Ken Tsutsui

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. ncbi request reprint Involvement of DNA topoisomerase IIbeta in neuronal differentiation
    K Tsutsui
    Department of Molecular Biology, Institute of Cellular and Molecular Biology, Okayama University Medical School, Okayama 700 8558, Japan
    J Biol Chem 276:5769-78. 2001
  2. pmc Topoisomerase IIbeta activates a subset of neuronal genes that are repressed in AT-rich genomic environment
    Kuniaki Sano
    Department of Neurogenomics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    PLoS ONE 3:e4103. 2008
  3. ncbi request reprint [Nuclear matrix-RNA connection]
    Ken Tsutsui
    Tanpakushitsu Kakusan Koso 51:1964-9. 2006
  4. doi request reprint Evaluation of pyrogallol-induced cytotoxicity in catalase-mutant escherichia coli and mutagenicity in Salmonella typhimurium
    Yoko Takemura
    Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Bull Environ Contam Toxicol 84:347-50. 2010
  5. doi request reprint Development of a new assay for evaluation of l-3,4-dihydroxyphenylalanine cytotoxicity in catalase-mutant Escherichia coli
    Da Hong Wang
    Department of Public Health, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Environ Toxicol Chem 27:1768-72. 2008
  6. ncbi request reprint Expression dynamics and functional implications of DNA topoisomerase II beta in the brain
    Kimiko M Tsutsui
    Department of Neuroanatomy and Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Anat Sci Int 81:156-63. 2006
  7. pmc Resveratrol inhibited hydroquinone-induced cytotoxicity in mouse primary hepatocytes
    Da Hong Wang
    Department of Public Health, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Int J Environ Res Public Health 9:3354-64. 2012
  8. pmc Regulation of DNA Topoisomerase IIbeta through RNA-dependent association with heterogeneous nuclear ribonucleoprotein U (hnRNP U)
    Shinji Kawano
    Department of Neurogenomics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700 8558, Japan
    J Biol Chem 285:26451-60. 2010
  9. pmc Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain
    Kimiko M Tsutsui
    Department of Neurogenomics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    Nucleic Acids Res 39:5067-81. 2011
  10. pmc Nuclear dynamics of topoisomerase IIβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain
    Akihisa Onoda
    Department of Neurogenomics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Nucleic Acids Res 42:9005-20. 2014

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Involvement of DNA topoisomerase IIbeta in neuronal differentiation
    K Tsutsui
    Department of Molecular Biology, Institute of Cellular and Molecular Biology, Okayama University Medical School, Okayama 700 8558, Japan
    J Biol Chem 276:5769-78. 2001
    ..The results suggest that topo IIbeta is involved in an early stage of granule cell differentiation by potentiating inducible neuronal genes to become transcribable probably through alterations in higher order chromatin structure...
  2. pmc Topoisomerase IIbeta activates a subset of neuronal genes that are repressed in AT-rich genomic environment
    Kuniaki Sano
    Department of Neurogenomics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    PLoS ONE 3:e4103. 2008
    ..Positioning of these genes and their control machinery may have developed recently in vertebrate evolution to support higher functions of central nervous system...
  3. ncbi request reprint [Nuclear matrix-RNA connection]
    Ken Tsutsui
    Tanpakushitsu Kakusan Koso 51:1964-9. 2006
  4. doi request reprint Evaluation of pyrogallol-induced cytotoxicity in catalase-mutant escherichia coli and mutagenicity in Salmonella typhimurium
    Yoko Takemura
    Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Bull Environ Contam Toxicol 84:347-50. 2010
    ..This study also suggests that newly established catalase mutant E. coli is probably useful in hazard identification of oxidative chemicals...
  5. doi request reprint Development of a new assay for evaluation of l-3,4-dihydroxyphenylalanine cytotoxicity in catalase-mutant Escherichia coli
    Da Hong Wang
    Department of Public Health, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Environ Toxicol Chem 27:1768-72. 2008
    ..coli in a dose-dependent manner, especially in the strains with lower catalase activities, implying the usefulness of these strains in assessment of oxidative chemicals...
  6. ncbi request reprint Expression dynamics and functional implications of DNA topoisomerase II beta in the brain
    Kimiko M Tsutsui
    Department of Neuroanatomy and Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Anat Sci Int 81:156-63. 2006
    ..Herein, we review a dynamic aspect of DNA topoisomerase II beta in the brain with special emphasis on developing cerebellar neurons...
  7. pmc Resveratrol inhibited hydroquinone-induced cytotoxicity in mouse primary hepatocytes
    Da Hong Wang
    Department of Public Health, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Int J Environ Res Public Health 9:3354-64. 2012
    ..The present study suggests that resveratrol protected the cells against hydroquinone-induced toxicity through its antioxidant function and possibly suppressive effect on the expression of cytochrome P450 2E1...
  8. pmc Regulation of DNA Topoisomerase IIbeta through RNA-dependent association with heterogeneous nuclear ribonucleoprotein U (hnRNP U)
    Shinji Kawano
    Department of Neurogenomics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700 8558, Japan
    J Biol Chem 285:26451-60. 2010
    ..Furthermore, the presence of SP120 was required for the stable expression of topo IIbeta in vivo. Thus, SP120 regulates the enzyme in dual ways...
  9. pmc Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain
    Kimiko M Tsutsui
    Department of Neurogenomics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    Nucleic Acids Res 39:5067-81. 2011
    ..Thus, these results imply that LEDGF/p75 guides its binding partners, including HIV-1 integrase, to the active transcription site through recognition of negative supercoils generated around it...
  10. pmc Nuclear dynamics of topoisomerase IIβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain
    Akihisa Onoda
    Department of Neurogenomics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Nucleic Acids Res 42:9005-20. 2014
    ..Taken together, these results suggest that both the subnuclear distribution and activity regulation of topo IIβ are mediated by the interplay between cellular RNA and the CRD. ..
  11. ncbi request reprint Localized expression of amphiphysin Ir, a retina-specific variant of amphiphysin I, in the ribbon synapse and its functional implication
    Osamu Hosoya
    Department of Neuroanatomy and Neurobiology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Eur J Neurosci 19:2179-87. 2004
    ..Amphiphysin Ir may play an essential role in the avid endocytic activity of ribbon synapses by associating with yet unknown protein partner(s) through its large insertional domain, which is absent from the conventional amphiphysin I...
  12. ncbi request reprint Dynamic view of the nuclear matrix
    Kimiko M Tsutsui
    Department of Neuroanatomy and Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Acta Med Okayama 59:113-20. 2005
    ..In this review, we attempt to redefine the nuclear matrix in light of recent findings and describe some useful techniques for the dynamic analysis of nuclear function...
  13. ncbi request reprint The SUMO pathway is required for selective degradation of DNA topoisomerase IIbeta induced by a catalytic inhibitor ICRF-193(1)
    Sevim Isik
    Department of Molecular Biology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    FEBS Lett 546:374-8. 2003
    ..When the SUMO conjugating enzyme Ubc9 was conditionally knocked out, the ICRF-induced degradation of topoisomerase IIbeta did not occur, suggesting that the SUMO modification pathway is essential for the degradation...
  14. pmc Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair
    Kyoko Nakamura
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    PLoS Genet 6:e1000828. 2010
    ..We propose that the BRCA1-CtIP complex plays a role in the nuclease-mediated elimination of oligonucleotides covalently bound to polypeptides from DSBs, thereby facilitating subsequent DSB repair...
  15. ncbi request reprint Novel splice variants of amphiphysin I are expressed in retina
    Yoshiko Terada
    Department of Ophthalmology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, Japan
    FEBS Lett 519:185-90. 2002
    ..Western blot analysis of various rat tissues with anti-insert B antibody confirmed the presence and tissue specificity of the variant proteins...
  16. ncbi request reprint Cytotoxicity of lawsone and cytoprotective activity of antioxidants in catalase mutant Escherichia coli
    Rani Sauriasari
    Department of Public Health, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Toxicology 235:103-11. 2007
    ..We suggest that lawsone cytotoxicity is probably mediated, at least in part, by the release of O(2)(-), H(2)O(2) and OH(-)...
  17. ncbi request reprint Involvement of oxidative stress in hydroquinone-induced cytotoxicity in catalase-deficient Escherichia coli mutants
    Masako Horita
    Okayama University Graduate School of Medicine and Dentistry, Department of Public Health, Okayama, Japan
    Free Radic Res 39:1035-41. 2005
    ..The present results suggest that H2O2 is probably involved in hydroquinone-induced cytotoxicity in catalase-deficient E. coli mutants and catalase plays an important role in protection of the cells against hydroquinone toxicity...
  18. ncbi request reprint Large-scale identification and mapping of nuclear matrix-attachment regions in the distal imprinted domain of mouse chromosome 7
    Wahyu Purbowasito
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
    DNA Res 11:391-407. 2004
    ..This study presents the first large-scale mapping of MARs in an imprinted domain and provides a platform for understanding the roles of MARs in imprinting...
  19. ncbi request reprint Inhibitory activity of plant stilbene oligomers against DNA topoisomerase II
    Masashi Yamada
    Meiji Dairies Corporation, Tokyo, Japan
    Biol Pharm Bull 29:1504-7. 2006
    ..In particular, specific inhibitory activity was observed in alpha-viniferin 13-O-beta-glucopryranoside (2) and hemsleyanol C (13)...
  20. ncbi request reprint Correlations between scaffold/matrix attachment region (S/MAR) binding activity and DNA duplex destabilization energy
    Jürgen Bode
    German Research Center for Biotechnology, RDIF Epigenetic Regulation, D 38124 Braunschweig, Mascheroder Weg 1, Germany
    J Mol Biol 358:597-613. 2006
    ....
  21. ncbi request reprint Nepalensinols D-G, new resveratrol oligomers from Kobresia nepalensis (Cyperaceae) as potent inhibitors of DNA topoisomerase II
    Masashi Yamada
    Meiji Dairies Corporation, Shinsuna, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 54:354-8. 2006
    ..These stilbenoids showed potent inhibitory activity against human topoisomerase II with IC50 values of 5-15 microM...