Masao Imaizumi

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Detection of misery perfusion with split-dose 123I-iodoamphetamine single-photon emission computed tomography in patients with carotid occlusive diseases
    Masao Imaizumi
    Division of Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Stroke 33:2217-23. 2002
  2. ncbi request reprint Clinical significance of cerebrovascular reserve in acetazolamide challenge -comparison with acetazolamide challenge H2O-PET and Gas-PET
    Masao Imaizumi
    Division of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Japan
    Ann Nucl Med 18:369-74. 2004
  3. doi request reprint Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET: a validation study in ex vivo rat brain
    Masao Imaizumi
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Japan
    Jpn J Radiol 27:252-6. 2009
  4. ncbi request reprint Spectral analysis of 99mTc-HMPAO for estimating cerebral blood flow: a comparison with H2(15)O PET
    Masashi Takasawa
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Japan
    Ann Nucl Med 18:243-9. 2004
  5. ncbi request reprint Statistical image analysis of cerebral blood flow in vascular dementia with small-vessel disease
    Takuya Yoshikawa
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine A8, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    J Nucl Med 44:505-11. 2003
  6. doi request reprint Statistical parametric analysis of cerebral blood flow in vascular dementia with small-vessel disease using Tc-HMPAO SPECT
    Hiroki Kato
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Japan
    Cerebrovasc Dis 26:556-62. 2008
  7. ncbi request reprint Interobserver variability of cerebral blood flow measurements obtained using spectral analysis and technetium-99m labeled compounds
    Masashi Takasawa
    Division of Strokology, Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Ann Nucl Med 17:255-9. 2003
  8. ncbi request reprint Diastolic blood pressure influences cerebrovascular reactivity measured by means of 123I-iodoamphetamine brain single photon emission computed tomography in medically treated patients with occlusive carotid or middle cerebral artery disease
    Yasuyuki Kimura
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, D9, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Ann Nucl Med 20:209-15. 2006
  9. ncbi request reprint Quantification of the heterogeneity of cerebral blood flow in vascular dementia
    Takuya Yoshikawa
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine A8, 2 2, Yamadaoka, Suita City, Osaka, 565 0871, Japan
    J Neurol 250:194-200. 2003
  10. ncbi request reprint Cerebral hemodynamics and metabolism in adult moyamoya disease: comparison of angiographic collateral circulation
    Rishu Piao
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Ann Nucl Med 18:115-21. 2004

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Detection of misery perfusion with split-dose 123I-iodoamphetamine single-photon emission computed tomography in patients with carotid occlusive diseases
    Masao Imaizumi
    Division of Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Stroke 33:2217-23. 2002
    ..In clinical practice, the detection of patients with misery perfusion through the use of widely available, noninvasive, and cost-effective modalities such as single-photon emission computed tomography (SPECT) is extremely important...
  2. ncbi request reprint Clinical significance of cerebrovascular reserve in acetazolamide challenge -comparison with acetazolamide challenge H2O-PET and Gas-PET
    Masao Imaizumi
    Division of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Japan
    Ann Nucl Med 18:369-74. 2004
    ..However, how precisely ACZ reflects cerebral hemodynamic impairment remains obscure. The present study aims to clarify the pathological significance of CVR in patients with occluded carotid arteries...
  3. doi request reprint Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET: a validation study in ex vivo rat brain
    Masao Imaizumi
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Japan
    Jpn J Radiol 27:252-6. 2009
    ..The present study aimed to test the possibility of simultaneous imaging with PET and magnetic resonance imaging (MRI) by means of the present PET device in ex vivo rat brain...
  4. ncbi request reprint Spectral analysis of 99mTc-HMPAO for estimating cerebral blood flow: a comparison with H2(15)O PET
    Masashi Takasawa
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Japan
    Ann Nucl Med 18:243-9. 2004
    ..The SA method should be especially useful for activation studies involving pharmacological intervention and/or clinical cases with an increased CBF...
  5. ncbi request reprint Statistical image analysis of cerebral blood flow in vascular dementia with small-vessel disease
    Takuya Yoshikawa
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine A8, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    J Nucl Med 44:505-11. 2003
    ..We then evaluated the clinical validity of these techniques for the imaging diagnosis of VaD...
  6. doi request reprint Statistical parametric analysis of cerebral blood flow in vascular dementia with small-vessel disease using Tc-HMPAO SPECT
    Hiroki Kato
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Japan
    Cerebrovasc Dis 26:556-62. 2008
    ..It still remains unclear, however, whether SVD may present with localized regional cerebral blood flow (rCBF) changes. We aimed to clarify the local rCBF changes associated with dementia in patients with early-stage SVD...
  7. ncbi request reprint Interobserver variability of cerebral blood flow measurements obtained using spectral analysis and technetium-99m labeled compounds
    Masashi Takasawa
    Division of Strokology, Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Ann Nucl Med 17:255-9. 2003
    ..Measurements carried out by two observers using both SA and GA exhibited a similar degree of interobserver variability. SA appears to have a satisfactory interobserver variability and may be more suitable for clinical applications...
  8. ncbi request reprint Diastolic blood pressure influences cerebrovascular reactivity measured by means of 123I-iodoamphetamine brain single photon emission computed tomography in medically treated patients with occlusive carotid or middle cerebral artery disease
    Yasuyuki Kimura
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, D9, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Ann Nucl Med 20:209-15. 2006
    ..In these patients, we investigated the possible relationship between the interval change in CVR and that in systemic blood pressure (BP)...
  9. ncbi request reprint Quantification of the heterogeneity of cerebral blood flow in vascular dementia
    Takuya Yoshikawa
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine A8, 2 2, Yamadaoka, Suita City, Osaka, 565 0871, Japan
    J Neurol 250:194-200. 2003
    ..In this study, we applied three-dimensional fractal analysis (3D-FA) to CBF SPECT images as a method for assessing the heterogeneity of the cerebral blood flow distribution in VaD...
  10. ncbi request reprint Cerebral hemodynamics and metabolism in adult moyamoya disease: comparison of angiographic collateral circulation
    Rishu Piao
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Ann Nucl Med 18:115-21. 2004
    ..The aim of the present study was to evaluate the hemodynamic and metabolic status in relation to the development of basal moyamoya vessels (BMVs)...
  11. ncbi request reprint Neural mechanism of residual inhibition of tinnitus in cochlear implant users
    Yasuhiro Osaki
    Department of Otorhinolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Japan
    Neuroreport 16:1625-8. 2005
    ..No significant activation was observed in the normal controls. Our results suggest that tinnitus and residual inhibition are related to cortical networks of auditory higher-order processing, memory and attention...
  12. ncbi request reprint Automatic determination of brain perfusion index for measurement of cerebral blood flow using spectral analysis and 99mTc-HMPAO
    Masashi Takasawa
    Division of Strokology, Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita City, Japan
    Eur J Nucl Med Mol Imaging 29:1443-6. 2002
    ..21 x-0.0075, r=0.800). Our results suggest that this automatic SA method provides an accurate estimate of BPI that can be used for the quantification of CBF using (99m)Tc-HMPAO SA...
  13. ncbi request reprint Critical analysis of hemodynamic insufficiency by head-up tilt in patients with carotid occlusive disease
    Manabu Sakaguchi
    Division of Strokology, Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Circ J 69:971-5. 2005
    ....
  14. ncbi request reprint Assessment of acetazolamide reactivity in cerebral blood flow using spectral analysis and technetium-99m hexamethylpropylene amine oxime
    Masashi Takasawa
    Division of Strokology, Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Japan
    J Cereb Blood Flow Metab 22:1004-9. 2002
    ..3 +/- 6.5% according to the BPIG values. These results suggest that the spectral analysis of 99mTc-HMPAO-generated data yields a more reliable BPI than GA for the quantification of CBF after acetazolamide administration...
  15. ncbi request reprint Hemodynamic influences of losartan on the brain in hypertensive patients
    Naohiko Oku
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan
    Hypertens Res 28:43-9. 2005
    ..The inclusion of losartan in anti-hypertensive regimens could be advantageous for cerebral circulation in patients with essential hypertension...
  16. ncbi request reprint Heterogeneity of cerebral blood flow in Alzheimer disease and vascular dementia
    Takuya Yoshikawa
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    AJNR Am J Neuroradiol 24:1341-7. 2003
    ..We examined the usefulness of 3D fractal analysis of CBF SPECT images to objectively quantify the heterogeneity of CBF in patients with AD and VaD...
  17. doi request reprint Simultaneous PET/MR body imaging in rats: initial experiences with an integrated PET/MRI scanner
    Mitsuaki Tatsumi
    Department of Nuclear Medicine, Osaka University Graduate School of Medicine, 2 2 D9 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Ann Nucl Med 26:444-9. 2012
    ..The purpose of this study was to report results of simultaneous PET/MRI of a rat body using this scanner with some radiotracers...
  18. ncbi request reprint Cerebral and cerebellar activation in power and precision grip movements: an H2 15O positron emission tomography study
    Masashi Takasawa
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan
    J Cereb Blood Flow Metab 23:1378-82. 2003
    ..Our findings indicate no difference in brain activation between the acts of power grip and precision grip without a target object...
  19. doi request reprint Diagnostic performance of fluorodeoxyglucose positron emission tomography/magnetic resonance imaging fusion images of gynecological malignant tumors: comparison with positron emission tomography/computed tomography
    Kazuya Nakajo
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Jpn J Radiol 28:95-100. 2010
    ..We compared the diagnostic accuracy of fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and PET/magnetic resonance imaging (MRI) fusion images for gynecological malignancies...
  20. ncbi request reprint Cortical processing of tactile language in a postlingually deaf-blind subject
    Yasuhiro Osaki
    Department of Otorhinolaryngology, Osaka University School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neuroreport 15:287-91. 2004
    ..Our results demonstrated that the deaf-blind subject is heavily involved in interpreting tactile language by enhancing cortical activation of cognitive and semantic processing...
  21. doi request reprint Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice
    Kazuhiro Nakatani
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Metabolism 64:1165-74. 2015
    ..The aims of the current study were to investigate the myocardial uptake of glucose and alterations in myocardial metabolites in wild-type (WT) and CD36 knockout (KO) mice...
  22. pmc Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, 31 Center Drive, MSC 2035, Bethesda, MD 20892 2035, USA
    Neuroimage 40:43-52. 2008
    ..In conclusion, with the exception of those subjects who appeared to have no PBR binding, [(11)C]PBR28 is a promising ligand to quantify PBRs and localize inflammation associated with increased densities of PBRs...
  23. ncbi request reprint In vivo and in vitro measurement of brain phosphodiesterase 4 in rats after antidepressant administration
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Synapse 61:78-86. 2007
    ..g., continuous infusion vs. intermittent injection of antidepressant) in large brain areas. However, the results do not deny possibility of changes in discrete areas, which were not studied in the current study applying PET...
  24. ncbi request reprint Quantification of brain phosphodiesterase 4 in rat with (R)-[11C]Rolipram-PET
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neuroimage 26:1201-10. 2005
    ..Phosphodiesterase 4 (PDE4) catabolizes the second messenger 3', 5'-cyclic adenosine monophosphate and may play a critical role in brain diseases. Our aim was to quantify PDE4 in rats with positron emission tomography (PET)...
  25. ncbi request reprint Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation
    Amira K Brown
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 2035, USA
    J Nucl Med 48:2072-9. 2007
    ..The aim of this study was to estimate the human radiation doses of (11)C-PBR28 based on biodistribution data in monkeys and humans. In addition, we scanned 1 human subject who fortuitously behaved as if he lacked the PBR binding protein...
  26. ncbi request reprint Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain
    Masao Imaizumi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2035, USA
    Synapse 61:595-605. 2007
    ..A critical factor for human use will be whether the tracer has adequately fast wash out from brain relative to the half-life of the radionuclide to obtain stable values of distribution volume...
  27. ncbi request reprint Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo
    Emmanuelle Briard
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Med Chem 51:17-30. 2008
    ..11)C] 3 and [ (11)C] 10 are effective for imaging PBR in monkey brain. [ (11)C] 10 especially warrants further evaluation in human subjects...
  28. ncbi request reprint PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat
    Masao Imaizumi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neurosci Lett 411:200-5. 2007
    ..In this first study to demonstrate neuroinflammation in vivo with small animal PET, [11C]PBR28 had adequate sensitivity to localize and quantify the associated increase in PBRs...
  29. ncbi request reprint PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements
    Sami S Zoghbi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 47:520-7. 2006
    ....
  30. pmc Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors
    Masao Imaizumi
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bldg 31, Rm B2B37, 31 Center Drive, MSC 2035, Bethesda, MD 20892 2035, USA
    Neuroimage 39:1289-98. 2008
    ..The objectives of the current study were to evaluate kinetics of brain uptake, and the influence of the peripheral binding on the arterial input function in rhesus monkey...