Okinawa Institute of Science and Technology
Organization: Okinawa Institute of Science and Technology
- A single amino-acid change in ERK1/2 makes the enzyme susceptible to PP1 derivativesShogo Endo
Unit for Molecular Neurobiology of Learning and Memory, Initial Research Project, Okinawa Institute of Science and Technology, Uruma, Japan
Biochem Biophys Res Commun 341:261-5. 2006..These results suggest that the Gln residue of subdomain V is important in determining the susceptibility of ERK1/2 to 1NA-PP1 without significant changes in their enzymatic characteristics...
- Synaptic plasticity in the basal gangliaJeffery R Wickens
Neurobiology Research Unit, Okinawa Institute of Science and Technology, Initial Research Project, 12 22 Suzaki, Uruma, Okinawa 904 2234, Japan
Behav Brain Res 199:119-28. 2009..Of particular interest is the question of how to link the molecular and cellular mechanisms of synaptic plasticity to learning operations at the systems level, which are expressed behaviourally as reinforcement-related learning...
- Patterns and pauses in Purkinje cell simple spike trains: experiments, modeling and theoryE De Schutter
Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Japan Theoretical Neurobiology, University of Antwerp, Belgium
Neuroscience 162:816-26. 2009..Conversely, the regular spike patterns may be a rate code, which presets the amplitude of future rebound bursts...
- Vesicular glutamate filling and AMPA receptor occupancy at the calyx of Held synapse of immature ratsTakayuki Yamashita
Okinawa Institute of Science and Technology Promotion Corporation, Okinawa 904 2234, Japan
J Physiol 587:2327-39. 2009..We conclude that rapid AMPAR desensitization, caused by glutamate released from multiple vesicles during synaptic transmission, underlies postsynaptic AMPAR saturation at this immature calyceal synapse before the onset of hearing...
- An advanced filter-feeder hypothesis for urochordate evolutionNori Satoh
Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
Zoolog Sci 26:97-111. 2009..Thus, urochordates are close relatives to vertebrates...
- Domain shuffling and the evolution of vertebratesTakeshi Kawashima
Okinawa Institute of Science and Technology, Uruma, Okinawa, Japan
Genome Res 19:1393-403. 2009..Our analyses shed new light on the role of domain shuffling, especially in the evolution of vertebrates and chordates...
- Neurobiology of ADHDGail Tripp
Human Developmental Neurobiology Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa 904 2234, Japan
Neuropharmacology 57:579-89. 2009..We discuss how a failure of this transfer may give rise to many symptoms of ADHD, and propose that methylphenidate might act to compensate for the proposed dopamine transfer deficit...
- Validation of decision-making models and analysis of decision variables in the rat basal gangliaMakoto Ito
Neural Computation Unit, Okinawa Institute of Science and Technology, Okinawa 904 2234, Japan or
J Neurosci 29:9861-74. 2009..Information represented in the NAc and VP might contribute to a choice mechanism that is situated elsewhere...
- A computational study on the role of gap junctions and rod Ih conductance in the enhancement of the dynamic range of the retinaRodrigo Publio
Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, Japan
PLoS ONE 4:e6970. 2009....
- A high recovery microsampling device based on a microdialysis probe for peptide samplingMichael C Roy
Okinawa Institute of Science and Technology OIST, Suzaki 12 2, Uruma, Okinawa 904 2234, Japan
Anal Biochem 399:305-7. 2010..A probe made of a low molecular weight cutoff membrane is suitable for filtering off proteins. The new probe can be a useful tool for high recovery of peptides from living tissues...
- Hippocampal cells encode places by forming small anatomical clustersN H Nakamura
Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
Neuroscience 166:994-1007. 2010..We propose that spatial encoding recruits specific cell ensembles in the hippocampus and that with repeated exposure to the same place the ensembles become better organized to more accurately represent the "spatial map."..
- Dealing with the devil in the detail - some thoughts about the next model of the basal gangliaGORDON ARBUTHNOTT
Brain Mechanisms for Behaviour Unit, Okinawa Institute of Science and Technology, Okinawa, Japan
Parkinsonism Relat Disord 15:S139-42. 2009..Then maybe a new functional model will emerge that is less tied to anatomical and physiological simplification, but perhaps will still allow us to engineer therapeutic strategies to help patients with movement disorders...
- Comparative dating of attine ant and lepiotaceous cultivar phylogenies reveals coevolutionary synchrony and discordAlexander S Mikheyev
Section of Integrative Biology, University of Texas, Austin, Texas 78712, USA
Am Nat 175:E126-33. 2010....
- Developmental shift to a mechanism of synaptic vesicle endocytosis requiring nanodomain Ca2+Takayuki Yamashita
Cellular and Molecular Synaptic Function Unit, Initial Research Project, Okinawa Institute of Science and Technology Promotion Corporation, Okinawa, Japan
Nat Neurosci 13:838-44. 2010....
- Rapid microsatellite isolation from a butterfly by de novo transcriptome sequencing: performance and a comparison with AFLP-derived distancesAlexander S Mikheyev
Okinawa Institute of Science and Technology, Onna, Japan
PLoS ONE 5:e11212. 2010..We attempted to circumvent this problem by bioinformatic mining of microsatellite sequences from a de novo-sequenced transcriptome of a butterfly (Euphydryas editha)...
- Sox genes in the coral Acropora millepora: divergent expression patterns reflect differences in developmental mechanisms within the AnthozoaChuya Shinzato
ARC Centre of Excellence for Coral Reef Studies and Comparative Genomics Centre, James Cook University, Townsville, Queensland 4811, Australia
BMC Evol Biol 8:311. 2008..To better understand both the evolution of the Sox family and the roles of these genes in cnidarians, we are studying the Sox gene complement of the coral, Acropora millepora (Class Anthozoa)...
- Finding intrinsic rewards by embodied evolution and constrained reinforcement learningEiji Uchibe
Okinawa Institute of Science and Technology, Okinawa 904 2234, Japan
Neural Netw 21:1447-55. 2008..We show in hardware experiments that the robots can find appropriate 'intrinsic' rewards for the vision of battery packs and other robots to promote approach behaviors...
- Forward shift from reverse replayAdam Ponzi
Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma shi, Okinawa, Japan
Cogn Neurodyn 3:39-46. 2009..Simulations show that the CA1 firing fields show positive movement in center of mass toward reward locations over many trials with negative shift in first few trials, and development of positive skew...
- [How does fission yeast cut8 regulate the nuclear localization of proteasome?]Kijiro Takeda
Tanpakushitsu Kakusan Koso 51:1241-4. 2006
- Central gustatory projections and side-specificity of operant antennal muscle conditioning in the honeybeeS Shuichi Haupt
Neurobiologie, Institut für Ökologie, TU Berlin FR1 1, Franklinstr 28 9, 10587, Berlin, Germany
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 193:523-35. 2007..With contralateral antennal sucrose stimulation, conditioning was unsuccessful. Thus, muscle activity induced by gustatory stimulation was important for learning success and conditioning was side-specific...
- Thinking outside the pyramidal cell: unexplored contributions of interneurons and neuropeptide Y to estrogen-induced synapse formation in the hippocampusNozomu H Nakamura
Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA
Rev Neurosci 18:1-13. 2007....
- Striatal contributions to reward and decision making: making sense of regional variations in a reiterated processing matrixJeffery R Wickens
Neurobiology Research Unit, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma City, Okinawa, Japan
Ann N Y Acad Sci 1104:192-212. 2007..These differences may be important for understanding regional variations in the contribution to reinforcement of habits, versus incentive processes that are sensitive to the value of expected rewards...
- Mapping function onto neuronal morphologyKlaus M Stiefel
Theoretical and Experimental Neurobiology Unit, Okinawa Institute of Science and Technology, 12 22, Suzaki, Uruma, Okinawa, Japan
J Neurophysiol 98:513-26. 2007..The automated mapping between neuronal function and structure introduced here could allow a large catalog of computational functions to be built indexed by morphological structure...
- Two-step, extensive alterations in the transcriptome from G0 arrest to cell division in Schizosaccharomyces pombeMizuki Shimanuki
Initial Research Project IRP, Okinawa Institute of Science and Technology Promotion Corporation OIST, Uruma 904 2234, Okinawa, Japan
Genes Cells 12:677-92. 2007....
- Dopaminergic mechanisms in actions and habitsJeffery R Wickens
Okinawa Institute of Science and Technology, Okinawa 904 2234, Japan
J Neurosci 27:8181-3. 2007..The locus of these actions within the cortical and corticostriatal circuitry is a focus on ongoing research...
- Research review: dopamine transfer deficit: a neurobiological theory of altered reinforcement mechanisms in ADHDGail Tripp
Human Developmental Neurobiology Unit, Okinawa Institute of Science and Technology, Uruma, Okinawa, Japan
J Child Psychol Psychiatry 49:691-704. 2008..The extent to which DTD explains symptoms of ADHD and effects of pharmacological interventions is discussed. We conclude by considering the neural changes underlying the etiology of DTD...
- Why are computational neuroscience and systems biology so separate?Erik De Schutter
Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Japan
PLoS Comput Biol 4:e1000078. 2008..Finally, I speculate about how the relationship between the two fields may evolve in the near future...
- GABAA receptors in deep cerebellar nuclei play important roles in mouse eyeblink conditioningToshiro Sakamoto
Unit for Molecular Neurobiology of Learning and Memory, Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma, Okinawa 904 2234, Japan
Brain Res 1230:125-37. 2008....
- Intrinsic gain modulation and adaptive neural codingSungho Hong
Physiology and Biophysics Department, University of Washington, Seattle, Washington, USA
PLoS Comput Biol 4:e1000119. 2008..Our results describe how both variance-dependent gain modulation and adaptive neural computation result from intrinsic nonlinearity...
- Gene expression profiling of neuropeptides in mouse cerebellum, hippocampus, and retinaKiyotaka Akiyama
Molecular Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, Japan
Nutrition 24:918-23. 2008..We examined gene expression profiling in single neuron types and small regions of the nervous system...
- Non-parametric algorithmic generation of neuronal morphologiesBenjamin Torben-Nielsen
TENU, Okinawa Institute of Science and Technology, Okinawa, Japan
Neuroinformatics 6:257-77. 2008..The opportunities and limitations of data-driven algorithmic reconstruction of neurons are discussed...
- JDRC 8: Cell biology and developmentMary Ann Price
Okinawa Institute of Science and Technology, 12 22 Suzaki, Uruma shi, Okinawa, 904 2234, Japan
Fly (Austin) 1:294-6. 2007..This review will cover diverse topics roughly divided into four areas: cell biology and signaling, the cytoskeleton, transcription and cell fate determination and metabolism...
- MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile dataTomáš Pluskal
G0 Cell Unit, Okinawa Institute of Science and Technology, Onna, Okinawa, Japan
BMC Bioinformatics 11:395. 2010..An ongoing challenge of these molecular profiling approaches, however, is the development of better data processing methods. Here we introduce a new generation of a popular open-source data processing toolbox, MZmine 2...