Haruhiko Kobashi

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. doi request reprint Efficacy and safety of entecavir in nucleoside-naive, chronic hepatitis B patients: phase II clinical study in Japan
    Haruhiko Kobashi
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 24:255-61. 2009
  2. pmc Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis B
    Haruhiko Kobashi
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Hepatol Int 3:403-10. 2009
  3. doi request reprint Laparoscopic findings of reddish markings predict hepatocellular carcinoma in patients with hepatitis B virus-related liver disease
    Bon Shoji
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata cho, Okayama, Japan
    J Gastroenterol 45:1172-82. 2010
  4. doi request reprint Prevalence and associated factors with esophageal varices in early primary biliary cirrhosis
    Fusao Ikeda
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 27:1320-8. 2012
  5. ncbi request reprint Lamivudine treatment improves the prognosis of fulminant hepatitis B
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
    Intern Med 47:1293-9. 2008
  6. doi request reprint Hepatitis B e antigen predicts delayed reduction of HBV DNA without viral breakthrough with adefovir dipivoxil and lamivudine: a 5-year study of patients with hepatitis B with lamivudine resistance
    Fusao Ikeda
    Dentistry and Pharmaceutical Sciences, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Okayama, Japan
    J Med Virol 84:1562-70. 2012
  7. doi request reprint Factors associated with adherence to combination therapy of interferon and ribavirin for patients with chronic hepatitis C: importance of patient's motivation and physician's treatment experience
    Daisuke Tanioka
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Liver Int 29:721-9. 2009
  8. ncbi request reprint A prospective and comparative cohort study on efficacy and drug resistance during long-term lamivudine treatment for various stages of chronic hepatitis B and cirrhosis
    Tomohiro Nishida
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 23:794-803. 2008
  9. doi request reprint Mortality rate of patients with asymptomatic primary biliary cirrhosis diagnosed at age 55 years or older is similar to that of the general population
    Junichi Kubota
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1, Shikata cho, Okayama, 700 8558, Japan
    J Gastroenterol 44:1000-6. 2009
  10. doi request reprint Long-term use of entecavir in nucleoside-naïve Japanese patients with chronic hepatitis B infection
    Osamu Yokosuka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    J Hepatol 52:791-9. 2010

Collaborators

Detail Information

Publications45

  1. doi request reprint Efficacy and safety of entecavir in nucleoside-naive, chronic hepatitis B patients: phase II clinical study in Japan
    Haruhiko Kobashi
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 24:255-61. 2009
    ..Entecavir has demonstrated clinical efficacy for chronic hepatitis B. This study evaluated the efficacy and safety of entecavir in nucleoside-naive Japanese chronic hepatitis B patients...
  2. pmc Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis B
    Haruhiko Kobashi
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Hepatol Int 3:403-10. 2009
    ..We observed two cases of genotypic ETVr with viral rebound and biochemical breakthrough during ETV treatment of nucleoside-naive patients with chronic hepatitis B (CHB)...
  3. doi request reprint Laparoscopic findings of reddish markings predict hepatocellular carcinoma in patients with hepatitis B virus-related liver disease
    Bon Shoji
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata cho, Okayama, Japan
    J Gastroenterol 45:1172-82. 2010
    ..The purpose of this study was to clarify factors predictive of HCC development for those patients...
  4. doi request reprint Prevalence and associated factors with esophageal varices in early primary biliary cirrhosis
    Fusao Ikeda
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 27:1320-8. 2012
    ..Recent routine testing for anti-mitochondrial antibodies has increased the number of patients with early primary biliary cirrhosis (PBC). The prevalence and clinical significance of esophageal varices in those patients remains obscure...
  5. ncbi request reprint Lamivudine treatment improves the prognosis of fulminant hepatitis B
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
    Intern Med 47:1293-9. 2008
    ..The aim of this study was to clarify the prognostic factors and the efficacy of lamivudine for fulminant hepatitis B in Japan, where the main infection genotype is B...
  6. doi request reprint Hepatitis B e antigen predicts delayed reduction of HBV DNA without viral breakthrough with adefovir dipivoxil and lamivudine: a 5-year study of patients with hepatitis B with lamivudine resistance
    Fusao Ikeda
    Dentistry and Pharmaceutical Sciences, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Okayama, Japan
    J Med Virol 84:1562-70. 2012
    ..HBe antigen levels at the initiation of therapy, and reductions in these levels during therapy are predictive of the therapeutic response to combination therapy with ADV and LAM for patients with LAM-resistant HBV...
  7. doi request reprint Factors associated with adherence to combination therapy of interferon and ribavirin for patients with chronic hepatitis C: importance of patient's motivation and physician's treatment experience
    Daisuke Tanioka
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Liver Int 29:721-9. 2009
    ..In this prospective study, we analysed the factors that might have an effect on adherence to therapy in patients who had initial or retreatment IFN therapy...
  8. ncbi request reprint A prospective and comparative cohort study on efficacy and drug resistance during long-term lamivudine treatment for various stages of chronic hepatitis B and cirrhosis
    Tomohiro Nishida
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 23:794-803. 2008
    ....
  9. doi request reprint Mortality rate of patients with asymptomatic primary biliary cirrhosis diagnosed at age 55 years or older is similar to that of the general population
    Junichi Kubota
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1, Shikata cho, Okayama, 700 8558, Japan
    J Gastroenterol 44:1000-6. 2009
    ..This study investigated the prognosis of asymptomatic PBC patients, focusing on age difference, to clarify its effect on the prognosis of PBC patients...
  10. doi request reprint Long-term use of entecavir in nucleoside-naïve Japanese patients with chronic hepatitis B infection
    Osamu Yokosuka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    J Hepatol 52:791-9. 2010
    ..To evaluate the long-term efficacy of entecavir in nucleoside-naïve chronic hepatitis B patients...
  11. ncbi request reprint Clinical features of Japanese elderly patients with type 1 autoimmune hepatitis
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
    Intern Med 46:1945-9. 2007
    ..In this study, we assessed the clinical features of Japanese elderly patients with type 1 autoimmune hepatitis...
  12. pmc Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients
    Masashi Tatsukawa
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
    BMC Cancer 11:458. 2011
    ..Hepatitis B virus (HBV) is a major cause of hepatocarcinogenesis.To identify mutations relevant to hepatocellular carcinoma (HCC) development, we compared the full genome sequences of HBV from the sera of patients with and without HCC...
  13. ncbi request reprint Prognostic factors for fatal outcomes prior to receiving liver transplantation in patients with non-acetaminophen-related fulminant hepatic failure
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 22:855-61. 2007
    ..Many patients continue to die due to the rapid development of cerebral edema and/or multiple organ failure prior to receiving a liver transplantation...
  14. ncbi request reprint A homosexual Japanese man with acute hepatitis due to hepatitis B virus genotype ae, concurrent with amebic colitis
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 61:35-9. 2007
    ..Furthermore, education of homosexual men regarding hepatitis B virus, hepatitis B virus vaccination, and amebiasis is urgently required...
  15. doi request reprint Serum levels of platelet-derived growth factor-BB and vascular endothelial growth factor as prognostic factors for patients with fulminant hepatic failure
    Hiroki Takayama
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 26:116-21. 2011
    ..The aim of the present study was to assess the role of angiogenic factors in fulminant hepatic failure (FHF)...
  16. doi request reprint Additive improvement induced by bezafibrate in patients with primary biliary cirrhosis showing refractory response to ursodeoxycholic acid
    Yasuto Takeuchi
    Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama, Japan
    J Gastroenterol Hepatol 26:1395-401. 2011
    ..However, some patients are refractory to UDCA. The aim of this study is to clarify the additive improvement induced by bezafibrate in patients refractory to UDCA...
  17. doi request reprint Prognostic importance of fucosylated alpha-fetoprotein in hepatocellular carcinoma patients with low alpha-fetoprotein
    Kazuhiro Nouso
    Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 26:1195-200. 2011
    ..However, it has been difficult to measure AFP-L3 under low AFP (≤ 20 ng/mL). The aim of this study was to elucidate the role of AFP-L3 in HCC patients with low AFP conditions...
  18. doi request reprint Clinical features of autoimmune hepatitis diagnosed based on simplified criteria of the International Autoimmune Hepatitis Group
    Yasuhiro Miyake
    Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Dig Liver Dis 42:210-5. 2010
    ..Recently, simplified diagnostic criteria for autoimmune hepatitis have been proposed...
  19. ncbi request reprint Clinical features of antinuclear antibodies-negative type 1 autoimmune hepatitis
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 39:241-6. 2009
    ..Regarding the diagnosis of ANA-negative AIH, the determination of ANA during follow-up and the response to immunosuppressive treatment may be helpful...
  20. ncbi request reprint Limitation of combination therapy of interferon and ribavirin for older patients with chronic hepatitis C
    Yoshiaki Iwasaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Hepatology 43:54-63. 2006
    ..Thus, treatment schedule should be modified, or other therapeutic modalities should be considered for older patients with chronic hepatitis C...
  21. ncbi request reprint Early detection and quantification of lamivudine-resistant hepatitis B virus mutants by fluorescent biprobe hybridization assay in lamivudine-treated patients
    Fumi Umeoka
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    J Gastroenterol 41:693-701. 2006
    ..The objective of this study was to develop a fluorescent biprobe hybridization (FBH) assay for the detection and quantification of HBV mutants in the clinical course of lamivudine-treated patients and to evaluate its clinical usefulness...
  22. ncbi request reprint Human leukocyte antigen DR status and clinical features in Japanese patients with type 1 autoimmune hepatitis
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 38:96-102. 2008
    ..Japanese patients with DR2 may have different clinical features from others. In addition, diagnoses of type 1 autoimmune hepatitis should be made carefully in Japanese patients with neither DR2 nor DR4 and in those aged <30 years...
  23. doi request reprint Meta-analysis: the effect of interferon on development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection
    Yasuhiro Miyake
    Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol 44:470-5. 2009
    ..However, discussion about the effect of interferon on the development of hepatocellular carcinoma (HCC) has been controversial...
  24. ncbi request reprint Clinical features of Japanese type 1 autoimmune hepatitis patients with zone III necrosis
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 37:801-5. 2007
    ..Furthermore, patients with zone III necrosis may respond better to corticosteroid treatment than those without...
  25. ncbi request reprint Entecavir Reduces Hepatocarcinogenesis in Chronic Hepatitis B Patients
    Tetsuya Yasunaka
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 70:1-12. 2016
    ..05). Only small numbers of HCCs occurred in other patients. In CHB patients aged > 35 years with HBV DNA > 4 log copies/mL and positive HBeAg, ETV treatment is recommended for the suppression of HCC development. ..
  26. doi request reprint Randomized trial of peginterferon alpha-2b plus low and escalating dose of ribavirin in patients with chronic hepatitis C with high viral load genotype 1
    Yoshiaki Iwasaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan Health Service Center, Okayama University, Okayama, Japan
    J Med Virol 87:625-33. 2015
    ..24%, P = 0.005). These data suggest that combination therapy with low and escalating dosing of ribavirin may be safer in elderly patients than that with standard dosing of ribavirin without impairing the treatment response...
  27. ncbi request reprint New prognostic scoring model for liver transplantation in patients with non-acetaminophen-related fulminant hepatic failure
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Transplantation 80:930-6. 2005
    ....
  28. doi request reprint Efficacy and cost-effectiveness of consensus interferon monotherapy with high-dose induction for hepatitis C patients with genotype 2
    Yoshiaki Iwasaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Scand J Gastroenterol 46:79-90. 2011
    ..We conducted a study to evaluate the efficacy, safety, and cost-effectiveness of consensus IFN monotherapy with high-dose induction for patients with chronic hepatitis C in clinical practice...
  29. ncbi request reprint Acute hepatitis due to hepatitis E virus genotype 1 as an imported infectious disease in Japan
    Koji Miyahara
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
    Intern Med 49:2613-6. 2010
    ..Thereafter, attention should be paid to HEV genotype 1 infection as an imported infectious disease...
  30. ncbi request reprint Lamivudine treatment in patients with HBV-related hepatocellular carcinoma--using an untreated, matched control cohort
    Cheng Yu Piao
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 59:217-24. 2005
    ..These results suggest that lamivudine treatment for patients with HCC may prevent death due to liver failure. Further prospective randomized studies using a larger number of patients are required...
  31. doi request reprint Hepatocellular carcinoma occurring in hepatobiliary fibropolycystic disease
    Hideaki Kinugasa
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 41:277-81. 2011
    ..HCC was suspected from these findings. She also suffered from multiple small cystic lesions in the liver. The surgically removed liver showed HCC arising in CHF, which is a rare histological finding...
  32. ncbi request reprint Clinical features of type 1 autoimmune hepatitis in adolescence and early adulthood
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 39:766-71. 2009
    ..However, they may frequently show atypical features, and the diagnosis of type 1 AIH in adolescence and early adulthood may be difficult and should be made carefully...
  33. doi request reprint Long-term outcome and hepatocellular carcinoma development in chronic hepatitis B or cirrhosis patients after nucleoside analog treatment with entecavir or lamivudine
    Haruhiko Kobashi
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Department of Clinical Research, Center for Liver Disease, Kawasaki Hospital, Kawasaki Medical School, Kawasaki Department of Internal Medicine, Tsuyama Central Hospital, Tsuyama, Japan
    Hepatol Res 41:405-16. 2011
    ..Conclusion:  NA exerted a long-term efficacy and improved hepatic reservation in CHB and cirrhosis. After NA treatment, AFP dropped to lower than 10 ng/mL with marked elevation of specificity, leading to an earlier detection of HCC...
  34. doi request reprint Diagnostic usefulness of precise examinations with intraductal ultrasonography, peroral cholangioscopy and laparoscopy of immunoglobulin G4-related sclerosing cholangitis
    Shigeru Horiguchi
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Dig Endosc 24:370-3. 2012
    ..In this case, biliary cancer was ruled out by observation with peroral cholangioscopy, and the spread of cholangitis in the liver periphery was verified with laparoscopy; this information could not be obtained with other modalities...
  35. ncbi request reprint A model for estimating cirrhosis in patients with type 1 autoimmune hepatitis
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 38:658-63. 2008
    ..Conclusion: It is suggested that this model could be useful for the estimation of cirrhosis in patients with type 1 autoimmune hepatitis...
  36. ncbi request reprint Persistent normalization of serum alanine aminotransferase levels improves the prognosis of type 1 autoimmune hepatitis
    Yasuhiro Miyake
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1, Shikata cho, Okayama 700 8558, Japan
    J Hepatol 43:951-7. 2005
    ..The present study was conducted in order to analyze the factors contributing to the outcomes of patients with type 1 autoimmune hepatitis...
  37. ncbi request reprint Prognostic model for hepatocellular carcinoma with time-dependent factors
    Kenji Kuwaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 65:11-9. 2011
    ..741, 0.727, 0.609, and 0.870, respectively. These results indicate that our time-dependent model can estimate the prognosis of HCC more precisely than traditional time-fixed models and can be used to re-predict the prognosis of HCC...
  38. ncbi request reprint Prevalence and outcomes of acute hepatitis B in Okayama, Japan, 2006-2010
    Nozomu Wada
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 68:243-7. 2014
    ..005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A. ..
  39. ncbi request reprint Surveillance of hepatocellular carcinoma in patients with hepatitis C virus infection may improve patient survival
    Hironori Tanaka
    Department of Gastroenterology, Hepatology, and Infectious Disease, Okayama University School of Medicine, Okayama, Japan
    Liver Int 26:543-51. 2006
    ..The benefit of surveillance of hepatocellular carcinoma (HCC) for patients with hepatitis C virus (HCV) infection, in terms of long-term survival, has not yet been established...
  40. doi request reprint Peritoneovenous shunting for refractory ascites results in worsening of nephrotic syndrome
    Akinobu Takaki
    Departments of Gastroenterology and Hepatology Medicine and Clinical Science Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Department of Internal Medicine, National Hospital Organization Minami Okayama, Okayama, Japan
    Hepatol Res 42:1048-53. 2012
    ..3-0.5 g/day and ammonia levels decreased. PVS may increase the excretion of urinary protein and increase ammonia levels in patients with complications of glomerulonephritis...
  41. ncbi request reprint Gene expression profiling in biliary epithelial cells of primary biliary cirrhosis using laser capture microdissection and cDNA microarray
    Nobuyuki Baba
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Transl Res 148:103-13. 2006
    ..Furthermore, two-way cluster analysis showed that the gene expression profiling in BEC of PBC were categorized into a separate cluster, distinct from CHC or normal subjects...
  42. doi request reprint A 27-year-old man who died of acute liver failure probably due to trichloroethylene abuse
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medical, Dentistry, and Pharmaceutical Sciences, Okayama, 700 8558, Japan
    J Gastroenterol 43:239-42. 2008
  43. doi request reprint Sepsis-associated liver injury: Incidence, classification and the clinical significance
    Haruhiko Kobashi
    Department of Hepatology, Japanese Red Cross Okayama Hospital Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Hepatol Res 43:255-66. 2013
    ..6%) than in those without (45.5%) (P < 0.0001). Conclusion:  Sepsis-associated liver injury, especially with jaundice, is a significant predictive sign of poor prognosis in patients with sepsis...
  44. ncbi request reprint Risk factors for hepatocellular carcinoma in Hepatitis C patients with sustained virologic response to interferon therapy
    Yoshiaki Iwasaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Liver Int 24:603-10. 2004
    ..Although a variety of papers demonstrated inhibited hepatocarcinogenesis with interferon (IFN) therapy for chronic hepatitis C, a small number of hepatocellular carcinomas (HCCs) were still observed even in sustained virologic responders...
  45. doi request reprint Effect of vitamin K2 on the recurrence of hepatocellular carcinoma
    Haruhiko Yoshida
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, and Department of Gastroenterology and Hepatology, Kanto Central Hospital, Tokyo, Japan
    Hepatology 54:532-40. 2011
    ..150 (95% confidence interval: 0.843-1.570, one-sided; P=0.811) between the placebo and combined active-drug groups, and the study was discontinued in March 2007...