Hirotsugu Iwatani

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. doi request reprint Quantitative change of IgA hinge O-glycan composition is a novel marker of therapeutic responses of IgA nephropathy
    Hirotsugu Iwatani
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 428:339-42. 2012
  2. doi request reprint Microarray analysis of tonsils of IgA nephropathy patients
    Hirotsugu Iwatani
    Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan
    Adv Otorhinolaryngol 72:75-8. 2011
  3. ncbi request reprint Kidney repair using stem cells: myth or reality as a therapeutic option?
    Hirotsugu Iwatani
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka Japan
    J Nephrol 23:143-6. 2010
  4. doi request reprint Urinary type IV collagen in nondiabetic kidney disease
    Yoshiyuki Furumatsu
    Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Nephron Clin Pract 117:c160-6. 2011
  5. doi request reprint Gene polymorphisms contributing to hypertension in immunoglobulin A nephropathy
    Maki Shinzawa
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Clin Exp Nephrol 16:250-8. 2012
  6. doi request reprint Microarray analysis of tonsils in immunoglobulin A nephropathy patients
    Kenichiro Iio
    Department of Geriatric Medicine and Nephrology, Osaka University, Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 393:565-70. 2010
  7. ncbi request reprint Hematopoietic and nonhematopoietic potentials of Hoechst(low)/side population cells isolated from adult rat kidney
    Hirotsugu Iwatani
    Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Suita, Osaka, Japan
    Kidney Int 65:1604-14. 2004
  8. doi request reprint Specialist care and improved long-term survival of dialysis patients
    Yoshiyuki Furumatsu
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Nephrol Dial Transplant 25:1930-5. 2010
  9. doi request reprint Pharmacokinetics of olmesartan medoxomil in hemodialysis patients: little effect of dialysis upon its pharmacokinetics
    Hirotaka Tanaka
    Department of Nephrology, Osaka University Graduate School of Medicine, B6 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Clin Exp Nephrol 13:61-5. 2009
  10. doi request reprint ACE insertion/deletion polymorphism (rs1799752) modifies the renoprotective effect of renin-angiotensin system blockade in patients with IgA nephropathy
    Junya Teranishi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Japan
    J Renin Angiotensin Aldosterone Syst 16:633-41. 2015

Collaborators

Detail Information

Publications33

  1. doi request reprint Quantitative change of IgA hinge O-glycan composition is a novel marker of therapeutic responses of IgA nephropathy
    Hirotsugu Iwatani
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 428:339-42. 2012
    ..Finally, the quantitative change of O-glycan composition is a novel marker of therapeutic response of IgAN...
  2. doi request reprint Microarray analysis of tonsils of IgA nephropathy patients
    Hirotsugu Iwatani
    Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan
    Adv Otorhinolaryngol 72:75-8. 2011
    ..The downregulated genes include the polymeric Ig receptor (pIgR) which was reportedly involved in single nucleotide polymorphism (SNP) of Japanese IgAN patients...
  3. ncbi request reprint Kidney repair using stem cells: myth or reality as a therapeutic option?
    Hirotsugu Iwatani
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka Japan
    J Nephrol 23:143-6. 2010
    ..The origin, localization and role of kidney stem cells are under investigation. We also discuss potential applications of embryonic stem cells and induced pluripotent stem cells in kidney regeneration...
  4. doi request reprint Urinary type IV collagen in nondiabetic kidney disease
    Yoshiyuki Furumatsu
    Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Nephron Clin Pract 117:c160-6. 2011
    ..However, in nondiabetic kidney disease, urinary type IV collagen (u-IVc) levels have not been extensively investigated. The aim of this study was to evaluate u-IVc levels in various nephropathies except diabetic nephropathy...
  5. doi request reprint Gene polymorphisms contributing to hypertension in immunoglobulin A nephropathy
    Maki Shinzawa
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Clin Exp Nephrol 16:250-8. 2012
    ..Identification of the genetic factor contributing to hypertension in patients with chronic kidney disease may potentially refine a therapeutic strategy...
  6. doi request reprint Microarray analysis of tonsils in immunoglobulin A nephropathy patients
    Kenichiro Iio
    Department of Geriatric Medicine and Nephrology, Osaka University, Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 393:565-70. 2010
    ..However, the gene expression difference between the tonsils in patients with IgAN and those in control patients is not established...
  7. ncbi request reprint Hematopoietic and nonhematopoietic potentials of Hoechst(low)/side population cells isolated from adult rat kidney
    Hirotsugu Iwatani
    Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Suita, Osaka, Japan
    Kidney Int 65:1604-14. 2004
    ..Although the regenerative stem cell is expected to exist in many adult tissues, the cell contributing to the regeneration of the kidney remains unknown in its type and origin...
  8. doi request reprint Specialist care and improved long-term survival of dialysis patients
    Yoshiyuki Furumatsu
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Nephrol Dial Transplant 25:1930-5. 2010
    ..We sought to determine whether specialist care can actually be associated with better survival rates in a nationwide Japanese dialysis cohort...
  9. doi request reprint Pharmacokinetics of olmesartan medoxomil in hemodialysis patients: little effect of dialysis upon its pharmacokinetics
    Hirotaka Tanaka
    Department of Nephrology, Osaka University Graduate School of Medicine, B6 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Clin Exp Nephrol 13:61-5. 2009
    ..This result suggests that plasma concentration of olmesartan medoxomil does not decrease during hemodialysis, and that it is not necessary to change prescription on hemodialysis day or not...
  10. doi request reprint ACE insertion/deletion polymorphism (rs1799752) modifies the renoprotective effect of renin-angiotensin system blockade in patients with IgA nephropathy
    Junya Teranishi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Japan
    J Renin Angiotensin Aldosterone Syst 16:633-41. 2015
    ..Little is known about genetic predictors that modify the renoprotective effect of renin-angiotensin system (RAS) blockade in IgA nephropathy (IgAN)...
  11. pmc IFI27 Is a Useful Genetic Marker for Diagnosis of Immunoglobulin A Nephropathy and Membranous Nephropathy Using Peripheral Blood
    Yasuyuki Nagasawa
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    PLoS ONE 11:e0153252. 2016
    ..Based on these results, we propose that IFI27 could serve as a noninvasive diagnostic marker for CGNs using peripheral blood. ..
  12. ncbi request reprint [Successful treatment of MPO-ANCA associated glomerulonephritis with high dose intravenous immunoglobulin]
    Tomoko Namba
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka
    Nihon Naika Gakkai Zasshi 94:1402-5. 2005
  13. ncbi request reprint Platelet-derived growth factor plays a critical role to convert bone marrow cells into glomerular mesangial-like cells
    Akira Suzuki
    Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Suita, Osaka, Japan
    Kidney Int 65:15-24. 2004
    ....
  14. ncbi request reprint E-cadherin and claudin-4 expression has circadian rhythm in adult rat kidney
    Masafumi Yamato
    Department of Geriatrics and Nephrology, Osaka University School of Medicine, Suita, Osaka, Japan
    J Nephrol 23:102-10. 2010
    ..Urinary sodium excretion varies during the day. It is unknown whether expression levels of cell-cell junctions in the kidney are dynamic and associated with urinary sodium excretion...
  15. ncbi request reprint Fetal cells in mother rats contribute to the remodeling of liver and kidney after injury
    Yu Wang
    Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Suita, Osaka, Japan
    Biochem Biophys Res Commun 325:961-7. 2004
    ..These results indicate that fetal cells are engrafted to maternal hematopoietic system without apparent injury and they also contribute to the repairing process of maternal liver and kidney...
  16. doi request reprint Cigarette smoking and progression of IgA nephropathy
    Ryohei Yamamoto
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Kidney Dis 56:313-24. 2010
    ..However, little information is available about an effect of cigarette smoking on progression of primary kidney diseases, including immunoglobulin A (IgA) nephropathy...
  17. doi request reprint Magnesium modifies the association between serum phosphate and the risk of progression to end-stage kidney disease in patients with non-diabetic chronic kidney disease
    Yusuke Sakaguchi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Kidney Int 88:833-42. 2015
    ..Thus, magnesium may act protectively against phosphate-induced kidney injury...
  18. doi request reprint CD16+CD56+ cells are a potential culprit for hematuria in IgA nephropathy
    Hirotsugu Iwatani
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Clin Exp Nephrol 19:216-24. 2015
    ..Hematuria is the first manifestation of urinary abnormality in immunoglobulin A nephropathy (IgAN). Hematuria has recently been reported as a risk factor for deterioration of renal function; however, its cause remains unknown...
  19. pmc Periodontal disease bacteria specific to tonsil in IgA nephropathy patients predicts the remission by the treatment
    Yasuyuki Nagasawa
    Department of Geriatric Medicine and Nephrology, Osaka University, Graduate School of Medicine, Yamada oka, Suita, Osaka, Japan Division of Kidney and Dialysis, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa cho, Nishinomiya, Japan
    PLoS ONE 9:e81636. 2014
    ..Moreover, these bacteria specific to IgAN might be candidate for the indicator which can predict the remission of IgAN treated by the combination of tonsillectomy and steroid pulse...
  20. doi request reprint Early plasma exchange for progressive liver failure in recipients of adult-to-adult living-related liver transplants
    Ryohei Yamamoto
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Blood Purif 28:40-6. 2009
    ..The aims of the present study were to evaluate the effectiveness of plasma exchange and discuss its indication...
  21. ncbi request reprint Integrated therapies including erythropoietin decrease the incidence of dialysis: lessons from mapping the incidence of end-stage renal disease in Japan
    Yoshiyuki Furumatsu
    Department of Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka A8, Suita City, Osaka 565 0871, Japan
    Nephrol Dial Transplant 23:984-90. 2008
    ..In order to test the hypothesis that the usage of EPO in predialysis CKD patients may ameliorate the progression of renal disease, we conducted a macro-level observational study dealing with all Japanese predialysis CKD patients...
  22. doi request reprint Assessment of coronary stenosis by a 16-slice MDCT scanner in asymptomatic diabetic patients starting dialysis therapy
    Kenichiro Iio
    Department of Nephrology, Izumisano Municipal Hospital, Rinku General Medical Center, Izumisano, Japan
    Nephron Clin Pract 109:c72-9. 2008
    ..The accuracy for the detection of coronary stenosis by multidetector row computed tomography (MDCT) has been getting more recognition. However, the usefulness of MDCT in patients with chronic kidney disease (CKD) has not been confirmed...
  23. doi request reprint Deficiency of N-acetylgalactosamine in O-linked oligosaccharides of IgA is a novel biologic marker for Crohn's disease
    Takahiro Inoue
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Inflamm Bowel Dis 18:1723-34. 2012
    ..We have reported that alteration of N-linked oligosaccharides of immunoglobulin (Ig) G is a novel diagnostic marker of IBD. Oligosaccharide alterations of IgA, however, have not been investigated in IBD patients...
  24. doi request reprint Self-reported sleep duration and prediction of proteinuria: a retrospective cohort study
    Ryohei Yamamoto
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Kidney Dis 59:343-55. 2012
    ..Although multiple studies have shown that sleep duration is a predictor of cardiovascular diseases and mortality, few studies have reported an association between sleep duration and chronic kidney disease...
  25. doi request reprint Kid-1 participates in regulating ERK phosphorylation as a part of the circadian clock output in rat kidney
    Masaya Yamato
    Department of Geriatrics and Nephrology, Osaka University School of Medicine, Suita, Japan
    J Recept Signal Transduct Res 29:94-9. 2009
    ..The data suggest that clock-controlled Kid-1 regulates the cell cycle of proliferating renal tubular epithelial cells through ERK phosphorylation...
  26. doi request reprint Valvular injury in a patient with PR3-ANCA-associated glomerulonephritis
    Hirotsugu Iwatani
    Osaka Kosei Nenkin Hospital, Osaka, Japan
    Nat Clin Pract Nephrol 4:576-82. 2008
    ..Management Immunosuppressants and corticosteroids...
  27. doi request reprint Urine osmolarity predicts the body weight-reduction response to tolvaptan in chronic kidney disease patients: a retrospective, observational study
    Hirotsugu Iwatani
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Nephron 130:8-12. 2015
    ..The aim of this study was to investigate whether urine osmolarity predicts the effect of tolvaptan in patients with decreased renal function...
  28. doi request reprint Minimal Change Nephrotic Syndrome Which Was Most Likely Caused by Chronic Sinusitis
    Hirotsugu Iwatani
    Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Japan
    Intern Med 54:2373-5. 2015
    ..Therefore, we herein report the first case of MCNS that attained complete remission following therapy for chronic sinusitis alone, which suggests a strong etiology of chronic sinusitis for MCNS. ..
  29. doi request reprint Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats
    Isao Matsui
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Physiol Renal Physiol 304:F751-60. 2013
    ..Our findings suggest that tubular luminal fetuin-A works as a natural inhibitor against calcification in the proximal tubules under PTH-loaded condition...
  30. ncbi request reprint Activation of the signal transducer and activator of transcription signaling pathway in renal proximal tubular cells by albumin
    Hideaki Nakajima
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    J Am Soc Nephrol 15:276-85. 2004
    ....
  31. ncbi request reprint A case of Wegener's granulomatosis with pulmonary bleeding successfully treated with double filtration plasmapheresis (DFPP)
    Hirotsugu Iwatani
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine A8, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Clin Exp Nephrol 8:369-74. 2004
    ..He rapidly entered remission after assistance through DFPP, suggesting the potential efficacy of DFPP for Wegener's granulomatosis, especially with pulmonary bleeding...
  32. ncbi request reprint Exacerbation of albuminuria and renal fibrosis in subtotal renal ablation model of adiponectin-knockout mice
    Koji Ohashi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Arterioscler Thromb Vasc Biol 27:1910-7. 2007
    ..In this study, we investigated the role of adiponectin for kidney disease in a subtotal nephrectomized mouse model...
  33. ncbi request reprint Retinoids regulate the repairing process of the podocytes in puromycin aminonucleoside-induced nephrotic rats
    Akira Suzuki
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Am Soc Nephrol 14:981-91. 2003
    ..The results obtained from PAN nephrosis rats might be applicable to human renal diseases...