Akinobu Takaki

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. pmc Molecular Mechanisms to Control Post-Transplantation Hepatitis B Recurrence
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Int J Mol Sci 16:17494-513. 2015
  2. pmc Molecular mechanisms and new treatment strategies for non-alcoholic steatohepatitis (NASH)
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Int J Mol Sci 15:7352-79. 2014
  3. pmc Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation?
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    J Gastroenterol 48:1373-83. 2013
  4. pmc Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama City, Okayama 700 8558, Japan
    Int J Mol Sci 14:20704-28. 2013
  5. ncbi request reprint Short-term high-dose followed by long-term low-dose hepatitis B immunoglobulin and lamivudine therapy prevented recurrent hepatitis B after liver transplantation
    Akinobu Takaki
    Department of Gastroenterology, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama City, Japan
    Transplantation 83:231-3. 2007
  6. pmc Hepatitis C virus NS4 protein impairs the Th1 polarization of immature dendritic cells
    A Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Viral Hepat 17:555-62. 2010
  7. pmc Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients
    Masashi Tatsukawa
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
    BMC Cancer 11:458. 2011
  8. ncbi request reprint Entecavir Reduces Hepatocarcinogenesis in Chronic Hepatitis B Patients
    Tetsuya Yasunaka
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 70:1-12. 2016
  9. doi request reprint Predicting the treatment effect of sorafenib using serum angiogenesis markers in patients with hepatocellular carcinoma
    Koji Miyahara
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 26:1604-11. 2011
  10. doi request reprint Des-γ-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma
    Minoru Matsubara
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Gastroenterol Hepatol 27:1602-8. 2012

Detail Information

Publications97

  1. pmc Molecular Mechanisms to Control Post-Transplantation Hepatitis B Recurrence
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Int J Mol Sci 16:17494-513. 2015
    ..The present protocol for post-OLT HBV control and the future prospects of newer treatment strategies are reviewed...
  2. pmc Molecular mechanisms and new treatment strategies for non-alcoholic steatohepatitis (NASH)
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Int J Mol Sci 15:7352-79. 2014
    ..Several long-term antioxidant protocols have failed to reduce mortality. New treatment modalities that incorporate current understanding of NAFLD molecular pathogenesis must be considered. ..
  3. pmc Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation?
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    J Gastroenterol 48:1373-83. 2013
    ..However, frequent immunoglobulin treatment is expensive and inconvenient. This study investigated the efficacy of hepatitis B virus (HBV) vaccination in preventing the recurrence of hepatitis B after living donor OLT...
  4. pmc Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama City, Okayama 700 8558, Japan
    Int J Mol Sci 14:20704-28. 2013
    ..Thus, targeting mitochondrial oxidative stress might be a good candidate for NASH treatment. Long term clinical intervention is needed to control this complex lifestyle-related disease. ..
  5. ncbi request reprint Short-term high-dose followed by long-term low-dose hepatitis B immunoglobulin and lamivudine therapy prevented recurrent hepatitis B after liver transplantation
    Akinobu Takaki
    Department of Gastroenterology, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama City, Japan
    Transplantation 83:231-3. 2007
    ..This method allows reliable and cost-effective control of hepatitis B recurrence...
  6. pmc Hepatitis C virus NS4 protein impairs the Th1 polarization of immature dendritic cells
    A Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Viral Hepat 17:555-62. 2010
    ..HCV nonstructural proteins, particularly NS4, change the iDC phenotype and reduce antigen-specific T-cell stimulatory function with Th1 cytokine reductions...
  7. pmc Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients
    Masashi Tatsukawa
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
    BMC Cancer 11:458. 2011
    ..Hepatitis B virus (HBV) is a major cause of hepatocarcinogenesis.To identify mutations relevant to hepatocellular carcinoma (HCC) development, we compared the full genome sequences of HBV from the sera of patients with and without HCC...
  8. ncbi request reprint Entecavir Reduces Hepatocarcinogenesis in Chronic Hepatitis B Patients
    Tetsuya Yasunaka
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 70:1-12. 2016
    ..05). Only small numbers of HCCs occurred in other patients. In CHB patients aged > 35 years with HBV DNA > 4 log copies/mL and positive HBeAg, ETV treatment is recommended for the suppression of HCC development. ..
  9. doi request reprint Predicting the treatment effect of sorafenib using serum angiogenesis markers in patients with hepatocellular carcinoma
    Koji Miyahara
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 26:1604-11. 2011
    ..We analyzed cytokines related to angiogenesis or cell proliferation, and tried to determine their utility as biomarkers of sorafenib treatment effect for HCC...
  10. doi request reprint Des-γ-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma
    Minoru Matsubara
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Gastroenterol Hepatol 27:1602-8. 2012
    ..In the present study, DCP-associated tumor angiogenesis was assessed by comparing hypovascular and common hypervascular HCC...
  11. doi request reprint Exon 2 deletion splice variant of gamma-glutamyl carboxylase causes des-gamma-carboxy prothrombin production in hepatocellular carcinoma cell lines
    Naoki Ueda
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Mol Oncol 2:241-9. 2008
    ..These results suggest that exon 2 deletion splice variant of GGCX causes dysfunction of GGCX enzyme activity resulting in DCP production in HCC cell lines...
  12. ncbi request reprint Lamivudine treatment improves the prognosis of fulminant hepatitis B
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
    Intern Med 47:1293-9. 2008
    ..The aim of this study was to clarify the prognostic factors and the efficacy of lamivudine for fulminant hepatitis B in Japan, where the main infection genotype is B...
  13. doi request reprint Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma
    Hideaki Kinugasa
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    J Gastroenterol 47:421-6. 2012
    ..The aim of this study was to determine the risk factors for local or intrahepatic distant recurrence after TACE in early-stage HCC...
  14. doi request reprint Laparoscopic findings of reddish markings predict hepatocellular carcinoma in patients with hepatitis B virus-related liver disease
    Bon Shoji
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata cho, Okayama, Japan
    J Gastroenterol 45:1172-82. 2010
    ..The purpose of this study was to clarify factors predictive of HCC development for those patients...
  15. doi request reprint Serum levels of platelet-derived growth factor-BB and vascular endothelial growth factor as prognostic factors for patients with fulminant hepatic failure
    Hiroki Takayama
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 26:116-21. 2011
    ..The aim of the present study was to assess the role of angiogenic factors in fulminant hepatic failure (FHF)...
  16. doi request reprint Low frequency of drug-resistant virus did not affect the therapeutic efficacy in daclatasvir plus asunaprevir therapy in patients with chronic HCV genotype-1 infection
    Hideaki Kinugasa
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Antivir Ther 21:37-44. 2016
    ..The efficacy of a direct-acting antiviral agent (DAA) is compromised by the development of drug resistance. The associations between resistance-associated virus (RAV) and therapeutic outcomes have not been well-understood...
  17. doi request reprint The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis
    Yasuto Takeuchi
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    J Gastroenterol 48:405-12. 2013
    ..This study was conducted to determine whether PNPLA3 rs738409 SNPs affect development and prognosis of hepatocellular carcinoma (HCC) in patients with various liver diseases...
  18. ncbi request reprint Des-gamma-carboxyl prothrombin-promoted vascular endothelial cell proliferation and migration
    Tatsuya Fujikawa
    Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    J Biol Chem 282:8741-8. 2007
    ..In conclusion, these results indicate that DCP is a novel type of vascular endothelial growth factor that possesses potent mitogenic and migrative activities...
  19. pmc Twist expression promotes migration and invasion in hepatocellular carcinoma
    Noriyuki Matsuo
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    BMC Cancer 9:240. 2009
    ..It is known to induce epithelial-mesenchymal transition (EMT). In this study, we evaluated the expression of twist and its effect on cell migration in hepatocellular carcinoma (HCC)...
  20. pmc Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma
    Junro Kataoka
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Oncol Rep 35:2576-82. 2016
    ..Importantly, loss of RUNX3 expression contributed to 5-FU and CDDP resistance by inducing MRP expression. These data have important implications in the study of chemotherapy resistance in HCC...
  21. doi request reprint Runt-related transcription factor 3 reverses epithelial-mesenchymal transition in hepatocellular carcinoma
    Shigetomi Tanaka
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Int J Cancer 131:2537-46. 2012
    ..These results suggest a novel mechanism by which loss or decreased expression of RUNX3 induces EMT via induction of JAG1 expression in low-EMT HCC...
  22. ncbi request reprint Combination of 5-FU and IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines
    Kazuko Koike
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Int J Oncol 29:1253-61. 2006
    ..In conclusion, caspase-8 is the most important factor that controls IFN and 5-FU-induced apoptosis in hepatoma cell lines...
  23. doi request reprint Clinical utility of high-throughput glycome analysis in patients with pancreatic cancer
    Kazuhiro Nouso
    Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, Okayama, 700 8558, Japan
    J Gastroenterol 48:1171-9. 2013
    ..The aim of this study was to determine the changes of the serum N-glycan profile comprehensively in a large number of pancreatic cancer patients and investigate its clinical utility...
  24. doi request reprint Serum levels of soluble adhesion molecules as prognostic factors for acute liver failure
    Atsuyuki Ohnishi
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Digestion 86:122-8. 2012
    ..We aimed to assess the usefulness of serum levels of soluble adhesion molecules as prognostic factors for acute liver failure (ALF)...
  25. ncbi request reprint A homosexual Japanese man with acute hepatitis due to hepatitis B virus genotype ae, concurrent with amebic colitis
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 61:35-9. 2007
    ..Furthermore, education of homosexual men regarding hepatitis B virus, hepatitis B virus vaccination, and amebiasis is urgently required...
  26. ncbi request reprint Early detection and quantification of lamivudine-resistant hepatitis B virus mutants by fluorescent biprobe hybridization assay in lamivudine-treated patients
    Fumi Umeoka
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    J Gastroenterol 41:693-701. 2006
    ..The objective of this study was to develop a fluorescent biprobe hybridization (FBH) assay for the detection and quantification of HBV mutants in the clinical course of lamivudine-treated patients and to evaluate its clinical usefulness...
  27. doi request reprint Synergistic anti-pancreatic cancer immunological effects by treatment with reduced expression in immortalized cells/dickkopf-3 protein and peripheral blood mononuclear cells
    Daisuke Uchida
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 31:1154-9. 2016
    ..We examined the antitumor immunological effects of human REIC/DKK3 protein against pancreatic cancer...
  28. doi request reprint Potential of alpha-fetoprotein as a prognostic marker after curative radiofrequency ablation of hepatocellular carcinoma
    Chihiro Dohi
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 46:916-23. 2016
    ..The aim of this study is to elucidate the risk factors for recurrence of HCC after radiofrequency ablation (RFA), focusing on the carcinogenic potential of the liver assessed by α-fetoprotein (AFP)...
  29. doi request reprint Association of hepatic oxidative stress and iron dysregulation with HCC development after interferon therapy in chronic hepatitis C
    Shintaro Nanba
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Clin Pathol 69:226-33. 2016
    ..The impact of excessive oxidative stress and iron dysregulation on the development of hepatocellular carcinoma (HCC) after interferon therapy has not been established...
  30. ncbi request reprint Local recurrence and complications after percutaneous radiofrequency ablation of hepatocellular carcinoma: a retrospective cohort study focused on tumor location
    Junichi Toshimori
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 69:219-26. 2015
    ....
  31. ncbi request reprint Aberrant Expression of Keratin 7 in Hepatocytes as a Predictive Marker of Rapid Progression to Hepatic Failure in Asymptomatic Primary Biliary Cirrhosis
    Hiroyuki Seki
    Department of aGastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 69:137-44. 2015
    ..Aberrant K-7 expression in hepatocytes can be used as an additional marker to predict rapid progression to liver failure in patients with aPBC at the time of diagnosis. ..
  32. pmc Enhancement of Programmed Death Ligand 2 on Hepatitis C Virus Infected Hepatocytes by Calcineurin Inhibitors
    Kazuko Koike
    1 Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan 2 Department of Gastroenterological Surgery Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan 3 Health Service Center, Okayama University, Okayama, Japan
    Transplantation 99:1447-54. 2015
    ..We hypothesized that this atypical molecule could affect the recurrence of post-OLT hepatitis. To test this hypothesis, we conducted immunohistochemical staining analysis and in vitro analysis of PD-L2...
  33. doi request reprint Prognostic value of altered N-glycosylation of circulating glycoproteins in patients with unresectable pancreatic cancer treated with gemcitabine
    Koji Miyahara
    From the Departments of Gastroenterology and Hepatology, and Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama City, Okayama, Japan Ezose Sciences Inc, Pine Brook, NJ Field of Drug Discovery Research, Faculty of Advanced Life Science, Graduate School of Life Science, Hokkaido University and Medicinal Chemistry Pharmaceuticals, CO, Ltd, Sapporo, Hokkaido, Japan
    Pancreas 44:551-6. 2015
    ..The objectives of this study were to examine the whole-serum N-glycan profile of patients with unresectable pancreatic cancer and to evaluate the ability of glycans to predict gemcitabine treatment efficacy and patient survival...
  34. ncbi request reprint Impact of comorbid hepatic steatosis on treatment of chronic hepatitis C in Japanese patients and the relationship with genetic polymorphism of IL28B, PNPLA3 and LDL receptor
    Yuki Moritou
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 68:17-22. 2014
    ..With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy. ..
  35. ncbi request reprint Hepatitis C virus-specific T-cell response correlates with hepatitis activity and donor IL28B genotype early after liver transplantation
    Ryuichiro Tsuzaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 68:291-302. 2014
    ..It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect. ..
  36. doi request reprint Loss of runt-related transcription factor 3 induces gemcitabine resistance in pancreatic cancer
    Shigeru Horiguchi
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita ku, Okayama, Japan
    Mol Oncol 7:840-9. 2013
    ..However, the precise function of RUNX3 in pancreatic cancer has not been fully elucidated. In this study, we aimed to determine the effect of decreased RUNX3 expression in pancreatic cancer...
  37. pmc Serial changes of serum growth factor levels and liver regeneration after partial hepatectomy in healthy humans
    Kazuyuki Matsumoto
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1, Shikata cho, Kita ku, Okayama 700 8558, Japan
    Int J Mol Sci 14:20877-89. 2013
    ..76) and POD 7 (r = 0.80). These results suggest that early-phase elevation of serum levels of HGF, leptin and M-CSF may be associated with the acceleration of liver regeneration after hepatectomy in humans. ..
  38. doi request reprint Prognotic impact of serum follistatin in patients with hepatocellular carcinoma
    Takeshi Tomoda
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama City, Okayama, Japan
    J Gastroenterol Hepatol 28:1391-6. 2013
    ..Recently, several reports have shown that FST regulates a variety of processes during tumor progression. Here, serum FST in patients with liver diseases was measured, and its clinical utility as a biomarker was assessed...
  39. doi request reprint Risk factors for acute renal injury in living donor liver transplantation: evaluation of the RIFLE criteria
    Masashi Utsumi
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Transpl Int 26:842-52. 2013
    ..Perioperative treatment strategies should be designed and balanced based on the risk factors for the further improvement of transplant prognosis...
  40. doi request reprint Hepatitis B e antigen predicts delayed reduction of HBV DNA without viral breakthrough with adefovir dipivoxil and lamivudine: a 5-year study of patients with hepatitis B with lamivudine resistance
    Fusao Ikeda
    Dentistry and Pharmaceutical Sciences, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Okayama, Japan
    J Med Virol 84:1562-70. 2012
    ..HBe antigen levels at the initiation of therapy, and reductions in these levels during therapy are predictive of the therapeutic response to combination therapy with ADV and LAM for patients with LAM-resistant HBV...
  41. doi request reprint Clinical utility of serum fucosylated hemopexin in Japanese patients with hepatocellular carcinoma
    Sayo Kobayashi
    Departments of Gastroenterology and Hepatology Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 42:1187-95. 2012
    ..Conclusion:  Fuc-Hpx is a valuable biomarker for HCC but it might be a marker for hypercarcinogenic liver rather than a marker for tumor-bearing liver...
  42. doi request reprint Prognostic importance of fucosylated alpha-fetoprotein in hepatocellular carcinoma patients with low alpha-fetoprotein
    Kazuhiro Nouso
    Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 26:1195-200. 2011
    ..However, it has been difficult to measure AFP-L3 under low AFP (≤ 20 ng/mL). The aim of this study was to elucidate the role of AFP-L3 in HCC patients with low AFP conditions...
  43. doi request reprint Clinical features of autoimmune hepatitis diagnosed based on simplified criteria of the International Autoimmune Hepatitis Group
    Yasuhiro Miyake
    Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Dig Liver Dis 42:210-5. 2010
    ..Recently, simplified diagnostic criteria for autoimmune hepatitis have been proposed...
  44. ncbi request reprint Clinical features of antinuclear antibodies-negative type 1 autoimmune hepatitis
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 39:241-6. 2009
    ..Regarding the diagnosis of ANA-negative AIH, the determination of ANA during follow-up and the response to immunosuppressive treatment may be helpful...
  45. ncbi request reprint Clinical features of Japanese elderly patients with type 1 autoimmune hepatitis
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
    Intern Med 46:1945-9. 2007
    ..In this study, we assessed the clinical features of Japanese elderly patients with type 1 autoimmune hepatitis...
  46. doi request reprint Feasibility and findings of colonoscopy for living-donor liver transplant candidates
    Shin Ishikawa
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Clin Gastroenterol 43:69-74. 2009
    ..The aim of this study is to investigate the feasibility and findings of colonoscopy before LDLT...
  47. doi request reprint Serum-inducible protein (IP)-10 is a disease progression-related marker for non-alcoholic fatty liver disease
    Nozomu Wada
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    Hepatol Int 11:115-124. 2017
    ..The objective of the present study was to identify disease progression-related cytokines and investigate the molecular pathogenesis of such changes in NASH...
  48. doi request reprint Oxidative stress balance is dysregulated and represents an additional target for treating cholangiocarcinoma
    Daisuke Uchida
    a Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Free Radic Res 50:732-43. 2016
    ....
  49. doi request reprint Dynamic computed tomography is useful for prediction of pathological grade in pancreatic neuroendocrine neoplasm
    Shigeru Horiguchi
    Dentistry and Pharmaceutical Science, Department of Gastroenterology and Hepatology in Okayama University Graduate School of Medicine, Okayama, Japan
    J Gastroenterol Hepatol . 2016
    ..No studies have examined the diagnostic ability of dynamic computed tomography (CT) for pathological grading of PNEN. We investigated the usefulness of EUS-FNA and dynamic CT in the diagnosis and pathological grading of PNEN...
  50. doi request reprint Serum N-glycan profiles in patients with intraductal papillary mucinous neoplasms of the pancreas
    Yutaka Akimoto
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan Electronic address
    Pancreatology 15:432-8. 2015
    ..The objectives of this study were to determine the serum N-glycan profile and to investigate its clinical utility in patients with IPMNs...
  51. doi request reprint A case of fulminant liver failure associated with hepatitis C virus
    Hiromitsu Kanzaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    Clin J Gastroenterol 7:170-4. 2014
    ..Severe hepatitis recurrence after liver transplantation might occur in patients with fulminant hepatitis due to HCV because of its monoclonal expansion...
  52. doi request reprint TLR4, TLR9, and NLRP3 in biliary epithelial cells of primary sclerosing cholangitis: relationship with clinical characteristics
    Hiroshi Matsushita
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 30:600-8. 2015
    ....
  53. doi request reprint Efficacy of hepatic arterial infusion chemotherapy in combination with irradiation for advanced hepatocellular carcinoma with portal vein invasion
    Hideki Onishi
    Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama City, Okayama, 700 8558, Japan
    Hepatol Int 9:105-12. 2015
    ..The purpose of this study was to determine the treatment effect of irradiation in combination with hepatic arterial infusion chemotherapy (HAIC) for these patients...
  54. pmc Serum glycan markers for evaluation of disease activity and prediction of clinical course in patients with ulcerative colitis
    Koji Miyahara
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Okayama, Japan
    PLoS ONE 8:e74861. 2013
    ..The aims of this study were to determine the change of whole-serum N-glycan profile in ulcerative colitis (UC) patients and to investigate its clinical utility...
  55. doi request reprint Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice
    Daisuke Kawai
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Okayama, Japan
    Hepatology 56:912-21. 2012
    ..After 8 weeks, hepatic tumors were evaluated. The number of tumors was significantly lower in the HW-STAM and PGZ-STAM groups than in the CW-STAM group. The maximum tumor size was smaller in the HW-STAM group than in the other groups...
  56. doi request reprint Anti-programmed cell death-1 antibody as a new serological marker for type 1 autoimmune hepatitis
    Kazuyuki Matsumoto
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 29:110-5. 2014
    ..This study aimed to investigate the association of serum anti-PD-1 antibodies with clinical characteristics of type 1 AIH...
  57. ncbi request reprint Eradication of hepatitis C virus subgenomic replicon by interferon results in aberrant retinol-related protein expression
    Kazuko Koike
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 66:461-8. 2012
    ..The alteration in RBP expression was also confirmed by ELISA and Western blot analysis. We conclude that protein expression profiling demonstrated that HCV replicon eradication affected retinol-related protein expression...
  58. ncbi request reprint Human leukocyte antigen DR status and clinical features in Japanese patients with type 1 autoimmune hepatitis
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 38:96-102. 2008
    ..Japanese patients with DR2 may have different clinical features from others. In addition, diagnoses of type 1 autoimmune hepatitis should be made carefully in Japanese patients with neither DR2 nor DR4 and in those aged <30 years...
  59. pmc Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis
    Yutaka Nakanishi
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    BMC Cancer 11:3. 2011
    ..Runt-related transcription factor 3 (RUNX3) is known as a tumor suppressor gene for gastric cancer and other cancers, this gene may be involved in the development of hepatocellular carcinoma (HCC)...
  60. doi request reprint Additive improvement induced by bezafibrate in patients with primary biliary cirrhosis showing refractory response to ursodeoxycholic acid
    Yasuto Takeuchi
    Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama, Japan
    J Gastroenterol Hepatol 26:1395-401. 2011
    ..However, some patients are refractory to UDCA. The aim of this study is to clarify the additive improvement induced by bezafibrate in patients refractory to UDCA...
  61. doi request reprint Oxidative stress controlling agents are effective for small intestinal injuries induced by non-steroidal anti-inflammatory drugs
    Yoshiyasu Kono
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 32:136-145. 2017
    ..To explore the contribution of oxidative stress and potential of anti-oxidants for NSAIDs-induced intestinal ulcers, we assessed human serum oxidative stress balance and the effect of anti-oxidants using a mouse model...
  62. ncbi request reprint Effectiveness of extending treatment duration in therapy with pegylated interferon and ribavirin for genotype 2 hepatitis C virus infection
    Shintarou Nanba
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 69:237-44. 2015
    ..This finding might be useful in creating a guideline for extending treatment duration for patients with CHC genotype 2. ..
  63. pmc Hepatic stellate cells promote upregulation of epithelial cell adhesion molecule and epithelial-mesenchymal transition in hepatic cancer cells
    Teruya Nagahara
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Shikata cho, Kita ku, Okayama 700 8558, Japan
    Oncol Rep 34:1169-77. 2015
    ..Taken together, humoral factors secreted from TWNT-1 promote upregulation of EpCAM and EMT in hepatic cancer cells. ..
  64. doi request reprint Randomized trial of peginterferon alpha-2b plus low and escalating dose of ribavirin in patients with chronic hepatitis C with high viral load genotype 1
    Yoshiaki Iwasaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan Health Service Center, Okayama University, Okayama, Japan
    J Med Virol 87:625-33. 2015
    ..24%, P = 0.005). These data suggest that combination therapy with low and escalating dosing of ribavirin may be safer in elderly patients than that with standard dosing of ribavirin without impairing the treatment response...
  65. doi request reprint Use of non-invasive serum glycan markers to distinguish non-alcoholic steatohepatitis from simple steatosis
    Yasushi Yamasaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Okayama
    J Gastroenterol Hepatol 30:528-34. 2015
    ....
  66. doi request reprint Frequency of regulatory T-cell and hepatitis C viral antigen-specific immune response in recurrent hepatitis C after liver transplantation
    Masashi Utsumi
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Transpl Immunol 31:33-41. 2014
    ..However, their frequencies and effects on HCV-specific immune responses have not been well investigated...
  67. pmc L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model with upregulation of mitochondrial pathway
    Hisashi Ishikawa
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    PLoS ONE 9:e100627. 2014
    ..Conclusion: L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model by upregulating the mitochondrial β-oxidation and redox system...
  68. doi request reprint Potential of adenovirus-mediated REIC/Dkk-3 gene therapy for use in the treatment of pancreatic cancer
    Daisuke Uchida
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 29:973-83. 2014
    ..In a prostate cancer study, an adenovirus vector carrying the REIC/Dkk-3 gene (Ad-REIC) induces apoptosis. In the current study, we examined the effects of REIC/Dkk-3 gene therapy in pancreatic cancer...
  69. doi request reprint Assessment of health-related quality of life and how it predicts the outcome of pegylated interferon and ribavirin therapy for chronic hepatitis C
    Hiroshi Matsushita
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 29:337-43. 2014
    ..The present study was planned to investigate the impact of HRQOL of patients with chronic hepatitis C (CHC) on the outcomes of therapy with pegylated interferon and ribavirin (RBV), in addition to IL28B polymorphisms...
  70. ncbi request reprint SIRS score reflects clinical features of non-acetaminophen-related acute liver failure with hepatic coma
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
    Intern Med 51:823-8. 2012
    ..This study aimed to investigate the impact of SIRS score on clinical features of non-acetaminophen-related ALF...
  71. ncbi request reprint [Mechanism of immune surveillance against HBV infection]
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine
    Nihon Rinsho 62:62-5. 2004
  72. ncbi request reprint [Correlation between the grade of immune response against hepatitis C virus (HCV) infection and MHC class II polymorphisms]
    Kazuko Koike
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry
    Nihon Rinsho 62:147-50. 2004
  73. ncbi request reprint Acute hepatitis due to hepatitis E virus genotype 1 as an imported infectious disease in Japan
    Koji Miyahara
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
    Intern Med 49:2613-6. 2010
    ..Thereafter, attention should be paid to HEV genotype 1 infection as an imported infectious disease...
  74. doi request reprint Long-term outcome and hepatocellular carcinoma development in chronic hepatitis B or cirrhosis patients after nucleoside analog treatment with entecavir or lamivudine
    Haruhiko Kobashi
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Department of Clinical Research, Center for Liver Disease, Kawasaki Hospital, Kawasaki Medical School, Kawasaki Department of Internal Medicine, Tsuyama Central Hospital, Tsuyama, Japan
    Hepatol Res 41:405-16. 2011
    ..Conclusion:  NA exerted a long-term efficacy and improved hepatic reservation in CHB and cirrhosis. After NA treatment, AFP dropped to lower than 10 ng/mL with marked elevation of specificity, leading to an earlier detection of HCC...
  75. ncbi request reprint A prospective and comparative cohort study on efficacy and drug resistance during long-term lamivudine treatment for various stages of chronic hepatitis B and cirrhosis
    Tomohiro Nishida
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 23:794-803. 2008
    ....
  76. ncbi request reprint Clinical features of type 1 autoimmune hepatitis in adolescence and early adulthood
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 39:766-71. 2009
    ..However, they may frequently show atypical features, and the diagnosis of type 1 AIH in adolescence and early adulthood may be difficult and should be made carefully...
  77. ncbi request reprint Prognostic model for hepatocellular carcinoma with time-dependent factors
    Kenji Kuwaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 65:11-9. 2011
    ..741, 0.727, 0.609, and 0.870, respectively. These results indicate that our time-dependent model can estimate the prognosis of HCC more precisely than traditional time-fixed models and can be used to re-predict the prognosis of HCC...
  78. doi request reprint Amino acid substitutions of hepatitis C virus core protein are not associated with intracellular antiviral response to interferon-α in vitro
    Fusao Ikeda
    Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Liver Int 30:1324-31. 2010
    ....
  79. ncbi request reprint Long-term monitoring of platelet count, as a non-invasive marker of hepatic fibrosis progression and/or regression in patients with chronic hepatitis C after interferon therapy
    Hideaki Taniguchi
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Gastroenterol Hepatol 21:281-7. 2006
    ..The aim of the present study was to assess hepatic fibrosis progression or regression of CHC patients by long-term monitoring of the platelet count...
  80. pmc Diagnostic role of 18F-fluorodeoxyglucose positron emission tomography for follicular lymphoma with gastrointestinal involvement
    Masaya Iwamuro
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700 8558, Japan
    World J Gastroenterol 18:6427-36; discussion p.6434. 2012
    ..To investigate the capacity for 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) to evaluate patients with gastrointestinal lesions of follicular lymphoma...
  81. doi request reprint Stage of hepatocellular carcinoma is associated with periodontitis
    Naofumi Tamaki
    Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Clin Periodontol 38:1015-20. 2011
    ..The Japan Integrated Stage (JIS) score is a novel staging system for HCC. The objective of the present study was to compare JIS scores in HCC patients with and without periodontitis...
  82. doi request reprint Fulminant hepatitis: Who survives without liver transplantation?
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 42:60-7. 2012
    ..In patients fulfilling any three parameters, intensive care including artificial liver support in expectation of hepatic regeneration during a few weeks may be possible...
  83. ncbi request reprint Endoscopic therapy for bleeding esophageal varices improves the outcome of Child C cirrhotic patients
    Shinichiro Hori
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Gastroenterol Hepatol 21:1704-9. 2006
    ..The management of esophageal varices is therefore important for patient survival. The purpose of this study was to clarify the predictive factors for mortality in patients with Child C cirrhosis presenting with variceal bleeding...
  84. doi request reprint Hepatocellular carcinoma occurring in hepatobiliary fibropolycystic disease
    Hideaki Kinugasa
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 41:277-81. 2011
    ..HCC was suspected from these findings. She also suffered from multiple small cystic lesions in the liver. The surgically removed liver showed HCC arising in CHF, which is a rare histological finding...
  85. pmc A preliminary study for constructing a bioartificial liver device with induced pluripotent stem cell-derived hepatocytes
    Masaya Iwamuro
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Biomed Eng Online 11:93. 2012
    ..The purpose of this paper was to test the feasibility of a bioartificial liver system with iPS cell-derived hepatocyte-like cells...
  86. doi request reprint Peritoneovenous shunting for refractory ascites results in worsening of nephrotic syndrome
    Akinobu Takaki
    Departments of Gastroenterology and Hepatology Medicine and Clinical Science Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Department of Internal Medicine, National Hospital Organization Minami Okayama, Okayama, Japan
    Hepatol Res 42:1048-53. 2012
    ..3-0.5 g/day and ammonia levels decreased. PVS may increase the excretion of urinary protein and increase ammonia levels in patients with complications of glomerulonephritis...
  87. ncbi request reprint Des-gamma-carboxy prothrombin is a potential autologous growth factor for hepatocellular carcinoma
    Mayumi Suzuki
    Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Biol Chem 280:6409-15. 2005
    ..Based on these results, we believe that DCP acts as an autologous mitogen for HCC cell lines. The Met-Janus kinase 1-STAT3 signaling pathway may be a major signaling pathway for DCP-induced cell proliferation...
  88. doi request reprint +49A/G polymorphism of cytotoxic T-lymphocyte antigen 4 gene in type 1 autoimmune hepatitis and primary biliary cirrhosis: A meta-analysis
    Yasuhiro Miyake
    Departments of Molecular Hepatology and Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 41:151-9. 2011
    ..Especially, while G/G genotype may be associated with the susceptibility to PBC, A/A genotype may be protective against type 1 AIH and PBC...
  89. ncbi request reprint [Determination of hepatitis B surface antigen subtypes]
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine
    Nihon Rinsho 62:149-52. 2004
  90. ncbi request reprint [Mechanisms of the immune surveillance against HCV infection]
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine
    Nihon Rinsho 62:143-6. 2004
  91. ncbi request reprint [A case of the usage of entecavir to prevent hepatitis B virus reactivation during chemotherapy in breast cancer patient]
    Takayuki Muraoka
    Dept of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Gan To Kagaku Ryoho 38:1861-4. 2011
    ..The HBV-DNA was decreased under the titer of detection and no re-increase in HBV-DNA was found during chemotherapy. Planned chemotherapy was accomplished safely without HBV reactivation...
  92. doi request reprint A 27-year-old man who died of acute liver failure probably due to trichloroethylene abuse
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medical, Dentistry, and Pharmaceutical Sciences, Okayama, 700 8558, Japan
    J Gastroenterol 43:239-42. 2008
  93. doi request reprint Hepatic toxicity and prognosis in hepatitis C virus-infected patients with diffuse large B-cell lymphoma treated with rituximab-containing chemotherapy regimens: a Japanese multicenter analysis
    Daisuke Ennishi
    Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Blood 116:5119-25. 2010
    ..HCV-RNA levels significantly increased during immunochemotherapy (P = .006). These results suggest that careful monitoring of hepatic function and viral load is indicated during immunochemotherapy for HCV-positive patients...
  94. ncbi request reprint Contrast-enhanced ultrasonography depicts small tumor vessels for the evaluation of pancreatic tumors
    Yuko Okamoto
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Eur J Radiol 61:163-9. 2007
    ..The aim of this study is to evaluate the efficacy of contrast-enhanced ultrasonography for the diagnosis of pancreatic tumors...
  95. ncbi request reprint Effects of pulsing procedure of interleukin-12 in combination with interleukin-2 on the activation of peripheral blood lymphocytes derived from patients with hepatocellular carcinoma
    Tomoyuki Sawayama
    Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Acta Med Okayama 57:285-92. 2003
    ..These results indicate that adoptive immunotherapy based on PBL pulsed with a combination of IL-2 and IL-12 may be a promising adjunctive strategy for HCC treatment...
  96. pmc Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis B
    Haruhiko Kobashi
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Hepatol Int 3:403-10. 2009
    ..We observed two cases of genotypic ETVr with viral rebound and biochemical breakthrough during ETV treatment of nucleoside-naive patients with chronic hepatitis B (CHB)...