Hideaki Kaneto

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint The JNK pathway as a therapeutic target for diabetes
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Expert Opin Ther Targets 9:581-92. 2005
  2. ncbi request reprint Crucial role of PDX-1 in pancreas development, beta-cell differentiation, and induction of surrogate beta-cells
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Med Chem 14:1745-52. 2007
  3. pmc Involvement of oxidative stress and the JNK pathway in glucose toxicity
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Rev Diabet Stud 1:165-74. 2004
  4. ncbi request reprint Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nat Med 10:1128-32. 2004
  5. ncbi request reprint Oxidative stress and the JNK pathway as a potential therapeutic target for diabetes
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Drug News Perspect 17:447-53. 2004
  6. ncbi request reprint A crucial role of MafA as a novel therapeutic target for diabetes
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 280:15047-52. 2005
  7. ncbi request reprint Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Mol Med (Berl) 83:429-39. 2005
  8. ncbi request reprint PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes 54:1009-22. 2005
  9. ncbi request reprint Role of PDX-1 and MafA as a potential therapeutic target for diabetes
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Diabetes Res Clin Pract 77:S127-37. 2007
  10. ncbi request reprint Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Biochem Cell Biol 37:1595-608. 2005

Detail Information

Publications98

  1. ncbi request reprint The JNK pathway as a therapeutic target for diabetes
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Expert Opin Ther Targets 9:581-92. 2005
    ..Taken together, the JNK pathway is likely to play a central role in the progression of insulin resistance and beta-cell dysfunction and, thus, could be a potential therapeutic target for diabetes...
  2. ncbi request reprint Crucial role of PDX-1 in pancreas development, beta-cell differentiation, and induction of surrogate beta-cells
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Med Chem 14:1745-52. 2007
    ..Furthermore, these transcription factors play a crucial role in inducing surrogate beta-cells from non-beta-cells and thus could be therapeutic targets for diabetes...
  3. pmc Involvement of oxidative stress and the JNK pathway in glucose toxicity
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Rev Diabet Stud 1:165-74. 2004
    ..Consequently, the JNK pathway plays a crucial role in the progression of pancreatic beta-cell dysfunction and insulin resistance and thus could be a potential therapeutic target for the "glucose toxicity" found in diabetes...
  4. ncbi request reprint Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nat Med 10:1128-32. 2004
    ..These data indicate that the JNK pathway is critically involved in diabetes and that the cell-permeable JNK-inhibitory peptide may have promise as a new therapeutic agent for diabetes...
  5. ncbi request reprint Oxidative stress and the JNK pathway as a potential therapeutic target for diabetes
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Drug News Perspect 17:447-53. 2004
    ..Taken together, oxidative stress and consequent activation of the JNK pathway are involved in progression of beta-cell dysfunction found in diabetes, and thus are a therapeutic target for diabetes...
  6. ncbi request reprint A crucial role of MafA as a novel therapeutic target for diabetes
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 280:15047-52. 2005
    ..These results suggest a crucial role of MafA as a novel therapeutic target for diabetes...
  7. ncbi request reprint Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Mol Med (Berl) 83:429-39. 2005
    ..Thus, the JNK pathway plays a central role in pathogenesis of type 2 diabetes and may be a potential target for diabetes therapy...
  8. ncbi request reprint PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes 54:1009-22. 2005
    ..Thus PDX-1/VP16 expression, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. This approach warrants further investigation and may have utility in the treatment of diabetes...
  9. ncbi request reprint Role of PDX-1 and MafA as a potential therapeutic target for diabetes
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Diabetes Res Clin Pract 77:S127-37. 2007
    ..Taken together, PDX-1 and MafA play a crucial role in inducing surrogate beta-cells and could be a therapeutic target for diabetes...
  10. ncbi request reprint Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Biochem Cell Biol 37:1595-608. 2005
    ..Thus, the c-Jun N-terminal kinase pathway plays a central role in pathogenesis of type 2 diabetes and could be a potential target for diabetes therapy...
  11. ncbi request reprint Involvement of oxidative stress in the pathogenesis of diabetes
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Antioxid Redox Signal 9:355-66. 2007
    ..Taken together, it is likely that oxidative stress and subsequent activation of the JNK pathway are involved in the pathogenesis of type 1 and type 2 diabetes...
  12. ncbi request reprint PDX-1 functions as a master factor in the pancreas
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Front Biosci 13:6406-20. 2008
    ..Thus, it is likely that alteration of such transcription factors explains, at least in part, the molecular mechanism for beta-cell glucose toxicity found in diabetes...
  13. ncbi request reprint Oxidative stress and pancreatic beta-cell dysfunction
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Ther 12:529-33. 2005
    ..Taken together, the oxidative stress-mediated activation of the JNK pathway leads to nucleocytoplasmic translocation of PDX-1 and thus is likely involved in the progression of beta-cell dysfunction found in diabetes...
  14. doi request reprint Role of MafA in pancreatic beta-cells
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Adv Drug Deliv Rev 61:489-96. 2009
    ..These results suggest that MafA plays a crucial role in pancreatic beta-cells and could be a novel therapeutic target for diabetes...
  15. ncbi request reprint Combination of MafA, PDX-1 and NeuroD is a useful tool to efficiently induce insulin-producing surrogate beta-cells
    Hideaki Kaneto
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Curr Med Chem 16:3144-51. 2009
    ..The combination of MafA, PDX-1 and NeuroD markedly induces insulin biosynthesis in various non-beta-cells and thereby is a useful tool to efficiently induce insulin-producing surrogate beta-cells...
  16. ncbi request reprint Oxidative stress and the JNK pathway are involved in the development of type 1 and type 2 diabetes
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Mol Med 7:674-86. 2007
    ..Taken together, it is likely that oxidative stress and subsequent activation of the JNK pathway are involved in the pathogenesis of type 1 and type 2 diabetes...
  17. doi request reprint Adiponectin G276T gene polymorphism is associated with cardiovascular disease in Japanese patients with type 2 diabetes
    Naoto Katakami
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Atherosclerosis 220:437-42. 2012
    ..In this study, we examined the relationship between CVD and adiponectin (ADIPOQ) gene G276T polymorphism that is associated with serum adiponectin level in a large cohort of type 2 diabetic patients...
  18. doi request reprint Serum endogenous secretory RAGE level is an independent risk factor for the progression of carotid atherosclerosis in type 1 diabetes
    Naoto Katakami
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Atherosclerosis 204:288-92. 2009
    ..The aim of the present study is to longitudinally evaluate the association between esRAGE and sRAGE levels and the progression of carotid intima-media thickness (IMT), a surrogate marker of atherosclerosis...
  19. ncbi request reprint The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation
    Dan Kawamori
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, Suita City, Japan
    J Biol Chem 281:1091-8. 2006
    ..Taken together, Foxo1 is involved in the nucleocytoplasmic translocation of PDX-1 by oxidative stress and the JNK pathway...
  20. doi request reprint Maximum carotid intima-media thickness improves the prediction ability of coronary artery stenosis in type 2 diabetic patients without history of coronary artery disease
    Yoko Irie
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Atherosclerosis 221:438-44. 2012
    ..However, it is unknown whether ultrasonic assessment of carotid atherosclerosis, including CIMT, improves the prediction ability for CAD over and above conventional coronary risk factors in the diabetic patients...
  21. ncbi request reprint Establishment of a non-invasive mouse reporter model for monitoring in vivo pdx-1 promoter activity
    Toshihiko Shiraiwa
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 361:739-44. 2007
    ..This transgenic mouse model would be useful to non-invasively monitor in vivo pdx-1 promoter activity and to screen new molecules which regulate PDX-1 expression...
  22. pmc Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes
    Taka Aki Matsuoka
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Diabetes 59:1709-20. 2010
    ..In this study, we examined the effects of c-Jun, which is known to be upregulated by ROS, on the expression of MafA under diabetic conditions...
  23. ncbi request reprint Pioglitazone reduces ER stress in the liver: direct monitoring of in vivo ER stress using ER stress-activated indicator transgenic mice
    Kazutomi Yoshiuchi
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Endocr J 56:1103-11. 2009
    ..These data indicate that pioglitazone treatment suppresses ER stress in the liver which may explain, at least in part, the pharmacological effects of pioglitazone to reduce insulin resistance...
  24. doi request reprint Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism as a potential risk factor for diabetic retinopathy in Japanese patients with type 2 diabetes
    Naoto Katakami
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Diabetes Res Clin Pract 89:e9-12. 2010
    ..The prevalence of diabetic retinopathy was higher as the number of G alleles increased, suggesting that the G allele of this polymorphism is a susceptibility allele for diabetic retinopathy...
  25. ncbi request reprint Beneficial effects of nateglinide on insulin resistance in type 2 diabetes
    Yoji Hazama
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes Res Clin Pract 71:251-5. 2006
    ..Nateglinide ameliorates insulin resistance as well as insulin secretory defects in type 2 diabetic patients...
  26. ncbi request reprint Marked increase of insulin gene transcription by suppression of the Rho/Rho-kinase pathway
    Yumiko Nakamura
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 350:68-73. 2006
    ..These results imply that Rho/Rho-kinase activation is involved in the suppression of insulin expression found in diabetes and that suppression of the Rho/Rho-kinase pathway could be a useful tool to augment insulin gene transcription...
  27. ncbi request reprint Association of serum YKL-40 levels with urinary albumin excretion rate in young Japanese patients with type 1 diabetes mellitus
    Fumie Sakamoto
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Endocr J 60:73-9. 2013
    ..YKL-40 could be a predictor to assess the risk of diabetic microangiopathy in the early stage in type 1 diabetic patients...
  28. doi request reprint Usefulness of lipoprotein ratios in assessing carotid atherosclerosis in Japanese type 2 diabetic patients
    Naoto Katakami
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Atherosclerosis 214:442-7. 2011
    ..However, there have been few reports about the usefulness of these indices for the assessment of early stage atherosclerosis in Japanese type 2 diabetic subjects...
  29. ncbi request reprint PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell function
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, Osaka, Japan
    Endocr J 55:235-52. 2008
    ..It is likely that alteration of such transcription factors explains, at least in part, the molecular mechanism for beta-cell glucose toxicity found in diabetes...
  30. pmc Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation
    Takeshi Miyatsuka
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Genes Dev 20:1435-40. 2006
    ..These results provide a mechanism of pancreatic metaplasia by which persistent PDX-1 expression cell-autonomously induces acinar-to-ductal transition through Stat3 activation...
  31. doi request reprint The utility of ultrasonic tissue characterization of carotid plaque in the prediction of cardiovascular events in diabetic patients
    Yoko Irie
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan
    Atherosclerosis 230:399-405. 2013
    ..The aim of this study was to evaluate whether non-invasive ultrasonic tissue characterization of carotid plaque using gray-scale median (GSM) can be a predictor of future cardiovascular disease (CVD) events in type 2 diabetic patients...
  32. doi request reprint Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice
    Satoshi Kawashima
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 404:534-40. 2011
    ..To examine if anti-diabetic reagents, such as insulin, pioglitazone (pio), and alogliptin (alo), have protective effects on β-cell mass and function in vivo, we treated obese diabetic db/db mice with these reagents...
  33. pmc A novel function of Onecut1 protein as a negative regulator of MafA gene expression
    Kaoru Yamamoto
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, 565 0871 Suita, Japan
    J Biol Chem 288:21648-58. 2013
    ..This study implicates the novel role of Onecut1 in the control of normal β cell differentiation and its involvement in β cell dysfunction under diabetic conditions by suppressing MafA gene expression. ..
  34. ncbi request reprint Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Japan
    Int J Biochem Cell Biol 38:782-93. 2006
    ..Thus, the c-Jun N-terminal kinase pathway plays a central role in pathogenesis of type 2 diabetes and could be a potential target for diabetes therapy...
  35. doi request reprint Endogenous secretory RAGE but not soluble RAGE is associated with carotid atherosclerosis in type 1 diabetes patients
    Naoto Katakami
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Diab Vasc Dis Res 5:190-7. 2008
    ..It is likely that circulating sRAGE and esRAGE are distinct markers and that circulating esRAGE levels, but not sRAGE levels, are associated with the status of early-stage atherosclerosis...
  36. doi request reprint Circulating soluble RAGE as a predictive biomarker of cardiovascular event risk in patients with type 2 diabetes
    Keiko Fujisawa
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Atherosclerosis 227:425-8. 2013
    ..59, 95% CI 1.04-2.45, p = 0.034), even after adjusting for conventional coronary risk factors. In summary, elevated sRAGE levels were associated with the increased risk of CVD in Japanese type 2 diabetic subjects...
  37. ncbi request reprint Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase
    Dan Kawamori
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    Diabetes 52:2896-904. 2003
    ....
  38. ncbi request reprint Involvement of endoplasmic reticulum stress in insulin resistance and diabetes
    Yoshihisa Nakatani
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 280:847-51. 2005
    ..This is the first report showing that ER stress plays a crucial role in the insulin resistance found in diabetes and thus could be a potential therapeutic target for diabetes...
  39. doi request reprint Sequential introduction and dosage balance of defined transcription factors affect reprogramming efficiency from pancreatic duct cells into insulin-producing cells
    Kazuyuki Miyashita
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Biochem Biophys Res Commun 444:514-9. 2014
    ..Further investigation should optimize the reprogramming conditions for the future cell therapy of diabetes. ..
  40. ncbi request reprint Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice
    Kazutomi Yoshiuchi
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 366:545-50. 2008
    ..In addition, our present results suggest that ERAI transgenic mice are very useful for evaluating in vivo ER stress, especially in the liver, during the development of insulin resistance...
  41. ncbi request reprint Probucol preserves pancreatic beta-cell function through reduction of oxidative stress in type 2 diabetes
    Shin ichi Gorogawa
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka Pref, Japan
    Diabetes Res Clin Pract 57:1-10. 2002
    ..05); glucose, 44.6+/-2.4 vs. 35.2+/-2.6 mmol/l (120 min, at 16 weeks; P<0.05). Thus, our present observations demonstrate the potential usefulness of probucol for treatment of type 2 diabetes...
  42. ncbi request reprint Modulation of the JNK pathway in liver affects insulin resistance status
    Yoshihisa Nakatani
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 279:45803-9. 2004
    ..Taken together, these findings suggest that suppression of the JNK pathway in liver exerts greatly beneficial effects on insulin resistance status and glucose tolerance in both genetic and dietary models of diabetes...
  43. ncbi request reprint Tissue-specific deletion of c-Jun in the pancreas has limited effects on pancreas formation
    Kaoru Yamamoto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 363:908-14. 2007
    ..Taken together, although we cannot exclude the possibility that c-Jun ablation is compensated by some unknown factors, c-Jun appears to be dispensable for pancreas development at least after ptf1a gene promoter is activated...
  44. ncbi request reprint Role of oxidative stress in pancreatic beta-cell dysfunction
    Yoshitaka Kajimoto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Ann N Y Acad Sci 1011:168-76. 2004
    ..Taken together, oxidative stress and consequent activation of the JNK pathway are involved in progression of beta-cell dysfunction found in diabetes. Antioxidants may serve as a novel mechanism-based therapy for type 2 diabetes...
  45. ncbi request reprint Possible novel index determined by the glucose clamp test for selection of a suitable therapy for each type 2 diabetic patient
    Shin ichi Gorogawa
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes Res Clin Pract 69:1-4. 2005
    ....
  46. ncbi request reprint No association of diabetic duration or insulin use with the prognosis of critical limb ischemia after endovascular therapy
    Mitsuyoshi Takahara
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 18:1102-9. 2011
    ..To examine whether diabetic duration and insulin use are independently associated with the prognosis of critical limb ischemia (CLI) after endovascular therapy...
  47. ncbi request reprint Decreased endogenous secretory advanced glycation end product receptor in type 1 diabetic patients: its possible association with diabetic vascular complications
    Naoto Katakami
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes Care 28:2716-21. 2005
    ..In the present study, we examined circulating endogenous secretory RAGE (esRAGE) levels in subjects with type 1 diabetes and explored the possible association between esRAGE levels and the severity of diabetic vascular complications...
  48. ncbi request reprint Clustering of several cardiovascular risk factors affects tissue characteristics of the carotid artery
    Naoto Katakami
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Japan
    Atherosclerosis 198:208-13. 2008
    ..898, 95%CI: 0.811-0.994, p=0.0374). These results suggest that clustering of the cardiovascular risk factors affects the Calibrated-IBS, an acoustic parameter of tissue characteristics of the intima-media complex in the carotid artery...
  49. ncbi request reprint Hepatic insulin resistance induced by chronic hindlimb ischemia
    Masahiro Hatazaki
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes Res Clin Pract 69:209-15. 2005
    ..In conclusion, chronic hindlimb ischemia impaired glucose tolerance associated with insulin resistance in the liver rather than the peripheral tissues...
  50. ncbi request reprint Glycated albumin is a better indicator for glucose excursion than glycated hemoglobin in type 1 and type 2 diabetes
    Kazutomi Yoshiuchi
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Endocr J 55:503-7. 2008
    ..28, P<0.001). In summary, GA could be a better marker for glycemic control than glycated hemoglobin in diabetic patients, especially for evaluating glycemic excursion, which is considered to be a major cause of diabetic angiopathy...
  51. ncbi request reprint MafA regulates expression of genes important to islet beta-cell function
    Taka Aki Matsuoka
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871 Japan
    Mol Endocrinol 21:2764-74. 2007
    ..The combination of PDX-1, BETA2, and MafA also induced the expression of other important regulators of islet beta-cell activity. These results support a critical role of MafA in islet beta-cell function...
  52. ncbi request reprint Combination of multiple genetic risk factors is synergistically associated with carotid atherosclerosis in Japanese subjects with type 2 diabetes
    Yoshimitsu Yamasaki
    Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Diabetes Care 29:2445-51. 2006
    ..However, the synergistic effects of SNPs have not been evaluated in detail...
  53. ncbi request reprint Predictive impact of adiponectin for detecting dysglycemia in non-fasting Japanese employees with metabolic risk factors
    Mitsuyoshi Takahara
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Endocr J 60:959-66. 2013
    ....
  54. ncbi request reprint Association of myeloperoxidase G-463A gene polymorphism with diabetic nephropathy in Japanese type 2 diabetic subjects
    Naoto Katakami
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Endocr J 60:457-71. 2013
    ..In conclusion, it is likely that the G allele of the MPO G-476T polymorphism is a susceptibility allele for renal injury in type 2 diabetic patients...
  55. ncbi request reprint Basal insulin requirements after progesterone treatment in a type 1 diabetic pregnant woman
    Shugo Sasaki
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan
    Intern Med 52:259-62. 2013
    ....
  56. doi request reprint Plasma pentraxin 3 levels are associated with carotid IMT in type 1 diabetic patients
    Naoto Katakami
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes Res Clin Pract 99:185-91. 2013
    ..The present study evaluated whether plasma PTX3 levels are associated with subclinical atherosclerosis in young subjects with type 1 diabetes...
  57. ncbi request reprint Oxidative stress and the JNK pathway in diabetes
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Diabetes Rev 1:65-72. 2005
    ..Taken together, the JNK pathway plays a crucial role in progression of insulin resistance as well as beta-cell dysfunction found in diabetes and thus could be a potential therapeutic target for diabetes...
  58. pmc Association of diabetes and hemodialysis with ankle pressure and ankle-brachial index in Japanese patients with critical limb ischemia
    Mitsuyoshi Takahara
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Diabetes Care 35:2000-4. 2012
    ....
  59. ncbi request reprint Role of copper ion in the pathogenesis of type 2 diabetes
    Ayako Tanaka
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Endocr J 56:699-706. 2009
    ..In conclusion, our present results suggest that copper ion is involved in the development of type 2 diabetes and thereby a potential therapeutic target for diabetes...
  60. ncbi request reprint Serum interleukin-18 levels are increased and closely associated with various soluble adhesion molecule levels in type 1 diabetic patients
    Naoto Katakami
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes Care 30:159-61. 2007
  61. ncbi request reprint Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice
    Shin ichi Gorogawa
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 319:1159-70. 2004
    ..Our present observations demonstrate a unique role of STAT3 in maintaining glucose-mediated early-phase insulin secretion and normal islet morphology...
  62. ncbi request reprint Ptf1a and RBP-J cooperate in activating Pdx1 gene expression through binding to Area III
    Takeshi Miyatsuka
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 362:905-9. 2007
    ..Our data suggest a novel transcriptional network, where Ptf1a and RBP-J cooperatively regulate Pdx1 gene expression through binding to Area III...
  63. doi request reprint Subclinical hypothyroidism is independently associated with albuminuria in people with type 2 diabetes
    Tetsuyuki Yasuda
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Diabetes Res Clin Pract 94:e75-7. 2011
    ..Multivariate logistic regression analyses demonstrated that serum TSH level was an independent risk factor of albuminuria...
  64. ncbi request reprint Role of pim-1 in smooth muscle cell proliferation
    Naoto Katakami
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 279:54742-9. 2004
    ....
  65. pmc Accumulation of gene polymorphisms related to plaque disruption and thrombosis is associated with cerebral infarction in subjects with type 2 diabetes
    Naoto Katakami
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Diabetes Care 33:390-5. 2010
    ..We simultaneously determined four relatively common genetic variants related to plaque rupture or subsequent local thrombus formation and evaluated the combined effect on cerebral infarction...
  66. ncbi request reprint Post-prandial hyperglycemia is an important predictor of the incidence of diabetic microangiopathy in Japanese type 2 diabetic patients
    Toshihiko Shiraiwa
    Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 336:339-45. 2005
    ..In conclusion, post-prandial hyperglycemia, rather than fasting glycemia or hemoglobin A1c levels, is an important predictor of the incidence of diabetic microangiopathy in Japanese type 2 diabetic patients...
  67. ncbi request reprint The impact of new-onset diabetes on arterial stiffness after renal transplantation
    Ken Kato
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Japan
    Endocr J 55:677-83. 2008
    ..Since NODAT patients have advanced arterial stiffness probably due to high blood pressure, strict control of blood pressure will be important for preventing the development of cardiovascular disease in NODAT...
  68. pmc Basal insulin requirement is ~30% of the total daily insulin dose in type 1 diabetic patients who use the insulin pump
    Akio Kuroda
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Diabetes Care 34:1089-90. 2011
    ..To investigate the basal insulin requirement in total daily insulin dose in Japanese type 1 diabetic patients who use the insulin pump...
  69. ncbi request reprint Efficacy of sitagliptin on blood glucose fluctuation in Japanese type 2 diabetic patients with basal-supported oral therapy
    Mitsuyoshi Takahara
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Endocr J 59:1131-6. 2012
    ..47). In conclusion, blood glucose fluctuation was significantly improved two months after adding sitagliptin and tapering glimepiride in type 2 diabetic Japanese patients who were treated by BOT with insulin glargine and glimepiride...
  70. doi request reprint Accumulation of gene polymorphisms related to oxidative stress is associated with myocardial infarction in Japanese type 2 diabetic patients
    Naoto Katakami
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Atherosclerosis 212:534-8. 2010
    ..We simultaneously determined 5 relatively common genetic variants related to oxidative stress and evaluated the combined effect on MI...
  71. ncbi request reprint Development of beta-cells in the native pancreas after pancreas allo-transplantation in the Spontaneously Diabetic Torii rat
    Kazunori Shimada
    Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    J Surg Res 145:229-37. 2008
    ..In this study, we evaluated the effect of fully allogeneic PTx (allo-PTx) under immunosuppression on the native pancreases in the recipients...
  72. pmc Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis
    Hideaki Kaneto
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mediators Inflamm 2010:453892. 2010
    ..Taken together, it is likely that ROS play an important role in the development of type 2 diabetes and atherosclerosis...
  73. ncbi request reprint Is central obesity a good predictor of carotid atherosclerosis in Japanese type 2 diabetes with metabolic syndrome?
    Tetsuyuki Yasuda
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Endocr J 54:695-702. 2007
    ....
  74. doi request reprint YKL-40, a new biomarker of endothelial dysfunction, is independently associated with albuminuria in type 2 diabetic patients
    Tetsuyuki Yasuda
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes Res Clin Pract 91:e50-2. 2011
    ..Multivariate logistic regression analyses demonstrated that serum YKL-40 level was a determinant of albuminuria independently of conventional risk factors...
  75. ncbi request reprint Association of coronary artery stenosis with carotid atherosclerosis in asymptomatic type 2 diabetic patients
    Yoko Irie
    Osaka Police Hospital, 10 31 Kitayama cho, Osaka, Japan
    J Atheroscler Thromb 18:337-44. 2011
    ..This study aimed to evaluate the association between coronary artery stenosis assessed by coronary computed tomography angiography (CCTA) and intima-media thickness (IMT) in asymptomatic type 2 diabetic patients...
  76. pmc The influence of glycemic control on the prognosis of Japanese patients undergoing percutaneous transluminal angioplasty for critical limb ischemia
    Mitsuyoshi Takahara
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Diabetes Care 33:2538-42. 2010
    ..To reveal the influence of preoperative factors on the prognosis of patients undergoing percutaneous transluminal angioplasty (PTA) for critical limb ischemia (CLI)...
  77. pmc Relationship between carotid intima-media thickness and the presence and extent of coronary stenosis in type 2 diabetic patients with carotid atherosclerosis but without history of coronary artery disease
    Ryuuichi Kasami
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Diabetes Care 34:468-70. 2011
    ..We examined the relationship between the presence and extent of coronary stenosis and carotid intima-media thickness (CIMT) in type 2 diabetic patients without history of coronary artery disease (CAD) but with carotid atherosclerosis...
  78. ncbi request reprint Association of soluble epoxide hydrolase gene polymorphism with insulin resistance in type 2 diabetic patients
    Kentaro Ohtoshi
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 331:347-50. 2005
    ..These results suggest that sEH and EDHF play some important role in the pathogenesis of insulin resistance found in type 2 diabetes...
  79. ncbi request reprint Transcription factors as therapeutic targets for diabetes
    Takeshi Miyatsuka
    Osaka University Graduate School of Medicine, Department of Internal Medicine and Therapeutics, 2 2 Yamadaoka, Suita 565 0871, Osaka, Japan
    Expert Opin Ther Targets 12:1431-42. 2008
    ..Understanding how pancreatic beta-cells are generated during pancreas development will provide information that can be applied to generating surrogate beta-cells...
  80. ncbi request reprint [Insulin resistance in pancreatic beta-cells: possible implication in beta-cell glucose toxicity]
    Hideaki Kaneto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
    Nihon Rinsho 64:203-11. 2006
  81. doi request reprint Effects of glimepiride and glibenclamide on carotid atherosclerosis in type 2 diabetic patients
    Naoto Katakami
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Diabetes Res Clin Pract 92:e20-2. 2011
    ..044±0.171 mm/year vs. 0.077±0.203 mm/year, p=0.0474)...
  82. doi request reprint Increased serum pigment epithelium-derived factor levels in type 1 diabetic patients with diabetic retinopathy
    Naoto Katakami
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes Res Clin Pract 81:e4-7. 2008
    ..38+/-3.87 microg/ml) compared to the patients without it (n=57, 7.68+/-2.80 microg/ml) (p=0.0013). Elevated PEDF levels may be related to the progression of diabetic retinopathy...
  83. ncbi request reprint Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the phosphatidylinositol 3-kinase/Akt pathway in vascular endothelial cells
    Tomoaki Murakami
    Department of Ophthalmology and Visual Sciences Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 280:31841-9. 2005
    ..These results demonstrated that Ang1 attenuates H2O2-induced SEK1/JNK phosphorylation through the PI 3-kinase/Akt pathway and inhibits the apoptosis of endothelial cells to oxidative stress...
  84. ncbi request reprint NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes
    Shigeru Yatoh
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes Metab Res Rev 23:239-49. 2007
    ..Our goal was to convert adult mouse hepatocytes to pancreatic beta-cells...
  85. ncbi request reprint Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression
    Hideaki Kaneto
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 277:30010-8. 2002
    ..In conclusion, activation of JNK is involved in the reduction of insulin gene expression by oxidative stress, and suppression of the JNK pathway protects beta-cells from oxidative stress...
  86. ncbi request reprint Endogenous secretory receptor for advanced glycation end product levels are inversely associated with HbA1c in type 2 diabetic patients
    Naoto Katakami
    Diabetes Care 29:469. 2006
  87. ncbi request reprint Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells
    Hideaki Kaneto
    Section on Islet Transplantation and Cell Biology and Section on Vascular Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 277:3680-5. 2002
    ..These results suggest that at least some of the reduction of insulin gene transcription found in the diabetic state is mediated by PKC beta2 regulation of c-myc expression...
  88. ncbi request reprint Postprandial hyperglycemia is a better predictor of the progression of diabetic retinopathy than HbA1c in Japanese type 2 diabetic patients
    Toshihiko Shiraiwa
    Diabetes Care 28:2806-7. 2005
  89. pmc The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance
    Cullen M Taniguchi
    Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Mol Cell Biol 27:2830-40. 2007
    ..Thus, p85alpha plays a dual role in regulating insulin sensitivity and may mediate cross talk between the PI3K and stress kinase pathways...
  90. ncbi request reprint Serum endogenous secretory RAGE levels are inversely associated with carotid IMT in type 2 diabetic patients
    Naoto Katakami
    Atherosclerosis 190:22-3. 2007
  91. ncbi request reprint Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology
    Hirofumi Noguchi
    Diabetes Research Institute Japan, Toyoake, Aichi 470 1192, Japan
    Cell Transplant 15:929-38. 2006
    ..These data suggest that the overexpression of transcription factors, especially NeuroD, facilitates pancreatic stem/progenitor cell differentiation into insulin-producing cells...
  92. ncbi request reprint Lipid-lowering with atorvastatin improves tissue characteristics of carotid plaque
    Naoto Katakami
    Atherosclerosis 183:369-71. 2005
  93. doi request reprint Dramatic improvement of subcutaneous insulin resistance with nafamostat ointment treatment
    Satoshi Kawashima
    Diabetes Care 31:e11. 2008
  94. ncbi request reprint Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner
    Ryo Suzuki
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 278:43691-8. 2003
    ....
  95. ncbi request reprint PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells
    Hirofumi Noguchi
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 52:1732-7. 2003
    ....
  96. ncbi request reprint Induction of Mad expression leads to augmentation of insulin gene transcription
    Giovanni Patanè
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, MA 02215, USA
    Biochem Biophys Res Commun 303:1199-208. 2003
    ..Such regulation of insulin expression by Mad with modulation of PDX-1 expression and DNA binding activity could offer useful therapeutic and/or experimental tools to promote insulin production in appropriate cell types...
  97. ncbi request reprint Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes
    D Ross Laybutt
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 51:1793-804. 2002
    ....
  98. ncbi request reprint Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation
    Hideaki Kaneto
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    J Biol Chem 277:12998-3006. 2002
    ..This mechanism may explain some of the beta-cell dysfunction found in diabetes...