial disease
    Shoko Tsuchikura
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Atherosclerosis 211:480-5. 2010
    ..We measured pulse wave velocity (PWV) in four arterial segments, and examined the relative changes in the four regional PWVs in patients with CAD, CVD or PAD...
  28. doi Plasma angiopoietin-like protein 3 (ANGPTL3) concentration is associated with uremic dyslipidemia
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Atherosclerosis 207:579-84. 2009
    ..Since the role of angiopoietin-like protein 3 (ANGPTL3) in uremic dyslipidemia is unknown, we examined its possible association with the lipoprotein abnormalities in patients with chronic renal failure (CRF)...
  29. doi Glimepiride increases high-density lipoprotein cholesterol via increasing adiponectin levels in type 2 diabetes mellitus
    Takahiro Araki
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Metabolism 58:143-8. 2009
    ..524, P = .036). In conclusion, glimepiride improved plasma adiponectin level, especially in the subjects with type 2 diabetes mellitus with low adiponectin level before treatment, and may directly contribute to improving HDL-c level...
  30. ncbi Phosphatidylinositol 3-kinase/Akt pathway regulates inflammatory mediators-induced calcification of human vascular smooth muscle cells
    Hirokazu Okazaki
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University, Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Osaka City Med J 55:71-80. 2009
    ..Phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway is involved in the regulation of cell metabolism, survival, migration, and inflammatory responses in various cell types...
  31. ncbi Altered relationship between body fat and plasma adiponectin in end-stage renal disease
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Metabolism 54:330-4. 2005
    ..Thus, plasma adipocytokine profile was altered in ESRD, and the effects of body fat and sex on adiponectin were less significant in the patients with ESRD...
  32. ncbi Association of serum fetuin-A with carotid arterial stiffness
    Katsuhito Mori
    Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Clin Endocrinol (Oxf) 66:246-50. 2007
    ..The objective of this study was to investigate the association between serum fetuin-A levels and arterial stiffness, a functional property of atherosclerosis, in healthy subjects...
  33. doi Effects of pioglitazone on serum fetuin-A levels in patients with type 2 diabetes mellitus
    Katsuhito Mori
    Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Metabolism 57:1248-52. 2008
    ..9 microg/mL, P = .006), whereas there were no changes in serum fetuin-A after intervention in either the Met or the Ex groups. We hypothesize that pioglitazone could partially ameliorate insulin resistance via modulating fetuin-A levels...
  34. ncbi Endogenous secretory receptor for advanced glycation end-products and cardiovascular disease in end-stage renal disease
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Ren Nutr 18:76-82. 2008
    ..Thus, we postulate that plasma esRAGE is a potential protective factor and a novel biomarker against the occurrence of cardiovascular disease in ESRD...
  35. doi Small dense low-density lipoprotein cholesterol concentration and carotid atherosclerosis
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Atherosclerosis 202:582-8. 2009
    ....
  36. ncbi Insulin resistance index as a predictor for pioglitazone treatment in type 2 diabetes
    Takahiro Araki
    Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
    Osaka City Med J 51:19-25. 2005
    ..The purpose of the present study was to investigate whether insulin resistance index, homeostasis model assessment index (HOMA-IR) is a useful predictor of hypoglycemic effect of pioglitazone in comparison with body mass index (BMI)...
  37. ncbi Plasma adiponectin level is associated with insulin-stimulated nonoxidative glucose disposal
    Hisayo Yokoyama
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    J Clin Endocrinol Metab 91:290-4. 2006
    ..Impaired nonoxidative glucose disposal and decrease in mitochondrial glucose oxidation both contribute to insulin resistance in diabetic subjects...
  38. ncbi Lower risk for cardiovascular mortality in oral 1alpha-hydroxy vitamin D3 users in a haemodialysis population
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Nephrol Dial Transplant 19:179-84. 2004
    ..We hypothesized that treatment with vitamin D(3) may be beneficial for survival in patients with end-stage renal disease (ESRD)...
  39. ncbi Effect of aerobic exercise on plasma adiponectin levels and insulin resistance in type 2 diabetes
    Hisayo Yokoyama
    Department of Metabolism, Osaka City University Graduate School of Medicine, Osaka, Japan
    Diabetes Care 27:1756-8. 2004
  40. ncbi Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia
    Yasukatsu Izumi
    Department of Pharmacology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
    Circulation 108:2812-8. 2003
    ..Therefore, we first examined the role of ASK1 in vascular remodeling...
  41. ncbi Arterial stiffness in predialysis patients with uremia
    Kayo Shinohara
    Department of Metabolism, Osaka City University Graduate School of Medicine, Osaka, Japan
    Kidney Int 65:936-43. 2004
    ..We compared aortic PWV of uremic patients before starting hemodialysis treatment with that of patients on maintenance hemodialysis...
  42. ncbi Antibody to oxidized low-density lipoprotein and cardiovascular mortality in end-stage renal disease
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Kidney Int 62:2230-7. 2002
    ..Immune response to oxidized low-density lipoprotein (oxLDL) may modulate the process of atherogenesis and cardiovascular disease...
  43. ncbi Induction of bone-type alkaline phosphatase in human vascular smooth muscle cells: roles of tumor necrosis factor-alpha and oncostatin M derived from macrophages
    Atsushi Shioi
    Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Circ Res 91:9-16. 2002
    ..These results suggest that macrophages may contribute to the development of vascular calcification through producing various inflammatory mediators, especially TNF-alpha and OSM...
  44. ncbi Insulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease
    Kayo Shinohara
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Am Soc Nephrol 13:1894-900. 2002
    ..In contrast, HOMA-IR did not show such a significant association with noncardiovascular mortality. These results indicate that insulin resistance is an independent predictor of cardiovascular mortality in ESRD...
  45. ncbi The 807T allele in alpha2 integrin is protective against atherosclerotic arterial wall thickening and the occurrence of plaque in patients with type 2 diabetes
    Takaaki Maeno
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Diabetes 51:1523-8. 2002
    ..These results suggest that the number of 807T alleles in alpha2 integrin is protective against atherosclerotic arterial wall thickening and the occurrence of plaque in patients with type 2 diabetes...
  46. ncbi Pulse wave velocity in lower-limb arteries among diabetic patients with peripheral arterial disease
    Hisayo Yokoyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 10:253-8. 2003
    ..The purpose of this study was to examine the possible alteration in pulse wave velocity (PWV) in lower-limb arteries among diabetic patients with PAD...
  47. doi Skin autofluorescence, a marker for advanced glycation end product accumulation, is associated with arterial stiffness in patients with end-stage renal disease
    Hiroki Ueno
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Metabolism 57:1452-7. 2008
    ....
  48. ncbi Clinical impact of metabolic syndrome by modified NCEP-ATPIII criteria on carotid atherosclerosis in Japanese adults
    Megumi Teramura
    Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 14:172-8. 2007
    ....
  49. ncbi Quantitative insulin sensitivity check index and the reciprocal index of homeostasis model assessment are useful indexes of insulin resistance in type 2 diabetic patients with wide range of fasting plasma glucose
    Hisayo Yokoyama
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    J Clin Endocrinol Metab 89:1481-4. 2004
    ..730, respectively; all subjects, r = 0.685; all P < 0.001). In conclusion, QUICKI and the reciprocal index of HOMA were highly correlated with Clamp-IR in type 2 diabetic patients with relatively wide ranges of fasting plasma glucose...
  50. ncbi Regional arterial stiffness in patients with type 2 diabetes and chronic kidney disease
    Eiji Kimoto
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Am Soc Nephrol 17:2245-52. 2006
    ..The cross-sectional result may explain the increased risk for cardiovascular disease in CKD, although longitudinal studies are needed to confirm it...
  51. ncbi Bone resorption associated with uncoupling of osteoclastic and osteoblastic activities in adult T cell leukemia with hypercalcemia: case report
    M Hino
    Department of Clinical Hematology, Osaka City University Medical School, Osaka, Japan
    Ann Hematol 80:426-9. 2001
    ..The ATL cells produced not only PTHrP but also IL-1alpha and IL-1beta. These results suggest that PTHrP may act as a humoral factor and IL-1 may act as a local factor in bone metabolism of ATL patients...
  52. ncbi Fibrillar collagen specifically regulates human vascular smooth muscle cell genes involved in cellular responses and the pericellular matrix environment
    T Ichii
    Department of Biochemistry, Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Circ Res 88:460-7. 2001
    ..Thus, polymerized type I collagen dynamically regulates gene expression, pericellular accumulation of extracellular matrix molecules, and the response to a given matrix molecule...
  53. doi Receptor for advanced glycation end-products (RAGE) regulation of adiposity and adiponectin is associated with atherogenesis in apoE-deficient mouse
    Hiroki Ueno
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Atherosclerosis 211:431-6. 2010
    ..Receptor for advanced glycation end-products (RAGE) has been shown to be involved in cardiovascular diseases. We examined the involvement of RAGE in atherosclerosis under non-diabetic status, and its relation to the effect on adiposity...
  54. ncbi Thrombospondin-1 mediates smooth muscle cell proliferation induced by interaction with human platelets
    Takuya Ichii
    Department of Biochemistry, Osaka City University Graduate School of Medicine, Osaka, Japan
    Arterioscler Thromb Vasc Biol 22:1286-92. 2002
    ..This study examined platelet-SMC interaction on fibrillar type I collagen and analyzed the role of thrombospondin (TSP)-1 in platelet-induced SMC proliferation...
  55. ncbi The combination of IMT and stiffness parameter beta is highly associated with concurrent coronary artery disease in type 2 diabetes
    Eiko Lee
    Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    J Atheroscler Thromb 16:33-9. 2009
    ..We examined the associations of stiffness parameter beta (ST) and IMT with concurrent CAD...
  56. ncbi Brachial-ankle pulse wave velocity as an index of central arterial stiffness
    Shoko Tsuchikura
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    J Atheroscler Thromb 17:658-65. 2010
    ..An automated device for brachial-ankle (ba) PWV is available, although information is limited whether baPWV reflects the stiffness of central or peripheral arteries. We therefore addressed this question in the present study...
  57. ncbi Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators
    Akane Kizu
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Cell Biochem 93:1011-9. 2004
    ..These findings provide a possible mechanism of statins to prevent the progression of calcification in inflammatory vascular diseases such as atherosclerosis and cardiac valvular calcification...
  58. doi Increased undercarboxylated osteocalcin/intact osteocalcin ratio in patients undergoing hemodialysis
    Y Nagata
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    Osteoporos Int 26:1053-61. 2015
    ..Consequently, serum ucOC/iOC ratio might lose its significance as a bone metabolic marker to indicate vitamin K deficiency in hemodialysis patients...
  59. ncbi Insulin allergy; desensitization with crystalline zinc-insulin and steroid tapering
    Hisayo Yokoyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, 1 4 3 Asahi machi, Abeno Ku, 545 8585 Osaka, Japan
    Diabetes Res Clin Pract 61:161-6. 2003
    ..We also report here the modified method of insulin desensitization using crystalline zinc-insulin with prednisolone tapering. This might be a simple and useful treatment for insulin allergy...
  60. doi Dialysis modality is independently associated with circulating endothelial progenitor cells in end-stage renal disease patients
    Hiroki Ueno
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Nephrol Dial Transplant 25:581-6. 2010
    ..Numbers of endothelial progenitor cells (EPC) have been shown to be decreased in subjects with end-stage renal disease (ESRD). It is not clear, however, whether dialysis modality affects circulating EPCs in ESRD subjects...
  61. ncbi Receptor for advanced glycation end products is involved in impaired angiogenic response in diabetes
    Takuhito Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Osaka 545 8585, Japan
    Diabetes 55:2245-55. 2006
    ..Thus, RAGE appears to be involved in impairment of angiogenesis in diabetes, and blockade of RAGE might be a potential therapeutic target...
  62. ncbi Regional arterial stiffness associated with ischemic heart disease in type 2 diabetes mellitus
    Sawako Hatsuda
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Atheroscler Thromb 13:114-21. 2006
    ..Thus, diabetic patients with IHD have increased stiffness of arteries, particularly of the aorta, supporting the concept that central arterial stiffness plays an important role in the development of IHD...
  63. ncbi Effect of atorvastatin on regional arterial stiffness in patients with type 2 diabetes mellitus
    Kayo Shinohara
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 12:205-10. 2005
    ..Arterial stiffness affects the blood flow of peripheral arteries. The purpose of this study was to evaluate the effect of cholesterol-lowering with atorvastatin on regional arterial stiffness in patients with type 2 diabetes mellitus...
  64. ncbi [EsRAGE]
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
    Nihon Rinsho 64:300-4. 2006
  65. doi Atheroprotective and plaque-stabilizing effects of enzymatically modified isoquercitrin in atherogenic apoE-deficient mice
    Koka Motoyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Nutrition 25:421-7. 2009
    ..The long-term antiatherogenic effect of EMIQ was examined using apolipoprotein E (apoE)-deficient atherogenic mice...
  66. ncbi Role of H1-calponin in pancreatic AR42J cell differentiation into insulin-producing cells
    Tomoaki Morioka
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Diabetes 52:760-6. 2003
    ..6 +/- 1.9%). These results suggest that regulation of h1-calponin is involved in the regulation of differentiation of AR42J cells into insulin-producing cells at least partly through modulating ARE transcriptional activity...
  67. ncbi Association of serum fetuin-A with insulin resistance in type 2 diabetic and nondiabetic subjects
    Katsuhito Mori
    Diabetes Care 29:468. 2006
  68. ncbi Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors
    Kouros Motamed
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 84:759-71. 2002
    ....
  69. ncbi [Diabetes mellitus and arteriosclerosis--recent findings in non-invasive testing]
    Yoshiki Nishizawa
    Nihon Naika Gakkai Zasshi 94:485-9. 2005
  70. ncbi Lipid accumulation in smooth muscle cells under LDL loading is independent of LDL receptor pathway and enhanced by hypoxic conditions
    Youichiro Wada
    Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Japan
    Arterioscler Thromb Vasc Biol 22:1712-9. 2002
    ..The effect of a variety of hypoxic conditions on lipid accumulation in smooth muscle cells (SMCs) was studied in an arterial wall coculture and monocultivation model...