Hitoshi Sugiyama

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. ncbi request reprint Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice
    Hitoshi Sugiyama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Nephrol Dial Transplant 20:2670-80. 2005
  2. pmc Serum high-sensitivity cardiac troponin T is a significant biomarker of left-ventricular diastolic dysfunction in subjects with non-diabetic chronic kidney disease
    Masashi Kitagawa
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Nephron Extra 1:166-77. 2011
  3. doi request reprint Unique microstructures and podocytic infolding in glomerular basement membrane associated with collagen diseases: a report of three cases
    Hitoshi Sugiyama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Okayama, Japan
    Clin Exp Nephrol 12:450-4. 2008
  4. ncbi request reprint Catalase deficiency renders remnant kidneys more susceptible to oxidant tissue injury and renal fibrosis in mice
    Mizuho Kobayashi
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Kidney Int 68:1018-31. 2005
  5. doi request reprint Sensitization to alloxan-induced diabetes and pancreatic cell apoptosis in acatalasemic mice
    Yoko Kikumoto
    Department of Medicine and Clinical Science, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Biochim Biophys Acta 1802:240-6. 2010
  6. ncbi request reprint Antiangiogenic endostatin peptide ameliorates renal alterations in the early stage of a type 1 diabetic nephropathy model
    Kunihiro Ichinose
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Diabetes 54:2891-903. 2005
  7. ncbi request reprint Regulation of angiogenic factors in angiotensin II infusion model in association with tubulointerstitial injuries
    Hiroyuki Kitayama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Am J Hypertens 19:718-27. 2006
  8. pmc Icodextrin increases technique survival rate in peritoneal dialysis patients with diabetic nephropathy by improving body fluid management: a randomized controlled trial
    Yuji Takatori
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Clin J Am Soc Nephrol 6:1337-44. 2011
  9. ncbi request reprint Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction
    Reiko Sunami
    Okayama Univ Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Am J Physiol Renal Physiol 286:F1030-8. 2004
  10. doi request reprint Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis
    Daisuke Saito
    Dept of Medicine and Clinical Science, Okayama Univ Graduate School of Medicine and Dentistry, Okayama, 700 8558, Japan
    Am J Physiol Renal Physiol 300:F873-86. 2011

Detail Information

Publications66

  1. ncbi request reprint Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice
    Hitoshi Sugiyama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Nephrol Dial Transplant 20:2670-80. 2005
    ....
  2. pmc Serum high-sensitivity cardiac troponin T is a significant biomarker of left-ventricular diastolic dysfunction in subjects with non-diabetic chronic kidney disease
    Masashi Kitagawa
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Nephron Extra 1:166-77. 2011
    ..Chronic kidney disease (CKD) is associated with left-ventricular (LV) diastolic dysfunction (LVDD) which progresses to diastolic heart failure. However, biomarkers predicting LVDD in patients with CKD are largely unknown...
  3. doi request reprint Unique microstructures and podocytic infolding in glomerular basement membrane associated with collagen diseases: a report of three cases
    Hitoshi Sugiyama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Okayama, Japan
    Clin Exp Nephrol 12:450-4. 2008
    ..The response to glucocorticoid therapy was favorable in two cases. The cause of these morphological changes in the GBM might be associated with autoimmune disorders...
  4. ncbi request reprint Catalase deficiency renders remnant kidneys more susceptible to oxidant tissue injury and renal fibrosis in mice
    Mizuho Kobayashi
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Kidney Int 68:1018-31. 2005
    ..Catalase is one of the important antioxidant enzymes regulating the levels of intracellular hydrogen peroxide and hydroxyl radical. The effect of catalase deficiency on progressive renal fibrosis has not been fully elucidated...
  5. doi request reprint Sensitization to alloxan-induced diabetes and pancreatic cell apoptosis in acatalasemic mice
    Yoko Kikumoto
    Department of Medicine and Clinical Science, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Biochim Biophys Acta 1802:240-6. 2010
    ..Treatment with telmisartan may prevent the onset of alloxan-induced diabetes even under acatalasemic conditions...
  6. ncbi request reprint Antiangiogenic endostatin peptide ameliorates renal alterations in the early stage of a type 1 diabetic nephropathy model
    Kunihiro Ichinose
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Diabetes 54:2891-903. 2005
    ..These results demonstrate the potential use of antiangiogenic endostatin peptide as a novel therapeutic agent in diabetic nephropathy...
  7. ncbi request reprint Regulation of angiogenic factors in angiotensin II infusion model in association with tubulointerstitial injuries
    Hiroyuki Kitayama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Am J Hypertens 19:718-27. 2006
    ..In the present study we investigated the renal expression of VEGF, Ang1, Ang2, and corresponding receptors in association with tubulointerstitial lesions in a rat ang II infusion model...
  8. pmc Icodextrin increases technique survival rate in peritoneal dialysis patients with diabetic nephropathy by improving body fluid management: a randomized controlled trial
    Yuji Takatori
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Clin J Am Soc Nephrol 6:1337-44. 2011
    ..However, there are no randomized controlled and long-term clinical trials in newly started PD patients with diabetic nephropathy...
  9. ncbi request reprint Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction
    Reiko Sunami
    Okayama Univ Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Am J Physiol Renal Physiol 286:F1030-8. 2004
    ..This study demonstrates that catalase deficiency enhanced tubulointerstitial injury and fibrosis in a murine model of UUO and thus supports the protective role of catalase in this model...
  10. doi request reprint Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis
    Daisuke Saito
    Dept of Medicine and Clinical Science, Okayama Univ Graduate School of Medicine and Dentistry, Okayama, 700 8558, Japan
    Am J Physiol Renal Physiol 300:F873-86. 2011
    ....
  11. doi request reprint Differential expression of glycogenes in tonsillar B lymphocytes in association with proteinuria and renal dysfunction in IgA nephropathy
    Tatsuyuki Inoue
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Clin Immunol 136:447-55. 2010
    ..These data suggest the downregulation of beta3GalT in tonsillar B lymphocytes to be closely associated with the clinical characteristics of IgAN...
  12. doi request reprint Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010
    Hitoshi Sugiyama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Clin Exp Nephrol 17:155-73. 2013
    ..3 %) and minor glomerular abnormalities (50.0 %) were the most common in 2010 in native kidneys in the J-RBR. Five new secondary and longitudinal research studies by the J-KDR were started in 2009 and one was started in 2010...
  13. pmc Acatalasemic mice are mildly susceptible to adriamycin nephropathy and exhibit increased albuminuria and glomerulosclerosis
    Keiichi Takiue
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Kita ku, Okayama 700 8558, Japan
    BMC Nephrol 13:14. 2012
    ..A functional catalase deficiency was hypothesized to exacerbate albuminuria and the progression of glomerulosclerosis in this model...
  14. ncbi request reprint Enhanced TGF-beta/Smad signaling in the early stage of diabetic nephropathy is independent of the AT1a receptor
    Yuko Okazaki
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Clin Exp Nephrol 11:77-87. 2007
    ..The aim of this study was to clarify the role of AII in the regulation of the TGF-beta system in the early stage of DN using AII type1a receptor-deficient(AT1a(-/-)) mice...
  15. pmc Vasohibin-1, a negative feedback regulator of angiogenesis, ameliorates renal alterations in a mouse model of diabetic nephropathy
    Tatsuyo Nasu
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Diabetes 58:2365-75. 2009
    ..Vasohibin-1 (VASH-1) is a unique endogenous angiogenesis inhibitor that is induced in endothelial cells by proangiogenic factors. We investigated the therapeutic efficacy of VASH-1 in an early diabetic nephropathy model...
  16. ncbi request reprint 2-(8-hydroxy-6-methoxy-1-oxo-1h-2-benzopyran-3-yl) propionic acid, an inhibitor of angiogenesis, ameliorates renal alterations in obese type 2 diabetic mice
    Kunihiro Ichinose
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Diabetes 55:1232-42. 2006
    ..Taken together, these results demonstrate the potential use of NM-3 as a novel therapeutic agent for renal alterations in type 2 diabetes...
  17. ncbi request reprint Elevated serum sFlt-1/Ang-2 ratio in women with preeclampsia
    Kumiko Hirokoshi
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Nephron Clin Pract 106:c43-50. 2007
    ....
  18. pmc Effluent free radicals are associated with residual renal function and predict technique failure in peritoneal dialysis patients
    Hiroshi Morinaga
    Department of Medicine and Clinical Science, Center for Chronic Kidney Disease and Peritoneal Dialysis, Okayama University Graduate School of Medicine, Okayama, Japan
    Perit Dial Int 32:453-61. 2012
    ..Residual renal function (RRF) is associated with low oxidative stress in peritoneal dialysis (PD). In the present study, we investigated the relationship between the impact of oxidative stress on RRF and patient outcomes during PD...
  19. doi request reprint Increased susceptibility to oxidant-mediated tissue injury and peritoneal fibrosis in acatalasemic mice
    Naomi Fukuoka
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Okayama, Japan
    Am J Nephrol 28:661-8. 2008
    ..Peritoneal fibrosis is a major complication leading to the loss of peritoneal function in patients undergoing peritoneal dialysis. However, the effect of catalase depletion on peritoneal fibrosis has not yet been investigated...
  20. doi request reprint Abnormalities of glycogenes in tonsillar lymphocytes in IgA nephropathy
    Tatsuyuki Inoue
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, and Department of Otolaryngology, National Hospital Organization Minami Okayama Medical Center, Okayama, Japan
    Adv Otorhinolaryngol 72:71-4. 2011
    ..These data suggest the downregulation of β3GalT in tonsillar B lymphocytes to be closely associated with the clinical characteristics of IgAN...
  21. pmc Suppression of adiponectin by aberrantly glycosylated IgA1 in glomerular mesangial cells in vitro and in vivo
    Tatsuyuki Inoue
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    PLoS ONE 7:e33965. 2012
    ....
  22. doi request reprint Development of angiotensin II-induced abdominal aortic aneurysms is independent of catalase in mice
    Haruhito A Uchida
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Cardiovasc Pharmacol 58:633-8. 2011
    ..22 ± 0.29 mm; wild, 1.21 ± 0.17 mm), or aortic deposition of lipid peroxidation products such as 4-hydroxy-2-nonenal. The development of AngII-induced AAAs is independent of catalase...
  23. doi request reprint Effects of icodextrin peritoneal dialysis solution on the peritoneal membrane in the STZ-induced diabetic rat model with partial nephrectomy
    Ai Nakao
    Department of Medicine and Clinical Science and 2Center for Chronic Kidney Disease and Peritoneal Dialysis, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Nephrol Dial Transplant 25:1479-88. 2010
    ..We examined the effect of glucose and icodextrin-based PDF on histological alterations of peritoneal membranes...
  24. ncbi request reprint Renal distribution of Vasohibin-1 in patients with chronic kidney disease
    Norikazu Hinamoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 68:219-33. 2014
    ..44, p=0.01) or medulla (r=0.63, p=0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2...
  25. pmc A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease
    Masashi Kitagawa
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    PLoS ONE 8:e56695. 2013
    ..However, it is unclear whether the serum Klotho levels are associated with signs of vascular dysfunction such as arterial stiffness, a major determinant of prognosis, in human subjects with chronic kidney disease (CKD)...
  26. doi request reprint A case of immunotactoid glomerulopathy exhibiting nephrotic syndrome successfully treated with corticosteroids and antihypertensive therapy
    Masaru Kinomura
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Clin Exp Nephrol 13:378-84. 2009
    ..This case demonstrates that accurate diagnosis of ITG may result in successful therapeutic outcome...
  27. ncbi request reprint Amelioration of cisplatin-induced acute renal injury by renal progenitor-like cells derived from the adult rat kidney
    Masaru Kinomura
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Cell Transplant 17:143-58. 2008
    ..These results suggest the therapeutic potential of this novel approach for patients with end-stage renal failure...
  28. ncbi request reprint Establishment and characterization of renal progenitor like cells from S3 segment of nephron in rat adult kidney
    Shinji Kitamura
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    FASEB J 19:1789-97. 2005
    ..These results suggest rKS56 cells possess character such as self-renewal, multi-plasticity and capability of tissue repair. rKS56 may possibly contribute to the future development of cell therapy for renal regeneration...
  29. ncbi request reprint Infusion of angiotensin II reduces loss of glomerular capillary area in the early phase of anti-Thy-1.1 nephritis possibly via regulating angiogenesis-associated factors
    Yuki Takazawa
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Kidney Int 68:704-22. 2005
    ....
  30. pmc Vasohibin-1 deficiency enhances renal fibrosis and inflammation after unilateral ureteral obstruction
    Hiroyuki Watatani
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700 8558, Japan
    Physiol Rep 2:. 2014
    ....
  31. pmc Urinary and plasma levels of vasohibin-1 can predict renal functional deterioration in patients with renal disorders
    Norikazu Hinamoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    PLoS ONE 9:e96932. 2014
    ....
  32. ncbi request reprint Mesangial cell Fas ligand: upregulation in human lupus nephritis and NF-kappaB-mediated expression in cultured human mesangial cells
    Tomoko Tsukinoki
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Clin Exp Nephrol 8:196-205. 2004
    ..Fas ligand (FasL) is a well-known death factor; however, the role of FasL in the regulation of human glomerulonephritis remains unclear...
  33. pmc Exacerbation of diabetic renal alterations in mice lacking vasohibin-1
    Norikazu Hinamoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    PLoS ONE 9:e107934. 2014
    ....
  34. ncbi request reprint ONO-1301, a sustained-release prostacyclin analog, ameliorates the renal alterations in a mouse type 2 diabetes model possibly through its protective effects on mesangial cells
    Hiroyuki Watatani
    Departments of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 69:1-15. 2015
    ..Taken together, these results suggest the potential therapeutic efficacy of the intermittent administration of SR-ONO against type 2 diabetic nephropathy, possibly through protective effects on mesangial cells. ..
  35. doi request reprint Clinical usefulness of a prognostic score in histological analysis of renal biopsy in patients with lupus nephritis
    Shoichiro Kojo
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama City, Okayama, 700 8558, Japan
    J Rheumatol 36:2218-23. 2009
    ..To evaluate active and chronic lesions in association with renal outcome according to the International Society of Nephrology/Renal Pathology Society classification in patients with lupus nephritis...
  36. ncbi request reprint Steroid pulse therapy impaired endothelial function while increasing plasma high molecule adiponectin concentration in patients with IgA nephropathy
    Haruhito Adam Uchida
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Nephrol Dial Transplant 21:3475-80. 2006
    ..Glucocorticoid (GC) affects vascular endothelial cells either favourably or harmfully depending upon the dosages and duration. We examined the effect of GC pulse therapy on vascular endothelial function...
  37. doi request reprint Sustained-release prostacyclin analog ONO-1301 ameliorates tubulointerstitial alterations in a mouse obstructive nephropathy model
    Tatsuyo Nasu
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Am J Physiol Renal Physiol 302:F1616-29. 2012
    ..Taken together, our findings suggest the potential therapeutic efficacies of ONO-1301 in suppressing tubulointerstitial alterations partly mediated via inducing HGF, an antifibrotic factor counteracting TGF-β...
  38. ncbi request reprint Altered levels of adipocytokines in association with insulin resistance in patients with systemic lupus erythematosus
    Ken Ei Sada
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Rheumatol 33:1545-52. 2006
    ..We evaluated IR in association with plasma concentrations of adipocytokines in patients with SLE...
  39. ncbi request reprint Overexpression of angiotensin type 2 receptor ameliorates glomerular injury in a mouse remnant kidney model
    Naoko Hashimoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Am J Physiol Renal Physiol 286:F516-25. 2004
    ..Taken together, our findings suggest that AT(2)R-mediated signaling may protect from glomerular injuries induced by (5/6)Nx and that overexpression of AT(2)R may serve as a potential therapeutic strategy for glomerular disorders...
  40. ncbi request reprint Increase of serum angiopoietin-2 during pregnancy is suppressed in women with preeclampsia
    Kumiko Hirokoshi
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Am J Hypertens 18:1181-8. 2005
    ....
  41. ncbi request reprint Tumstatin peptide, an inhibitor of angiogenesis, prevents glomerular hypertrophy in the early stage of diabetic nephropathy
    Yoshihiko Yamamoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Diabetes 53:1831-40. 2004
    ..Taken together, these results demonstrate the potential use of antiangiogenic tumstatin peptide as a novel therapeutic agent in early diabetic nephropathy...
  42. doi request reprint The urinary levels of prostanoid metabolites predict acute kidney injury in heterogeneous adult Japanese ICU patients: a prospective observational study
    Haruyo Ujike-Omori
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    Clin Exp Nephrol 19:1024-36. 2015
    ..Prostanoids regulate numerous biological functions, including hemodynamics and renal tubular transport. We herein investigated the ability of urinary prostanoid metabolites to predict the onset of AKI in critically ill adult patients...
  43. ncbi request reprint Downregulation of the beta1,3- galactosyltransferase gene in tonsillar B lymphocytes and aberrant lectin bindings to tonsillar IgA as a pathogenesis of IgA nephropathy
    Tatsuyuki Inoue
    Departmentsof Medicine and Clinical Science Okayama University Graduate School of Medicine, Okayama, Japan
    Contrib Nephrol 157:120-4. 2007
    ..Since O-glycans in IgA are produced by glycosyltransferases, we hypothesized that dysregulation of the enzymes is associated with underglycosylation...
  44. pmc The therapeutic potential of synthetic human atrial natriuretic peptide in nephrotic syndrome: a randomized controlled trial
    Motoko Kanzaki
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Int J Nephrol Renovasc Dis 5:91-6. 2012
    ..The efficacy of synthetic human atrial natriuretic peptide (hANP) for nephrotic syndrome to ameliorate the systemic edema and retain renal functions has not been fully demonstrated...
  45. doi request reprint C-reactive protein is associated with cigarette smoking-induced hyperfiltration and proteinuria in an apparently healthy population
    Rani Sauriasari
    Department of Public Health, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hypertens Res 33:1129-36. 2010
    ..This finding suggests that hs-CRP may help mediate the alteration of renal function in smokers...
  46. ncbi request reprint A novel variant apolipoprotein E Okayama in a patient with lipoprotein glomerulopathy
    Masaru Kinomura
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Nephrol Dial Transplant 23:751-6. 2008
  47. ncbi request reprint Glomerular cell apoptosis in human lupus nephritis
    Hirofumi Makino
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, 700 8558 Okayama, Japan
    Virchows Arch 443:67-77. 2003
    ..These data suggest that apoptosis is increased, but not decreased in glomeruli from patients with lupus nephritis. The signals that could induce glomerular cell apoptosis in lupus nephritis will need to be identified...
  48. pmc A case of focal segmental glomerulosclerosis in an adult patient with hypogammaglobulinemia superimposed on membranoproliferative glomerulonephritis in childhood
    Kenji Tsuji
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    BMC Nephrol 13:46. 2012
    ..Common variable immunodeficiency (CVID) is a disorder characterized by hypogammaglobulinemia without a known predisposing cause...
  49. ncbi request reprint [Infection and chronic kidney disease]
    Shigeru Akagi
    Center for Chronic Kidney Disease and Peritoneal Dialysis, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    Nihon Rinsho 66:1794-8. 2008
    ..Thorough preventive/therapeutic strategies should be taken against these infections for improving clinical outcome...
  50. ncbi request reprint Transforming growth factor-beta 1 induces vascular endothelial growth factor expression in murine proximal tubular epithelial cells
    Shinji Kitamura
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Nephron Exp Nephrol 95:e79-86. 2003
    ..This regulatory mechanism may be associated with the progression of tubulointerstitial lesions in renal disorders...
  51. doi request reprint Japan Renal Biopsy Registry: the first nationwide, web-based, and prospective registry system of renal biopsies in Japan
    Hitoshi Sugiyama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Clin Exp Nephrol 15:493-503. 2011
    ....
  52. pmc The possible involvement of intestine-derived IgA1: a case of IgA nephropathy associated with Crohn's disease
    Tomohiro Terasaka
    Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    BMC Nephrol 17:122. 2016
    ..Intestinal mucosal plasma cells mainly secrete IgA2. Nevertheless, IgA1 deposition is strongly implicated as being the primary cause of IgA nephropathy...
  53. ncbi request reprint A paraganglioma in a hypertensive patient with unilateral renal hypoplasia
    Tomohiro Terasaka
    Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama
    Acta Med Okayama 69:119-22. 2015
    ....
  54. pmc The selection of peritoneal mesothelial cells is important for cell therapy to prevent peritoneal fibrosis
    Shinji Kitamura
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Tissue Eng Part A 20:529-39. 2014
    ..Furthermore, the differences in the morphological cell characteristics may influence their role in peritoneal regeneration. ..
  55. ncbi request reprint Fabry disease exhibiting recurrent stroke and persistent inflammation
    Yoko Kikumoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
    Intern Med 49:2247-52. 2010
    ..These cases suggest that Fabry disease should be considered in young patients with cryptogenic stroke or CNS manifestations and fever of unknown origin...
  56. doi request reprint Peritoneovenous shunting for refractory ascites results in worsening of nephrotic syndrome
    Akinobu Takaki
    Departments of Gastroenterology and Hepatology Medicine and Clinical Science Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Department of Internal Medicine, National Hospital Organization Minami Okayama, Okayama, Japan
    Hepatol Res 42:1048-53. 2012
    ..3-0.5 g/day and ammonia levels decreased. PVS may increase the excretion of urinary protein and increase ammonia levels in patients with complications of glomerulonephritis...
  57. doi request reprint Clinical and histological features of lupus nephritis in Japan: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR)
    Keiju Hiromura
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Nephrology (Carlton) . 2016
    ..The Japan Renal Biopsy Registry (J-RBR) is a nationwide registry of renal biopsies. Here, we report a cross-sectional analysis of Japanese LN using the J-RBR database...
  58. ncbi request reprint Long-term observation of osteomalacia caused by adefovir-induced Fanconi's syndrome
    Tomohiro Terasaka
    Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 68:53-6. 2014
    ..Early diagnosis is important for the reversibility of bone damage and for a better renal prognosis. ..
  59. ncbi request reprint Pathogenesis of IgA nephropathy
    Jun Wada
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Semin Nephrol 23:556-63. 2003
    ....
  60. ncbi request reprint Cyanotic congenital heart disease associated with glomerulomegaly and focal segmental glomerulosclerosis: remission of nephrotic syndrome with angiotensin converting enzyme inhibitor
    Kazuyuki Hida
    Department of Medicine III, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Nephrol Dial Transplant 17:144-7. 2002
  61. ncbi request reprint [Severe sleep apnea as a cause of hypertension]
    Hisanao Norii
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama
    Nihon Naika Gakkai Zasshi 93:2204-6. 2004
  62. ncbi request reprint An elderly patient with severe acute renal failure due to sodium bromate intoxication
    Haruhito A Uchida
    Department of Nephrology and Dialysis, Kure Kyosai Hospital, Okayama
    Intern Med 45:151-4. 2006
    ..To the best of our knowledge this is the first report of an elderly patient that demonstrates the clinical benefit of hemodialysis therapy for bromate intoxication...
  63. ncbi request reprint Characterization of acatalasemic erythrocytes treated with low and high dose hydrogen peroxide. Hemolysis and aggregation
    Noriyoshi Masuoka
    Department of Life Science, Okayama University of Science, 700 0005, Japan
    J Biol Chem 281:21728-34. 2006
    ..These species induce hemolysis of erythrocytes, polymerization of hemoglobin, and aggregation of the acatalasemic erythrocytes. A mechanism for the onset of Takarara disease is proposed...
  64. ncbi request reprint [Chronic kidney diseases: its concept]
    Hitoshi Sugiyama
    Nihon Naika Gakkai Zasshi 96:864-8. 2007
  65. ncbi request reprint Successful treatment of progressive Henoch-Schönlein purpura nephritis with tonsillectomy and steroid pulse therapy
    Hitoshi Sugiyama
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry
    Intern Med 44:611-5. 2005
    ..The combination therapy resulted in a significant decrease in proteinuria, improvement of renal function and the disappearance of microhematuria. The patient finally reached a stage of clinical remission...
  66. ncbi request reprint Implication of apoptosis in progression of renal diseases
    Naoki Kashihara
    Division of Nephrology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan
    Contrib Nephrol 139:156-72. 2003